LOCUS       NM_053568               1844 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus phosphate cytidylyltransferase 2, ethanolamine
            (Pcyt2), mRNA.
ACCESSION   NM_053568
VERSION     NM_053568.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Bleijerveld,O.B., Klein,W., Vaandrager,A.B., Helms,J.B. and
            Houweling,M.
  TITLE     Control of the CDPethanolamine pathway in mammalian cells: effect
            of CTP:phosphoethanolamine cytidylyltransferase overexpression and
            the amount of intracellular diacylglycerol
  JOURNAL   Biochem J 379 (Pt 3), 711-719 (2004)
   PUBMED   14759225
  REMARK    GeneRIF: supply of CDPethanolamine, via the expression level of
            ECT, is an important factor governing the rate of PtdEtn
            biosynthesis in mammalian cells, under the condition that the
            amount of DAG is not limiting
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Bladergroen,B.A., Houweling,M., Geelen,M.J. and van Golde,L.M.
  TITLE     Cloning and expression of CTP:phosphoethanolamine
            cytidylyltransferase cDNA from rat liver
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 107-114 (1999)
   PUBMED   10493918
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053568.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF080568.1, SRR22582424.2105239.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000010.1  106394336-106394468 c
            134-222             JAXUCZ010000010.1  106392648-106392736 c
            223-384             JAXUCZ010000010.1  106392026-106392187 c
            385-451             JAXUCZ010000010.1  106391441-106391507 c
            452-536             JAXUCZ010000010.1  106390700-106390784 c
            537-581             JAXUCZ010000010.1  106390446-106390490 c
            582-635             JAXUCZ010000010.1  106390074-106390127 c
            636-774             JAXUCZ010000010.1  106389503-106389641 c
            775-857             JAXUCZ010000010.1  106389004-106389086 c
            858-935             JAXUCZ010000010.1  106388624-106388701 c
            936-1001            JAXUCZ010000010.1  106388369-106388434 c
            1002-1067           JAXUCZ010000010.1  106388154-106388219 c
            1068-1156           JAXUCZ010000010.1  106387937-106388025 c
            1157-1844           JAXUCZ010000010.1  106387156-106387843 c
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1844
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /note="phosphate cytidylyltransferase 2, ethanolamine"
                     /db_xref="GeneID:89841"
                     /db_xref="RGD:619970"
     exon            1..133
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1259
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /EC_number="2.7.7.14"
                     /note="CTP:phosphoethanolamine cytidylyltransferase;
                     phosphorylethanolamine transferase;
                     CTP:phopshoethanolamine cytidylyltransferase"
                     /codon_start=1
                     /product="ethanolamine-phosphate cytidylyltransferase"
                     /protein_id="NP_446020.1"
                     /db_xref="GeneID:89841"
                     /db_xref="RGD:619970"
                     /translation="MIRNGHGAGGAAGLKGPGGQRTVRVWCDGCYDMVHYGHSNQLRQ
                     ARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETL
                     DKHNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAH
                     HSSQEMSSEYREYADSFGKPPHPTPAGDTLSSEVSSQCPGGQSPWTGVSQFLQTSQKI
                     IQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLQEVHKLAKRPYVIAGLHFDQEVNRY
                     KGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLNHFKVDLVCHGKTEIVPDR
                     DGSDPYEEPKRRGIFCQIDSGSDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFLEAL
                     RQQEAQPRGETD"
     exon            134..222
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            223..384
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            385..451
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            452..536
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            537..581
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            582..635
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            636..774
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            775..857
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            858..935
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1001
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1067
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1156
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1844
                     /gene="Pcyt2"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtcgcgg gagctgccag gacttgcggg gggcctctgg tgccatgatc cggaacgggc
       61 acggggctgg cggcgctgct gggctgaagg gtccgggcgg ccagcgcacc gtgcgggtgt
      121 ggtgcgatgg ctgctatgac atggtgcatt acggccactc caaccagcta cgccaggcgc
      181 gggccatggg ggactacctc atcgtgggcg tgcatactga cgaggagatt gccaagcata
      241 aggggccccc ggtgtttacc caggaggagc ggtacaagat ggtacaggcc atcaagtggg
      301 tggatgaagt ggtaccggct gctccctacg tcaccacact ggagacactg gacaagcaca
      361 actgtgactt ctgcgttcat ggcaatgaca tcacgctgac agtagatggc cgagatacct
      421 acgaggaagt gaagcaggct gggaggtaca gagagtgcaa acgcacccag ggtgtgtcca
      481 ccacagacct cgtgggtcgc atgctgctgg tgaccaaggc ccaccatagc agccaggaga
      541 tgtcctctga gtaccgggaa tatgctgaca gttttggcaa gccccctcac ccgacacctg
      601 ccggggacac actttcctca gaagtctcct cccagtgccc tggggggcag agcccctgga
      661 caggggtgtc ccagttccta cagacatccc agaagatcat ccagtttgct tctgggaagg
      721 agccccagcc cggggagaca gtcatctatg tggctggtgc ctttgacctg ttccacatcg
      781 ggcacgtgga cttcctacag gaggtgcaca agctagccaa gaggccctac gtcatcgccg
      841 gcctacactt tgaccaggaa gtaaaccggt acaagggcaa gaactacccc atcatgaacc
      901 tgcatgagcg gactctcagt gtgctggcct gccggtatgt ttcagaagtg gtgattgggg
      961 caccgtactc cgtcacagca gagctcctga atcatttcaa ggtggacctg gtgtgtcatg
     1021 ggaagacaga aattgtaccc gacagggatg ggtctgaccc ctacgaggag cccaagagaa
     1081 gaggcatttt ctgtcagatt gacagtggca gtgacctcac tacagacctg attgtgcaaa
     1141 ggatcatcaa gaacaggttg gagtacgaag cacggaatca gaagaaggaa gccaaggaat
     1201 tagccttttt ggaggccctg aggcagcagg aggcacagcc cagaggggag actgactagc
     1261 ttctgacccg gagacgtcat tcacgccctt gccctgtgcc cacctcatct ctccctgccc
     1321 tgctctgctt ctgtgtcttg gtgtcagctc acacaattcc aaaggaaact ggccttgctg
     1381 agggtgctgt ccctgcctgc ctgcagcagg ctctcagtcc tttccactga gctgctcaga
     1441 gagggtagct agcccagtgg ggcagccccg tggacaggat aagcagacgg cacctgtgac
     1501 tggaggagtg ttgctgtgta tccttggcat ccacgggttc caactgccac tgtcccagtt
     1561 tggctgggga tacccctcct gcctgactgg aagctgcact tctgcccacc gagctttggt
     1621 gaaaggtaca gaggctttgg ggacctctgt tcctgggcca ccctgcacgt gggcaccctc
     1681 taccttgggg cacgttctag caccccattc ctgactccta gaagatgcac ttgcccgggt
     1741 ggctgggcca gcgtggctgc cctccgcaca gacttcctgg tcctcgtttg tacctcagtg
     1801 gctgatgtaa acctctttgg ctcaactgaa taaagcctag tggg
//
