LOCUS       NM_001029910            5775 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus programmed cell death 6 interacting protein
            (Pdcd6ip), mRNA.
ACCESSION   NM_001029910 XM_576494
VERSION     NM_001029910.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5775)
  AUTHORS   Salim,S., Nasir,J. and Chen,P.E.
  TITLE     Overexpression of the dopamine receptor-interacting protein
            Alix/AIP1 modulates NMDA receptor-triggered cell death
  JOURNAL   FEBS Lett 593 (12), 1381-1391 (2019)
   PUBMED   31077357
  REMARK    GeneRIF: demonstrate a previously unreported role for Alix as a
            potential modulator of NMDAR function
REFERENCE   2  (bases 1 to 5775)
  AUTHORS   Campos,Y., Qiu,X., Gomero,E., Wakefield,R., Horner,L.,
            Brutkowski,W., Han,Y.G., Solecki,D., Frase,S., Bongiovanni,A. and
            d'Azzo,A.
  TITLE     Alix-mediated assembly of the actomyosin-tight junction polarity
            complex preserves epithelial polarity and epithelial barrier
  JOURNAL   Nat Commun 7, 11876 (2016)
   PUBMED   27336173
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5775)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   4  (bases 1 to 5775)
  AUTHORS   Colombo,M., Moita,C., van Niel,G., Kowal,J., Vigneron,J.,
            Benaroch,P., Manel,N., Moita,L.F., Thery,C. and Raposo,G.
  TITLE     Analysis of ESCRT functions in exosome biogenesis, composition and
            secretion highlights the heterogeneity of extracellular vesicles
  JOURNAL   J Cell Sci 126 (Pt 24), 5553-5565 (2013)
   PUBMED   24105262
REFERENCE   5  (bases 1 to 5775)
  AUTHORS   Sandrin,V. and Sundquist,W.I.
  TITLE     ESCRT requirements for EIAV budding
  JOURNAL   Retrovirology 10, 104 (2013)
   PUBMED   24107264
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5775)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
REFERENCE   7  (bases 1 to 5775)
  AUTHORS   Schmidt,M.H.H., Chen,B., Randazzo,L.M. and Bogler,O.
  TITLE     SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse
            cytoskeletal elements, including FAKs, and modulate cell adhesion
  JOURNAL   J Cell Sci 116 (Pt 14), 2845-2855 (2003)
   PUBMED   12771190
  REMARK    GeneRIF: adaptor protein SETA (CIN85) and its binding partner AIP1
            are involved with the cytoskeleton and in the regulation of cell
            adhesion
REFERENCE   8  (bases 1 to 5775)
  AUTHORS   Chen,B., Borinstein,S.C., Gillis,J., Sykes,V.W. and Bogler,O.
  TITLE     The glioma-associated protein SETA interacts with AIP1/Alix and
            ALG-2 and modulates apoptosis in astrocytes
  JOURNAL   J Biol Chem 275 (25), 19275-19281 (2000)
   PUBMED   10858458
REFERENCE   9  (bases 1 to 5775)
  AUTHORS   Missotten,M., Nichols,A., Rieger,K. and Sadoul,R.
  TITLE     Alix, a novel mouse protein undergoing calcium-dependent
            interaction with the apoptosis-linked-gene 2 (ALG-2) protein
  JOURNAL   Cell Death Differ 6 (2), 124-129 (1999)
   PUBMED   10200558
REFERENCE   10 (bases 1 to 5775)
  AUTHORS   Vito,P., Pellegrini,L., Guiet,C. and D'Adamio,L.
