LOCUS       NM_001009542            1385 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus programmed cell death 10 (Pdcd10), mRNA.
ACCESSION   NM_001009542
VERSION     NM_001009542.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Iruzubieta,P., Campo-Caballero,D., Equiza,J., Albajar,I.,
            Sulibarria,N., Saez,R., Andres,N., Mondragon,E., Zulaica,M., de
            Arce,A., Urtasun,M. and Lopez de Munain,A.
  TITLE     Description of Two Families with New Mutations in Familial Cerebral
            Cavernous Malformations Genes
  JOURNAL   J Stroke Cerebrovasc Dis 30 (12), 106130 (2021)
   PUBMED   34597987
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Peng,W., Wu,X., Feng,D., Zhang,Y., Chen,X., Ma,C., Shen,H., Li,X.,
            Li,H., Zhang,J. and Chen,G.
  TITLE     Cerebral cavernous malformation 3 relieves subarachnoid
            hemorrhage-induced neuroinflammation in rats through inhibiting
            NF-kB signaling pathway
  JOURNAL   Brain Res Bull 160, 74-84 (2020)
   PUBMED   32302649
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Abou-Fadel,J., Qu,Y., Gonzalez,E.M., Smith,M. and Zhang,J.
  TITLE     Emerging roles of CCM genes during tumorigenesis with potential
            application as novel biomarkers across major types of cancers
  JOURNAL   Oncol Rep 43 (6), 1945-1963 (2020)
   PUBMED   32186778
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Mardakheh,F.K., Self,A. and Marshall,C.J.
  TITLE     RHO binding to FAM65A regulates Golgi reorientation during cell
            migration
  JOURNAL   J Cell Sci 129 (24), 4466-4479 (2016)
   PUBMED   27807006
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Scimone,C., Bramanti,P., Ruggeri,A., Donato,L., Alafaci,C.,
            Crisafulli,C., Mucciardi,M., Rinaldi,C., Sidoti,A. and D'Angelo,R.
  TITLE     CCM3/SERPINI1 bidirectional promoter variants in patients with
            cerebral cavernous malformations: a molecular and functional study
  JOURNAL   BMC Med Genet 17 (1), 74 (2016)
   PUBMED   27737651
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Ma,X., Zhao,H., Shan,J., Long,F., Chen,Y., Chen,Y., Zhang,Y.,
            Han,X. and Ma,D.
  TITLE     PDCD10 interacts with Ste20-related kinase MST4 to promote cell
            growth and transformation via modulation of the ERK pathway
  JOURNAL   Mol Biol Cell 18 (6), 1965-1978 (2007)
   PUBMED   17360971
REFERENCE   8  (bases 1 to 1385)
  AUTHORS   Denier,C., Labauge,P., Bergametti,F., Marchelli,F., Riant,F.,
            Arnoult,M., Maciazek,J., Vicaut,E., Brunereau,L. and
            Tournier-Lasserve,E.
  TITLE     Genotype-phenotype correlations in cerebral cavernous malformations
            patients
  JOURNAL   Ann Neurol 60 (5), 550-556 (2006)
   PUBMED   17041941
REFERENCE   9  (bases 1 to 1385)
  AUTHORS   Guclu,B., Ozturk,A.K., Pricola,K.L., Bilguvar,K., Shin,D.,
            O'Roak,B.J. and Gunel,M.
  TITLE     Mutations in apoptosis-related gene, PDCD10, cause cerebral
            cavernous malformation 3
  JOURNAL   Neurosurgery 57 (5), 1008-1013 (2005)
   PUBMED   16284570
REFERENCE   10 (bases 1 to 1385)
  AUTHORS   Bergametti,F., Denier,C., Labauge,P., Arnoult,M., Boetto,S.,
            Clanet,M., Coubes,P., Echenne,B., Ibrahim,R., Irthum,B.,
            Jacquet,G., Lonjon,M., Moreau,J.J., Neau,J.P., Parker,F.,
            Tremoulet,M. and Tournier-Lasserve,E.
