LOCUS       NM_001107582            1621 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus programmed cell death 1 ligand 2 (Pdcd1lg2),
            mRNA.
ACCESSION   NM_001107582 XM_001079586 XM_219777
VERSION     NM_001107582.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Wang T, Chen S, Wang X, Huang Y, Qiu J, Fei Y, Chaulagain A, Chen
            Y, Wang Y, Lin L, Yan B, Wang Y, Wang W, Zhao W and Zhong Z.
  TITLE     Aberrant PD-1 ligand expression contributes to the myocardial
            inflammatory injury caused by Coxsackievirus B infection
  JOURNAL   Antiviral Res 166, 1-10 (2019)
   PUBMED   30904424
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   He H, Zhou Y, Zhou Y, Zhuang J, He X, Wang S and Lin W.
  TITLE     Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation
            through Upregulation of Programmed Cell Death Protein 1 in a Rat
            Spinal Cord Injury Model
  JOURNAL   J Neurotrauma 35 (21), 2591-2603 (2018)
   PUBMED   29665726
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Wilson JK, Zhao Y, Singer M, Spencer J and Shankar-Hari M.
  TITLE     Lymphocyte subset expression and serum concentrations of PD-1/PD-L1
            in sepsis - pilot study
  JOURNAL   Crit Care 22 (1), 95 (2018)
   PUBMED   29661225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Singh A, Mohan A, Dey AB and Mitra DK.
  TITLE     Inhibiting the programmed death 1 pathway rescues Mycobacterium
            tuberculosis-specific interferon gamma-producing T cells from
            apoptosis in patients with pulmonary tuberculosis
  JOURNAL   J Infect Dis 208 (4), 603-615 (2013)
   PUBMED   23661793
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   Cao J, Liu FX and Yu MX.
  TITLE     Expression of programmed death 1 and its ligands in the liver of
            autoimmune hepatitis C57BL/6 mice
  JOURNAL   Chin Med J (Engl) 122 (16), 1941-1946 (2009)
   PUBMED   19781375
REFERENCE   6  (bases 1 to 1621)
  AUTHORS   Vogt L, Schmitz N, Kurrer MO, Bauer M, Hinton HI, Behnke S, Gatto
            D, Sebbel P, Beerli RR, Sonderegger I, Kopf M, Saudan P and
            Bachmann MF.
  TITLE     VSIG4, a B7 family-related protein, is a negative regulator of T
            cell activation
  JOURNAL   J Clin Invest 116 (10), 2817-2826 (2006)
   PUBMED   17016562
REFERENCE   7  (bases 1 to 1621)
  AUTHORS   Liang SC, Greenwald RJ, Latchman YE, Rosas L, Satoskar A, Freeman
            GJ and Sharpe AH.
  TITLE     PD-L1 and PD-L2 have distinct roles in regulating host immunity to
            cutaneous leishmaniasis
  JOURNAL   Eur J Immunol 36 (1), 58-64 (2006)
   PUBMED   16358363
REFERENCE   8  (bases 1 to 1621)
  AUTHORS   Brown JA, Dorfman DM, Ma FR, Sullivan EL, Munoz O, Wood CR,
            Greenfield EA and Freeman GJ.
  TITLE     Blockade of programmed death-1 ligands on dendritic cells enhances
            T cell activation and cytokine production
  JOURNAL   J Immunol 170 (3), 1257-1266 (2003)
   PUBMED   12538684
REFERENCE   9  (bases 1 to 1621)
  AUTHORS   Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi
            A, Shin T, Pardoll DM and Tsuchiya H.
  TITLE     B7-DC, a new dendritic cell molecule with potent costimulatory
            properties for T cells
  JOURNAL   J Exp Med 193 (7), 839-846 (2001)
   PUBMED   11283156
REFERENCE   10 (bases 1 to 1621)
  AUTHORS   Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I,
            Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K,
            Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H,
            Okazaki T, Honjo T, Sharpe AH and Freeman GJ.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JACYVU010000047.1.
