LOCUS       NM_001107452            1531 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus programmed cell death 6 (Pdcd6), mRNA.
ACCESSION   NM_001107452 XM_001056202 XM_217732
VERSION     NM_001107452.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Sargeant,J., Seiler,D.K., Costain,T., Madreiter-Sokolowski,C.T.,
            Gordon,D.E., Peden,A.A., Malli,R., Graier,W.F. and Hay,J.C.
  TITLE     ALG-2 and peflin regulate COPII targeting and secretion in response
            to calcium signaling
  JOURNAL   J Biol Chem 297 (6), 101393 (2021)
   PUBMED   34762908
  REMARK    GeneRIF: ALG-2 and peflin regulate COPII targeting and secretion in
            response to calcium signaling.
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Kanadome,T., Shibata,H., Kuwata,K., Takahara,T. and Maki,M.
  TITLE     The calcium-binding protein ALG-2 promotes endoplasmic reticulum
            exit site localization and polymerization of Trk-fused gene (TFG)
            protein
  JOURNAL   FEBS J 284 (1), 56-76 (2017)
   PUBMED   27813252
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Ma,J., Zhang,X., Feng,Y., Zhang,H., Wang,X., Zheng,Y., Qiao,W. and
            Liu,X.
  TITLE     Structural and Functional Study of Apoptosis-linked
            Gene-2.Heme-binding Protein 2 Interactions in HIV-1 Production
  JOURNAL   J Biol Chem 291 (52), 26670-26685 (2016)
   PUBMED   27784779
REFERENCE   4  (bases 1 to 1531)
  AUTHORS   McGourty,C.A., Akopian,D., Walsh,C., Gorur,A., Werner,A.,
            Schekman,R., Bautista,D. and Rape,M.
  TITLE     Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent
            Co-adaptor
  JOURNAL   Cell 167 (2), 525-538 (2016)
   PUBMED   27716508
REFERENCE   5  (bases 1 to 1531)
  AUTHORS   Tanner,J.J., Frey,B.B., Pemberton,T. and Henzl,M.T.
  TITLE     EF5 Is the High-Affinity Mg(2+) Site in ALG-2
  JOURNAL   Biochemistry 55 (36), 5128-5141 (2016)
   PUBMED   27541325
REFERENCE   6  (bases 1 to 1531)
  AUTHORS   Lee,J.H., Rho,S.B. and Chun,T.
  TITLE     Programmed cell death 6 (PDCD6) protein interacts with
            death-associated protein kinase 1 (DAPk1): additive effect on
            apoptosis via caspase-3 dependent pathway
  JOURNAL   Biotechnol Lett 27 (14), 1011-1015 (2005)
   PUBMED   16132846
REFERENCE   7  (bases 1 to 1531)
  AUTHORS   Rao,R.V., Poksay,K.S., Castro-Obregon,S., Schilling,B., Row,R.H.,
            del Rio,G., Gibson,B.W., Ellerby,H.M. and Bredesen,D.E.
  TITLE     Molecular components of a cell death pathway activated by
            endoplasmic reticulum stress
  JOURNAL   J Biol Chem 279 (1), 177-187 (2004)
   PUBMED   14561754
REFERENCE   8  (bases 1 to 1531)
  AUTHORS   Kitaura,Y., Satoh,H., Takahashi,H., Shibata,H. and Maki,M.
  TITLE     Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized
            by dimerization through their fifth EF-hand regions
  JOURNAL   Arch Biochem Biophys 399 (1), 12-18 (2002)
   PUBMED   11883899
REFERENCE   9  (bases 1 to 1531)
  AUTHORS   Missotten,M., Nichols,A., Rieger,K. and Sadoul,R.
  TITLE     Alix, a novel mouse protein undergoing calcium-dependent
            interaction with the apoptosis-linked-gene 2 (ALG-2) protein
  JOURNAL   Cell Death Differ 6 (2), 124-129 (1999)
   PUBMED   10200558
REFERENCE   10 (bases 1 to 1531)
  AUTHORS   Vito,P., Lacana,E. and D'Adamio,L.
