LOCUS       NM_020098              19903 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus piccolo (presynaptic cytomatrix protein) (Pclo),
            transcript variant 1, mRNA.
ACCESSION   NM_020098
VERSION     NM_020098.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 19903)
  AUTHORS   Falck,J., Bruns,C., Hoffmann-Conaway,S., Straub,I., Plautz,E.J.,
            Orlando,M., Munawar,H., Rivalan,M., Winter,Y., Izsvak,Z.,
            Schmitz,D., Hamra,F.K., Hallermann,S., Garner,C.C. and Ackermann,F.
  TITLE     Loss of Piccolo Function in Rats Induces Cerebellar Network
            Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes
  JOURNAL   J Neurosci 40 (14), 2943-2959 (2020)
   PUBMED   32122952
  REMARK    GeneRIF: Loss of Piccolo Function in Rats Induces Cerebellar
            Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like
            Phenotypes.
REFERENCE   2  (bases 1 to 19903)
  AUTHORS   Tao-Cheng,J.H.
  TITLE     Immunogold labeling of synaptic vesicle proteins in developing
            hippocampal neurons
  JOURNAL   Mol Brain 13 (1), 9 (2020)
   PUBMED   31959215
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 19903)
  AUTHORS   Ackermann,F., Schink,K.O., Bruns,C., Izsvak,Z., Hamra,F.K.,
            Rosenmund,C. and Garner,C.C.
  TITLE     Critical role for Piccolo in synaptic vesicle retrieval
  JOURNAL   Elife 8, e46629 (2019)
   PUBMED   31074746
  REMARK    GeneRIF: Piccolo is critical for the recycling and maintenance of
            synaptic vesicles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 19903)
  AUTHORS   Parthier,D., Kuner,T. and Korber,C.
  TITLE     The presynaptic scaffolding protein Piccolo organizes the readily
            releasable pool at the calyx of Held
  JOURNAL   J Physiol 596 (8), 1485-1499 (2018)
   PUBMED   29194628
  REMARK    GeneRIF: Piccolo organizes the readily releasable pool of synaptic
            vesicles at the calyx of Held.
REFERENCE   5  (bases 1 to 19903)
  AUTHORS   Terry-Lorenzo,R.T., Torres,V.I., Wagh,D., Galaz,J., Swanson,S.K.,
            Florens,L., Washburn,M.P., Waites,C.L., Gundelfinger,E.D.,
            Reimer,R.J. and Garner,C.C.
  TITLE     Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone
            Proteins Piccolo and Bassoon
  JOURNAL   PLoS One 11 (12), e0167535 (2016)
   PUBMED   27907191
  REMARK    GeneRIF: The findings provide a mechanism for the presynaptic
            targeting of Trio and support a model in which Piccolo and Bassoon
            play a role in regulating neurotransmission through interactions
            with proteins, including Trio, that modulate the dynamic assembly
            of F-actin during cycles of synaptic vesicle exo- and endocytosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 19903)
  AUTHORS   Dick,O., Hack,I., Altrock,W.D., Garner,C.C., Gundelfinger,E.D. and
            Brandstatter,J.H.
  TITLE     Localization of the presynaptic cytomatrix protein Piccolo at
            ribbon and conventional synapses in the rat retina: comparison with
            Bassoon
  JOURNAL   J Comp Neurol 439 (2), 224-234 (2001)
   PUBMED   11596050
REFERENCE   7  (bases 1 to 19903)
  AUTHORS   Gerber,S.H., Garcia,J., Rizo,J. and Sudhof,T.C.
  TITLE     An unusual C(2)-domain in the active-zone protein piccolo:
            implications for Ca(2+) regulation of neurotransmitter release
  JOURNAL   EMBO J 20 (7), 1605-1619 (2001)
   PUBMED   11285225
REFERENCE   8  (bases 1 to 19903)
  AUTHORS   Zhai,R.G., Vardinon-Friedman,H., Cases-Langhoff,C., Becker,B.,
            Gundelfinger,E.D., Ziv,N.E. and Garner,C.C.
  TITLE     Assembling the presynaptic active zone: a characterization of an
            active one precursor vesicle
  JOURNAL   Neuron 29 (1), 131-143 (2001)
   PUBMED   11182086
REFERENCE   9  (bases 1 to 19903)
  AUTHORS   Fenster,S.D., Chung,W.J., Zhai,R., Cases-Langhoff,C., Voss,B.,
            Garner,A.M., Kaempf,U., Kindler,S., Gundelfinger,E.D. and
            Garner,C.C.