            
            [WARNING] On Mar 29, 2024 this sequence was replaced by
            NM_001107582.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001107582.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JACYVU010000047.1  14179734-14179957
            225-292             JACYVU010000047.1  14198696-14198763
            293-598             JACYVU010000047.1  14211313-14211618
            599-868             JACYVU010000047.1  14224478-14224747
            869-1004            JACYVU010000047.1  14228084-14228219
            1005-1621           JACYVU010000047.1  14244115-14244731
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1621
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="programmed cell death 1 ligand 2"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
     exon            1..224
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            225..292
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1044
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="PD-1 ligand 2; PDCD1 ligand 2; programmed death
                     ligand 2"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 2 precursor"
                     /protein_id="NP_001101052.2"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
                     /translation="MLLLLLILNLSSQLHHIAALFTVTAPKEVYTVDFGSSVSLECDF
                     DRRECTELEGIRASLQKVENDTSSQSQRATLLEELLPLGKASFHIPSVQVRDSGQYRC
                     LVICGAAWDYKYLTVKVKASYVRIDTGILEVPGTGEVQLICQARGYPLAEVSWQNVSV
                     PANTSHIRTPEGLYQVTSVLRLKPQPNRNFSCMFWNAHMKELTSAIIDPLSWMEPKVP
                     RTRSLHAFIPACTVALIFLATVIAQRKRLWGKLYSRKRSEPAVLGVGKIQ"
     exon            293..598
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..868
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1004
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1621
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accacatctt ttgttccccc ttgttggtta tatcctaatg tcaaatgtgg gcataccttt
       61 gtggcgcccc cctgtcttcc aaccagaggg gatgcactgg ctgctcctgt tgtggacagg
      121 tttggttggt ggtgtaattg gcttctgagg aacctgatac aaagagtgac tatgtgtagc
      181 cttttctctg tgtctttgtc tgacgagttg tgttgagtcc tgatattgat acagaccatg
      241 ctgctcctgc tgctgatact gaacctgagc tcgcaacttc atcacatagc agctttattc
      301 acggtgacag cccctaagga ggtgtacacc gtagacttcg gcagcagtgt gagcctggag
      361 tgtgattttg accgcagaga atgcaccgag ctagaaggaa taagagccag tttgcagaag
      421 gtagaaaacg atacttcttc acaaagtcaa agagccaccc tgctggaaga gctgcttccc
      481 ctggggaagg cttcgttcca catccccagt gtccaagtga gagattcagg gcagtaccgt
      541 tgtctggtca tctgcggggc cgcctgggac tacaagtacc tgacggtgaa agtcaaagct
      601 tcttacgtga ggatagacac tgggatccta gaggttccag ggacagggga ggtgcagctc
      661 atctgccagg ctagaggtta ccccctagca gaagtgtcct ggcaaaatgt cagtgttcct
      721 gccaacacca gccacatcag gacccctgaa ggcctctacc aggtcaccag tgttctgcgc
      781 ctgaagcctc agcctaacag aaacttcagc tgcatgttct ggaatgctca catgaaggag
      841 cttacttcag ccatcattga ccctctgagt tggatggaac ccaaagtccc cagaacacgg
      901 tcacttcatg ctttcatccc ggcctgcact gtcgctctca tcttcctagc cacagtgata
      961 gcccagagaa agaggctctg gggaaagctg tattctagaa aaagatctga gcctgcggtc
     1021 ttgggagttg ggaagatcca ataggaaatc ctcaagaggc ttctggactc aaagtgagaa
     1081 tctagcagag ccgccatttg cacttttcga atgctgatca ggagcttgca ggactgccaa
     1141 gactgccttc ccttcctctc aagactctct ctgaacaaaa acaaccacaa tggcacccta
     1201 gagtcctccc tccccccccc ccctggggat cctggacccc agtgaagccc ttcctggttt
     1261 ccagggtgaa aacaaaagga attgttcttc ctcctccccc tgcgttccac ggggagacaa
     1321 ggaaattccc agttactaaa atagattgtg ttgataatag agttttttaa tatctgtcat
     1381 ttcctctggg gatttggaag tttcagaaag ggtttttagt aaacaaagtc ataactgatg
     1441 tgtttcactg catcctagaa tcctggcagc ctctgaagtt ctgattatca ggaagcattt
     1501 gagtacacaa ctgtggaatt tgtttctact tttctttttt taaagctgag tcacacaagg
     1561 catttgttgt aacctgtgat gtcactgttt attgatctct tctctttcaa ctacattttt
     1621 t
//
