LOCUS       NM_012872               1272 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosducin (Pdc), mRNA.
ACCESSION   NM_012872
VERSION     NM_012872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1272)
  AUTHORS   Kacirova,M., Novacek,J., Man,P., Obsilova,V. and Obsil,T.
  TITLE     Structural Basis for the 14-3-3 Protein-Dependent Inhibition of
            Phosducin Function
  JOURNAL   Biophys J 112 (7), 1339-1349 (2017)
   PUBMED   28402877
  REMARK    GeneRIF: 14-3-3 protein-mediated inhibition of Pdc binding to
            Gtbetagamma is based on steric occlusion of Pdc's Gtbetagamma
            binding surface.
REFERENCE   2  (bases 1 to 1272)
  AUTHORS   Kacirova,M., Kosek,D., Kadek,A., Man,P., Vecer,J., Herman,P.,
            Obsilova,V. and Obsil,T.
  TITLE     Structural Characterization of Phosducin and Its Complex with the
            14-3-3 Protein
  JOURNAL   J Biol Chem 290 (26), 16246-16260 (2015)
   PUBMED   25971962
  REMARK    GeneRIF: C-terminal domain of Pdc interacts with the outside
            surface of the 14-3-3 dimer.
REFERENCE   3  (bases 1 to 1272)
  AUTHORS   Rezabkova,L., Kacirova,M., Sulc,M., Herman,P., Vecer,J.,
            Stepanek,M., Obsilova,V. and Obsil,T.
  TITLE     Structural modulation of phosducin by phosphorylation and 14-3-3
            protein binding
  JOURNAL   Biophys J 103 (9), 1960-1969 (2012)
   PUBMED   23199924
  REMARK    GeneRIF: 14-3-3 phosphorylation of Pdc at Ser-54 and Ser-73 affects
            the structure of the whole Pdc molecule.
REFERENCE   4  (bases 1 to 1272)
  AUTHORS   Lobanova,E.S., Finkelstein,S., Herrmann,R., Chen,Y.M., Kessler,C.,
            Michaud,N.A., Trieu,L.H., Strissel,K.J., Burns,M.E. and
            Arshavsky,V.Y.
  TITLE     Transducin gamma-subunit sets expression levels of alpha- and
            beta-subunits and is crucial for rod viability
  JOURNAL   J Neurosci 28 (13), 3510-3520 (2008)
   PUBMED   18367617
REFERENCE   5  (bases 1 to 1272)
  AUTHORS   Song,H., Belcastro,M., Young,E.J. and Sokolov,M.
  TITLE     Compartment-specific phosphorylation of phosducin in rods underlies
            adaptation to various levels of illumination
  JOURNAL   J Biol Chem 282 (32), 23613-23621 (2007)
   PUBMED   17569665
  REMARK    GeneRIF: phosducin has a role in regulating signaling in the rod
            outer segment compartment and there are distinct functions for
            phosphorylation sites 54 and 71
REFERENCE   6  (bases 1 to 1272)
  AUTHORS   Nakano,K., Chen,J., Tarr,G.E., Yoshida,T., Flynn,J.M. and
            Bitensky,M.W.
  TITLE     Rethinking the role of phosducin: light-regulated binding of
            phosducin to 14-3-3 in rod inner segments
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4693-4698 (2001)
   PUBMED   11287646
REFERENCE   7  (bases 1 to 1272)
  AUTHORS   Gaudet,R., Savage,J.R., McLaughlin,J.N., Willardson,B.M. and
            Sigler,P.B.
  TITLE     A molecular mechanism for the phosphorylation-dependent regulation
            of heterotrimeric G proteins by phosducin
  JOURNAL   Mol Cell 3 (5), 649-660 (1999)
   PUBMED   10360181
REFERENCE   8  (bases 1 to 1272)
  AUTHORS   Craft,C.M., Lolley,R.N., Seldin,M.F. and Lee,R.H.
  TITLE     Rat pineal gland phosducin: cDNA isolation, nucleotide sequence,
            and chromosomal assignment in the mouse
  JOURNAL   Genomics 10 (2), 400-409 (1991)
   PUBMED   2071146
REFERENCE   9  (bases 1 to 1272)
  AUTHORS   Lee,R.H., Fowler,A., McGinnis,J.F., Lolley,R.N. and Craft,C.M.
  TITLE     Amino acid and cDNA sequence of bovine phosducin, a soluble
            phosphoprotein from photoreceptor cells
  JOURNAL   J Biol Chem 265 (26), 15867-15873 (1990)
   PUBMED   2203790
REFERENCE   10 (bases 1 to 1272)
  AUTHORS   Abe,T., Nakabayashi,H., Tamada,H., Takagi,T., Sakuragi,S.,
            Yamaki,K. and Shinohara,T.