  TITLE     Piccolo, a presynaptic zinc finger protein structurally related to
            bassoon
  JOURNAL   Neuron 25 (1), 203-214 (2000)
   PUBMED   10707984
REFERENCE   10 (bases 1 to 19903)
  AUTHORS   Wang,X., Kibschull,M., Laue,M.M., Lichte,B., Petrasch-Parwez,E. and
            Kilimann,M.W.
  TITLE     Aczonin, a 550-kD putative scaffolding protein of presynaptic
            active zones, shares homology regions with Rim and Bassoon and
            binds profilin
  JOURNAL   J Cell Biol 147 (1), 151-162 (1999)
   PUBMED   10508862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 2, 2021 this sequence version replaced NM_020098.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF227534.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               JAXUCZ010000004.1  21004638-21005111   c
            475-1933            JAXUCZ010000004.1  20998140-20999598   c
            1934-3391           JAXUCZ010000004.1  20978277-20979734   c
            3392-4099           JAXUCZ010000004.1  20858703-20859410   c
            4100-9167           JAXUCZ010000004.1  20841455-20846522   c
            9168-11185          JAXUCZ010000004.1  20839081-20841098   c
            11186-13373         JAXUCZ010000004.1  20798133-20800320   c
            13374-13510         JAXUCZ010000004.1  20793541-20793677   c
            13511-13601         JAXUCZ010000004.1  20788649-20788739   c
            13602-13727         JAXUCZ010000004.1  20766588-20766713   c
            13728-13836         JAXUCZ010000004.1  20744453-20744561   c
            13837-13904         JAXUCZ010000004.1  20743845-20743912   c
            13905-14116         JAXUCZ010000004.1  20742789-20743000   c
            14117-14167         JAXUCZ010000004.1  20737519-20737569   c
            14168-14292         JAXUCZ010000004.1  20735230-20735354   c
            14293-14319         JAXUCZ010000004.1  20731409-20731435   c
            14320-14413         JAXUCZ010000004.1  20715349-20715442   c
            14414-14485         JAXUCZ010000004.1  20714162-20714233   c
            14486-14666         JAXUCZ010000004.1  20712788-20712968   c
            14667-14861         JAXUCZ010000004.1  20710340-20710534   c
            14862-15003         JAXUCZ010000004.1  20692853-20692994   c
            15004-15071         JAXUCZ010000004.1  20687715-20687782   c
            15072-15206         JAXUCZ010000004.1  20653387-20653521   c
            15207-15352         JAXUCZ010000004.1  20652841-20652986   c
            15353-19903         JAXUCZ010000004.1  20646604-20651154   c
FEATURES             Location/Qualifiers
     source          1..19903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..19903
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /note="piccolo (presynaptic cytomatrix protein)"
                     /db_xref="GeneID:56768"
                     /db_xref="RGD:69406"
     exon            1..474
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..15493
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein piccolo; presynaptic cytomatrix protein;
                     multidomain presynaptic cytomatrix protein Piccolo;
                     protein piccolo-like"
                     /codon_start=1
                     /product="protein piccolo isoform 1"
                     /protein_id="NP_064483.2"
                     /db_xref="GeneID:56768"
                     /db_xref="RGD:69406"
                     /translation="MGNEASLEGEGLPEGLAAAAGGAGGSGSALHPGIPAGMEADLSQ
                     LSEEERRQIAAVMSRAQGLPKGSVPAAAAESPSMHRKQELDSSQAPQQPGKPPDPGRP
                     TQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPL
                     SAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKSEGMAKPPLQQPSPKPIPK
                     QQGQVKEVIQQDSSPKSVSSQQAEKVKPQAPGTGKPSQQSPAQTPAQQASPGKPVAQQ
                     PGSAKATVQQPGPAKSPAQPAGTGKSPAQPPAKTPGQQAGLEKTSSSQQPGPKSLAQT
                     PGHGKFPLGPVKSPAQQPGTAKHPAQQPGPQTAAKVPGPTKTPAQQSGPGKTPAQQPG
                     PTKPSPQQPIPAKPQPQQPVATKTQPQQSAPAKPQPQQPAPAKPQPQQPTPAKPQPQP
                     PTPAKPQPQPPTATKPQPQPPTATKPHHQQPGLAKPSAQQPTKSISQTVTGRPLQPPP
                     TSAAQTPAQGLSKTICPLCNTTELLLHIPEKANFNTCTECQSTVCSLCGFNPNPHLTE
                     IKEWLCLNCQMQRALGGDLAAAIPSSPQPTPKAATAPTATASKSPVPSQQASPKKEPP
                     SKQDSPKALESKKPPEPKKPPEPKKPPEPKKPPPLVKQPTLHGPTPATAPQLPVAEAL
                     PEPAPPKEPSGPLPEQAKAPVGDVEPKQPKMTETRADIQSSSTTKPDILSSQVQSQAQ
                     VKTASPLKTDSAKPSQSFPPTGEKTTPLDSKAMPRPASDSKIISQPGPGSESKDPKHI
