LOCUS       NM_145085               2292 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus prenylcysteine oxidase 1 (Pcyox1), mRNA.
ACCESSION   NM_145085
VERSION     NM_145085.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2292)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 2292)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 2292)
  AUTHORS   Mancone,C., Amicone,L., Fimia,G.M., Bravo,E., Piacentini,M.,
            Tripodi,M. and Alonzi,T.
  TITLE     Proteomic analysis of human very low-density lipoprotein by
            two-dimensional gel electrophoresis and MALDI-TOF/TOF
  JOURNAL   Proteomics 7 (1), 143-154 (2007)
   PUBMED   17154273
REFERENCE   4  (bases 1 to 2292)
  AUTHORS   Beigneux,A., Withycombe,S.K., Digits,J.A., Tschantz,W.R.,
            Weinbaum,C.A., Griffey,S.M., Bergo,M., Casey,P.J. and Young,S.G.
  TITLE     Prenylcysteine lyase deficiency in mice results in the accumulation
            of farnesylcysteine and geranylgeranylcysteine in brain and liver
  JOURNAL   J Biol Chem 277 (41), 38358-38363 (2002)
   PUBMED   12151402
REFERENCE   5  (bases 1 to 2292)
  AUTHORS   Kitagawa,K., Yagyu,K., Yamamoto,A., Hattori,N., Omori,K., Zeng,X.T.
            and Inagaki,C.
  TITLE     Molecular cloning and characterization of the Cl(-) pump-associated
            55-kDa protein in rat brain
  JOURNAL   Biochem Biophys Res Commun 289 (2), 363-371 (2001)
   PUBMED   11716481
REFERENCE   6  (bases 1 to 2292)
  AUTHORS   Tschantz,W.R., Zhang,L. and Casey,P.J.
  TITLE     Cloning, expression, and cellular localization of a human
            prenylcysteine lyase
  JOURNAL   J Biol Chem 274 (50), 35802-35808 (1999)
   PUBMED   10585463
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078719.1.
            
            On Jun 10, 2007 this sequence version replaced NM_145085.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078719.1, AF332142.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132304, SAMD00132306
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2292
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /note="prenylcysteine oxidase 1"
                     /db_xref="GeneID:246302"
                     /db_xref="RGD:628652"
     exon            1..152
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1555
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /EC_number="1.8.3.5"
                     /note="chloride ion pump-associated 55 kDa protein"
                     /codon_start=1
                     /product="prenylcysteine oxidase 1 precursor"
                     /protein_id="NP_659553.1"
                     /db_xref="GeneID:246302"
                     /db_xref="RGD:628652"
                     /translation="MGRFAATLVGSLFGLGLLLCGLGRLASAEPRAPPEKIAIVGAGI
                     GGTSSAYYLRKKFGKDVKIDVFEREEIGGRLATLKVQGHDYEAGGSVIHPLNLHMKRF
                     VKELGLSSVPASGGLVGVYNGKSLVFEESSWFIINVIKLVWRYGFQSLRMHMWVEDLL
                     DKFMRIYRYQSHDYAFSSVEKLMYAIGGDDYVRLLNQTLRENLKKAGFSETFLNEMIA
                     PVMKVNFGQSTDLNAFVGAVSMTAADSNLWAVEGGNKVVCSGLLQASNSNLISGSVMS
                     IEKTRTKQTGTPPKMYEVVYKTGSEIHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEE
                     FNDPYQQLVTTLIKGELNSTLFSSRHKDQFGLSAILVTDDSDMFINSLSIVASVSHKE
                     GPPPAVDGMHVWKTFSKDILTKEQISKLFLSYDYAVRKPWLSYPYYNPPQKCPSIILH
                     DRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQDDLYEKLKTEL"
     exon            153..359
