LOCUS       NM_022381               1160 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus proliferating cell nuclear antigen (Pcna), mRNA.
ACCESSION   NM_022381
VERSION     NM_022381.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1160)
  AUTHORS   Babaeenezhad,E., Hadipour Moradi,F., Rahimi Monfared,S.,
            Fattahi,M.D., Nasri,M., Amini,A., Dezfoulian,O. and Ahmadvand,H.
  TITLE     D-Limonene Alleviates Acute Kidney Injury Following Gentamicin
            Administration in Rats: Role of NF-kappaB Pathway, Mitochondrial
            Apoptosis, Oxidative Stress, and PCNA
  JOURNAL   Oxid Med Cell Longev 2021, 6670007 (2021)
   PUBMED   33510839
  REMARK    GeneRIF: D-Limonene Alleviates Acute Kidney Injury Following
            Gentamicin Administration in Rats: Role of NF-kappaB Pathway,
            Mitochondrial Apoptosis, Oxidative Stress, and PCNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1160)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1160)
  AUTHORS   Zhao,W.P., Wang,H.W., Liu,J., Tan,P.P., Luo,X.L., Zhu,S.Q.,
            Chen,X.L. and Zhou,B.H.
  TITLE     Positive PCNA and Ki-67 Expression in the Testis Correlates with
            Spermatogenesis Dysfunction in Fluoride-Treated Rats
  JOURNAL   Biol Trace Elem Res 186 (2), 489-497 (2018)
   PUBMED   29748930
  REMARK    GeneRIF: Data show that the positive expression of proliferating
            cell nuclear antigen (PCNA) and Ki-67 antigen (Ki-67) is related to
            the fluoride-induced spermatogenesis dysfunction in the testis.
REFERENCE   4  (bases 1 to 1160)
  AUTHORS   Kim,H.L., Nam,S.M., Chang,B.J., Nahm,S.S. and Lee,J.H.
  TITLE     Ultrastructural Changes and Expression of PCNA and RPE65 in Sodium
            Iodate-Induced Acute Retinal Pigment Epithelium Degeneration Model
  JOURNAL   Neurochem Res 43 (5), 1010-1019 (2018)
   PUBMED   29569173
  REMARK    GeneRIF: The damaged retinal pigment epithelium showed earlier
            expression of PCNA and RPE65 than photoreceptor out segments
REFERENCE   5  (bases 1 to 1160)
  AUTHORS   Yueduan,W., Jinhua,Z., Changling,D., Yuhong,Z., Lifang,W., Bing,S.
            and Jing,W.
  TITLE     [Significance of the expression of proliferating cell nuclear
            antigen and P53 in the regeneration process of an atrophic parotid
            gland]
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 35 (6), 583-587 (2017)
   PUBMED   29333769
  REMARK    GeneRIF: explored the expression and significance of proliferating
            cell nuclear antigen (PCNA) and P53 in regenerating rat atrophy
            parotid gland from the gene and protein levels.
REFERENCE   6  (bases 1 to 1160)
  AUTHORS   Ohyama,C., Ito,A., Tokuyama,S., Nakazumi,H., Suzuki,K.,
            Kawamura,S., Sato,M., Saito,S., Yoshikawa,K., Hoshi,S. et al.
  TITLE     [Clinical significance of proliferating cell nuclear antigen (PCNA)
            and argyrophilic nucleolar organizer region (AgNOR) in testicular
            tumors]
  JOURNAL   Nihon Hinyokika Gakkai Zasshi 86 (10), 1543-1551 (1995)
   PUBMED   7474604
REFERENCE   7  (bases 1 to 1160)
  AUTHORS   Levavasseur,F., Burbelo,P.D., Cariou,S., Lietard,J., Yamada,Y. and
            Clement,B.
  TITLE     Nuclear recruitment of A1p145 subunit of replication factor C in
            the early G1 phase of the cell cycle in Faza 567 hepatoma cell line
            and hepatocyte primary cultures
  JOURNAL   FEBS Lett 363 (1-2), 132-136 (1995)
   PUBMED   7729533
REFERENCE   8  (bases 1 to 1160)
  AUTHORS   Theocharis,S.E., Skopelitou,A.S., Margeli,A.P., Pavlaki,K.J. and
            Kittas,C.
