LOCUS       NM_019237               1547 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus procollagen C-endopeptidase enhancer (Pcolce),
            mRNA.
ACCESSION   NM_019237
VERSION     NM_019237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1547)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 1547)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 1547)
  AUTHORS   Stamer,W.D., Hoffman,E.A., Luther,J.M., Hachey,D.L. and Schey,K.L.
  TITLE     Protein profile of exosomes from trabecular meshwork cells
  JOURNAL   J Proteomics 74 (6), 796-804 (2011)
   PUBMED   21362503
REFERENCE   4  (bases 1 to 1547)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (bases 1 to 1547)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 1547)
  AUTHORS   Steiglitz,B.M., Keene,D.R. and Greenspan,D.S.
  TITLE     PCOLCE2 encodes a functional procollagen C-proteinase enhancer
            (PCPE2) that is a collagen-binding protein differing in
            distribution of expression and post-translational modification from
            the previously described PCPE1
  JOURNAL   J Biol Chem 277 (51), 49820-49830 (2002)
   PUBMED   12393877
REFERENCE   7  (bases 1 to 1547)
  AUTHORS   Matsui,A., Yanase,M., Tomiya,T., Ikeda,H., Fujiwara,K. and Ogata,I.
  TITLE     Stabilization of RNA strands in protein synthesis by type I
            procollagen C-proteinase enhancer protein, a potential RNA-binding
            protein, in hepatic stellate cells
  JOURNAL   Biochem Biophys Res Commun 290 (3), 898-902 (2002)
   PUBMED   11798157
  REMARK    GeneRIF: role in stabilization of RNA in noncollagenous protein
            synthesis as well as collagen synthesis in hepatic stellate cells
REFERENCE   8  (bases 1 to 1547)
  AUTHORS   Ogata,I., Auster,A.S., Matsui,A., Greenwel,P., Geerts,A.,
            D'Amico,T., Fujiwara,K., Kessler,E. and Rojkind,M.
  TITLE     Up-regulation of type I procollagen C-proteinase enhancer protein
            messenger RNA in rats with CCl4-induced liver fibrosis
  JOURNAL   Hepatology 26 (3), 611-617 (1997)
   PUBMED   9303490
REFERENCE   9  (bases 1 to 1547)
  AUTHORS   Takahara,K., Kessler,E., Biniaminov,L., Brusel,M., Eddy,R.L.,
            Jani-Sait,S., Shows,T.B. and Greenspan,D.S.
  TITLE     Type I procollagen COOH-terminal proteinase enhancer protein:
            identification, primary structure, and chromosomal localization of
            the cognate human gene (PCOLCE)
  JOURNAL   J Biol Chem 269 (42), 26280-26285 (1994)
   PUBMED   7523404
REFERENCE   10 (bases 1 to 1547)
  AUTHORS   Kessler,E., Mould,A.P. and Hulmes,D.J.
