LOCUS       NM_022265               2368 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus programmed cell death 4 (Pdcd4), mRNA.
ACCESSION   NM_022265 XM_006231613
VERSION     NM_022265.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2368)
  AUTHORS   Chai,L., Wang,Q., Wang,Y., Li,D., Zhang,Q., Chen,Y., Liu,J.,
            Chen,H., Qiu,Y., Shen,N., Wang,J., Xie,X. and Li,M.
  TITLE     Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates
            MIF-induced PASMCs proliferation/migration and vascular remodeling
  JOURNAL   Eur J Pharmacol 956, 175968 (2023)
   PUBMED   37549728
  REMARK    GeneRIF: Downregulation of PDCD4 through STAT3/ATF6/autophagy
            mediates MIF-induced PASMCs proliferation/migration and vascular
            remodeling.
REFERENCE   2  (bases 1 to 2368)
  AUTHORS   Du,X., Osoro,E.K., Chen,Q., Yan,X., Gao,D., Wu,L., Ren,J., Feng,L.,
            Wu,N., Lu,K., Yang,X., Zhong,B., Han,Y., Zhang,F., Li,D., Lan,X.
            and Lu,S.
  TITLE     Pdcd4 promotes lipid deposition by attenuating PPARalpha-mediated
            fatty acid oxidation in hepatocytes
  JOURNAL   Mol Cell Endocrinol 545, 111562 (2022)
   PUBMED   35051553
  REMARK    GeneRIF: Pdcd4 promotes lipid deposition by attenuating
            PPARalpha-mediated fatty acid oxidation in hepatocytes.
REFERENCE   3  (bases 1 to 2368)
  AUTHORS   Qi,H., Zhang,J., Shang,Y., Yuan,S. and Meng,C.
  TITLE     Argon inhibits reactive oxygen species oxidative stress via the
            miR-21-mediated PDCD4/PTEN pathway to prevent myocardial
            ischemia/reperfusion injury
  JOURNAL   Bioengineered 12 (1), 5529-5539 (2021)
   PUBMED   34506261
  REMARK    GeneRIF: Argon inhibits reactive oxygen species oxidative stress
            via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial
            ischemia/reperfusion injury.
REFERENCE   4  (bases 1 to 2368)
  AUTHORS   Osoro,E.K., Du,X., Liang,D., Lan,X., Farooq,R., Huang,F., Zhu,W.,
            Ren,J., Sadiq,M., Tian,L., Yang,X., Li,D. and Lu,S.
  TITLE     Induction of PDCD4 by albumin in proximal tubule epithelial cells
            potentiates proteinuria-induced dysfunctional autophagy by
            negatively targeting Atg5
  JOURNAL   Biochem Cell Biol 99 (5), 617-628 (2021)
   PUBMED   33831322
  REMARK    GeneRIF: Induction of PDCD4 by albumin in proximal tubule
            epithelial cells potentiates proteinuria-induced dysfunctional
            autophagy by negatively targeting Atg5.
REFERENCE   5  (bases 1 to 2368)
  AUTHORS   Zhang,Q., Cao,Y., Liu,Y., Huang,W., Ren,J., Wang,P., Song,C.,
            Fan,K., Ba,L., Wang,L. and Sun,H.
  TITLE     Shear stress inhibits cardiac microvascular endothelial cells
            apoptosis to protect against myocardial ischemia reperfusion injury
            via YAP/miR-206/PDCD4 signaling pathway
  JOURNAL   Biochem Pharmacol 186, 114466 (2021)
   PUBMED   33610591
  REMARK    GeneRIF: Shear stress inhibits cardiac microvascular endothelial
            cells apoptosis to protect against myocardial ischemia reperfusion
            injury via YAP/miR-206/PDCD4 signaling pathway.
REFERENCE   6  (bases 1 to 2368)
  AUTHORS   Hilliard,A., Hilliard,B., Zheng,S.J., Sun,H., Miwa,T., Song,W.,
            Goke,R. and Chen,Y.H.
  TITLE     Translational regulation of autoimmune inflammation and lymphoma
            genesis by programmed cell death 4
  JOURNAL   J Immunol 177 (11), 8095-8102 (2006)
   PUBMED   17114484
REFERENCE   7  (bases 1 to 2368)
  AUTHORS   Palamarchuk,A., Efanov,A., Maximov,V., Aqeilan,R.I., Croce,C.M. and
            Pekarsky,Y.