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /inference="alignment:Splign:2.1.0"
     exon            360..534
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /inference="alignment:Splign:2.1.0"
     exon            535..746
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /inference="alignment:Splign:2.1.0"
     exon            747..896
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /inference="alignment:Splign:2.1.0"
     exon            897..2233
                     /gene="Pcyox1"
                     /gene_synonym="Clp55"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggcgga cccgcggtca gtttgcagct gcgggaggcc atggggcgct tcgccgctac
       61 gctggtgggc tcgctgttcg gtctggggct gctgctgtgt ggtctaggca ggctggcgag
      121 cgccgagccc cgggcccctc cggaaaagat cgcaatagtt ggtgctggaa tcggtggtac
      181 ttcctcggcc tattatcttc ggaagaaatt tgggaaggac gtgaagattg atgtgtttga
      241 aagagaagaa atcgggggcc gtttggctac tttgaaggtg caaggtcatg actacgaagc
      301 agggggttca gtcattcacc ctctaaattt gcacatgaag cgatttgtca aagagctggg
      361 tctctccagt gtgcccgctt caggtggcct ggtgggagtg tacaatggga agtctctggt
      421 gtttgaggag agcagctggt ttataatcaa cgtgattaag ctggtgtggc gctatggatt
      481 tcagtccctg agaatgcaca tgtgggtaga agacctgctc gacaagttca tgaggatcta
      541 tcgttaccag tcccatgact atgccttcag tagcgtagaa aagttgatgt acgccattgg
      601 aggggatgac tatgtcagac tgctcaacca aactctccgt gaaaacctga agaaagcagg
      661 cttctctgag acgttcctca atgagatgat cgctcctgtc atgaaggtca attttggcca
      721 aagcactgac ctcaatgctt ttgtgggtgc agtatcaatg actgctgctg attccaacct
      781 ttgggcagtg gaaggtggta ataaagttgt ttgctcaggg ctccttcagg cctctaacag
      841 caatcttata tctggctctg taatgtcaat agagaagaca aggaccaagc agacaggaac
      901 ccccccgaag atgtatgaag tggtttataa aacaggatct gagatccatt ctgacttcta
      961 tgacattgtc cttgtggctg ccccattgaa tcggaagatg tccaacataa ccttccgaaa
     1021 ttttgatccc cccatcgagg aattcaatga cccatatcaa cagctcgtga caactctcat
     1081 caaaggagag ctcaattcta ccctcttcag ctccaggcac aaggatcagt tcggcctgtc
     1141 tgcgattctt gtcactgatg actcagatat gtttatcaac agcctgtcca ttgtggcctc
     1201 tgtaagtcat aaggagggtc ccccaccggc agtggatggc atgcatgtgt ggaagacctt
     1261 ctccaaggac attctcacca aagaacaaat ctcaaagctc ttcctgtcct acgattatgc
     1321 tgtgcggaag ccgtggctgt cctaccctta ctacaatcct cctcagaagt gtccctccat
     1381 tatcctccat gaccggctct attacctcaa tggcatcgag tttgctgcca gctgcatgga
     1441 gatgagtgcc atcgctggct acaacgcagc gctccttgcc taccaccgtt ggaacggcaa
     1501 tgaggacatg atcgatcagg acgacctgta tgaaaagctt aagacagaac tgtaattgag
     1561 cactgcccct ccccagagca ccctgctctc caaggattga gtcaacaaag tcttccccag
     1621 cacctctctt gtgggtcgtg aagcgtccct gttcctcgga gaactcgatg ttctgtcaga
     1681 atgtcttcgc gctttggttt tgggggaggt gcaggattga acctgaggcc ctgtgcatgc
     1741 tgggcaagcg ctctgctact gagctgagct acacacctcg ccctcatcca tggttttgtt
     1801 tttggttttt ttttttttca gactgggtct cactaagttg tccaggtgga atcctcccgc
     1861 ctcagcctcc aaagggcctg gaattacagg ccctccatat taggcctggt tgttaaccat
     1921 ttgaagaaac atttgagtgt ttcccaggct tgtccagttt taagagtcat ctggaacttg
     1981 atagacttgt cagcctgggt ttgcttaggt tgtaatcttt ctctctcttc ttcttcgggg
     2041 gcagttaaca actaggtctt agtctgcacc ctaggctgga actcattatt aagcccaggt
     2101 tggtctttaa atcacagcaa tcctcctgtc tcaacctcct atgggctgga tacaggtgtt
     2161 tcccagttcc tggaagttta cacttttttg atgtaaatgt tctcaagcct aaagtcagac
     2221 tttaagaatg tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aa
//
