LOCUS       NM_022247               2299 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus phosducin like (Pdcl), mRNA.
ACCESSION   NM_022247
VERSION     NM_022247.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2299)
  AUTHORS   Pusapati,G.V., Kong,J.H., Patel,B.B., Krishnan,A., Sagner,A.,
            Kinnebrew,M., Briscoe,J., Aravind,L. and Rohatgi,R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi:
            10.1016/j.devcel.2018.01.002.. PMID: 29401421]
REFERENCE   2  (bases 1 to 2299)
  AUTHORS   Lai,C.W., Kolesnikov,A.V., Frederick,J.M., Blake,D.R., Jiang,L.,
            Stewart,J.S., Chen,C.K., Barrow,J.R., Baehr,W., Kefalov,V.J. and
            Willardson,B.M.
  TITLE     Phosducin-like protein 1 is essential for G-protein assembly and
            signaling in retinal rod photoreceptors
  JOURNAL   J Neurosci 33 (18), 7941-7951 (2013)
   PUBMED   23637185
REFERENCE   3  (bases 1 to 2299)
  AUTHORS   McLaughlin,J.N., Thulin,C.D., Hart,S.J., Resing,K.A., Ahn,N.G. and
            Willardson,B.M.
  TITLE     Regulatory interaction of phosducin-like protein with the cytosolic
            chaperonin complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7962-7967 (2002)
   PUBMED   12060742
  REMARK    GeneRIF: results suggest that the interaction between PhLP and
            complex polypeptide 1 (CCT) may be a means to regulate
            CCT-dependent protein folding or alternatively, to control the
            availability of PhLP to modulate G protein signaling
REFERENCE   4  (bases 1 to 2299)
  AUTHORS   Thibault,C., Feng Wang,J., Charnas,R., Mirel,D., Barhite,S. and
            Miles,M.F.
  TITLE     Cloning and characterization of the rat and human phosducin-like
            protein genes: structure, expression and chromosomal localization
  JOURNAL   Biochim Biophys Acta 1444 (3), 346-354 (1999)
   PUBMED   10095058
REFERENCE   5  (bases 1 to 2299)
  AUTHORS   Thibault,C., Sganga,M.W. and Miles,M.F.
  TITLE     Interaction of phosducin-like protein with G protein betagamma
            subunits
  JOURNAL   J Biol Chem 272 (19), 12253-12256 (1997)
   PUBMED   9139665
REFERENCE   6  (bases 1 to 2299)
  AUTHORS   Miles,M.F., Barhite,S., Sganga,M. and Elliott,M.
  TITLE     Phosducin-like protein: an ethanol-responsive potential modulator
            of guanine nucleotide-binding protein function
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10831-10835 (1993)
   PUBMED   8248177
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022247.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L15354.1, BC097322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000003.1  41529391-41529506   c
            117-293             JAXUCZ010000003.1  41527618-41527794   c
            294-475             JAXUCZ010000003.1  41526072-41526253   c
            476-2299            JAXUCZ010000003.1  41520481-41522304   c
FEATURES             Location/Qualifiers
     source          1..2299
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q11"
     gene            1..2299
                     /gene="Pdcl"
                     /gene_synonym="Pdcl1; Phlp"
                     /note="phosducin like"
                     /db_xref="GeneID:64013"
                     /db_xref="RGD:621135"
     exon            1..116
                     /gene="Pdcl"
                     /gene_synonym="Pdcl1; Phlp"
                     /inference="alignment:Splign:2.1.0"
     exon            117..293
                     /gene="Pdcl"
                     /gene_synonym="Pdcl1; Phlp"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1027
                     /gene="Pdcl"
                     /gene_synonym="Pdcl1; Phlp"
                     /EC_number="1.14.99.1"
                     /note="phosducin-like 1"
                     /codon_start=1
                     /product="phosducin-like protein"
