LOCUS       NM_019279                945 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus proprotein convertase subtilisin/kexin type 1
            inhibitor (Pcsk1n), mRNA.
ACCESSION   NM_019279
VERSION     NM_019279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Gouraud,S.S., Heesom,K., Yao,S.T., Qiu,J., Paton,J.F. and Murphy,D.
  TITLE     Dehydration-induced proteome changes in the rat
            hypothalamo-neurohypophyseal system
  JOURNAL   Endocrinology 148 (7), 3041-3052 (2007)
   PUBMED   17412804
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Chakraborty,T.R., Tkalych,O., Nanno,D., Garcia,A.L., Devi,L.A. and
            Salton,S.R.
  TITLE     Quantification of VGF- and pro-SAAS-derived peptides in endocrine
            tissues and the brain, and their regulation by diet and cold stress
  JOURNAL   Brain Res 1089 (1), 21-32 (2006)
   PUBMED   16631141
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Morgan,D.J., Mzhavia,N., Peng,B., Pan,H., Devi,L.A. and Pintar,J.E.
  TITLE     Embryonic gene expression and pro-protein processing of proSAAS
            during rodent development
  JOURNAL   J Neurochem 93 (6), 1454-1462 (2005)
   PUBMED   15935061
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Wei,S., Feng,Y., Che,F.Y., Pan,H., Mzhavia,N., Devi,L.A.,
            McKinzie,A.A., Levin,N., Richards,W.G. and Fricker,L.D.
  TITLE     Obesity and diabetes in transgenic mice expressing proSAAS
  JOURNAL   J Endocrinol 180 (3), 357-368 (2004)
   PUBMED   15012590
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Wada,M., Ren,C.H., Koyama,S., Arawaka,S., Kawakatsu,S., Kimura,H.,
            Nagasawa,H., Kawanami,T., Kurita,K., Daimon,M., Hirano,A. and
            Kato,T.
  TITLE     A human granin-like neuroendocrine peptide precursor (proSAAS)
            immunoreactivity in tau inclusions of Alzheimer's disease and
            parkinsonism-dementia complex on Guam
  JOURNAL   Neurosci Lett 356 (1), 49-52 (2004)
   PUBMED   14746899
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Mzhavia,N., Qian,Y., Feng,Y., Che,F.Y., Devi,L.A. and Fricker,L.D.
  TITLE     Processing of proSAAS in neuroendocrine cell lines
  JOURNAL   Biochem J 361 (Pt 1), 67-76 (2002)
   PUBMED   11742530
REFERENCE   7  (bases 1 to 945)
  AUTHORS   Bures,E.J., Courchesne,P.L., Douglass,J., Chen,K., Davis,M.T.,
            Jones,M.D., McGinley,M.D., Robinson,J.H., Spahr,C.S., Sun,J.,
            Wahl,R.C. and Patterson,S.D.
  TITLE     Identification of incompletely processed potential carboxypeptidase
            E substrates from CpEfat/CpEfat mice
  JOURNAL   Proteomics 1 (1), 79-92 (2001)
   PUBMED   11680901
REFERENCE   8  (bases 1 to 945)
  AUTHORS   Qian,Y., Devi,L.A., Mzhavia,N., Munzer,S., Seidah,N.G. and
            Fricker,L.D.
  TITLE     The C-terminal region of proSAAS is a potent inhibitor of
            prohormone convertase 1
  JOURNAL   J Biol Chem 275 (31), 23596-23601 (2000)
   PUBMED   10816562
REFERENCE   9  (bases 1 to 945)
  AUTHORS   Fricker,L.D., McKinzie,A.A., Sun,J., Curran,E., Qian,Y., Yan,L.,
            Patterson,S.D., Courchesne,P.L., Richards,B., Levin,N., Mzhavia,N.,
            Devi,L.A. and Douglass,J.
  TITLE     Identification and characterization of proSAAS, a granin-like
            neuroendocrine peptide precursor that inhibits prohormone
            processing
  JOURNAL   J Neurosci 20 (2), 639-648 (2000)
   PUBMED   10632593
REFERENCE   10 (bases 1 to 945)
  AUTHORS   Donadel,G., Marinos,N., DeSilva,M.G., Lu,J., Notkins,A.L. and
            Lan,M.S.
