LOCUS       NM_053823               5241 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus proprotein convertase subtilisin/kexin type 5
            (Pcsk5), mRNA.
ACCESSION   NM_053823 XM_001078022 XM_342032
VERSION     NM_053823.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5241)
  AUTHORS   Tong,J., Zhang,M., Li,X. and Ren,G.
  TITLE     MicroRNA-338-3p regulates age-associated osteoporosis via targeting
            PCSK5
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33313955
  REMARK    GeneRIF: MicroRNA3383p regulates ageassociated osteoporosis via
            targeting PCSK5.
REFERENCE   2  (bases 1 to 5241)
  AUTHORS   Tang,X.B., Chen,L., Wang,W.L., Yuan,Z.W. and Bai,Y.Z.
  TITLE     Spatiotemporal expression of proprotein convertase subtilisin/kexin
            type 5 in the development of anorectal malformations in fetal rats
  JOURNAL   J Mol Histol 48 (5-6), 379-387 (2017)
   PUBMED   28975535
  REMARK    GeneRIF: downregulation of Pcsk5 during cloaca development into the
            rectum and urethra might be related to the formation of anorectal
            malformations.
REFERENCE   3  (bases 1 to 5241)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (bases 1 to 5241)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 5241)
  AUTHORS   Kato,S., Zhang,R. and Roberts,J.D. Jr.
  TITLE     Proprotein convertases play an important role in regulating PKGI
            endoproteolytic cleavage and nuclear transport
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 305 (2), L130-L140 (2013)
   PUBMED   23686857
  REMARK    GeneRIF: overexpression of PCs, furin and PC5, but not PC7, which
            are all expressed in SMC, increase PKGI cleavage in a
            dose-dependent manner
REFERENCE   6  (bases 1 to 5241)
  AUTHORS   De Bie,I., Marcinkiewicz,M., Malide,D., Lazure,C., Nakayama,K.,
            Bendayan,M. and Seidah,N.G.
  TITLE     The isoforms of proprotein convertase PC5 are sorted to different
            subcellular compartments
  JOURNAL   J Cell Biol 135 (5), 1261-1275 (1996)
   PUBMED   8947550
REFERENCE   7  (bases 1 to 5241)
  AUTHORS   Decroly,E., Wouters,S., Di Bello,C., Lazure,C., Ruysschaert,J.M.
            and Seidah,N.G.
  TITLE     Identification of the paired basic convertases implicated in HIV
            gp160 processing based on in vitro assays and expression in CD4(+)
            cell lines
  JOURNAL   J Biol Chem 271 (48), 30442-30450 (1996)
   PUBMED   8940009
  REMARK    Erratum:[J Biol Chem 1997 Mar 28;272(13):8836]
REFERENCE   8  (bases 1 to 5241)
  AUTHORS   Mercure,C., Jutras,I., Day,R., Seidah,N.G. and Reudelhuber,T.L.
  TITLE     Prohormone convertase PC5 is a candidate processing enzyme for
            prorenin in the human adrenal cortex
  JOURNAL   Hypertension 28 (5), 840-846 (1996)
   PUBMED   8901832
REFERENCE   9  (bases 1 to 5241)
  AUTHORS   Lusson,J., Vieau,D., Hamelin,J., Day,R., Chretien,M. and
            Seidah,N.G.
  TITLE     cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a
            candidate proprotein convertase expressed in endocrine and
            nonendocrine cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6691-6695 (1993)
   PUBMED   8341687
REFERENCE   10 (bases 1 to 5241)
  AUTHORS   Nakagawa,T., Hosaka,M., Torii,S., Watanabe,T., Murakami,K. and
            Nakayama,K.
