LOCUS       NP_062110                468 aa            linear   ROD 02-JUN-2024
DEFINITION  procollagen C-endopeptidase enhancer 1 precursor [Rattus
            norvegicus].
ACCESSION   NP_062110
VERSION     NP_062110.1
DBSOURCE    REFSEQ: accession NM_019237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 468)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (residues 1 to 468)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (residues 1 to 468)
  AUTHORS   Stamer,W.D., Hoffman,E.A., Luther,J.M., Hachey,D.L. and Schey,K.L.
  TITLE     Protein profile of exosomes from trabecular meshwork cells
  JOURNAL   J Proteomics 74 (6), 796-804 (2011)
   PUBMED   21362503
REFERENCE   4  (residues 1 to 468)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (residues 1 to 468)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (residues 1 to 468)
  AUTHORS   Steiglitz,B.M., Keene,D.R. and Greenspan,D.S.
  TITLE     PCOLCE2 encodes a functional procollagen C-proteinase enhancer
            (PCPE2) that is a collagen-binding protein differing in
            distribution of expression and post-translational modification from
            the previously described PCPE1
  JOURNAL   J Biol Chem 277 (51), 49820-49830 (2002)
   PUBMED   12393877
REFERENCE   7  (residues 1 to 468)
  AUTHORS   Matsui,A., Yanase,M., Tomiya,T., Ikeda,H., Fujiwara,K. and Ogata,I.
  TITLE     Stabilization of RNA strands in protein synthesis by type I
            procollagen C-proteinase enhancer protein, a potential RNA-binding
            protein, in hepatic stellate cells
  JOURNAL   Biochem Biophys Res Commun 290 (3), 898-902 (2002)
   PUBMED   11798157
  REMARK    GeneRIF: role in stabilization of RNA in noncollagenous protein
            synthesis as well as collagen synthesis in hepatic stellate cells
REFERENCE   8  (residues 1 to 468)
  AUTHORS   Ogata,I., Auster,A.S., Matsui,A., Greenwel,P., Geerts,A.,
            D'Amico,T., Fujiwara,K., Kessler,E. and Rojkind,M.
  TITLE     Up-regulation of type I procollagen C-proteinase enhancer protein
            messenger RNA in rats with CCl4-induced liver fibrosis
  JOURNAL   Hepatology 26 (3), 611-617 (1997)
   PUBMED   9303490
REFERENCE   9  (residues 1 to 468)
  AUTHORS   Takahara,K., Kessler,E., Biniaminov,L., Brusel,M., Eddy,R.L.,
            Jani-Sait,S., Shows,T.B. and Greenspan,D.S.
  TITLE     Type I procollagen COOH-terminal proteinase enhancer protein:
            identification, primary structure, and chromosomal localization of
            the cognate human gene (PCOLCE)
  JOURNAL   J Biol Chem 269 (42), 26280-26285 (1994)
   PUBMED   7523404
REFERENCE   10 (residues 1 to 468)
  AUTHORS   Kessler,E., Mould,A.P. and Hulmes,D.J.
  TITLE     Procollagen type I C-proteinase enhancer is a naturally occurring
            connective tissue glycoprotein
  JOURNAL   Biochem Biophys Res Commun 173 (1), 81-86 (1990)
   PUBMED   2256940
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U94710.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U94710.1, FQ209381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Rattus norvegicus"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     Protein         1..468
                     /product="procollagen C-endopeptidase enhancer 1
                     precursor"
                     /note="procollagen C-proteinase enhancer protein;
                     procollagen C-endopeptidase enhancer 1; PCPE-1;
                     procollagen C-proteinase enhancer 1; procollagen
                     COOH-terminal proteinase enhancer 1; type 1 procollagen
                     C-proteinase enhancer protein; type I procollagen
                     COOH-terminal proteinase enhancer; procollagen
                     C-endopeptidase enhancer protein"
                     /calculated_mol_wt=47682
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2521
     mat_peptide     25..468
                     /product="Procollagen C-endopeptidase enhancer 1.
                     /id=PRO_0000022025"
                     /note="propagated from UniProtKB/Swiss-Prot (O08628.1)"
                     /calculated_mol_wt=47682
     Site            28
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08628.1)"
     Region          36..146
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (O08628.1)"
     Site            order(44,46,48,75,80,118,142,144,146)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (O08628.1)"
     Region          158..271
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(166,168,170,198,203,242,266,268,270..271)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          271..341
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O08628.1)"
     Region          334..460
                     /region_name="NTR_PCOLCE"
                     /note="NTR domain, PCOLCE subfamily; Procollagen
                     C-endopeptidase enhancers (PCOLCEs) are extracellular
                     matrix proteins that enhance the activity of procollagen
                     C-proteases, by binding to the procollagen I C-peptide.
                     They contain a C-terminal NTR domain, which...; cd03576"
                     /db_xref="CDD:239631"
     Site            454
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08628.1)"
     CDS             1..468
                     /gene="Pcolce"
                     /gene_synonym="PCPE"
                     /coded_by="NM_019237.1:62..1468"
                     /db_xref="GeneID:29569"
                     /db_xref="RGD:3270"
ORIGIN      
        1 mlpaaltsll gpfllawvlp largqtpnyt rpvflcggdv tgesgyvase gfpnlyppnk
       61 kciwtitvpe gqtvslsfrv fdmelhpscr ydalevfags gtsgqrlgrf cgtfrpapvv
      121 apgnqvtlrm ttdegtggrg fllwysgrat sgtehqfcgg rmekaqgtlt tpnwpesdyp
      181 pgiscswhii apsnqvimlt fgkfdvepdt ycrydsvsvf ngavsddskr lgkfcgdkap
      241 spissegnel lvqfvsdlsv tadgfsasyr tlprdaveke sapspgedaq hgpqsrsdpk
      301 tgtgpkvkpp skpkvqpvek pegspatqat pvapdapsit cpkqykrsgt lqsnfcsssl
      361 vvtgtvkamv rgpgegltvt vsllgvyktg dldlpspasg tslkfyvpck qmppmkkgas
      421 yllmgqveen rgpilppesf vvlyrpnqdq ilsnlskrkc psqprpda
//
