LOCUS       NM_019246               3485 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus proprotein convertase subtilisin/kexin type 7
            (Pcsk7), mRNA.
ACCESSION   NM_019246
VERSION     NM_019246.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3485)
  AUTHORS   Kato,S., Zhang,R. and Roberts,J.D. Jr.
  TITLE     Proprotein convertases play an important role in regulating PKGI
            endoproteolytic cleavage and nuclear transport
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 305 (2), L130-L140 (2013)
   PUBMED   23686857
  REMARK    GeneRIF: overexpression of PCs, furin and PC5, but not PC7, which
            are all expressed in SMC, increase PKGI cleavage in a
            dose-dependent manner
REFERENCE   2  (bases 1 to 3485)
  AUTHORS   Rousselet,E., Benjannet,S., Hamelin,J., Canuel,M. and Seidah,N.G.
  TITLE     The proprotein convertase PC7: unique zymogen activation and
            trafficking pathways
  JOURNAL   J Biol Chem 286 (4), 2728-2738 (2011)
   PUBMED   21075846
  REMARK    GeneRIF: PC7 is distinct from other proprotein convertases in its
            zymogen activation, subcellular localization, and trafficking.
REFERENCE   3  (bases 1 to 3485)
  AUTHORS   Wickham,L., Benjannet,S., Marcinkiewicz,E., Chretien,M. and
            Seidah,N.G.
  TITLE     Beta-amyloid protein converting enzyme 1 and brain-specific type II
            membrane protein BRI3: binding partners processed by furin
  JOURNAL   J Neurochem 92 (1), 93-102 (2005)
   PUBMED   15606899
REFERENCE   4  (bases 1 to 3485)
  AUTHORS   van de Loo,J.W., Creemers,J.W., Bright,N.A., Young,B.D.,
            Roebroek,A.J. and Van de Ven,W.J.
  TITLE     Biosynthesis, distinct post-translational modifications, and
            functional characterization of lymphoma proprotein convertase
  JOURNAL   J Biol Chem 272 (43), 27116-27123 (1997)
   PUBMED   9341152
REFERENCE   5  (bases 1 to 3485)
  AUTHORS   Seidah,N.G., Hamelin,J., Mamarbachi,M., Dong,W., Tardos,H.,
            Mbikay,M., Chretien,M. and Day,R.
  TITLE     cDNA structure, tissue distribution, and chromosomal localization
            of rat PC7, a novel mammalian proprotein convertase closest to
            yeast kexin-like proteinases
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3388-3393 (1996)
   PUBMED   8622945
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019246.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U36580.1, SRR26360176.1952556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000008.1  55098821-55098940
            121-240             JAXUCZ010000008.1  55100345-55100464
            241-717             JAXUCZ010000008.1  55101088-55101564
            718-852             JAXUCZ010000008.1  55102203-55102337
            853-1018            JAXUCZ010000008.1  55102892-55103057
            1019-1109           JAXUCZ010000008.1  55104941-55105031
            1110-1164           JAXUCZ010000008.1  55106441-55106495
            1165-1303           JAXUCZ010000008.1  55107163-55107301
            1304-1404           JAXUCZ010000008.1  55108057-55108157
            1405-1572           JAXUCZ010000008.1  55110597-55110764
            1573-1680           JAXUCZ010000008.1  55111120-55111227
            1681-1783           JAXUCZ010000008.1  55111653-55111755
            1784-1940           JAXUCZ010000008.1  55117779-55117935
            1941-2035           JAXUCZ010000008.1  55118564-55118658
            2036-2129           JAXUCZ010000008.1  55119450-55119543
            2130-2247           JAXUCZ010000008.1  55119779-55119896
            2248-3485           JAXUCZ010000008.1  55120170-55121407
FEATURES             Location/Qualifiers