  TITLE     Cloning of AIP1, a novel protein that associates with the
            apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction
  JOURNAL   J Biol Chem 274 (3), 1533-1540 (1999)
   PUBMED   9880530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 6, 2013 this sequence version replaced NM_001029910.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.34892.1,
                                           SRR26643293.47923.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JAXUCZ010000008.1  122524653-122524993 c
            342-396             JAXUCZ010000008.1  122517771-122517825 c
            397-466             JAXUCZ010000008.1  122515361-122515430 c
            467-594             JAXUCZ010000008.1  122509812-122509939 c
            595-748             JAXUCZ010000008.1  122507955-122508108 c
            749-849             JAXUCZ010000008.1  122506032-122506132 c
            850-966             JAXUCZ010000008.1  122503680-122503796 c
            967-1189            JAXUCZ010000008.1  122497786-122498008 c
            1190-1313           JAXUCZ010000008.1  122496232-122496355 c
            1314-1491           JAXUCZ010000008.1  122494296-122494473 c
            1492-1603           JAXUCZ010000008.1  122491249-122491360 c
            1604-1773           JAXUCZ010000008.1  122490085-122490254 c
            1774-2022           JAXUCZ010000008.1  122479819-122480067 c
            2023-2157           JAXUCZ010000008.1  122478511-122478645 c
            2158-2252           JAXUCZ010000008.1  122477455-122477549 c
            2253-2373           JAXUCZ010000008.1  122474411-122474531 c
            2374-2564           JAXUCZ010000008.1  122473315-122473505 c
            2565-5775           JAXUCZ010000008.1  122469223-122472433 c
FEATURES             Location/Qualifiers
     source          1..5775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5775
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /note="programmed cell death 6 interacting protein"
                     /db_xref="GeneID:501083"
                     /db_xref="RGD:68357"
     exon            1..341
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2739
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /note="ALG-2 interacting protein 1; ALG-2 interacting
                     protein X"
                     /codon_start=1
                     /product="programmed cell death 6-interacting protein"
                     /protein_id="NP_001025081.2"
                     /db_xref="GeneID:501083"
                     /db_xref="RGD:68357"
                     /translation="MASFIWVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAE
                     ELSKLRRSALGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKG
                     SLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKTAAKQYQFASGAF
                     LHIKDTVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLAN
                     QAADYFGDAFKQCQYKDALPKEVFPTLAAKQCIMQANAEYHQSILAKQQKKFGEEIAR
                     LQHAAELIKNVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGK
                     ATLVKPTPVNVPISQKFTDLFEKMVPVSVQQSLAVFSQRKADLVNRSIAQMREATTLA
                     NGVLASLNLPAAIEDVSGDTVPQSILTKSTAVVEQGGIQTVDQLIKELPELLQRNREI
                     LEESLRLLDEEEATDNDLRAKFKDRWQRTPSNDLYKPLRAEGAKFRAVLDKAVQADGQ
                     VKERYQSHRDTIALLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEIKKER
                     EGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRIYGGLTTKVQESLKKQEG
                     LLKNIQVSHQEFSKMKQSNSEASLREEVLKNLATAYDNFVELVANLKEGTKFYNELTE
                     ILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPPPAYQSSPAGGHATAPT
                     PAPRTMPPAKPQPPARPPPPVLPANRVPPAAAATAPAGVGTASAAPPQTPGSAPPPQA
                     QGPPYPTYPGYPGYCQMPMPMGYNPYTYGQYNMPYPPVYHQSPGQAPYPGPQQPTYPF
                     PQPPQQSYYPQQ"
     exon            342..396
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            397..466
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            467..594
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            595..748