  CONSRTM   Societe Francaise de Neurochirurgie
  TITLE     Mutations within the programmed cell death 10 gene cause cerebral
            cavernous malformations
  JOURNAL   Am J Hum Genet 76 (1), 42-51 (2005)
   PUBMED   15543491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 10, 2021 this sequence version replaced NM_001009542.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067245.1, FQ213019.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000002.1  162644535-162644612 c
            79-297              JAXUCZ010000002.1  162626594-162626812 c
            298-351             JAXUCZ010000002.1  162619186-162619239 c
            352-469             JAXUCZ010000002.1  162614527-162614644 c
            470-596             JAXUCZ010000002.1  162613309-162613435 c
            597-675             JAXUCZ010000002.1  162606991-162607069 c
            676-758             JAXUCZ010000002.1  162606653-162606735 c
            759-1385            JAXUCZ010000002.1  162602516-162603142 c
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..1385
                     /gene="Pdcd10"
                     /note="programmed cell death 10"
                     /db_xref="GeneID:494345"
                     /db_xref="RGD:1359329"
     exon            1..78
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
     exon            79..297
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..840
                     /gene="Pdcd10"
                     /codon_start=1
                     /product="programmed cell death protein 10"
                     /protein_id="NP_001009542.1"
                     /db_xref="GeneID:494345"
                     /db_xref="RGD:1359329"
                     /translation="MTMEEMKTEAEAASMVSMPLYAVMYPVFNELERVNLSAAQTLRA
                     AFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLN
                     EKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEH
                     QKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA"
     exon            298..351
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
     exon            352..469
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
     exon            470..596
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
     exon            597..675
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
     exon            676..758
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1385
                     /gene="Pdcd10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtcgccg gagtgaattg atccgggagt tgaagagggc tccaaaggtg ggaagtgaag
       61 tccgtgcctc agttactggt tgctgttctt ttttgtgccc cattctttat cgtatacaca
      121 tacagaaggg gagaaattgg gcagtgaatg acgcttcctc tgcattctag cgttgctttt
      181 cctgctctcg ctggcctgtg actgaggatg acaatggaag agatgaagac tgaagctgag
      241 gccgcgtcca tggtttccat gcctctctac gcagtcatgt accctgtgtt taacgagcta
      301 gaacgagtaa atttgtctgc agctcagact ctgagagccg ctttcattaa ggctgaaaag
      361 gaaaatccag gcctcacaca agacatcatt atgaaaatct tagagaaaaa aagtgtagaa
      421 gttaacttca ctgagtccct tcttcgtatg gcagctgatg acgtagaaga gtacatgatt
      481 gaacgaccag agccagaatt ccaggaccta aatgaaaagg cacgggcact taaacagatt
      541 ctcagtaaga ttccagacga gatcaatgac agagtgaggt ttctgcagac aatcaaggat
      601 atagctagtg caataaaaga actacttgat acagtgaata atgtctttaa aaaatatcaa
      661 taccagaacc gcagggcact tgaacaccaa aagaaagaat ttgtaaaata ctccaaaagt
      721 ttcagtgaca ctctgaagac atattttaaa gatggcaagg caataaatgt gttcataagt
      781 gccaaccggc taattcatca aaccaacttg atacttcaga ccttcaaaac tgtggcctga
      841 agctgtatat gttcagagat gtacttctca gtggcagtat taaactgcac ttatctgtaa
      901 atttaaagtc tgactgtata aattaccagc cctcctgagg ggtctaatcc aggatgttga
      961 atgggattat cgccatctta caccgtattt ttgtaaaatg tagcttaatc ataacctcac
     1021 actgaagatt ttgcatcact tttgctatta tcattctttt aagaattata agccaaaaga
     1081 atttacgcct taatgtgtca ttatataaca ttccttacaa gaaatgtaaa tattggtgtt
     1141 tgtttctgac attttaactt gaaagcgata tgctgcaaga taatgtattt aacaatattt
     1201 ggtggcaaat attcaataaa tagtttacat ctgttaaaca tttctttact tgaaaaaaag
     1261 atgcatatat atatgtgtgt gtgtatatat gatcagaaga ccaagacaac ttggtataat
     1321 gttaaagatc ttctaatggg agcttactag cagtttatca aataataaag caacaagaat
     1381 tccta
//
