LOCUS       NM_031076               6627 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pericentriolar material 1 (Pcm1), mRNA.
ACCESSION   NM_031076 XM_001057686 XM_001057919 XM_001057980 XM_344524
VERSION     NM_031076.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6627)
  AUTHORS   Zhang,B., Wang,G., Xu,X., Yang,S., Zhuang,T., Wang,G., Ren,H.,
            Cheng,S.Y., Jiang,Q. and Zhang,C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   2  (bases 1 to 6627)
  AUTHORS   Zoubovsky,S., Oh,E.C., Cash-Padgett,T., Johnson,A.W., Hou,Z.,
            Mori,S., Gallagher,M., Katsanis,N., Sawa,A. and Jaaro-Peled,H.
  TITLE     Neuroanatomical and behavioral deficits in mice haploinsufficient
            for Pericentriolar material 1 (Pcm1)
  JOURNAL   Neurosci Res 98, 45-49 (2015)
   PUBMED   25697395
REFERENCE   3  (bases 1 to 6627)
  AUTHORS   Staples,C.J., Myers,K.N., Beveridge,R.D., Patil,A.A., Howard,A.E.,
            Barone,G., Lee,A.J., Swanton,C., Howell,M., Maslen,S., Skehel,J.M.,
            Boulton,S.J. and Collis,S.J.
  TITLE     Ccdc13 is a novel human centriolar satellite protein required for
            ciliogenesis and genome stability
  JOURNAL   J Cell Sci 127 (Pt 13), 2910-2919 (2014)
   PUBMED   24816561
REFERENCE   4  (bases 1 to 6627)
  AUTHORS   Greer,Y.E., Westlake,C.J., Gao,B., Bharti,K., Shiba,Y.,
            Xavier,C.P., Pazour,G.J., Yang,Y. and Rubin,J.S.
  TITLE     Casein kinase 1delta functions at the centrosome and Golgi to
            promote ciliogenesis
  JOURNAL   Mol Biol Cell 25 (10), 1629-1640 (2014)
   PUBMED   24648492
REFERENCE   5  (bases 1 to 6627)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6627)
  AUTHORS   Nachury,M.V., Loktev,A.V., Zhang,Q., Westlake,C.J., Peranen,J.,
            Merdes,A., Slusarski,D.C., Scheller,R.H., Bazan,J.F.,
            Sheffield,V.C. and Jackson,P.K.
  TITLE     A core complex of BBS proteins cooperates with the GTPase Rab8 to
            promote ciliary membrane biogenesis
  JOURNAL   Cell 129 (6), 1201-1213 (2007)
   PUBMED   17574030
REFERENCE   7  (bases 1 to 6627)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   8  (bases 1 to 6627)
  AUTHORS   Kubo,A. and Tsukita,S.
  TITLE     Non-membranous granular organelle consisting of PCM-1: subcellular
            distribution and cell-cycle-dependent assembly/disassembly
  JOURNAL   J Cell Sci 116 (Pt 5), 919-928 (2003)
   PUBMED   12571289
REFERENCE   9  (bases 1 to 6627)
  AUTHORS   Balczon,R., Simerly,C., Takahashi,D. and Schatten,G.
  TITLE     Arrest of cell cycle progression during first interphase in murine
            zygotes microinjected with anti-PCM-1 antibodies
  JOURNAL   Cell Motil Cytoskeleton 52 (3), 183-192 (2002)
   PUBMED   12112146
REFERENCE   10 (bases 1 to 6627)
  AUTHORS   Kubo,A., Sasaki,H., Yuba-Kubo,A., Tsukita,S. and Shiina,N.
