LOCUS       NM_173151               1953 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus phosphate cytidylyltransferase 1B, choline
            (Pcyt1b), mRNA.
ACCESSION   NM_173151
VERSION     NM_173151.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1953)
  AUTHORS   Ridsdale,R., Tseu,I., Wang,J. and Post,M.
  TITLE     Functions of membrane binding domain of CTP:phosphocholine
            cytidylyltransferase in alveolar type II cells
  JOURNAL   Am J Respir Cell Mol Biol 43 (1), 74-87 (2010)
   PUBMED   19684306
REFERENCE   2  (bases 1 to 1953)
  AUTHORS   Lee,J., Johnson,J., Ding,Z., Paetzel,M. and Cornell,R.B.
  TITLE     Crystal structure of a mammalian CTP: phosphocholine
            cytidylyltransferase catalytic domain reveals novel active site
            residues within a highly conserved nucleotidyltransferase fold
  JOURNAL   J Biol Chem 284 (48), 33535-33548 (2009)
   PUBMED   19783652
  REMARK    GeneRIF: The 2.2-A structure reveals a CCT236 homodimer in complex
            with the reaction product, CDP-choline.
REFERENCE   3  (bases 1 to 1953)
  AUTHORS   Carter,J.M., Demizieux,L., Campenot,R.B., Vance,D.E. and Vance,J.E.
  TITLE     Phosphatidylcholine biosynthesis via CTP:phosphocholine
            cytidylyltransferase 2 facilitates neurite outgrowth and branching
  JOURNAL   J Biol Chem 283 (1), 202-212 (2008)
   PUBMED   17981805
  REMARK    GeneRIF: Results highlight the importance of CTbeta2 in neurons for
            promoting neurite outgrowth and branching and represent the first
            identification of a lipid biosynthetic enzyme that facilitates
            these functions.
REFERENCE   4  (bases 1 to 1953)
  AUTHORS   Jackowski,S., Rehg,J.E., Zhang,Y.M., Wang,J., Miller,K., Jackson,P.
            and Karim,M.A.
  TITLE     Disruption of CCTbeta2 expression leads to gonadal dysfunction
  JOURNAL   Mol Cell Biol 24 (11), 4720-4733 (2004)
   PUBMED   15143167
REFERENCE   5  (bases 1 to 1953)
  AUTHORS   Karim,M., Jackson,P. and Jackowski,S.
  TITLE     Gene structure, expression and identification of a new
            CTP:phosphocholine cytidylyltransferase beta isoform
  JOURNAL   Biochim Biophys Acta 1633 (1), 1-12 (2003)
   PUBMED   12842190
REFERENCE   6  (bases 1 to 1953)
  AUTHORS   Xiong,Y., Liu,X., Wang,Y. and Du,Y.
  TITLE     Cloning of cytidine triphosphate: phosphocholine
            cytidylyltransferase mRNA upregulated by a neuropeptide
            arginine-vasopressin((4-8)) in rat hippocampus
  JOURNAL   Neurosci Lett 283 (2), 129-132 (2000)
   PUBMED   10739892
REFERENCE   7  (bases 1 to 1953)
  AUTHORS   Xiong,Y., Wang,Y., Liu,X.L. and Du,Y.C.
