LOCUS       NM_001106247             657 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus programmed cell death 5 (Pdcd5), mRNA.
ACCESSION   NM_001106247 XM_001079809 XM_214911
VERSION     NM_001106247.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 657)
  AUTHORS   Ye X, Fang H, Feng Y, Qian H, Wu Z and Chen S.
  TITLE     MiR-10b-3p Protects Cerebral I/R Injury through Targeting
            Programmed Cell Death 5 (PDCD5)
  JOURNAL   Crit Rev Eukaryot Gene Expr 31 (6), 85-98 (2021)
   PUBMED   34936294
  REMARK    GeneRIF: MiR-10b-3p Protects Cerebral I/R Injury through Targeting
            Programmed Cell Death 5 (PDCD5).
REFERENCE   2  (bases 1 to 657)
  AUTHORS   Jiang Z, Chen CH, Chen YY, Han JY, Riley J and Zhou CM.
  TITLE     Autophagic effect of programmed cell death 5 (PDCD5) after focal
            cerebral ischemic reperfusion injury in rats
  JOURNAL   Neurosci Lett 566, 298-303 (2014)
   PUBMED   24614334
  REMARK    GeneRIF: PDCD5 was a key regulator of autophagy that might play an
            important role following middle cerebral artery
            occlusion/reperfusion injury.
REFERENCE   3  (bases 1 to 657)
  AUTHORS   Tracy CM, Gray AJ, Cuellar J, Shaw TS, Howlett AC, Taylor RM,
            Prince JT, Ahn NG, Valpuesta JM and Willardson BM.
  TITLE     Programmed cell death protein 5 interacts with the cytosolic
            chaperonin containing tailless complex polypeptide 1 (CCT) to
            regulate beta-tubulin folding
  JOURNAL   J Biol Chem 289 (7), 4490-4502 (2014)
   PUBMED   24375412
REFERENCE   4  (bases 1 to 657)
  AUTHORS   Xiao J, Liu C, Li G, Peng S, Hu J, Qu L, Lv P, Zhang Y, Ma D and
            Chen Y.
  TITLE     PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+)
            regulatory T cells and suppressing Th17 and Th1 responses
  JOURNAL   J Autoimmun 47, 34-44 (2013)
   PUBMED   24012345
REFERENCE   5  (bases 1 to 657)
  AUTHORS   Chen CH, Jiang Z, Yan JH, Yang L, Wang K, Chen YY, Han JY, Zhang JH
            and Zhou CM.
  TITLE     The involvement of programmed cell death 5 (PDCD5) in the
            regulation of apoptosis in cerebral ischemia/reperfusion injury
  JOURNAL   CNS Neurosci Ther 19 (8), 566-576 (2013)
   PUBMED   23638963
  REMARK    GeneRIF: PDCD5-induced apoptosis and over-expression of PDCD5 are
            harmful to ischemic neurons in cerebral ischemia/reperfusion
            injury.
REFERENCE   6  (bases 1 to 657)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 657)
  AUTHORS   Ling X, Liu Y, Fan H, Zhong Y, Li D and Wang Y.
  TITLE     Studies on interactions of programmed cell death 5 (PDCD5) and its
            related peptides with heparin by capillary zone electrophoresis
  JOURNAL   Anal Bioanal Chem 387 (3), 909-916 (2007)
   PUBMED   17165023
REFERENCE   8  (bases 1 to 657)
  AUTHORS   Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, Alaluf I,
            Swerdlin N, Perzov N, Danon T, Liron Y, Raveh T, Carpenter AE,
            Lahav G and Alon U.
  TITLE     Dynamic proteomics in individual human cells uncovers widespread
            cell-cycle dependence of nuclear proteins
  JOURNAL   Nat Methods 3 (7), 525-531 (2006)
   PUBMED   16791210
REFERENCE   9  (bases 1 to 657)
  AUTHORS   Chen LN, Wang Y, Ma DL and Chen YY.
  TITLE     Short interfering RNA against the PDCD5 attenuates cell apoptosis
            and caspase-3 activity induced by Bax overexpression
  JOURNAL   Apoptosis 11 (1), 101-111 (2006)
   PUBMED   16374546
REFERENCE   10 (bases 1 to 657)
  AUTHORS   Liu H, Wang Y, Zhang Y, Song Q, Di C, Chen G, Tang J and Ma D.
  TITLE     TFAR19, a novel apoptosis-related gene cloned from human leukemia
            cell line TF-1, could enhance apoptosis of some tumor cells induced
            by growth factor withdrawal
  JOURNAL   Biochem Biophys Res Commun 254 (1), 203-210 (1999)
   PUBMED   9920759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214911.2, XM_001079809.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV216669.1, DV216663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..657
                     /gene="Pdcd5"
                     /note="programmed cell death 5"
                     /db_xref="GeneID:292814"
                     /db_xref="RGD:1310561"
     exon            1..193
                     /gene="Pdcd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..505
                     /gene="Pdcd5"
                     /codon_start=1
                     /product="programmed cell death protein 5"
                     /protein_id="NP_001099717.1"
                     /db_xref="GeneID:292814"
                     /db_xref="RGD:1310561"
                     /translation="MADEELEALRKQRLAELQAKHGDPGDAAQQEAKQREAEMRNSIL
                     AQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSGKVSEQGLIEILEKVSQQ
                     TEKKTTVKFNRRKVMDSDEDDDY"
     exon            194..231
                     /gene="Pdcd5"
                     /inference="alignment:Splign:2.1.0"
     exon            232..293
                     /gene="Pdcd5"
                     /inference="alignment:Splign:2.1.0"
     exon            294..385
                     /gene="Pdcd5"
                     /inference="alignment:Splign:2.1.0"
     exon            386..457
                     /gene="Pdcd5"
                     /inference="alignment:Splign:2.1.0"
     exon            458..657
                     /gene="Pdcd5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagtaaa aggcgccgtg ctcgagtctc aggctgaagc gattccaacc gagtgtaccg
       61 gagggccggt gcggctgcgc gaccacccga cggccgctgc gcctgcgcga cgttggacag
      121 ccgcgccatg gcggacgaag aactcgaggc gctgagaaag cagaggctgg ccgagctgca
      181 ggccaagcac ggagatcctg gtgatgcagc ccaacaggaa gcaaaacaaa gggaagcaga
      241 aatgagaaac agtatcttag cccaagttct ggatcagtca gcccgggcca ggttaagtaa
      301 cttagcactt gtgaagcctg agaaaacgaa agcagtggag aactacctta tacagatggc
      361 acggtatgga cagctgagtg ggaaggtgtc agaacaaggg ttaatagaaa tactcgagaa
      421 agtcagccaa cagacagaaa agaaaacaac agtgaaattc aacagaagaa aagtaatgga
      481 ctcagatgaa gatgatgatt actaaagagg acgtgcttag acagacccac ggagcaggtc
      541 taggacagtt accacctgta aatgtttact ttgttccctg tctatatgcc ttttgaaaaa
      601 aataaacttg tacctcaaac tcaaacagtt tgggtgtctc agaatcccag gcacttc
//