  TITLE     Centriolar satellites: molecular characterization, ATP-dependent
            movement toward centrioles and possible involvement in ciliogenesis
  JOURNAL   J Cell Biol 147 (5), 969-980 (1999)
   PUBMED   10579718
  REMARK    Erratum:[J Cell Biol 1999 Dec 27;147(7):1585]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_344524.3, XM_001057686.1, XM_001057919.1, XM_001057980.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.58956.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000016.1  57808398-57808599   c
            203-317             JAXUCZ010000016.1  57790477-57790591   c
            318-563             JAXUCZ010000016.1  57788491-57788736   c
            564-833             JAXUCZ010000016.1  57787419-57787688   c
            834-1004            JAXUCZ010000016.1  57785297-57785467   c
            1005-1182           JAXUCZ010000016.1  57778282-57778459   c
            1183-1292           JAXUCZ010000016.1  57775344-57775453   c
            1293-1509           JAXUCZ010000016.1  57773726-57773942   c
            1510-1708           JAXUCZ010000016.1  57771863-57772061   c
            1709-1882           JAXUCZ010000016.1  57771007-57771180   c
            1883-2037           JAXUCZ010000016.1  57770364-57770518   c
            2038-2264           JAXUCZ010000016.1  57770017-57770243   c
            2265-2407           JAXUCZ010000016.1  57766778-57766920   c
            2408-2537           JAXUCZ010000016.1  57766511-57766640   c
            2538-2678           JAXUCZ010000016.1  57763975-57764115   c
            2679-2869           JAXUCZ010000016.1  57762763-57762953   c
            2870-3067           JAXUCZ010000016.1  57760246-57760443   c
            3068-3287           JAXUCZ010000016.1  57758439-57758658   c
            3288-3433           JAXUCZ010000016.1  57758187-57758332   c
            3434-3624           JAXUCZ010000016.1  57757505-57757695   c
            3625-3796           JAXUCZ010000016.1  57754230-57754401   c
            3797-4155           JAXUCZ010000016.1  57751375-57751733   c
            4156-4320           JAXUCZ010000016.1  57738087-57738251   c
            4321-4493           JAXUCZ010000016.1  57732773-57732945   c
            4494-4625           JAXUCZ010000016.1  57732312-57732443   c
            4626-4746           JAXUCZ010000016.1  57729964-57730084   c
            4747-4905           JAXUCZ010000016.1  57728766-57728924   c
            4906-5042           JAXUCZ010000016.1  57728295-57728431   c
            5043-5177           JAXUCZ010000016.1  57726093-57726227   c
            5178-5375           JAXUCZ010000016.1  57720060-57720257   c
            5376-5438           JAXUCZ010000016.1  57718137-57718199   c
            5439-5574           JAXUCZ010000016.1  57717753-57717888   c
            5575-5735           JAXUCZ010000016.1  57717184-57717344   c
            5736-5808           JAXUCZ010000016.1  57715741-57715813   c
            5809-6068           JAXUCZ010000016.1  57714267-57714526   c
            6069-6161           JAXUCZ010000016.1  57713424-57713516   c
            6162-6276           JAXUCZ010000016.1  57713228-57713342   c
            6277-6627           JAXUCZ010000016.1  57711833-57712183   c
FEATURES             Location/Qualifiers
     source          1..6627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..6627
                     /gene="Pcm1"
                     /note="pericentriolar material 1"
                     /db_xref="GeneID:81740"
                     /db_xref="RGD:620901"