  TITLE     Cloning of a Gene in Rat Brain Induced to Be Expressed Differently
            by AVP(4-8) with Differential Display PCR
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31 (5),
            509-512 (1999)
   PUBMED   12114961
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173151.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF190256.1, SRR26643298.32012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000021.1  62398818-62398944
            128-227             JAXUCZ010000021.1  62423990-62424089
            228-344             JAXUCZ010000021.1  62427862-62427978
            345-496             JAXUCZ010000021.1  62438972-62439123
            497-575             JAXUCZ010000021.1  62441352-62441430
            576-718             JAXUCZ010000021.1  62446979-62447121
            719-907             JAXUCZ010000021.1  62450069-62450257
            908-1953            JAXUCZ010000021.1  62461732-62462777
FEATURES             Location/Qualifiers
     source          1..1953
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1953
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /note="phosphate cytidylyltransferase 1B, choline"
                     /db_xref="GeneID:286936"
                     /db_xref="RGD:708434"
     exon            1..127
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1120
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /EC_number="2.7.7.15"
                     /note="choline phosphate cytidylyltransferase 1 beta; CT
                     B; CCT B; phosphorylcholine transferase B;
                     CTP:phosphocholine cytidylyltransferase B; phosphate
                     cytidylyltransferase 1, choline, beta"
                     /codon_start=1
                     /product="choline-phosphate cytidylyltransferase B"
                     /protein_id="NP_775174.2"
                     /db_xref="GeneID:286936"
                     /db_xref="RGD:708434"
                     /translation="MPVLTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAP
                     APFADESSCQCQAPHEKLTIAQARLGTPVDRPVRVYADGIFDLFHSGHARALMQAKTL
                     FPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEK
                     HKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYAR
                     RNLQRGYTAKELNVSFINEKKYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQ
                     KWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSP
                     SPTFSWLPNKTSPPSSPKAASASISSMSEGDEDEK"
     exon            128..227
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            228..344
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            345..496
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            497..575
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            576..718
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            719..907
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1953
                     /gene="Pcyt1b"
                     /gene_synonym="CCT-beta; Cctbeta; CTB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcactggcc atgccagtac ttaccactga tgctgagtca gaaacaggta tcccaaaatc
       61 cctttccaat gagcctccct cagaaaccat ggaggaaata gagcacacat gcccacagcc
      121 tcgactgacc ctgactgcac cagccccatt tgccgatgag tccagctgcc agtgccaagc
      181 gcctcatgaa aaactgacca ttgctcaggc ccgcttagga actccagttg acaggcctgt
      241 tagagtatat gcagacggaa tattcgacct cttccactca ggtcatgcaa gggcacttat
      301 gcaagcaaaa accctgtttc ccaacagcta cttgttggta ggagtttgca gtgatgacct
      361 aactcacaaa ttcaaaggtt ttactgtgat gaatgaggca gagagatatg aagctctcag
      421 acactgtcgc tacgtggacg aagtcatcag agatgcacca tggactctta ctccagagtt
      481 tctggaaaaa cacaagattg actttgtggc tcacgatgac attccgtact catctgccgg
      541 ttctgatgac gtttataagc atatcaagga agcaggcatg tttgttccaa cacaaagaac
      601 agaaggcatc tcaacatcag acatcatcac cagaattgtc cgtgactatg acgtatatgc
      661 ccggcgtaat ctccagagag ggtacacagc caaggagctg aatgtcagct ttataaacga
      721 gaagaagtac cgtttccaga accaggtgga caagatgaaa gaaaaggtca agaatgtgga
      781 ggaaagatca aaggaatttg ttaacagagt agaagaaaag agtcacgacc taattcaaaa
      841 gtgggaagaa aaatcaagag aattcattgg caacttccta gaattgtttg ggccagatgg
      901 tgcatggaag cagatgttcc aggagaggag tagccggatg ctacaggcct tatctccaaa
      961 gcagagtcct gtgagcagcc cgacccggag ccggtcccct tcccgctctc catctcctac
     1021 cttctcctgg ctcccaaaca agacctctcc cccttcctca cccaaagcag cctcagcctc
     1081 catcagcagc atgagtgagg gggatgagga tgagaagtaa aggtgcctgg ttaacaagtg
     1141 cacaccacac aggaagggaa ggggtcccgg gatgcctggg tggtgttgag ctgcagctct
     1201 gccaggagat gggagttctg ccatgggagt tactagggcc agctcctttt ccttctccat
     1261 tcaatctggc ctgggctcag catagaggtt tctgacgtga caacccacac aaaccttagc
     1321 atcatagaaa caccctgctt tagccctgct atggaaaggt ccagagcggg ggtggggatt
     1381 tagctcagtg gtagagcgct tgcctagcaa gcacaaggcc ctgggttcgg tccccagctc
     1441 tggaaaaaaa aagaggaaag gtccagagca ctccatgaag tggggtgact tctgctttgg
     1501 tccacacttc tatctgtagc caatgagcca cctgcagaag tggctgctgc ctcaccctgc
     1561 tatctccagc cctcaaagag ccttgcacgt tacctcctct cacccgcgct ctcccagaat
     1621 gaattccctt ccaactgagg tggctaagtg cttccaaaat gggcacgtca aagaccagtt
     1681 ccagccttct tggttcagcc ttctaaggcc tgatggaatg catcaacact ttcccattcc
     1741 aggaccctga ctcagacgct gcttcacttt ggtcagatag aaaagtgtga cctttaacct
     1801 ctcattcaaa ggacagttgt gtcaaggtga actccaccta aggcctgaca tgcttctggc
     1861 tgtactttct tgtcactggc atgatgacac tgttttccag aaattacctg aattgatgga
     1921 aatcgcaaca aggaaacctg tcttatctaa aaa
//
