LOCUS       NM_017225               1771 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus phosphatidylcholine transfer protein (Pctp),
            transcript variant 1, mRNA.
ACCESSION   NM_017225
VERSION     NM_017225.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Kang,H.W., Ribich,S., Kim,B.W., Hagen,S.J., Bianco,A.C. and
            Cohen,D.E.
  TITLE     Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis
            and enlarged mitochondria in brown adipose tissue
  JOURNAL   J Lipid Res 50 (11), 2212-2221 (2009)
   PUBMED   19502644
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Wu,M.K. and Cohen,D.E.
  TITLE     Altered hepatic cholesterol metabolism compensates for disruption
            of phosphatidylcholine transfer protein in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 289 (3), G456-G461 (2005)
   PUBMED   15845870
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Roderick,S.L., Chan,W.W., Agate,D.S., Olsen,L.R., Vetting,M.W.,
            Rajashankar,K.R. and Cohen,D.E.
  TITLE     Structure of human phosphatidylcholine transfer protein in complex
            with its ligand
  JOURNAL   Nat Struct Biol 9 (7), 507-511 (2002)
   PUBMED   12055623
REFERENCE   5  (bases 1 to 1771)
  AUTHORS   Wu,M.K., Boylan,M.O. and Cohen,D.E.
  TITLE     Cloning and gene structure of rat phosphatidylcholine transfer
            protein, Pctp
  JOURNAL   Gene 235 (1-2), 111-120 (1999)
   PUBMED   10415339
REFERENCE   6  (bases 1 to 1771)
  AUTHORS   Geijtenbeek,T.B., Smith,A.J., Borst,P. and Wirtz,K.W.
  TITLE     cDNA cloning and tissue-specific expression of the
            phosphatidylcholine transfer protein gene
  JOURNAL   Biochem J 316 (Pt 1) (Pt 1), 49-55 (1996)
   PUBMED   8645232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1 and FN798833.1.
            
            On Apr 13, 2016 this sequence version replaced NM_017225.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078854.1, AF040261.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                JAXUCZ010000010.1  75326404-75326432   c
            30-732              FN798833.1         1-703
            733-1771            JAXUCZ010000010.1  75305999-75307037   c
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1771
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /note="phosphatidylcholine transfer protein"
                     /db_xref="GeneID:29510"
                     /db_xref="RGD:3276"
     exon            1..175
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..679
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /note="isoform 1 is encoded by transcript variant 1; START
                     domain-containing protein 2; stAR-related lipid transfer
                     protein 2"
                     /codon_start=1
                     /product="phosphatidylcholine transfer protein isoform 1"
                     /protein_id="NP_058921.1"
                     /db_xref="GeneID:29510"
                     /db_xref="RGD:3276"
                     /translation="MAGPAAHFSDEQFREACAELQKPALTGADWQLLVEASGITIYRL
                     LDQSTGLYEYKVFGVLESCIPSLLADVYMDLDYRKKWDQYVKELYEKSFDGQMVAYWE
                     VKYPFPLSNRDYVYTRQRRDLDVDGRKIYVVLAQNISVPQFPEKSGVIRVKQYKQSLA
                     IESDGKKGSRVFMYYFDNPGGQIPSWLINWAAKNGVPSFLKDMVKACQNYHKKT"
     exon            176..293
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..373
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..545
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..613
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..1771
                     /gene="Pctp"
                     /gene_synonym="PC-TP; stARD2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgctcgga gcgctgtatc ccggctgcgg aaggatggcg gggcccgcag cccacttctc
       61 ggacgagcag ttccgggagg cttgtgccga gctccagaag ccggcgctaa ctggggcgga
      121 ttggcagctc ctggtagaag cctcaggcat aaccatctac cggctgctgg accagtcaac
      181 tggactttac gagtataaag tgtttggagt cctggaaagt tgcataccat ctctactcgc
      241 agacgtttac atggacttag actacaggaa aaaatgggac cagtacgtga aagaactcta
      301 tgagaagtcg tttgacggac agatggtggc gtactgggaa gtgaagtacc ctttccctct
      361 gtccaacaga gattatgtct acacccgcca gcggcgagac ctggatgtgg acgggaggaa
      421 gatctacgtg gtcctggccc agaatatctc tgtacctcag tttccggaga agtctggggt
      481 aatccgagtg aagcagtaca agcagagcct ggcgatcgag agcgatggca agaaggggag
      541 cagagttttc atgtactact ttgataaccc gggtggccaa attccgtcct ggctcattaa
      601 ctgggcagcc aagaatggag ttccaagctt tttgaaagac atggtgaaag cgtgtcagaa
      661 ctaccacaag aaaacctaag gaggagaccg ggaccccggc atccatgaaa gacacctctg
      721 gatgtgctac accaactgaa gctcgccctt ctgttcccac cttcaaagcg ctacacaccc
      781 ccaaggcatg cttgcctctg tccggctcca tcactgactt ctttcccact ggtcatagtc
      841 agagcctact accttcttcc actgtcgaat ggggggtccc atacttgtgt atgtttcatt
      901 aggaaaatcc ttagtgggga aaaagagcta ttctgttgtg ccatttttgg ggggatgagt
      961 gagaagagga agggtggcaa gatataagag tggcccttcc tggaaagcag gctcacttca
     1021 gcattctctc ttgcaactag aagtggcttt tggtccacag ttgaccttct aggttcgaat
     1081 cccacagtga tgcctgttct cttgatgcct cgctgactca ggctgggatt tgaggtgaca
     1141 agcaagtgtg gctgtgtttc tacttgggca tgatcagtag ttgctgtggt atcagaccac
     1201 actgaggagt gtcccaggcc tgactgagca catgctgaga tgagcaaggt ttcctaattg
     1261 tcaacatctg gatctttttc ctttcccata atccactgag aaaacgctgt ctatacctct
     1321 tgagcagtgc atttcactgc aagccccagg tttccgagac agcgtgtgtg tagtacgctg
     1381 actgtatctt actaaagtga cttccccttc tagagcgttt ggagatgttg aagggacaat
     1441 aatggtttac aacggagtga aattgacgta gtgatttggt gtgctcttca cctttttctc
     1501 aggaattcta cctcttcaga acagggactc tcagaaccct gcgtctgatc ctcaattttt
     1561 gtaggaaaat agattcagtg gccaagacac agccttaatg atctcaggga aaagttgtag
     1621 tcaatcactc tgtgcaaacc ttgactaaag gatatggaaa ctcaagatgc aaagacagag
     1681 gaaaggatct gtttgagtgg gatttcttag agtgtgtgtt ctttctggga agaaagttgt
     1741 gttccatgaa taaacacagt gacttatgtt t
//