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            749..849
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            850..966
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1189
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1313
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1491
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1603
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1773
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2022
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2157
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2252
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2373
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2564
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..5775
                     /gene="Pdcd6ip"
                     /gene_synonym="AIP1; Alix; RGD1561176"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggctccaa gcgctggcgg cccagtccgt cggcccgtcg gtccgctcgt ccgctgccgg
       61 tgccgagcgc gcctaggccg tcgtcgctgt cccttcgtct gtccggcccg aagcggcggc
      121 cgggcgctca ccatggcgtc gttcatctgg gtgcagctga agaagacctc ggaggtggac
      181 ctggccaagc cgctggtcaa gttcatccag cagacgtacc cgagcggcgg cgaggagcag
      241 gcccagtact gccgcgcggc cgaggagctc agcaagctgc ggcgctcggc gctcggccgc
      301 ccgctggaca agcacgaggg cgcgctggag acgctgctga gatattatga ccagatttgt
      361 tctattgaac ccaagttccc attttctgaa aatcagatct gcttgacatt tacgtggaag
      421 gatgcttttg ataaaggttc cctttttgga ggatctgtaa aattggctct tgcaagctta
      481 ggatatgaaa agagctgtgt gttgttcaac tgtgctgcct tagctagcca gatcgcagca
      541 gagcagaacc tggataatga tgaaggactg aaaaccgctg ctaagcagta ccagtttgct
      601 agtggtgcct ttttacatat taaagacaca gttttatctg ccttaagtcg agagcctact
      661 gtggacatat ctccagatac tgtggggacc ctcagtctta ttatgctggc ccaagctcaa
      721 gaagtatttt tcttaaaagc cacaagagat aagatgaagg atgccatcat agcgaagctg
      781 gccaatcagg ctgccgatta ctttggcgat gctttcaaac agtgtcagta caaagatgcc
      841 ctccccaagg aggtattccc taccctggct gcaaagcagt gcatcatgca ggctaatgct
      901 gagtaccacc agtccatcct ggccaagcag cagaagaagt ttggggaaga gatcgcaagg
      961 ttgcagcatg cagcagaact gattaagaat gtggcctctc gctatgatga atatgtcaat
     1021 gtgaaggatt tttctgacaa aatcaaccgt gccctggctg cagcaaagaa ggataatgat
     1081 tttatttatc atgaccgtgt tccggacctt aaggatctgg atcctattgg caaagccacg
     1141 cttgtgaaac ccactccagt taatgtaccc atcagccaga agttcacgga tttgtttgag
     1201 aagatggtgc ctgtgtctgt gcagcagtcc ctggctgtgt ttagtcagag gaaagctgac
     1261 ttggttaaca gatcaatcgc tcagatgaga gaagctacaa ctttggcaaa tggagtactg
     1321 gcttccctta accttccagc agcaattgaa gatgtgtctg gagacactgt acctcagtct
     1381 atacttacca agtccacagc tgtagtcgag cagggaggca tccagactgt cgaccagctg
     1441 ataaaagagc tgcctgagct gctacaaaga aatagggaaa tattagagga gtcactaaga
     1501 ttgttggatg aagaagaagc aactgataat gacttaagag caaaattcaa ggaccggtgg
     1561 caaaggactc catccaatga cctgtacaag cctttacgag cagagggagc caagttcaga
     1621 gccgttttag ataaagcggt gcaagcggat ggacaggtga aggagcgcta ccagtcccac
     1681 cgagacacca tcgcccttct gtgtaagcca gagccggagc tgaatgccgc catcccttct
     1741 gctaacccag caaagaccat gcagggcagt gaggttgtaa atgtcttaaa atccttatta
     1801 tcaaatcttg atgaaataaa gaaggaaaga gagggtcttg agaatgacct gaagtcagtg
     1861 aattttgaca tgacaagcaa gtttttgaca gctctggccc aagatggcgt gataaatgag
     1921 gaggctcttt ctgtcactga gctggatcgg atctatggtg ggctaacaac taaagttcaa
     1981 gagtctctga agaaacagga gggacttcta aaaaatatac aggtctcaca ccaggaattc
     2041 tccaaaatga agcagtctaa cagtgaggcc agcctgaggg aagaggtcct gaagaactta
     2101 gcgaccgcgt acgacaactt cgtggagctc gtagctaact tgaaagaggg cacaaagttt
     2161 tacaatgagc tgactgaaat cctggtcagg ttccagaaca aatgcagtga catagtgttt
     2221 gcacggaaga cggaaagaga tgagctcttg aaggatctgc agcagagcat tgccagagag
     2281 cccagcgctc cttctatccc tccgccagca tatcagtcct ccccagcagg gggacatgcg
     2341 acagctccaa ctccagctcc aagaaccatg ccgcctgcta agccccagcc tccagcccgg
     2401 cctccacctc ctgtgcttcc tgcaaaccga gttcctcctg ctgctgccgc tactgcccct
     2461 gcaggggtgg ggactgcttc agcagcaccg ccacagaccc ctggctctgc tccccctcca