  TITLE     Molecular cloning and characterization of a highly basic protein,
            IA-4, expressed in pancreatic islets and brain
  JOURNAL   Neuroendocrinology 67 (3), 190-196 (1998)
   PUBMED   9630436
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF181561.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF181561.1, FQ214158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..945
                     /gene="Pcsk1n"
                     /gene_synonym="Saas"
                     /note="proprotein convertase subtilisin/kexin type 1
                     inhibitor"
                     /db_xref="GeneID:246333"
                     /db_xref="RGD:3617"
     exon            1..135
                     /gene="Pcsk1n"
                     /gene_synonym="Saas"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..804
                     /gene="Pcsk1n"
                     /gene_synonym="Saas"
                     /function="inhibits prohormone processing"
                     /note="granin-like neuroendocrine peptide; proSAAS;
                     pro-SAAS; proprotein convertase 1 inhibitor; proSAAS-like"
                     /codon_start=1
                     /product="proSAAS precursor"
                     /protein_id="NP_062152.1"
                     /db_xref="GeneID:246333"
                     /db_xref="RGD:3617"
                     /translation="MAGSPLLCGPRAGGVGLLVLLLLGLLRLPPTLSARPVKEPRSLS
                     AASAPLAETSTPLRLRRAVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQ
                     ARVLAQLLRAWGSPRASDPPLAPDDDPDAPAAQLARALLRARLDPAALAAQLVPAPAP
                     AAALRPRPPVYDDGPTGPDVEDAADETPDVDPELLRYLLGRILTGSSEPEAAPAPRRL
                     RRAVDQDLGPEVPPENVLGALLRVKRLENSSPQAPARRLLPP"
     exon            136..608
                     /gene="Pcsk1n"
                     /gene_synonym="Saas"
                     /inference="alignment:Splign:2.1.0"
     exon            609..941
                     /gene="Pcsk1n"
                     /gene_synonym="Saas"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      939
                     /gene="Pcsk1n"
                     /gene_synonym="Saas"
ORIGIN      
        1 agcccggctc gttggggcag catggcgggg tcgccgctgc tctgcgggcc gagggccggg
       61 ggcgtaggcc ttttggtgct gctgctcttg ggtcttctga ggctgccccc caccttgtca
      121 gcgaggcccg tgaaggaacc ccgcagtctg agcgcagcat ccgcgccctt ggctgagacg
      181 agcactcccc tccgcttgcg tcgggccgtg ccccgaggag aggcggcggg tgcggtgcag
      241 gagctggcgc gggcgctggc gcacctgctg gaggccgaga gacaggagcg cgcgcgtgct
      301 gaggcgcagg aggcggagga tcagcaggca cgggtcctgg cacagctgct gcgcgcctgg
      361 ggctccccgc gtgcctcgga cccgcccttg gccccggatg acgacccgga cgctcccgct
      421 gcacagctcg cccgtgctct gctccgagct cgcctagacc cggccgccct ggcggctcag
      481 cttgtccccg cccctgcccc tgccgctgcg ctgcgacccc ggcccccagt gtatgacgat
      541 ggccccaccg gcccagacgt cgaggatgcc gctgacgaga ctcctgatgt ggaccctgag
      601 ctgctgaggt acttgctagg gcggatcctc accggaagtt cggagccaga ggctgctccg
      661 gccccgcgcc gcctccgccg agctgtggac caggatttgg gtcccgaggt gcctcctgag
      721 aacgtactgg gggctctgct acgcgtcaaa cgtctcgaga actcctcgcc ccaggcaccg
      781 gcacgccgcc tcctgcctcc ctgagcgcta ctacattctg cacgccctgg aacccaggag
      841 cgccccagca accctgactc cctgccagca cgtccacggc tgcttacccc ggcaacctcc
      901 catcccctga gccctccctc aataaatgca atctgtagca aaaaa
//