  TITLE     Proliferating cell nuclear antigen (PCNA) expression in
            regenerating rat liver after partial hepatectomy
  JOURNAL   Dig Dis Sci 39 (2), 245-252 (1994)
   PUBMED   7906221
REFERENCE   9  (bases 1 to 1160)
  AUTHORS   Liu,Y.C. and Bambara,R.A.
  TITLE     Gene expression of PCNA/cyclin in adult tissues and the R3230AC
            mammary tumor of rat
  JOURNAL   Biochem Biophys Res Commun 161 (2), 873-882 (1989)
   PUBMED   2567593
REFERENCE   10 (bases 1 to 1160)
  AUTHORS   Matsumoto,K., Moriuchi,T., Koji,T. and Nakane,P.K.
  TITLE     Molecular cloning of cDNA coding for rat proliferating cell nuclear
            antigen (PCNA)/cyclin
  JOURNAL   EMBO J 6 (3), 637-642 (1987)
   PUBMED   2884104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y00047.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022381.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00047.1, FQ220101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1160
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W/Fu"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1160
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /note="proliferating cell nuclear antigen"
                     /db_xref="GeneID:25737"
                     /db_xref="RGD:3269"
     exon            1..283
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..848
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /note="cyclin"
                     /codon_start=1
                     /product="proliferating cell nuclear antigen"
                     /protein_id="NP_071776.1"
                     /db_xref="GeneID:25737"
                     /db_xref="RGD:3269"
                     /translation="MFEARLIQGSILKKVLEALKDLINEACWDISSGGVNLQSMDSSH
                     VSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALV
                     FEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI
                     SCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVSIEMNEPVQLTFALRYLNFFTKA
                     TPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS"
     exon            284..381
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            382..449
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            450..644
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            645..768
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1160
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1160
                     /gene="Pcna"
                     /gene_synonym="Pcna/cyclin; PCNAR"
                     /note="polyA site"
ORIGIN      
        1 ttgtcagcaa gacctcgctc cccttacagt aactctcatc tagacgtcgc aactccgcca
       61 ccatgtttga ggcacgcctg atccagggct ccatcctgaa gaaggtgctg gaggccctca
      121 aagacctcat caatgaggcc tgctgggaca tcagttcggg cggcgtgaac ctacagagca
      181 tggattcgtc tcacgtctcc ttagtgcagc ttactctgcg ctccgaaggc ttcgacacat
      241 accgctgcga tcgcaacctg gccatgggcg tgaacctcac cagcatgtcc aaaattctaa
      301 aatgtgctgg taatgaagac atcattacat taagggctga agataatgct gataccttag
      361 cactagtatt tgaagcacca aatcaagaga aagtttcaga ctatgagatg aagttaatgg
      421 acttagacgt tgagcaactt ggaatcccag aacaggagta cagctgcgta gtaaagatgc
      481 catctggtga atttgcacgt atatgccggg accttagcca tattggagat gctgtggtga
      541 tctcctgtgc aaaggacggg gtgaagtttt ctgcgagtgg ggagcttggc aatgggaaca
      601 ttaagttgtc ccagacaagc aatgttgata aagaagagga agctgtgtcc atagagatga
      661 atgagccagt tcagctaact tttgctctga ggtacctgaa ctttttcaca aaagccactc
      721 cactgtctcc tacagtaaca ctcagtatgt ctgcagatgt accccttgtt gtagagtata
      781 aaattgctga catgggacac ttaaagtatt atttggctcc caagatcgaa gatgaagaag
      841 gatcttaggc gttgctagaa attgagaaac taaacctttg acgatcgctt ctgagatgcc
      901 agcgtgttct gaggtctttt ctgtcaccaa gtttgtacct gagtattctt aaatattaaa
      961 ataaaatgta gatatcttct gtaaataacc ttttttttcc tctccataat ttgcttacag
     1021 aataagctcc aaagtaaaaa ctggttttgt taacataaat gtctctgcct tacaaatact
     1081 ggtgattttc ataaatgatc ttgacgctaa atgcagtttt aagaaatatt tttcaattta
     1141 aataaagtta actgaatttg
//