  TITLE     Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and
            Alzheimer's disease gene ALG-3
  JOURNAL   Science 271 (5248), 521-525 (1996)
   PUBMED   8560270
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474002.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001056202.1, XM_217732.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213638.1, FQ234686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..1531
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /note="programmed cell death 6"
                     /db_xref="GeneID:308061"
                     /db_xref="RGD:1311239"
     exon            1..223
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..698
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /note="apoptosis-linked gene 2 protein homolog"
                     /codon_start=1
                     /product="programmed cell death protein 6"
                     /protein_id="NP_001100922.1"
                     /db_xref="GeneID:308061"
                     /db_xref="RGD:1311239"
                     /translation="MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVIS
                     DNELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTY
                     DRDNSGMIDKHELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQR
                     LTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV"
     exon            224..285
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..330
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..489
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..599
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..1531
                     /gene="Pdcd6"
                     /gene_synonym="ALG-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgactcaa aggcacgcgc ttccgttgtt cccaggaagt tgtgggctcc tggttctgcc
       61 cctgacttga ggcggaagca cagcttttgg agctgggccg cgggaccgct gtgcatcagc
      121 ccatggctgc ctactcctac cgcccaggcc caggtgctgg ccctggccct gctgctggag
      181 ctgcactgcc agaccagagc ttcctgtgga acgtcttcca gcgggttgat aaagacagga
      241 gcggagtgat ttcagacaat gaacttcagc aagcattatc caatggtaca tggactccgt
      301 ttaatccagt gactgtgagg tcaatcattt ctatgtttga ccgagaaaac aaggctggtg
      361 tgaacttcag tgaattcaca ggtgtgtgga agtatatcac agactggcag aatgtcttcc
      421 ggacctacga cagggacaac tctgggatga ttgacaagca tgagctcaaa caagcactct
      481 caggttttgg ctaccggctc tctgatcagt tccatgacat cctcatccga aaatttgaca
      541 ggcaaggacg agggcagatc gcgttcgatg acttcatcca gggctgcatc gtcttgcaga
      601 ggttgacaga catattcaga cgctatgaca cggatcagga tggctggatt caggtgtctt
      661 acgagcagta tctctccatg gttttcagca ttgtataacc aggccttgtg aacatccagc
      721 acggcatgca aaaaactgaa gatgccaaat tccttacctg tgctagaaca gggcatggct
      781 gcagtgagac gctgcccttc ccgttgactg tatagctaat tcttggggac ctggctgtac
      841 atatgtgaat actctggtca gtgactctgt agtggcaatc tagctccact gttagaacac
      901 agacgttggg gttgctgact gattgtgcca tgaggtgaga cctaataatg gttcaggatt
      961 ctgctcccaa actatcatgt tcttttctag atgcctctaa ttctgtagtc gagatgctct
     1021 ccttagccaa tagaatgtta atataatatg gaacttgcac agaaggcttt tcatgtgcct
     1081 tactttttaa aacgaaattt tatccattgg aatatgtaac ataagcaata aagtaatgat
     1141 acagactgtc tagttttggc tggtttttgt tttgttttgt tttgctttaa ctaaacaggt
     1201 ggaagaaatg taccctttgt taccactcta gttgttgtgt gaacatggga gagtgggacc
     1261 taaaaataac gcagactgaa gtctcacaca atagccaatt ttatttagag catcagaaaa
     1321 tgtatactct tgagtgtgaa gaagaatcac atgcgagatg ttcaatcaca aagacatggc
     1381 aaaagcatgt tttttctgtg aaggcacatg aatgacagct gctgcagtaa actcctgtct
     1441 gccatagctg ggaaaagcac aacaccacat ccaggaccaa gtctatgtat gaagaacagg
     1501 tcgtgtagca taaacaataa agtgttgata c
//
