LOCUS       NM_022236               3394 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphodiesterase 10A (Pde10a), transcript
            variant 1, mRNA.
ACCESSION   NM_022236
VERSION     NM_022236.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3394)
  AUTHORS   Sukhanov,I., Dorotenko,A., Fesenko,Z., Savchenko,A., Efimova,E.V.,
            Mor,M.S., Belozertseva,I.V., Sotnikova,T.D. and Gainetdinov,R.R.
  TITLE     Inhibition of PDE10A in a New Rat Model of Severe Dopamine
            Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease
            Therapy
  JOURNAL   Biomolecules 13 (1), 9 (2022)
   PUBMED   36671394
  REMARK    GeneRIF: Inhibition of PDE10A in a New Rat Model of Severe Dopamine
            Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease
            Therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3394)
  AUTHORS   Song,H., Fang,S., Gao,J., Wang,J., Cao,Z., Guo,Z., Huang,Q., Qu,Y.,
            Zhou,H. and Yu,J.
  TITLE     Quantitative Proteomic Study Reveals Up-Regulation of cAMP
            Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury
  JOURNAL   J Proteome Res 17 (2), 858-869 (2018)
   PUBMED   29215295
  REMARK    GeneRIF: cAMP signaling pathway-related proteins, Pde10a and Gnal,
            may play important roles in the pathogenesis and recovery of mild
            traumatic brain injury.
REFERENCE   3  (bases 1 to 3394)
  AUTHORS   Diggle,C.P., Sukoff Rizzo,S.J., Popiolek,M., Hinttala,R.,
            Schulke,J.P., Kurian,M.A., Carr,I.M., Markham,A.F., Bonthron,D.T.,
            Watson,C., Sharif,S.M., Reinhart,V., James,L.C.,
            Vanase-Frawley,M.A., Charych,E., Allen,M., Harms,J., Schmidt,C.J.,
            Ng,J., Pysden,K., Strick,C., Vieira,P., Mankinen,K., Kokkonen,H.,
            Kallioinen,M., Sormunen,R., Rinne,J.O., Johansson,J., Alakurtti,K.,
            Huilaja,L., Hurskainen,T., Tasanen,K., Anttila,E., Marques,T.R.,
            Howes,O., Politis,M., Fahiminiya,S., Nguyen,K.Q., Majewski,J.,
            Uusimaa,J., Sheridan,E. and Brandon,N.J.
  TITLE     Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a
            Hyperkinetic Movement Disorder with Onset in Infancy
  JOURNAL   Am J Hum Genet 98 (4), 735-743 (2016)
   PUBMED   27058446
REFERENCE   4  (bases 1 to 3394)
  AUTHORS   Wilson,J.M., Ogden,A.M., Loomis,S., Gilmour,G., Baucum,A.J. 2nd,
            Belecky-Adams,T.L. and Merchant,K.M.
  TITLE     Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces
            greater induction of c-Fos in dopamine D2 neurons than in D1
            neurons in the neostriatum
  JOURNAL   Neuropharmacology 99, 379-386 (2015)
   PUBMED   26256420
  REMARK    GeneRIF: Through a combination of pharmacological and genetic
            tools, study provides convergent evidence of D2 (rather than D1)
            pathway dominant effects of PDE10A inhibition in rodents
REFERENCE   5  (bases 1 to 3394)
  AUTHORS   Yang,S.W., Smotryski,J., McElroy,W.T., Tan,Z., Ho,G., Tulshian,D.,
            Greenlee,W.J., Guzzi,M., Zhang,X., Mullins,D., Xiao,L., Hruza,A.,
            Chan,T.M., Rindgen,D., Bleickardt,C. and Hodgson,R.
  TITLE     Discovery of orally active pyrazoloquinolines as potent PDE10
            inhibitors for the management of schizophrenia
  JOURNAL   Bioorg Med Chem Lett 22 (1), 235-239 (2012)
   PUBMED   22142545
  REMARK    GeneRIF: analysis of orally active pyrazoloquinolines as potent
            PDE10 inhibitors for the management of schizophrenia in the rat
            model
REFERENCE   6  (bases 1 to 3394)
  AUTHORS   O'Connor,V., Genin,A., Davis,S., Karishma,K.K., Doyere,V., De
            Zeeuw,C.I., Sanger,G., Hunt,S.P., Richter-Levin,G., Mallet,J.,
            Laroche,S., Bliss,T.V. and French,P.J.