  TITLE     Identification and functional expression of a new member of the
            mammalian Kex2-like processing endoprotease family: its striking
            structural similarity to PACE4
  JOURNAL   J Biochem 113 (2), 132-135 (1993)
   PUBMED   8468318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Mar 3, 2013 this sequence version replaced
            XM_001078022.2, XM_342032.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14933.2, SRR26643429.5170.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000001.1  224694143-224694347 c
            206-310             JAXUCZ010000001.1  224648525-224648629 c
            311-424             JAXUCZ010000001.1  224604226-224604339 c
            425-568             JAXUCZ010000001.1  224565042-224565185 c
            569-645             JAXUCZ010000001.1  224562299-224562375 c
            646-734             JAXUCZ010000001.1  224530938-224531026 c
            735-907             JAXUCZ010000001.1  224529243-224529415 c
            908-1120            JAXUCZ010000001.1  224508370-224508582 c
            1121-1221           JAXUCZ010000001.1  224497702-224497802 c
            1222-1325           JAXUCZ010000001.1  224472888-224472991 c
            1326-1443           JAXUCZ010000001.1  224450896-224451013 c
            1444-1632           JAXUCZ010000001.1  224449776-224449964 c
            1633-1769           JAXUCZ010000001.1  224441619-224441755 c
            1770-1913           JAXUCZ010000001.1  224436777-224436920 c
            1914-2016           JAXUCZ010000001.1  224431452-224431554 c
            2017-2210           JAXUCZ010000001.1  224428856-224429049 c
            2211-2295           JAXUCZ010000001.1  224424967-224425051 c
            2296-2393           JAXUCZ010000001.1  224420824-224420921 c
            2394-2523           JAXUCZ010000001.1  224420168-224420297 c
            2524-2639           JAXUCZ010000001.1  224419320-224419435 c
            2640-5241           JAXUCZ010000001.1  224413648-224416249 c
FEATURES             Location/Qualifiers
     source          1..5241
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..5241
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /note="proprotein convertase subtilisin/kexin type 5"
                     /db_xref="GeneID:116548"
                     /db_xref="RGD:620326"
     exon            1..205
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..2755
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /EC_number="3.4.21.-"
                     /note="subtilisin/kexin-like protease PC5; proprotein
                     convertase 6"
                     /codon_start=1
                     /product="proprotein convertase subtilisin/kexin type 5
                     preproprotein"
                     /protein_id="NP_446275.1"
                     /db_xref="GeneID:116548"
                     /db_xref="RGD:620326"
                     /translation="MDWGWGSRCCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVK
                     IAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKV
                     EWIQQQVVKKRTKRDYDLSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKR
                     GYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRC
                     AGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGP
                     DDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYT
                     ISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAP
                     MAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMD
                     AEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLE
                     HVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERA
                     AGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVED
                     PTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGHFH
                     ADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICG
                     KCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFCATCAGAG
                     ADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCS
                     SCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQ
                     G"
     exon            206..310
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            311..424
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            425..568
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            569..645
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            646..734
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            735..907
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1120
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1221
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1325
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1443
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1632
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1769
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1913
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2016
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2210
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2295
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2393
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2523
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2639
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..5241
                     /gene="Pcsk5"
                     /gene_synonym="Pc5; PC6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaccatg gactggggct gggggagccg ctgctgtcgc ccgggacggc gggatctgct
       61 gtgcgtgctg gcactgctcg ccggctgtct gctcccagtg tgccggacgc gtgtctacac
      121 caaccactgg gcagtgaaga tcgccggcgg attcgcggag gcagaccgca tagccagcaa
      181 gtacggattc atcaacgtag gacagatcgg tgcgctgaag gactactatc atttctacca
      241 cagtaggacc attaaaagat ctgttctctc aagcagagga acccacagtt tcatttcaat
      301 ggaaccaaag gtggagtgga tccaacagca agtggtgaaa aaacgaacca agagagatta
      361 tgacctcagt cgtgcccagt cgacttactt caatgatcct aagtggccaa gtatgtggta
      421 catgcactgc agtgacaaca cacatccttg ccagtcggac atgaatattg aaggagcctg
      481 gaagagaggc tacacgggga agaacatcgt ggtgactatc ctggatgatg gcatcgagag
      541 aacccacccc gatctgatgc aaaactacga tgctctggca agttgcgatg tgaatgggaa
      601 tgacttggat ccgatgcctc gttatgatgc aagcaatgaa aacaagcatg ggacccgctg
      661 tgccggagaa gtggcagcca ctgcgaacaa ctctcactgc accgttggaa tcgctttcaa
      721 cgccaaaatc ggaggtgtga gaatgctgga tggtgatgtc accgacatgg tggaggcaaa
      781 gtctgtcagc tataacccac agcatgtaca catctacagt gccagctggg gcccagatga
      841 tgatggcaag accgtggatg ggccagctcc cctcacccgg caagcctttg agaatggtgt
      901 gagaatgggt cggagaggcc ttggttctgt gtttgtgtgg gcatctggca atggtggacg
      961 gagtaaggac cactgctctt gtgatggcta taccaacagc atctatacca tctccatcag
     1021 cagtacggcc gaaagtggaa agaaaccttg gtacttggaa gagtgttcgt ctacactggc
     1081 cacaacctac agcagtggag aatcctatga taagaaaata atcactactg atctaaggca
     1141 gcggtgcaca gacaatcaca ctggaacatc agcctcagcc cccatggctg ctggcatcat
     1201 tgccctggcc ctggaagcca atccgtttct gacctggaga gacgtacagc atgttattgt
     1261 caggacttcc cgtgcgggac atttgaacgc taatgactgg aaaaccaatg ctgctggttt
     1321 taaggtgagc catctctatg gatttggact gatggatgct gaagccatgg tgatggaggc
     1381 agagaagtgg acaactgttc ctcagcagca cgtgtgtgtg gagagcacgg accgacaaat
     1441 caagaccatt cgcccaaaca gtgcagtgcg ctccatctac aaagcctcag gctgctcgga
     1501 taatcccaac catcatgtca attacctgga gcatgtagtc gtgcgtatta ccatcacaca
     1561 tccacggagg ggagacctgg ccatctatct gacctcaccc tcaggaacaa gatcccagct
     1621 tttggccaac aggctatttg atcattccat ggaaggattt aagaactggg agttcatgac
     1681 cattcattgc tggggagaac gggctgctgg ggactgggtc cttgaagttt atgatactcc
     1741 atctcaactg aggaacttca agactccagg taaattgaaa gaatggtcct tagtcctcta
     1801 tggcacatcc gtacagccat actccccaac caacgagttt cccaaagtgg aacgcttccg
     1861 ctacagccgg gtggaggacc ccacagatga ctatggtgct gaagattatg caggtccttg
     1921 tgaccctgag tgcagtgaag ttggatgtga tgggccggga ccggatcact gcactgactg
     1981 tttacactat cactacaagc tgaagaataa caccagaatc tgtgtctcca gctgccctcc