     source          1..3485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3485
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /note="proprotein convertase subtilisin/kexin type 7"
                     /db_xref="GeneID:29606"
                     /db_xref="RGD:3275"
     exon            1..120
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            121..240
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            241..717
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2604
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /EC_number="3.4.21.-"
                     /note="rPC7; prohormone convertase PC7; proprotein
                     convertase PC7; subtilisin/kexin-like protease PC7;
                     prohormone convertase 7; proprotein convertase 7"
                     /codon_start=1
                     /product="proprotein convertase subtilisin/kexin type 7
                     precursor"
                     /protein_id="NP_062119.1"
                     /db_xref="GeneID:29606"
                     /db_xref="RGD:3275"
                     /translation="MPKGRQKVPRLDARLGLPICLCLELAIFFLVPQVMGLTEAGGLD
                     TLGAGGLSWAVHLDSLEGERKEESLIQQANAVAQAAGLVNAGRIGELQGHYLFVQPAG
                     HGQAMEAEAMRQQAEAVLAKHEAVRWHSEQRLLKRAKRSIHFNDPKYPQQWHLNNRRS
                     PGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPH
                     PDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKH
                     YQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHND
                     NCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQ
                     KGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATQYEDHRADWLT
                     NEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVL
                     WNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPN
                     GFNDWTFSTVRCWGERARGVYRLVIRDVGDEPLQVGILQQWQLTLYGSTWSPVDIKDR
                     QSLLESAMSGKYLHDDFTLPCPPGLKIPEEDGYSITPNTLKTLVLVGCFSVFWTIYYM
                     LEVCLSQRSKASTHGCRRGCCPWPPQSQNSKEVGTALESMPLCSSKDLDGVDSEHGDC
                     TTASSLLAPELLGEADWSLSQNSKSDLDCPPHQPPDLKDGQIC"
     exon            718..852
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1018
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1109
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1164
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1303
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1404
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1572
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1680
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1783
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1940
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2035
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2129
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2247
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..3485
                     /gene="Pcsk7"
                     /gene_synonym="PC7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtgatgt tgctgtcagt ggcgcctccg gctcccggga agctgagagt ttccgcaggg
       61 tggcggctgc ggcggcggcg gcagcggtag caactgcaac agtagcaacg aaggctgtgg
      121 gtctgcagct gtgttcccag tcgacattgc tcacggtgaa ggtgacatct ccctccagtt
      181 tcacaaaatg agtgtggtat ggttacgaag accaggacct aaacttcaca gagagcccag
      241 cctgctgttc tgatgccgaa agggagacag aaagtcccac gcttggatgc ccgcctgggc
      301 ctgcctatct gcctctgtct ggaattagcc atcttctttc tggttcccca ggtcatgggc
      361 ctaacagagg caggtggtct tgacaccttg ggtgcagggg ggctaagctg ggctgtacat
      421 ctggacagcc tagaaggtga gaggaaggaa gagagtctga tacaacaggc aaatgctgtg
      481 gcccaggcag cggggctggt gaatgctggg cgcattggag agctccaggg gcactacctc