  TITLE     Differential amplification of intron-containing transcripts reveals
            long term potentiation-associated up-regulation of specific Pde10A
            phosphodiesterase splice variants
  JOURNAL   J Biol Chem 279 (16), 15841-15849 (2004)
   PUBMED   14752115
  REMARK    GeneRIF: a subset of Pde10A splice variants are up-regulated after
            long term potentiation induction
REFERENCE   7  (bases 1 to 3394)
  AUTHORS   Kotera,J., Sasaki,T., Kobayashi,T., Fujishige,K., Yamashita,Y. and
            Omori,K.
  TITLE     Subcellular localization of cyclic nucleotide phosphodiesterase
            type 10A variants, and alteration of the localization by
            cAMP-dependent protein kinase-dependent phosphorylation
  JOURNAL   J Biol Chem 279 (6), 4366-4375 (2004)
   PUBMED   14604994
  REMARK    GeneRIF: PDE10A proteins, especially PDE10A2, are more abundant in
            membrane fractions than in cytosolic fractions of striatum
REFERENCE   8  (bases 1 to 3394)
  AUTHORS   Seeger,T.F., Bartlett,B., Coskran,T.M., Culp,J.S., James,L.C.,
            Krull,D.L., Lanfear,J., Ryan,A.M., Schmidt,C.J., Strick,C.A.,
            Varghese,A.H., Williams,R.D., Wylie,P.G. and Menniti,F.S.
  TITLE     Immunohistochemical localization of PDE10A in the rat brain
  JOURNAL   Brain Res 985 (2), 113-126 (2003)
   PUBMED   12967715
  REMARK    GeneRIF: High levels of mRNA are observed in most of the neuronal
            cell bodies of striatal complex.PDE10A-like immunoreactivity is
            dense throughout the striatal neuropil, as well as in the internal
            capsule, globus pallidus, and substantia nigra.
REFERENCE   9  (bases 1 to 3394)
  AUTHORS   Fujishige,K., Kotera,J. and Omori,K.
  TITLE     Striatum- and testis-specific phosphodiesterase PDE10A isolation
            and characterization of a rat PDE10A
  JOURNAL   Eur J Biochem 266 (3), 1118-1127 (1999)
   PUBMED   10583409
REFERENCE   10 (bases 1 to 3394)
  AUTHORS   Soderling,S.H., Bayuga,S.J. and Beavo,J.A.
  TITLE     Isolation and characterization of a dual-substrate
            phosphodiesterase gene family: PDE10A
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 7071-7076 (1999)
   PUBMED   10359840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 25, 2020 this sequence version replaced NM_022236.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB027155.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               JAXUCZ010000001.1  54500873-54501206   c
            335-463             JAXUCZ010000001.1  54401779-54401907   c
            464-492             JAXUCZ010000001.1  54381896-54381924   c
            493-613             JAXUCZ010000001.1  54372942-54373062   c
            614-663             JAXUCZ010000001.1  54371553-54371602   c
            664-804             JAXUCZ010000001.1  54358731-54358871   c
            805-960             JAXUCZ010000001.1  54356988-54357143   c
            961-1011            JAXUCZ010000001.1  54355700-54355750   c
            1012-1070           JAXUCZ010000001.1  54355129-54355187   c
            1071-1122           JAXUCZ010000001.1  54353273-54353324   c
            1123-1265           JAXUCZ010000001.1  54350645-54350787   c
            1266-1358           JAXUCZ010000001.1  54348522-54348614   c
            1359-1545           JAXUCZ010000001.1  54346280-54346466   c
            1546-1688           JAXUCZ010000001.1  54338070-54338212   c
            1689-1772           JAXUCZ010000001.1  54337156-54337239   c
            1773-1923           JAXUCZ010000001.1  54334823-54334973   c
            1924-2079           JAXUCZ010000001.1  54331951-54332106   c
            2080-2252           JAXUCZ010000001.1  54329814-54329986   c
            2253-2364           JAXUCZ010000001.1  54324829-54324940   c
            2365-2445           JAXUCZ010000001.1  54322671-54322751   c
            2446-2534           JAXUCZ010000001.1  54320786-54320874   c