     exon            1..202
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..317
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..6302
                     /gene="Pcm1"
                     /codon_start=1
                     /product="pericentriolar material 1 protein"
                     /protein_id="NP_112338.1"
                     /db_xref="GeneID:81740"
                     /db_xref="RGD:620901"
                     /translation="MATGGGPFEEVMHDQDLPNWSNDSVDDRLNNMEWGGQQKKANRS
                     SEKNKKKFGVASDKRVTNDISPESSPGVGRRRTKVPHTFPHSRYMTQMSVPEQAELEK
                     LKQRINFSDLDQRSIGSDSQGRATAANNKRQLGENRKPFNFLPMQINTNKSKDATASL
                     PKRETTTSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITK
                     ASSMREDLVEKNERSANVERLTHLIEHLKEQEKSYMKFLQKILARDPQQEPMEETENL
                     KKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVTETTGSLSGVSI
                     TSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREISQSRNPSVSEHLPDE
                     KVQLFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSFVPSTSLPRSGDKRSSTVALS
                     APVGFAPAVNGESNSLISSVPCPAASLVSQNESENEGHLNPAEKLQKLNEVQKRLNEL
                     RELVHYYEQTSDMMTDAVNENTKDEETEESEYDSEHEHSEPVTNIRNPQVASTWNEVN
                     TNSNTQRGSNNREGRSINSSCEINNRSAANIRPLTTPLLDCRYNREGEQRLRVARGED
                     EEEEVEEEGVSGASLSSRRSSLVDEAPEDEEFEQKISRLMAAKEKLKQLQDLVAMVQD
                     DDATQVLVPAASNLDDFYVAEEDTKQNSNNARENSNKVDTGVNEKTREKFYEAKLQQQ
                     QRELKQLQEERKKLIEIQEKIQAVQKACPDLQLSATSISSGPTKKYLPAITSTPTVNE
                     NETSTSKCDIEPEDSSVVDNELWSDMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE
                     TASPVAVSLRSDGSENLGTPQQSRTEKTMATWGGSTQCALDEDGDEDGYLSEGIVRTD
                     EEEEEEQDASSNDNFPMYHPSMNQNSYNVKETKNRWKNHRPVSADGNYRPLAKTRQQN
                     ISMQRQENLRWVSELSYIEEKEQWQEQINQLKKQLDFSVNICQTLMQDQQTLSCLLQT
                     LLTGPYSVLPSNVASPQVHLIMHQLNQCYTQLTWQQNNVQRLKQMLTELMRQQNQHPE
                     KPRSKERGSSASHPSSPSLFCPFSFPTQPVNLLNLPGFTNFPSFAPGMNFSPLFPSNF
                     GDFSQNVSTPTEQQQPLAQNPSGKTEYMAFPKPFESSSSLGAEKQRNQKQPEEETENT
                     KTPWLYDQEGGVEKPFFKTGFAVSVEKATNSNRKRQPDTSRRGRQFDEESLESFSSMP
                     DPIDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKTIGYESASVSS
                     TCEPCKSRNRHSAQTEEPVQAKLFSRKNHEQLEKIIKYSRSAEISSETGSDFSMFEAL
                     RDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESDE
                     KEGENIKSVNSGTWVASNSELTPSESLVTTDDETFEKNFERETHKITEQNDADNVSVM
                     SVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTETESNSNMRCTCRVIEDEDGAA
                     ATTTVSNAEETPIIENHSSPQPTSDVSAVPCPRIDTQQLDRQIKAIMKEVIPFLKEHM
                     DEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGE
                     DLLVEISEVLFNELAFFKLMQDLDNNSIAVKQRCKRKIEAAGVIQSYAKEAKRILEGD
                     RGSPAGEIDDEDKDKDETETVKQTQTSEVYDAKGPKNVRSDVSDQEEDEESERCPVSI
                     NLSKAESQALTNYGSGEDENEDEEMEDFEESPVDVQTSLQANTETTEENEHDNQVLQH
                     DLEKTQESTNVPSDQEGTSKNDQDSSPVKPCYLNILENEQHLNSATHKDSLTTTTDSS
                     KQPDPMPLPLTASETLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQ
                     KSDEEDFVKVEDLPLKLTVCSEAELRKKMVEEEQKNHLAGEICEMQTEELAGNPQILK
                     EPETVGAQSV"
     exon            318..563
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..833
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1004