  TITLE     Analysis of the human, bovine and rat 33-kDa proteins and cDNA in
            retina and pineal gland
  JOURNAL   Gene 91 (2), 209-215 (1990)
   PUBMED   2210381
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M33528.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012872.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M33528.1, M33530.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1272
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..1272
                     /gene="Pdc"
                     /gene_synonym="33DPTP; MEKA; Rpr1"
                     /note="phosducin"
                     /db_xref="GeneID:25343"
                     /db_xref="RGD:3277"
     exon            1..57
                     /gene="Pdc"
                     /gene_synonym="33DPTP; MEKA; Rpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..142
                     /gene="Pdc"
                     /gene_synonym="33DPTP; MEKA; Rpr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..822
                     /gene="Pdc"
                     /gene_synonym="33DPTP; MEKA; Rpr1"
                     /note="PHD; RPR-1; rod photoreceptor 1; 33 kDa
                     phototransducing protein; Phototransducing protein, 33 kDa
                     (phosducin)"
                     /codon_start=1
                     /product="phosducin"
                     /protein_id="NP_037004.1"
                     /db_xref="GeneID:25343"
                     /db_xref="RGD:3277"
                     /translation="MEEAASQSLEEDFEGQATHTGPKGVINDWRKFKLESEDGDSIPP
                     SKKEILRQMSSPQSRDDKDSKERMSRKMSIQEYELIHQDKEDEGCLRKYRRQCMQDMH
                     QKLSFGPRYGFVYELETGEQFLETIEKEQKVTTIVVNIYEDGVRGCDALNSSLECLAA
                     EYPMVKFCKIRASNTGAGDRFSSDVLPTLLIYKGGELISNFISVAEQFAEDFFAADVE
                     SFLNEYGLLPEREIHDLGQTNTEDEDIE"
     exon            143..294
                     /gene="Pdc"
                     /gene_synonym="33DPTP; MEKA; Rpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..1272
                     /gene="Pdc"
                     /gene_synonym="33DPTP; MEKA; Rpr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagattct cacccactgg acataatcta ggactccagg aacagagacc ccaaactact
       61 acaccgaaca caacccataa aatggaagaa gccgcaagcc aaagcttaga ggaagatttt
      121 gaaggacagg ccacacacac aggacccaaa ggagtaataa atgactggag aaagtttaaa
      181 ttagaaagtg aagatggtga ttcaattcca cccagcaaga aggagatcct cagacaaatg
      241 tcctctcctc agagcagaga tgacaaagac tcgaaagaaa gaatgagcag aaagatgagc
      301 attcaagaat atgaactaat tcatcaggac aaagaagatg aaggttgcct tcgcaaatac
      361 cgcagacagt gcatgcagga tatgcatcag aagctgagct ttgggcctag gtatgggttt
      421 gtgtatgagc tggaaacagg ggagcaattc ctggaaacca tcgaaaagga gcagaaggtc
      481 accaccatcg tggttaacat ttacgaggat ggtgtcaggg gctgtgacgc actcaacagc
      541 agtttagaat gccttgcagc agagtaccca atggtcaagt tctgtaaaat aagagcttcg
      601 aatactggag ctggggaccg cttttcctca gacgtactcc cgacattgct catatacaaa
      661 ggtggggagc tcataagcaa ttttattagt gtcgctgaac aatttgccga agattttttc
      721 gctgcggatg tggagtcttt cctaaatgaa tatggcttac taccagaaag agagatacat
      781 gacctagggc agaccaacac ggaagatgaa gatatcgagt aagcacgcac ggtgcagtat
      841 ctcgtgacta tcctttgcac agtgaacatc gatggttttt ttggtagtat ctatattcct
      901 ttagcaaaca ctaaatacag tcaggccaac tcaaattggg gaggggacac taaaattatg
      961 taaatagcat ttttagtact aattattcaa attgagataa tattttactg caaaaaatat
     1021 tgtggttctg agcaaataac tactgaacag aggaggtggg tgatgtcaac gttaggtcat
     1081 tgtaaaaatc cctttccagt tccgtgttag cttattactc ctccttttcc ccttggcatt
     1141 tatttttggg cttttgaggc tgaatgctac ttataaattg gtttgtatga taagaataaa
     1201 gtcctatgaa gaaacaaata gtctgtctaa agtctgccgt gagtcaagga cttaaaaact
     1261 tcataaagct tt
//