  TITLE     Procollagen type I C-proteinase enhancer is a naturally occurring
            connective tissue glycoprotein
  JOURNAL   Biochem Biophys Res Commun 173 (1), 81-86 (1990)
   PUBMED   2256940
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U94710.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U94710.1, FQ209381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1547
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /note="procollagen C-endopeptidase enhancer"
                     /db_xref="GeneID:29569"
                     /db_xref="RGD:3270"
     exon            1..153
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1468
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /note="procollagen C-proteinase enhancer protein;
                     procollagen C-endopeptidase enhancer 1; PCPE-1;
                     procollagen C-proteinase enhancer 1; procollagen
                     COOH-terminal proteinase enhancer 1; type 1 procollagen
                     C-proteinase enhancer protein; type I procollagen
                     COOH-terminal proteinase enhancer; procollagen
                     C-endopeptidase enhancer protein"
                     /codon_start=1
                     /product="procollagen C-endopeptidase enhancer 1
                     precursor"
                     /protein_id="NP_062110.1"
                     /db_xref="GeneID:29569"
                     /db_xref="RGD:3270"
                     /translation="MLPAALTSLLGPFLLAWVLPLARGQTPNYTRPVFLCGGDVTGES
                     GYVASEGFPNLYPPNKKCIWTITVPEGQTVSLSFRVFDMELHPSCRYDALEVFAGSGT
                     SGQRLGRFCGTFRPAPVVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGG
                     RMEKAQGTLTTPNWPESDYPPGISCSWHIIAPSNQVIMLTFGKFDVEPDTYCRYDSVS
                     VFNGAVSDDSKRLGKFCGDKAPSPISSEGNELLVQFVSDLSVTADGFSASYRTLPRDA
                     VEKESAPSPGEDAQHGPQSRSDPKTGTGPKVKPPSKPKVQPVEKPEGSPATQATPVAP
                     DAPSITCPKQYKRSGTLQSNFCSSSLVVTGTVKAMVRGPGEGLTVTVSLLGVYKTGDL
                     DLPSPASGTSLKFYVPCKQMPPMKKGASYLLMGQVEENRGPILPPESFVVLYRPNQDQ
                     ILSNLSKRKCPSQPRPDA"
     exon            154..262
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            263..521
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            522..646
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            647..783
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1064
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1142
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1313
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1530
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgctgc tgctgctgct gctgttgctg ctgctgctgt ttccagcact ccccctacac
       61 aatgctgcct gctgccctaa cctccctgct ggggccattc cttctagcct gggtgctgcc
      121 tcttgcccga ggccagaccc ccaactacac gagaccagtg ttcctgtgtg gaggggatgt
      181 gaccggggag tcgggttacg tggcaagtga gggtttcccc aacctctacc ccccaaacaa
      241 gaagtgcatc tggacaataa cggtgcctga gggccagact gtgtccctgt ccttccgagt
      301 ctttgatatg gaactccacc cttcctgccg ctatgatgct ctggaggtct ttgctggatc
      361 cgggacctca ggccagcgac ttggacgctt ctgtggcacc ttcaggcctg cgcctgtagt
      421 tgcacctggc aaccaagtga ctttaaggat gacaactgac gagggcactg ggggacgagg
      481 attcctgctc tggtacagcg gtcgggccac ctcaggcact gagcaccagt tttgcggggg
      541 gcggatggag aaggcgcagg gaaccctgac cacgcccaac tggcctgagt cggattaccc
      601 cccaggcatc agctgttcct ggcacatcat tgcaccctca aaccaggtga tcatgctaac
      661 cttcgggaag tttgatgtgg agcctgacac atactgccga tatgactctg tcagtgtgtt
      721 caatggagct gtgagtgacg actcaaagag gctggggaaa ttttgcggag acaaggcccc
      781 tagccccatc tcttccgaag ggaatgagct cctggtccag tttgtatcag atctcagtgt
      841 cactgccgat ggcttctcag cctcctacag gaccctgcca cgggatgccg tggaaaagga
      901 gtcagcccca agtccagggg aggatgcaca gcatggtccc cagtcccgct ctgaccctaa
      961 gacaggaact gggcccaaag tcaaaccacc cagtaagcct aaagtccagc ctgtagagaa
     1021 acctgagggc tctcctgcta cccaggcaac tccagttgct ccagatgccc ccagcatcac
     1081 ttgcccaaag cagtacaagc ggtcaggcac cttgcagagc aacttttgct ccagtagcct
     1141 ggtggtgaca ggaacagtga aggccatggt ccggggccca ggggagggcc tcactgtcac
     1201 cgtcagtctc ctgggtgtct acaaaaccgg agacctggac ctgccctctc cagctagtgg
     1261 cacctctctg aagttctatg tgccctgcaa gcagatgccc cccatgaaga aaggagccag
     1321 ttacctgctg atgggtcagg tggaagagaa cagaggcccc atccttcctc cggagagctt
     1381 cgtggtgctc tacaggccca accaggacca gatcctgagt aacctaagca agagaaagtg
     1441 cccctcccag cctaggccag atgcctgatg tcctcgccag atcagagtgt ggtgctttta
     1501 tccaaataaa tgtttcttga ctcaggaagg aaaaaaaaaa aaaaaaa
//