            2535-3394           JAXUCZ010000001.1  54317738-54318597   c
FEATURES             Location/Qualifiers
     source          1..3394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3394
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /note="phosphodiesterase 10A"
                     /db_xref="GeneID:63885"
                     /db_xref="RGD:68434"
     exon            1..334
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2652
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /EC_number="3.1.4.17"
                     /note="isoform 1 is encoded by transcript variant 1; cAMP
                     and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
                     10A; testis-specific phosphodiesterase PDE10A2"
                     /codon_start=1
                     /product="cAMP and cAMP-inhibited cGMP 3',5'-cyclic
                     phosphodiesterase 10A isoform 1"
                     /protein_id="NP_071572.1"
                     /db_xref="GeneID:63885"
                     /db_xref="RGD:68434"
                     /translation="MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFV
                     SESVSAETVEKWLKRKNNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDN
                     HLLLYELSSIIRIATKADGFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTT
                     ISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYR
                     HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVA
                     IDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
                     SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVV
                     QMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSI
                     CTSEEWQGLMHFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKL
                     CRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLD
                     HRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE
                     IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLW
                     PVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTT
                     LTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPATSKSTSEKPTRKVDD"
     exon            335..463
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..492
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            493..613
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..663
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..804
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            805..960
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1011
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1070
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1122
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1265
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1358
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1545
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1688
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1772
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1923
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2079
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2252
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2364
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2445
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2534
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..3394
                     /gene="Pde10a"
                     /gene_synonym="Pde10a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcggcg ggcggtggcg gctcttcctt tcgcctgcga tccaaggctt gctgctccca
       61 gcccgctccg ggccccggcc acctccaccg ccgcggctcc ccttacaccc gggcgcacac
      121 cgcgcggact ccttgggttt tccgggtgcc ggcgggggct gccctggcct cggccccggc
      181 tctgcggccg gtggccgaac tccgtggcgg ccccgaggca ccgccctccc ccttgccact
      241 gcctggccgc tgctcttcgg ctccgacatg gaagatggac cctctaacaa tgcgagttgc