     2041 tggccacttc catgctgaca agaagaggtg ccggaagtgc gcccccaact gcgagtcctg
     2101 ctttggtagc catgctgatc agtgcctgtc ctgtaaatat ggctacttcc tgaatgaaga
     2161 aactagcagc tgtgttgctc agtgccctga ggggtcatac caggatatca agaaaaatat
     2221 ctgtgggaaa tgcagcgaga actgtaagac gtgcactgga tttcacaact gcacagagtg
     2281 caagggcggg ttaagcctcc agggatcccg ctgttctgtc acctgcgagg atggacagtt
     2341 cttcagtggt cacgattgcc agccctgcca ccgcttctgt gccacctgtg ctggggccgg
     2401 agccgatgga tgtattaact gcaccgaggg ttatgtcatg gaggagggaa gatgtgtaca
     2461 gagctgtagt gtgagctact acttggacca ctctttagag ggtggataca agtcctgcaa
     2521 gagatgtgat aacagctgct tgacatgcaa tggcccagga ttcaagaact gctccagctg
     2581 ccccagtggc tatctattag acttgggaat gtgtcagatg ggagccatct gcaaggatgc
     2641 aacggaagag tcctgggcag aaggaggctt ctgtatgctt gtgaaaaaga acaatctatg
     2701 tcagcggaaa gttctacaac aactgtgctg caaaacatgt acattccaag gctgagcagc
     2761 caccttacat ccctgttcct gtagacttat agattattcc atattattaa agaaaaaaag
     2821 ccaaaaactg caaaccacct ctctctttct tgctatcttt tttttttctc tctctctatc
     2881 tcaagtttgt gcagggagat ggtgaactgt tttgtcagaa cttaaataga agaaaaagaa
     2941 aaagcctaca acaagcctac cttttataac tggctgttta gtgttaaaca accagaatca
     3001 cagagacagt attgtataac caaagtattt gatgccaaaa tttgacgtta aagtaatgat
     3061 ttgatttcct gccctggttt gaaggtccat tttattcctt tgcagtcact cactgtttct
     3121 cctttaaaaa ttcctaaaaa ataatttttc cccaaaaaca tcacaaaagc acacatagat
     3181 cagaatgaac agagagcttt tgcctcagtc gtttttctgg ctttcgtctg cagccaggga
     3241 aaaggacagg aaactggacc ttaggatcct gcacagtgtg tcatgtcttg gtgtttcacg
     3301 attccatggc gacacctttc cacacatgat ttgctttgta ccttgcattc tgttctgttt
     3361 gggtgggttt tggtttttta tttttttttt ttgcactttt cttacctgat aagtctcctc
     3421 cactggcttc atcagacaga ctttctgcca ctggcgtttc aaacactgtc aattgggtta
     3481 ttttttacac agctggtaaa atggattgtt ctacagagtc aaatggatgg tagaagcatg
     3541 tgatatccag aagggctgag gctggtccag gtcccccgaa gcccagagag ccttctgtag
     3601 gctctgtaca acctctcggt gctatctagc cattcccccc tactgttatt tttaactacc
     3661 atcagaaatt acatttgtca cagtgagaag catttggatt atgatgcagg aaatttcttc
     3721 ctggggtcaa aggtttctaa gaagtcctgt attttttaag agatgaaatt tatttaaata
     3781 atatttaagc tcacgcttac actagtggag cagcaatttt caatggtgct tattacatgc
     3841 gttgtctcct gtcattctaa ggaaataaaa ctggaaattg aatgtgggtg gcatgattgt
     3901 accctcctgg ttctgtattt tctcattcct ctgtccttct ataactaggg atcatgttct
     3961 tattatgcac ctgtccaccg aatgtcatgg agctggggtc agtttctttg attcaaaatg
     4021 tgcttgctgg ttttctgtga ctccataaac atttcgtaga acctagaata ctaattgata
     4081 gagaaactac tttgcatctg tggttgaaaa tgatgaacct gataaatctt ttggtagttc
     4141 ctctgagaat aactgatatc acacaccttc atttatccta tcaaatctct gtggtgacct
     4201 catggactgg ggacatggcc aggtatctcc aggctctaag ctttggaaag ccgcacttcc
     4261 aagatgctgt ggcttcgctg ctgagaagac aatggtgctc ttgggaagga gctgggatgt
     4321 ggaggctaaa gtccctgctc acacaaacaa gcagtaaaca gcctaccctg gaaatatccc
     4381 taggcaacaa agttcacttc tagctgcagg tacataatga gaaattggtc tatcgaaccc
     4441 tttccaatgt taccgagtca ggtgattcac aggaactaag gaattggcag cttatgctgg
     4501 gcaacttttt cctctttaga acactgttgg ctcttctgac ttgaggagca gagggattcc
     4561 tgaccacagt gtattcttct tatgtttaaa cacacaagct ttaaatgaac agacgtaaac
     4621 ataagccaga cagatggcaa agactagact tgcctgcaaa caaatggagt tgattaggca
     4681 agtctataca attagaggca cagggtcaca gtaatacaaa agataaagct gatatctttg
     4741 tccttagaaa attaaccacc agtatgatag caaaatcact ggggtccacc gctgtgcatt
     4801 ccacatccca ctgaagatgc aggtgcacat cacggaaata ccggtttaac aactcgtgtg
     4861 ttactgcctc atttatctac attattaact agaacataat gctttcaaag tttacgttaa
     4921 tgttatatat tatgtataaa tatatatatt cataatgagt atatgtgatg gatagcacaa
     4981 agtttggaga cgtgacaaat gctcttatcc tctggagaca aacgtcctat tttctgtttt
     5041 cttttatctt tcgatcttta attcactaat taatagtgac ctgttgttaa atccaaatcc
     5101 actttgctga aaaatactgt acatgtgtaa aatgttcagt tgtttttttt gtaaaatata
     5161 gaacagttgt aattgatact ggcccaaatc aatgttattc catattttat tttttctatt
     5221 aaattaacct aagttcctgt t
//
