LOCUS       NM_031638               1134 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus programmed cell death 2 (Pdcd2), mRNA.
ACCESSION   NM_031638 XM_001056283 XM_341763
VERSION     NM_031638.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Kokorina,N.A., Granier,C.J., Zakharkin,S.O., Davis,S., Rabson,A.B.
            and Sabaawy,H.E.
  TITLE     PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage
            differentiation of human hematopoietic stem/progenitor cells
  JOURNAL   Exp Hematol 40 (12), 1028-1042 (2012)
   PUBMED   22922207
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Baron,B.W., Hyjek,E., Gladstone,B., Thirman,M.J. and Baron,J.M.
  TITLE     PDCD2, a protein whose expression is repressed by BCL6, induces
            apoptosis in human cells by activation of the caspase cascade
  JOURNAL   Blood Cells Mol Dis 45 (2), 169-175 (2010)
   PUBMED   20605493
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Shakib,K., Norman,J.T., Fine,L.G., Brown,L.R. and
            Godovac-Zimmermann,J.
  TITLE     Proteomics profiling of nuclear proteins for kidney fibroblasts
            suggests hypoxia, meiosis, and cancer may meet in the nucleus
  JOURNAL   Proteomics 5 (11), 2819-2838 (2005)
   PUBMED   15942958
REFERENCE   6  (bases 1 to 1134)
  AUTHORS   Owens,G.P., Hahn,W.E. and Cohen,J.J.
  TITLE     Identification of mRNAs associated with programmed cell death in
            immature thymocytes
  JOURNAL   Mol Cell Biol 11 (8), 4177-4188 (1991)
   PUBMED   2072913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_001056283.1, XM_341763.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80601.1, FQ134673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000001.1  65163192-65163524   c
            334-573             JAXUCZ010000001.1  65162575-65162814   c
            574-705             JAXUCZ010000001.1  65161943-65162074   c
            706-809             JAXUCZ010000001.1  65159260-65159363   c
            810-923             JAXUCZ010000001.1  65158346-65158459   c
            924-1134            JAXUCZ010000001.1  65158034-65158244   c
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1134
                     /gene="Pdcd2"
                     /note="programmed cell death 2"
                     /db_xref="GeneID:58934"
                     /db_xref="RGD:61887"
     exon            1..333
                     /gene="Pdcd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1082
                     /gene="Pdcd2"
                     /note="zinc finger protein Rp-8"
                     /codon_start=1
                     /product="programmed cell death protein 2"
                     /protein_id="NP_113826.1"
                     /db_xref="GeneID:58934"
                     /db_xref="RGD:61887"
                     /translation="MAAVVPVTVELGFVEEAPAWRLRSEQFPSKVGGRPAWLALAELP
                     GPGALACARCGRPLAFLLQVYAPLPGRDEAFHRSLFLFCCREPLCCAGLRVFRNQLPR
                     KNAFYSYEPPSETGASDTECVCLQLKSGAHLCRVCGCLAPMTCSRCKQAHYCSKEHQT
                     LDWQLGHKQACTQSDHLDHMVPDHNFLFPEFEIVTETEDEIGPEVVEMEDYSEVIGSM
                     EGVPEEELDSMAKHESKEDHIFQKFKSKIALEPEQILRYGRGIKPIWISGENIPQEKD
                     IPDCSCGAKRIFEFQVMPQLLNHLKADRLGTSVDWGILAVFTCAESCSLGIGYTEEFV
                     WKQDVTETP"
     exon            334..573
                     /gene="Pdcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..705
                     /gene="Pdcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..809
                     /gene="Pdcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..923
                     /gene="Pdcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1134
                     /gene="Pdcd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacacgtgac cacactcttc cggtctggtg ggcagagtcc tgctgggagc atggctgccg
       61 ttgtgccagt tacggtggag ttgggcttcg ttgaggaggc accggcctgg aggctgcgca
      121 gcgagcagtt tccaagcaaa gtgggcgggc ggcctgcgtg gttggccctg gcggagctgc
      181 ccggacctgg ggcgctggcg tgcgcgcgtt gcggccgccc gctcgccttc ctgctgcaag
      241 tgtacgcacc gcttccgggt cgggacgaag ccttccaccg tagcctcttt ctcttctgct
      301 gtcgagagcc gctgtgttgc gccggcctgc gagtttttcg taatcagcta ccaaggaaaa
      361 atgcatttta ctcatatgag cccccttctg aaacgggagc ttcggataca gaatgtgtgt
      421 gcctccaact taagtctgga gctcatctct gcagggtttg tggttgcttg gcccctatga
      481 catgctctag gtgcaaacag gcacattact gcagcaagga acatcagaca ttagactggc
      541 agctcggcca caagcaggct tgtacacagt cagaccattt agaccatatg gttccagacc
      601 ataacttcct gtttccagaa tttgaaattg taacagaaac agaagacgag attgggcctg
      661 aggtggtgga aatggaggat tactctgaag ttataggaag catggaggga gtacctgagg
      721 aagaactaga ttccatggca aagcatgaat ccaaggagga tcacatattc caaaagttta
      781 aatccaaaat agcccttgaa ccagagcaga ttctcaggta tggaagaggt attaaaccca
      841 tctggatttc tggtgaaaat attcctcaag aaaaagatat tccagattgc tcatgtggtg
      901 ccaagagaat atttgaattc caggtcatgc ctcagctgtt gaaccaccta aaggcagaca
      961 gactgggtac aagtgtggac tggggcatct tggctgtctt cacctgtgct gagagctgca
     1021 gcctgggcat cgggtacaca gaagaatttg tgtggaaaca ggatgtgaca gagacaccgt
     1081 gaaaggtgtt aaattcttaa aaataaatgt tccttatgcc tcactacctc acaa
//