      541 tttgtccagc cagctgggca cgggcaagcc atggaggcgg aggccatgcg gcaacaggca
      601 gaggctgtgt tagccaagca tgaagctgtg cgctggcact cagagcagag gctgctgaag
      661 agggccaagc gcagcatcca cttcaatgat cccaagtatc ctcaacagtg gcacctgaat
      721 aatcggcgga gcccaggaag agacatcaat gtgacaggtg tgtgggagag aaatgtaact
      781 gggcgagggg tgacggtggt agtggtggac gacggagtgg agcacaccgt ccaggacatt
      841 gcacccaact atagcccaga gggaagctat gacctcaact ctaatgaccc agatcctatg
      901 ccccaccctg atgaggagaa cggtaaccac catgggaccc ggtgtgcagg agaaattgca
      961 gctgtgccca acaacagctt ctgtgcagta ggtgtggcct atgggagccg aatagcaggt
     1021 atccgggtgc tggatggacc actcacagac agtatggaag ctgtggcatt caacaaacac
     1081 tatcagatca atgacatcta cagctgcagc tggggccccg atgatgatgg gaagacagtg
     1141 gatggtcctc atcagcttgg gaaggctgcc ttacaacatg gagtgatggc tggtcgccaa
     1201 ggctttggaa gtatctttgt ggttgccagt ggtaatggtg gccagcacaa tgacaactgc
     1261 aactatgatg gctatgccaa ctccatctac actgtcacca taggagctgt ggatgaggag
     1321 ggacggatgc ctttttatgc agaggagtgt gcctccatgc tggcagtcac cttcagtgga
     1381 ggagacaaga tgctgcggag cattgtgact actgactggg accttcagaa gggcactggc
     1441 tgcactgaag gccacacagg aacctcagct gcagcccctc tagcagctgg catgatagct
     1501 ctcatgctgc aggtgcggcc ctgcctcacg tggcgggatg tccagcacat cattgtcttc
     1561 acagccactc agtatgaaga tcatcgtgca gactggctca ctaatgaggc tggattcagc
     1621 cacagccatc agcatggttt cggcctgctc aacgcctgga gacttgtcaa tgcagccaag
     1681 atctggacgt ctgtccctta cttagcttcc tatgtcagcc ccatgctgaa agaaaataag
     1741 gctgttccac ggtcccccca ctctctggag gtcctatgga atgtcagcag gacggacctg
     1801 gagatgtcgg ggctgaagac cctggaacat gtggcggtga cagtctccat cactcaccca
     1861 cgacgtggca gcttagaact gaaactgttt tgtcccagtg gcatgatgtc tttgatcggc
     1921 gcgccccgca gcatggactc ggaccctaac ggcttcaatg actggacatt ttccactgtg
     1981 cggtgctggg gggaaagagc aagaggagtc tacagactgg ttatcaggga tgtaggagat
     2041 gagccgctcc aggtgggcat cctccagcag tggcagctga cgctgtatgg ctccacgtgg
     2101 agtccagtag acatcaagga cagacaaagt ctcttagaaa gtgctatgag tggaaaatac
     2161 ctgcatgatg acttcactct gccttgccca cctggactga aaattcctga ggaggatggt
     2221 tacagcatta cccctaacac actcaagacc cttgtgctgg ttggctgctt cagtgtcttc
     2281 tggaccattt actacatgct agaagtgtgc ctgagccaga ggagcaaggc ttccacccat
     2341 ggctgcagga gaggatgctg cccctggccc ccacaaagcc aaaactccaa ggaagtgggg
     2401 acagcactag aatcaatgcc actgtgcagc agcaaggacc tggatggagt ggattcagag
     2461 cacggggact gcacaactgc ctctagcttg ctggccccag agctgctggg ggaagctgac
     2521 tggagtctgt cccagaacag taagagtgac ctggattgtc ctccccacca acccccagac
     2581 ctgaaggatg gacagatctg ctgaccccag agcccagctt cttccatgta caacaggctc
     2641 ttcctaaact tggttatgag gctttcaatc atggatgctc aggagagaat ggtcctgata
     2701 gtgacatctg ccacccaagg cctctgaagc attctcagcc ttctcaagag ggtgagggcc
     2761 atcttaatta agcgcagtgg taagggactg gtgttcatgg ctcctctagc tgagctttgc
     2821 tgagagcctt tcgacaaggg gttggcgccc aggccaggca gcccttgatt tcatctctct
     2881 cgggctagtc actgtcctcg gccatcagga cctccacccc ttcacaagtt atgcagcagg
     2941 tgcctgtata cctaggaaca ctctcaacag aagtgccgct gtaccgaggg cccagagaga
     3001 ggctggcaag agcctagaca tgcctaccct gaaagcagct gccttcatta ccctttcctg
     3061 tgtgcctgtt ctgaagcccg taccttcact accactcacc cttcctgctg aaggaatggt
     3121 ggcgtgtccc aggaaaactg ggaggcacag gattcccagc cagcaccctt gctgcctcac
     3181 tggggaagtt gtcctgctgg gctgcagaga gctgagacac agtgttgtct aagatagcat
     3241 gggagcccct gcctatgacc acctgtcttc ctctgcaaag tgctcaggga aatggccttc
     3301 attccagagg ccagctgtcc gcctgacttt tcctccattc ttggccttct ccccttccca
     3361 tctttggagc taattgttaa tatgaatttt ttaatgctta agatttgatt tttacttttc
     3421 aaagcaacat tttgttgaat ttttttctgc acagctttcc aaaataaaaa gcagaagtaa
     3481 aaaaa
//