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1182
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1292
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1509
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1708
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1882
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2037
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2264
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2407
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2537
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2678
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2869
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3067
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3287
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3433
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3624
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3796
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..4155
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4320
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4493
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4494..4625
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..4746
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..4905
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4906..5042
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            5043..5177
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            5178..5375
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            5376..5438
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            5439..5574
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            5575..5735
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            5736..5808
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            5809..6068
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            6069..6161
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            6162..6276
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
     exon            6277..6627
                     /gene="Pcm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggtcct aagatggcgg tggctgcggc ggttggcgcc tagttagcta atgtagacaa
       61 ggcggccatt gggctttggg cagtaagggg aactcctggg cctcccttcc gcggtcttcg
      121 aggaagaacc gctgctggtg gcggctcctg gaagggccga ctgccactcc gcccttggca
      181 ggaggggcgg cttcgtttac agagaattaa ttagagccaa catggccacg ggaggaggtc
      241 cttttgaaga agtcatgcat gatcaggact taccgaactg gagcaatgac agtgtggatg
      301 acagactcaa taatatggag tggggtggcc aacagaagaa ggccaacaga tcatcagaaa
      361 agaataagaa aaagtttggt gtagcaagtg ataagagggt aactaacgat atttctccgg
      421 agtcatcacc aggagttgga aggcgaagaa caaaggtccc acacacgttt ccgcacagta
      481 gatacatgac tcagatgtct gttccagagc aggccgaact agagaagctt aaacagcgga
      541 taaacttcag cgatttagat cagagaagta ttggaagtga ttctcaaggt agagcaacgg
      601 cggctaacaa caaacgtcag cttggtgaaa atcgaaagcc cttcaacttt ttgcctatgc
      661 agattaatac taacaagagc aaggatgcca ctgcaagtct tccaaaaaga gagacaacta
      721 cgtcagcaca gtgcaaagag ctgtttgctt ctgctctaag taatgacctt ttgcaaaact
      781 gtcaagtctc tgaagaagat gggagaggag agcctgcaat ggagagcagc cagattgtaa
      841 gcaggcttgt tcaaattcgt gactatatta ctaaagctag ttctatgcga gaagatcttg
      901 tagagaaaaa tgaaagatct gctaatgttg agcgtcttac tcatctaata gagcacctta
      961 aagaacaaga aaagtcatat atgaaatttc tccagaaaat cctagccaga gatcctcagc
     1021 aggagcctat ggaagagaca gaaaatttga agaaacaaca tgatttatta aaaagaatgt