  TITLE     Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
  JOURNAL   Cancer Res 65 (24), 11282-11286 (2005)
   PUBMED   16357133
REFERENCE   8  (bases 1 to 2368)
  AUTHORS   Lankat-Buttgereit,B., Gregel,C., Knolle,A., Hasilik,A., Arnold,R.
            and Goke,R.
  TITLE     Pdcd4 inhibits growth of tumor cells by suppression of carbonic
            anhydrase type II
  JOURNAL   Mol Cell Endocrinol 214 (1-2), 149-153 (2004)
   PUBMED   15062553
  REMARK    GeneRIF: transfected Pdcd4 suppresses carbonic anhydrase type II
            protein expression in HEK293 and Bon-1 carcinoid cells; the
            translation inhibitor pdcd4 represses endocrine tumor cell growth
            by suppression of carbonic anhydase II
REFERENCE   9  (bases 1 to 2368)
  AUTHORS   Goke,A., Goke,R., Knolle,A., Trusheim,H., Schmidt,H., Wilmen,A.,
            Carmody,R., Goke,B. and Chen,Y.H.
  TITLE     DUG is a novel homologue of translation initiation factor 4G that
            binds eIF4A
  JOURNAL   Biochem Biophys Res Commun 297 (1), 78-82 (2002)
   PUBMED   12220511
REFERENCE   10 (bases 1 to 2368)
  AUTHORS   Kang,M.J., Ahn,H.S., Lee,J.Y., Matsuhashi,S. and Park,W.Y.
  TITLE     Up-regulation of PDCD4 in senescent human diploid fibroblasts
  JOURNAL   Biochem Biophys Res Commun 293 (1), 617-621 (2002)
   PUBMED   12054647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 7, 2022 this sequence version replaced
            XM_006231613.4, NM_022265.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167751.1, SRR26643429.6044.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000001.1  262926695-262926784
            91-197              JAXUCZ010000001.1  262930329-262930435
            198-500             JAXUCZ010000001.1  262932300-262932602
            501-595             JAXUCZ010000001.1  262934128-262934222
            596-709             JAXUCZ010000001.1  262935892-262936005
            710-931             JAXUCZ010000001.1  262941386-262941607
            932-1029            JAXUCZ010000001.1  262942924-262943021
            1030-1144           JAXUCZ010000001.1  262943709-262943823
            1145-1252           JAXUCZ010000001.1  262945589-262945696
            1253-1363           JAXUCZ010000001.1  262945917-262946027
            1364-1503           JAXUCZ010000001.1  262946715-262946854
            1504-2368           JAXUCZ010000001.1  262948717-262949581
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2368
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /note="programmed cell death 4"
                     /db_xref="GeneID:64031"
                     /db_xref="RGD:620816"
     exon            1..90
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            91..197
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1564
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /note="eIF4G-like protein; death up-regulated gene
                     protein; death-upregulated"
                     /codon_start=1
                     /product="programmed cell death protein 4"
                     /protein_id="NP_071601.2"
                     /db_xref="GeneID:64031"
                     /db_xref="RGD:620816"
                     /translation="MDVENEQILNVNPTDPDNLSDSLFSGDEENAGTEEIKNEINGNW
                     ISASTINEARINAKAKRRLRKNSSRDSGRGDSVSDNGSEAVRSGVAVPTSPKGRLLDR
                     RSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLD
                     ETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREM
                     TSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCN
                     TYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQPVNHLVKEIDML
                     LKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLESTGESAFKMMLDLLKSLWK
                     SSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSR
                     GRKRFVSEGDGGRLKPESY"
     exon            198..500
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            501..595
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            596..709
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            710..931
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1029
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1144
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1252
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1363
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1503
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..2368
                     /gene="Pdcd4"
                     /gene_synonym="Dug"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcgctc cgaggcggtg gcggaggctg aggagcgggg tcggggcccg gcggaccaga
       61 gacccgggcg agcggtggcg gcccgagggg attctaaagg aagacttcca tttagtaatt
      121 tgcgtataat cagtgcaagt gaaattaagg aaaaatggat gtagaaaacg agcagatact
      181 gaatgtgaac cccactgacc ctgacaattt aagtgactct ctcttttctg gagatgaaga
      241 aaatgctggc actgaggaaa taaagaatga aataaatgga aattggatct ccgcatctac
      301 tattaatgaa gctagaatta atgctaaagc aaaaagacga ctgcggaaaa attcatcccg
      361 ggactctggc cgaggcgatt cagtcagtga taatggaagt gaagcagtta gaagtggagt
      421 agctgtgccc accagtccaa aaggaaggtt gctagatagg cggtccagat ctgggaaagg
      481 aagggggctg ccaaagaaag gtggtgcagg aggcaagggt gtctggggca cacctggaca
      541 ggtatatgat gtggaggagg tggatgtgaa agatccaaac tatgatgatg accaggagaa
      601 ctgtgtttat gagactgtgg ttctgcccct ggatgagacg gcgtttgaga agacgttaac
      661 acccatcata caggagtact ttgagcacgg agatacgaac gaagtcgcgg agatgttaag
      721 ggatttgaac cttggggaga tgaagagtgg tgtgcccgtg ttggcagtgt ccttagcctt
      781 ggaggggaaa gccagtcacc gggagatgac ttccaagctg ctttctgacc tttgcgggac
      841 agtgatgagc acaaatgacg tggaaaagtc atttgacaag ttgttgaagg atctccccga
      901 gctagccttg gacactccga gagcaccaca gttggtgggc cagtttattg ctagagctgt
      961 tggagatggg atcttgtgta acacctacat cgatagctac aaaggcactg tggactgcgt
     1021 ccaggccagg gctgctttgg acaaggctac tgtgctcctg agtatgtcta aaggtggaaa
     1081 gcgtaaggat agtgtgtggg gatccggagg agggcagcag cctgtcaatc accttgttaa
     1141 agagatcgat atgctgctta aagagtattt gctctctgga gatatgtctg aagctgagca
     1201 ctgccttaag gaactggaag taccgcattt ccaccacgag ctggtatatg aggccattgt
     1261 aatggtttta gagtcaactg gagaaagtgc attcaagatg atgttagatt tattaaaatc
     1321 cttgtggaag tcttctacta ttaccataga ccaaatgaaa agaggttatg agagaattta
     1381 taatgaaatt ccggatatta atctggatgt cccacactca tactctgtgc ttgagagatt
     1441 tgtggaggaa tgttttcagg ctggaatcat ttccaaacaa ctccgagatc tttgtccatc
     1501 aaggggaaga aagcgttttg taagtgaagg agatggaggt cgtcttaaac ctgagagcta
     1561 ctgagcacag caactcttac agtcagtctt aggtgttacc aagaacagat ctcaattgta
     1621 agagttgtca gcacagcttt tcttttttct ttttgttttt gttattgttt tttttttctt
     1681 tttttaaaga atttgttttg ggtacaaggc atttctaaaa ttttataaac ttacatttaa
     1741 tgggaatttt tgaaggaagt attttctttt ttttcttttt tttttctttg aggggaaatt
     1801 aaaggaggga ccgaagagta accacctatg tgtggggtgt tctgataagc tactttctaa
     1861 gtgccatgtt tatgacctaa tcattccaag ttttgcattc atgtacgact gccactcctt
     1921 tctttcaagg acagtgtttt ttgtagtaaa atcactggtt tatacaaagc tttagttagg
     1981 ggtgaagtga agctgctaaa ccccattttg gctgctgctg tggagatgct gtgctttgag
     2041 agtaaacaca cacacacaca cacacacaca cacacacaca cacgcataca cgtacataga
     2101 catacacaca cagacacgca cacacgtaca tagacataca cacacagaca cgcacacaca
     2161 tacacgcaca cagatttttg tcttaacgga ctttaagaag cgagttagtc atgagacttt
     2221 ttcgtctttc cagggaacgt attgattgcc cttaaatatt agacagttaa gtaaatggtg
     2281 gctggaacat ctatttttct acaaaactgg aaaaacgaac ccggttctac aagaatgtac
     2341 aacaaaataa aacatgtgaa cactgtca
//