      301 ttccgaaggc tgaccgagtg tttcctcagc cccagtttga cggatgaaaa ggtgaaggcc
      361 tatctttccc tccatcccca ggtattagac gagtttgttt ctgaaagtgt tagtgcggag
      421 accgtggaga agtggctgaa gaggaaaaac aacaaagcag aagatgaacc atctcctaag
      481 gaagtcagca ggtaccagga cacgaacatg cagggagtcg tgtacgagct gaacagctac
      541 atagagcagc gcctggacac cggcggggac aaccacctgc tcctgtacga gctaagcagt
      601 atcatcagga tagccacaaa agccgacgga tttgcactgt acttccttgg agagtgcaat
      661 aatagtctgt gtgtcttcac accacccgga atgaaggaag gtcaaccccg tctcatcccc
      721 gcagggccca tcacccaggg caccaccatc tctgcctatg tggccaagtc taggaagacc
      781 ctgctggtag aggacatcct tggggatgag cgatttccca gaggcactgg tctggagtca
      841 ggaacccgaa tccagtctgt cctttgcttg cctattgtca ctgccattgg agacttgatt
      901 ggcatccttg aactgtacag gcactggggc aaagaggcct tctgcctcag ccatcaggag
      961 gttgcaaccg ccaatctcgc ttgggcttcc gtagcaatac accaggtgca ggtgtgcaga
     1021 ggtctcgcca agcagaccga actgaatgac ttcctgctcg atgtatcaaa gacatacttt
     1081 gataacatag tcgccataga ctctctactt gaacacatca tgatatatgc aaaaaatcta
     1141 gtgaacgccg accgctgcgc gctcttccag gtggaccaca agaacaagga gctgtattcg
     1201 gacctgtttg acattgggga ggagaaggag gggaagcccg tcttcaagaa gaccaaggag
     1261 atcagatttt ccattgagaa agggattgct ggtcaagtgg caagaacggg agaagtcctg
     1321 aacattcctg atgcctacgc agacccgcgc tttaacaggg aggtggacct gtacacaggc
     1381 tataccacgc ggaacattct gtgtatgccc atagtgagcc gcggcagcgt gatcggtgtg
     1441 gtgcaaatgg ttaacaagat cagcggcagc gccttctcca agacggatga gaacaacttc
     1501 aagatgtttg ctgtcttctg cgctctggcc ctgcactgcg ctaacatgta ccacaggatc
     1561 cgccactcag agtgcatcta cagggttacc atggagaagc tgtcttacca cagcatctgc
     1621 acctctgagg aatggcaagg cctcatgcac ttcaacttgc cagcacgcat ctgccgggac
     1681 atcgagctat tccactttga cattggtcct ttcgagaaca tgtggcctgg gatctttgtc
     1741 tacatgatcc atcggtcttg tgggacatcc tgttttgaac ttgaaaaatt gtgccgtttt
     1801 atcatgtctg tgaagaagaa ctataggcgg gttccttacc acaactggaa gcatgcagtc
     1861 acggtggcgc actgcatgta cgccatactt caaaacaaca atggcctctt cacagacctt
     1921 gagcgcaaag gcctgctaat tgcctgtctg tgccatgacc tggaccacag gggcttcagt
     1981 aacagctacc tgcagaaatt cgaccacccc ctggctgcgt tgtactccac ctccaccatg
     2041 gagcaacacc acttctccca gacggtgtcc atcctccagc tggaaggaca caacatcttc
     2101 tccaccctga gctccagcga gtacgagcag gtgctggaga tcatccgcaa agccatcatc
     2161 gccactgacc tcgcactgta ctttgggaac aggaagcagt tggaggagat gtaccagaca
     2221 gggtcgctga acctccacaa ccagtcccat cgagaccgtg tcatcggctt gatgatgact
     2281 gcctgcgatc tttgctctgt gacgaaacta tggccagtta caaaattgac agcaaatgat
     2341 atatatgcag agttctgggc tgagggggat gagatgaaga agttggggat acagcccatc
     2401 cctatgatgg acagagacaa gcgagatgaa gtccctcaag gacagcttgg attctacaat
     2461 gctgtggcca tcccctgcta taccaccctg acgcagatcc tcccacccac agagcctctg
     2521 ctgaaggcct gcagggataa cctcaatcag tgggagaagg taattcgagg ggaagagaca
     2581 gcaatgtgga tttcaggccc agcaactagc aaaagcacat ctgagaagcc gaccaggaag
     2641 gtcgatgact gatcctgagg tgatgtctgc ctagcaactg actcaacctg cttctgtgac
     2701 ttcgttcttt ttatttttat ttttttaacg gggtgaaaac ctctctcaga aggtaccgtc
     2761 gcatatccat gtgaagcaga tgactccctg cgcacacctc ggaccgtgag caacccgggc
     2821 tccaccgtgt tcagacgtcg gctattccat ggctccgcct gactcccgaa tgccatttgc
     2881 taccaggcca gaactgcgct ggctggaggg ggcagagacg acaggagggg ttcttacctg
     2941 catccttcca tgagggtgtg gttctgtgtt tcatctctaa cagagatgct actgcttggt
     3001 ggcgtttgtt agaaatggga cacacgcccc tgtcgtgaag tttacatgtg accttcttgt
     3061 aggtaacttg agttcgtagc ctgggacccc tgtaatgaag gttacagtcc acaggtgata
     3121 gagaaattca agctgtaagt tacaggtgca ctataagtgt gttcattcag tttacctggg
     3181 ggcatggagg tgagtcagct ccacgaggaa ggaagcatac ctctgccctc atcaagggga
     3241 cacagggtac atcccaggca tcagagaact gcagctcacc tcaaaccatg tcaaagaatt
     3301 aaaacacacc cccatcccct cactgtagcc tttggcaact tcgccaaacc cttcacacaa
     3361 agaaaataaa agtaaggcgt ataaatttcc tcca
//