     1081 tacaacagca ggaacagctg cgagctctac agggccgaca agctgctctg ctagctttgc
     1141 agcataaagc agagcaagct atagctgtga tggatgactc tgttgttaca gaaactacag
     1201 gaagcttatc tggagtcagc atcacatctg aactaaatga agaactgaat gatttaattc
     1261 agcgtttcca taatcagctt cgtgattctc agcctccagc tgttccagac aacagaagac
     1321 aggcggaaag tctttcatta actagagaga tttctcagag cagaaatccc tcagtttctg
     1381 aacatttacc tgatgaaaaa gtacagctgt ttagcaaaat gagagtacta caggaaaaga
     1441 aacagaaaat ggacaaatta cttggagaac ttcataccct ccgagatcag catctgaaca
     1501 actcatcctt tgtgccttca acttctctcc caagaagtgg ggataagaga agttcaactg
     1561 tagctctctc tgctcctgtg ggctttgcac cagctgttaa tggagagtcc aatagtctta
     1621 tctcatctgt tccttgtcct gccgcctctc tagtttctca gaatgagagt gaaaatgaag
     1681 gtcatctaaa tccagctgaa aaactacaga agttaaatga agttcaaaag agattgaatg
     1741 aactgagaga attagttcat tattatgaac aaacatcaga tatgatgaca gatgctgtaa
     1801 atgaaaatac aaaagatgaa gaaactgaag agtcagaata cgattctgaa catgaacatt
     1861 ctgagcctgt tactaacatt agaaatccac aggtagcttc cacctggaat gaagtgaata
     1921 ctaacagtaa cacacagcgc ggctctaata atagagaagg gcgatccatt aattctagct
     1981 gtgaaattaa taacagatct gctgccaaca tcagacctct aaccacgcct ctcttagact
     2041 gtcgatataa cagagaagga gaacagaggc tgcgtgtagc acgtggtgaa gatgaggaag
     2101 aggaagtaga agaggaagga gtcagtgggg cttcattatc tagtcgtagg agcagtctgg
     2161 ttgatgaggc accagaagat gaagagtttg aacagaagat tagtagactc atggctgcaa
     2221 aagagaaact taaacagctc caggatcttg ttgctatggt gcaggatgat gatgcaactc
     2281 aagtgcttgt tcctgctgca tcaaatttgg atgacttcta tgtagcagaa gaagatacca
     2341 aacaaaattc caataatgca agagaaaatt ctaataaagt agatactggg gtaaatgaaa
     2401 aaacaagaga gaaattttat gaggccaaac tacagcagca gcagagagag cttaaacagt
     2461 tgcaggagga aagaaagaaa ttgattgaaa ttcaagagaa aattcaagca gttcaaaagg
     2521 catgccctga ccttcagcta tcagccacta gtataagtag tggtcccaca aaaaaatatc
     2581 tgccagctat tacgtcaact ccgactgtta atgagaatga gactagtaca agcaagtgtg
     2641 atattgagcc tgaagattca tcagtagtgg ataatgagct gtggtcagac atgcgaagac
     2701 atgaaatgtt gagggaagag ctgcgacaga gaaggaagca acttgaagct ctaatggctg
     2761 aacaccagag gaggcaaggg ctggctgaga ccgcatctcc agtggctgtg tcactgagaa
     2821 gtgacggatc tgagaacctg ggcactcctc agcaaagtag gacagaaaaa acaatggcaa
     2881 cctggggagg ctctactcag tgtgcattag atgaagatgg agatgaggat ggttatcttt
     2941 cagaaggaat tgttcgaaca gatgaagagg aagaagagga gcaggatgcc agttccaatg
     3001 ataacttccc tatgtatcat cctagcatga atcaaaattc ctacaatgta aaggaaacca
     3061 aaaacaggtg gaagaaccat cgccctgttt cagcagatgg gaattaccgt cctttagcca
     3121 agacaaggca gcagaatatc agcatgcaac gacaagaaaa cctacgatgg gtgtcagagc
     3181 tctcttacat agaagagaag gaacagtggc aagaacaaat taatcagcta aagaaacaac
     3241 ttgatttcag tgtcaatatt tgtcagactc tgatgcaaga ccagcagact ttatcttgct
     3301 tgctgcagac tcttctaaca ggtccataca gtgttctgcc cagcaatgta gcgtcccctc
     3361 aagtacacct tatcatgcac cagctgaacc agtgctacac acagctaaca tggcagcaga
     3421 ataatgtcca gaggttaaaa caaatgctaa ctgaacttat gcgccaacaa aatcagcacc
     3481 cagaaaagcc tagaagcaaa gaaagaggca gcagtgcctc acacccctct tctcccagtt
     3541 tattttgtcc tttcagcttc ccaacacagc ctgtaaattt gctgaacctg cctgggttta
     3601 ctaacttccc atcttttgca ccaggaatga atttcagccc tttatttcct tctaattttg
     3661 gagatttttc tcagaatgtt tctacaccca ctgaacagca gcagccatta gctcaaaatc
     3721 cttcagggaa aacagagtat atggctttcc caaaaccctt tgaaagcagt tcttctcttg
     3781 gagcagaaaa gcaaaggaat cagaaacagc ctgaagagga aactgaaaac actaagacac