                     /protein_id="NP_071583.1"
                     /db_xref="GeneID:64013"
                     /db_xref="RGD:621135"
                     /translation="MTTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPASSSTPA
                     EAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEE
                     EEQQKQKDLQEKISGKMTLKECGMMDKNLDDEEFLQQYRKQRMDEMRQQLHKGPQFKQ
                     VLEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLAAEYPTVKFCRVR
                     SSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPE
                     KEVLVLTSVRNSATCHSEDSDLEID"
     exon            294..475
                     /gene="Pdcl"
                     /gene_synonym="Pdcl1; Phlp"
                     /inference="alignment:Splign:2.1.0"
     exon            476..2299
                     /gene="Pdcl"
                     /gene_synonym="Pdcl1; Phlp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccactgcagc ttttctctgt tgcttaaggc tttcggttac ttctctttct ctaagcgagc
       61 gttctttgtt ggtgaccgga gttgctagtc cagaaggaac agactgagtg agcgaggcgc
      121 catgacaacc ctggatgaca agttgctggg ggagaaattg cagtactact acagcaccag
      181 tgaggatgag gacagtgacc atgaagacaa agacagaggc aggggagccc cagccagtag
      241 ttccacgcct gcggaggctg agctggcagg cgaaggcatt tcagtcaata caggtccaaa
      301 aggggtgatc aatgactggc gccgcttcaa gcagttggag acagaacaga gggaggagca
      361 gtgccgggag atggagcggc tgatcaaaaa gctgtctatg agctgcaggt cccatctgga
      421 tgaagaggag gagcagcaga aacagaagga cctccaggag aaaatcagtg ggaagatgac
      481 tctgaaggag tgtggtatga tggacaagaa tttggatgat gaagagtttc tgcagcagta
      541 tcggaagcag aggatggacg agatgcggca gcagcttcat aaagggcccc aattcaagca
      601 agtgcttgag atccccagtg gagaaggatt tttagatatg attgataaag aacagaaaag
      661 cacccttatc atggttcata tttatgaaga tggtgtccca gggactgaag ccatgaatgg
      721 ctgcatgatc tgccttgccg cagagtaccc cactgtcaaa ttctgccgag tgaggagctc
      781 ggttattggg gccagcagtc gttttacccg gaatgccctt cctgctctgc tcatctacaa
      841 ggcgggtgaa ttgattggca attttgttcg tgtcactgac cagctgggcg aagatttctt
      901 tgctgtagac cttgaagctt tcctgcagga atttggattg ctcccagaaa aggaagtctt
      961 ggtgctgaca tctgtgcgaa actctgccac ctgtcacagt gaagacagcg atctagaaat
     1021 agattgaact gataatccag ttctgtagct gtctcattgt ttgggctaga ggacacatgt
     1081 ctgtatttat ttctgtcctt cctgtcttct ggctttacag ctgctctttg tagtctggtt
     1141 tagcatgtgg aaagtcaaga aactcagatt aaatcagaat cctgactcac tttgtggcta
     1201 gcagtaaagc gatttctaat tatatagaca ggaagctggg ttcttgagct gtttacatct
     1261 ctagcgtgac atctctgaaa ttgtttccag tcaatattga catggcaccc ttgaaggcaa
     1321 tgtcttgaaa attgtcttct gatgacctca gaattccacc aggtctgaga gtagaattcc
     1381 ctagtgagtg tgttctgtgc agtgtaaaca gtgcatttcc ataatcactt gattgcaaat
     1441 catgtttact tgcaatcaga ctgtacttat tttctccaga tccttttcta ctagggtcca
     1501 tacaaggttg ggaatatagc tcagtggtga actcttaacc tagcatacac gtagctccaa
     1561 ggtatctgat tcccacccag cactgtcaaa actaaaggtt ccagatggtg cctgatgctg
     1621 tagttagcag tggtctctgc tgagggagtc actggtccag tccagcataa tgaagtatga
     1681 acaggaaggg atgttttctt gctgactgct gtcatgatgt tgggaagcag gcatcctatt
     1741 gactgacact ggtgtgtata gagcttgaaa acctcagtag gaggaccttt ctgtatcctg
     1801 ctcatcagca tcttttcctc tgttatttag caaggtaatg ctttgtttaa cctttttaac
     1861 tttttaaaaa gctttttttg cctattagaa aaaaattcat atttactaga ggaaaattgg
     1921 ccaaaataca gatgcaaaaa tggtttaaaa atataattct gccacctgaa tactgtatgt
     1981 tttggtacca ttcatatata gggttttttt tttaatgtat tctagggttt ttttttttat
     2041 ggattcatag gctttggttt gtctttaaat gacattggga tcattctgag catactgtca
     2101 gatagtgtga tcagttacta acagaagttt ttcatgctgt taaatactct tctgtaatat
     2161 tttaataact gttgatattc cattgatttg ctgaaatctg gtgtttgggt tttagaaaga
     2221 tagcaaactt ttttattata aactttctat tatgaaacat gtttatcata gaacatacaa
     2281 taaaaattaa gttaaaaag
//