     2521 caggctcagg gaccaccgta tcccacctat ccaggatatc ccgggtattg ccaaatgccc
     2581 atgcccatgg gctacaaccc ctacacatat ggccagtaca atatgccgta cccaccggtg
     2641 tatcaccaga gccctggaca ggctccgtac ccaggacccc agcagcctac ctaccccttc
     2701 cctcagcccc cgcagcagtc atactatcca cagcagtaat gccaccacgc gctgctggtt
     2761 cagatcagag cgacaggaca gcggctgcca ccacgctcta agccacactc tggccactcg
     2821 agaatatctc gctctcctga tgcctgtgga tgatttctgt ctgtggataa aaccgaaggc
     2881 tgggccccac ctccacattt gatcgcactt gtgagattct gctgctgttg cagcataaac
     2941 gctagctatg atagcaatgg aaaaaattac agttccataa aacgctgaaa atgacaatta
     3001 aacctgcaag tgaaaccttt gaaattagca tactttataa gatgaggttg ggacaaggat
     3061 ggcttaaata ctgatattta aggaaaaagt tttctttctc ttggtttatt gatttagttt
     3121 aatttctatt atgatatttt gcataatcaa ggcattgtaa atcttataat ttaaaaataa
     3181 attacttacg aacagttgtc attgttatgg tttgtccttg attctcattg ctgtctgatt
     3241 cctttctggt gttagcctct cctttgtatg ttcacaggct ccgtgtactg tgttggactg
     3301 catggactgc agactggcag tcaggtgagg gctgccctga gagcccaagc gcaccagctt
     3361 gtctgccata ctctccttag tcagtcctgt tgacactgat ttttaaaagt cctataatgt
     3421 gggagacaca cacaattgtt accaaagatt cttcaaataa atataaaatt taaaagtatg
     3481 tatttaatgt tttattatta gattttccaa gaaaatgatg caaattctgg taataattca
     3541 cttcccttac ccataatccg gtcaaagtga gtagttttag ccgtacagtg ccaggatgtg
     3601 tagagcctgg cgaaagctcc tgtgcctttc tcgtccttgg ctccatctac tcttgtcctg
     3661 tgatggtgac tgtgcgcagt gtactggaac agatcttctt aacccttctt ttcaaatttc
     3721 atattatgat tttttatttt ctgtggttcc tggaagctga ggttattctg taatccagga
     3781 gcatgtaaga caattggtgg ggctgcgtgc aagccccaaa cagtgaggtc tcgggggctc
     3841 tgcctgtgcg aggctcttgt ccaacagaac aggcgtacag acagatttcc taatctgtgt
     3901 ttgtcttcta agtttaatgc tgacatcttg tttctcatct cgtttaaatg atactgtcac
     3961 ttagtcctca ttgctctcaa tgacaattca ggctgatact ttcaaatgta agactgaaga
     4021 tacgattgta caagggagta aactggttta aatgtgtgta tttaaagctc cgtgctttgt
     4081 tgtatgcaga aaacacagac caatcgccgg gaatgtggac attggcttaa acctcgacaa
     4141 aacgtaacaa acgtgccatt gctcagctcc gtgctccgcg gtactcggtg tatgagacag
     4201 tgtatttgaa tcctctgtaa atgcatttga attttatatt ctcccctcct gagttcttat
     4261 actgacacga gacatccccc gagttaggga gctcccagac tgctagtgta ttccttacta
     4321 atgcaaaaca accaccaaaa gaaaaaaata gaaaaaagaa aaaaaaagtg gcctgaatat
     4381 tctcttgggg aaagggggtt ggaggtctaa cgggaagggc aagtgcatca gagagccaaa
     4441 gggaggaggg gtcaggccgg cggccatttc ctcctgccct gtgctatgct tccaggctca
     4501 cagcggacag tcagcggggg agggcccctt ccagttgcct cccagctcag ctcctgaggg
     4561 aagcctcttg ccaggtgtct cccccttcac gctgctcagg atgctccggt ctcgggtcag
     4621 gtgcccttac cctgcagcgc caactttgcc ttcctaggcc tgttcggttt gctggccgga
     4681 agcctcctca tgcgcctgtt gtctagatgg cgtccctcac catcagcaca ccctaactgt
     4741 gctccgttgg ctgtgctctt tagaacacac tgcagaagtt agcacgcacg atggctgttt
     4801 actcggaggt agaaggttcc actctggctt aagtatgtta tcccgtgttt ataatgagac
     4861 tttctgcaac cttcttaagt ggaggtgcct gtccccaggc catgtatgtt ggctttttaa
     4921 gcctcttaag aagtggatta cctgccaact actgaagctt tgtggagaca ccagtcagaa
     4981 gaggggaaac catccaactt ggatttcctg cccccagcga tggatgggtg gcttgactac
     5041 tcagtgtggt gtcggtctct gagctgaaga accgtttctt tgttctttgg tccctttctt
     5101 gattgagtgg tcgcatgtca cgctgcatag caaccagtct ctgagacccc gagtctgtac
     5161 cccggcacct ttgcaattat gtcccccagt ataacccacc tctgtcccag ccagctacct
     5221 ttctagccaa gacagattcg cggtatcttt ttttccccaa ttgagattta cagtttgtaa
     5281 atttgtgtac atttcctaat ttcatgaaca ggtaaaatag taaccaggcc tcagtttgct
     5341 agtgggagtt tttaagtccg tgactagtat gtcttgaagc cttgctacag ccctgtggcc
     5401 tgtcacttct cagacgtgca gtcagttgac ccatagtgtg gaaccgggcg cagctgggca
     5461 cggccttcca agaagagtta aaattgctgg tttaagtaca gactttagaa ctaaatggaa
     5521 gagcaaagaa ggaaaattat atttttaaca aaagagaata ttcaggcttt atttctggta
     5581 tgaaatttat atttttaaag aatatatatc ctatattatc acaccggaga ctttagattc
     5641 ctttctggtt acagacattg ctggtagttg gattctattt ttattgtatt catttatttc
     5701 tcttaggggg aaaattgtaa agaaacaaag attccggatg aatgtatcct agaaataaaa
     5761 gttgagagat tctta
//