     3841 catggttata tgatcaagaa ggaggagtag aaaagccatt tttcaagact ggatttgcag
     3901 tgtctgtaga gaaagctaca aatagtaacc gcaaacgtca accagataca agcaggagag
     3961 gacgtcagtt tgatgaagag tcattggaaa gctttagcag tatgcctgac cccatagatc
     4021 caaccacagt aactaaaaca tttaaaacaa ggaaagcatc tgcacaggcc agcctggctt
     4081 ctaaagacaa aactcccaaa tcaaagagta agaagaggaa ttctactcag ctgaaaagta
     4141 gagttaaaac tattgggtat gaaagtgcca gtgtgtctag cacatgtgaa ccttgcaaaa
     4201 gtaggaacag acattcagcc cagactgaag agcctgttca agcaaagtta ttcagcagaa
     4261 agaatcatga acagctggaa aaaataataa aatatagtag gtctgcagaa atatcttcag
     4321 aaactggaag tgatttttcc atgtttgaag ctttacggga tactatttat tccgaagtgg
     4381 ctacattaat ttctcaaaat gaatctcgtc cacattttct tattgaactt ttccatgagc
     4441 tgcagctcct caatacagac tacttgagac agagagcttt atatgcgctg caggatattg
     4501 tatccagaca tatttctgaa agtgatgaaa aagaagggga aaatataaag tctgtgaatt
     4561 ctggcacttg ggtggcatca aactccgaac ttactccaag tgagagcctt gttactactg
     4621 atgatgaaac gtttgagaag aactttgaaa gagaaacaca taaaataact gaacagaatg
     4681 atgctgacaa tgtgagtgtc atgtctgtgt cttccaactt tgagccattt gcaacagacg
     4741 acctaggcaa caccgtgatt cacttggatc aagcattagc cagaatgaga gaatatgaac
     4801 gcatgaagac tgagacagaa agtaactcaa atatgagatg cacttgcagg gttattgagg
     4861 atgaagatgg tgctgccgcc accaccacag tcagtaatgc agaagaaact cccattattg
     4921 agaatcacag ttcaccacaa cctacaagtg acgtttctgc cgtcccctgt cctagaattg
     4981 acactcagca actggaccgc caaattaaag caattatgaa agaagtcatt ccctttttga
     5041 aggagcacat ggatgaagta tgttcttctc agcttctcac ttcagtgaga cgtatggtgt
     5101 tgacccttac ccagcagaac gacgagagca aagagtttgt gaagttcttt cataaacagc
     5161 taggaagtat attacaggat tcactagcaa aatttgcagg cagaaaactg aaagactgtg
     5221 gagaagatct tcttgtggag atatctgaag tgttgtttaa tgaattggct ttctttaagc
     5281 tcatgcaaga tttggataat aacagcatag ctgttaaaca gagatgcaaa aggaaaattg
     5341 aagcagctgg agtgatacag tcttatgcaa aagaggccaa aaggattctt gaaggagatc
     5401 gtggctcacc tgctggagag attgatgatg aagacaaaga caaggatgag actgaaactg
     5461 ttaagcagac tcagacttca gaagtatatg atgctaaagg tcccaaaaat gtaagatctg
     5521 atgtttctga tcaagaggaa gatgaagaaa gtgaacggtg tccagtgtct atcaatctat
     5581 ctaaagcaga aagtcaggct ttaactaatt atggaagtgg agaagatgag aatgaggatg
     5641 aagaaatgga agactttgaa gagagtcctg tggatgttca gacttcgctt caggctaaca
     5701 ctgaaactac agaagaaaat gaacatgaca atcaggttct gcaacatgat cttgaaaaaa
     5761 cacaagaaag tacaaatgta ccatcagacc aagaaggaac tagtaaaaat gatcaagaca
     5821 gctctcctgt gaaaccttgt tatctcaata tcttggaaaa tgaacagcat ttaaacagtg
     5881 ctacccataa ggactcactc actactacta ctgattcatc taaacagcct gaccctatgc
     5941 cattaccctt gactgcaagt gaaaccctag tgcctagagt caaagaagtt aaatctgctc
     6001 aggagactcc cgagagctct ctggctggaa gtcctgacac tgaatctcca gtgttagtca
     6061 atgactacga agcagaatct ggtaacataa gtcaaaagtc tgatgaagaa gactttgtga
     6121 aagttgagga cttgccactc aaactgacag tctgttcaga ggcagagctg aggaagaaaa
     6181 tggtagaaga agaacagaaa aaccatttag ctggtgagat atgtgaaatg cagactgaag
     6241 aattagctgg aaaccctcag atactgaaag aacctgaaac agtgggagcc cagagtgtat
     6301 gaaatgtctg cagaaactca tctaactctc ttacatagtc agcacagtaa aaaaaaaaaa
     6361 aaaaaaagac actaaataaa catttgtttt ggtctgtata aaatgtaaat tagtttgaca
     6421 ctgcattttt gatgggtgtg ctaatttctg cccatggcag tttaaaacat tagagtctga
     6481 atcctggaca gattcaaacc ttgacacact gtgggatttt tcttttgctt ttatttttct
     6541 tatgatcttg acccctaacc ctcattgtga catttggtgt gttaacttta aatgtagttt
     6601 taaataaagt ttgaacttat ctgtaaa
//