                     DPIQKKDEPKKAQPKGSPKPETKPVPKGSPTPSGTRPTAGQAAPPSQQPPKPQEQSRR
                     FSLNMGGITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQQGPHPQTGPAA
                     PSKQAPTPSQSPAAQGPAKSTGQLPPAPAKATAVKKEAKAAAAENLESKPEQAPTAKK
                     TEKDKKPPPAKVGKPPPSEPEKAVPAHKPDKTTKPKPACPLCRTELNLGSQEPPNFNT
                     CTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDMGKMPPAPSGPKASP
                     MPAPAEPSSQKTPTGTQVKGKKKEAEGKTEAEKPVPEKETASIEKTPPMVTTDQKLEE
                     SEGKKSKVSALPEKKPSEEEKAISADKKERKPPAEEKPPLEEKKPIPVDKKLPPEAKP
                     LSSEGEEKHEILKAHVQIPEEEPTGKVAAKTGEEEQQPDSRPEALPGATPLTLPKAGE
                     KERAVAQPQAEGSSKDGQGERSKEKTEKEEDKSDTSSSQQPKSPQGLSDTGYSSDGIS
                     GSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVG
                     EKAEKKTQPQKISPEKPQDQQKTQTASETLDITISEEEIKESQEKKVSPKKDSEQGFP
                     SRKEHKEKPELVDDLSPRRASYDSVEDSSESENSPVVRRKRRTSIGSSSSDEYKQEDS
                     QGSGEEEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEISGVGESQKREEAKGKGKGV
                     AGKHRRLTRKSSTSFDDDAGRRHSWHDEDDETFDESPELKFRETKSQESEELVVAGGG
                     GLRRFKTIELNSTIADKYSSESSQKKTILYFDEEPELEMESLTDSPEDRSRGEGSSSL
                     HASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEE
                     LREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDA
                     SPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPAAVSLYS
                     PTDEQSVMQKEGVQKALKSAEEMYEEMMQKPHKYKAFPAANERDEVFEKEPLYGGMLI
                     EDYIYESLVEDTYNGSVDGSLLTRQEEQNGFMQQRGREQKVRLQEQIYDDPMQKISDL
                     QKEFYELESLHSVVPQEDIVSSSYIIPESHEIVDLGSMVMSTSEEKKLLDADSAYEEL
                     MRRQQVQVTDGSSPVQTTIGDDMAESTLDFDRVQDASLTSSILSGASLTDSTSSATLS
                     IPDVKITQHFSAEELEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSL
                     TSSISSVCTTDSSSPVTTLDSLTTVYTEPADVMTKFKDSEEISSTYFPGSIIDYPEDI
                     SVSLDRTIMPESRTNEDQIVLSFSGMAPSVVESVGTKPERPQADTISTDLPISEKDLI
                     KGKKETGDGIILEVLDAYKDKREESEAELTKISLPEPGLAQAPSSVTAPQIKEQHVSP
                     HSVSGKISGQEKPTYRLPSGSLPVSTHPSKSRPFFRSSSLDISAQPPPPPPPPPPPPP
                     PPPPPPPPPLPPATSPKPPTYPKKKLAVAATVTSTTIVTTHVDALTTVEAAAARRSNG
                     LPATKMCATAPPPVPPKPSQIPTGLVFTHRPEAIKPPIAPKPAVPQIPVTTQKPTDTC
                     PKPTGLSLTSTMSLNLVTSADYKLPSPTSPLSPHSNKSSPRYSKSLMDTYVVITLPSE
                     PGTPTDSSAQAITSWPLGSPPKDLVSLETVFSVVPPMTATEIPSASQPTLYASGALGT
                     FSAGPAVTPSLFQTVPTPLTQFLPAEVSKPEVSAVRSTVPSVAPRSVSIPIPPEPLAL
                     DRHQYKENGKLPLVGDAIDLRTIPKTEEKATEKCMDLSASAVDVKRQTTVNEVYRRQI
                     SAVQPSIINLSAASSLVTPITMDSKTVAVVTCTDTTVYTTGTESQGGIEHAVTSPLQL
                     TTSKHTELPYRKPSSQAFPTIRDEAPINLSLGPSAQAVMLAVTKPVTVPPVGVTNGWT
                     DSTLSQGVADGEVVDLSTSKSHRTVVTMDESTSNVVTKIIEDDEKPVDLTAGRRAVCC
                     DMVYTLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNL
                     AEAGHFFYKSKNAFDYSGGTGAAVDLTSGRVSTGEVMDYSSKTTGPYPETRQVISGVG
                     ISTPQYSTARMTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTV
                     RDLSGIPTTDAMTSLSALHQSQPMPRSYFITTGASETDIAVTGIDINASLQTITMETL
                     PAEAMDSVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELEKIKQQRF
                     AEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQ
                     QLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYDPSGTSSPQTTTEQAILEGQYAATEGS
                     QFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVK
                     EEKQPKKRSSGAKVRGQYDEMGESVADDPRNLKKIVDSGVQTDDEETADRSYASRRRR
                     TKKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPLSKVSSVAVQTV
                     AEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDSDTQSPP
                     YLGATSPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGNAL
                     EPAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSR
                     APFQYSEGFTTKGSQTMTASGTQKKVKRTLPNPPPEEVSTGTQSTYSTMGTASRRRMC
                     RTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKE
                     ALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPSRVESQHGVERPRTAPQTEFSQFI
                     PPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQP
                     TFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQ
                     PLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHT
                     SRNYVLIDDIGDITKGTAALSTAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQT
                     SSRLHSYVKAEEDPMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHF
                     PKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDY
                     PTYMSSGTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSA
                     LQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFGHSS
                     SSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRD
                     QFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKP
                     RESRLENGHGLDRKLPERLVHSRPLSQHQEQILQMNGKTIHYIFPHARIKITRDSKDH
                     TVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEHTGKLMEGMQVLEWNGVPLT
                     SKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLELHEPPKVDKAKSPGVDPKQ
                     LAAELQKVSLQQSPLVMSSVVEKGSHAHSGPTSAGSSSVPSPGQPGSPSVSKKKHSST
                     KPTDATKAASHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPG
                     RGQVMVVQNASAEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRF
                     SSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQNSQQSPKPSVIKSR
                     SHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVAQTHLEDAG
                     VAIAAAEAAVQQLRIQPTKPTNHRPAESSVSTGSSGSSVGSGYSVDSEGSSCVAGEPN
                     LLPIPRIGKMGQNGQDPVKQPGMGATDTEGKTQVMGEIKLALKKEMKTDGEQLIVEIL
                     QCRNITYKFKSPDHLPDLYVKLYVINISTQKKVIKKKTRVCRHDREPSFNETFRFSLS
                     PAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLVSPTQTH"
     exon            475..1933
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..3391
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..4099
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..9167
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            9168..11185
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            11186..13373
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            13374..13510
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            13511..13601
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            13602..13727
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            13728..13836
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            13837..13904
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            13905..14116
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14117..14167
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14168..14292
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14293..14319
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14320..14413
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14414..14485
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14486..14666
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14667..14861
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            14862..15003
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            15004..15071
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            15072..15206
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            15207..15352
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
     exon            15353..19903
                     /gene="Pclo"
                     /gene_synonym="aczonin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggaggca acccggaggc agggtgtgag aagcttccct ggcgctgtcc aacatggagg
       61 agctgacggc cgccggcaaa gcctgcggag cggactgagc tcgcgtctct tctccaggca
      121 gcagggaggg cgcggagcct acagggctgg gcagcctgca cgccccgggg cggaccccgg
      181 ctggcggggc tcggacggct acgggcttct gcaccgggac gtgtcccgcc gagccatggg
      241 caacgaggcg agcttggaag gggaagggct ccccgaaggg ctggcggcgg ccgcaggcgg
      301 ggctggcggt tcggggagcg ccctgcaccc cgggatccca gccggcatgg aggcggacct
      361 gagccagctg agcgaggagg agaggagaca gatcgctgct gtcatgtcaa gggcgcaggg
      421 gctgcccaag ggaagcgtcc ccgcggccgc tgcggagtcg ccctccatgc acaggaaaca
      481 agagttggat agtagtcagg ctccacaaca accaggaaag ccaccggacc ctgggcgtcc
      541 cactcagcct ggtctcagta aaagcagaac tacggacacg tttaggtcag agcagaagct
      601 gcctggaagg agtccgtcca cgatcagctt gaaagaatcg aagtccagaa ctgattttaa
      661 ggaagaatac aagtctagta tgatgcctgg tttcttctca gatgttaacc cgttaagtgc
      721 tgtctcctct gttgtaaata aattcaaccc ttttgatttg atatcagact ctgaggcatc
      781 ccaggaggaa actacaaaga aacaaaaagt tgtccagaag gagcaaggga aatcggaagg
      841 aatggcaaaa cctcccttac agcaaccatc acctaagccg atccctaaac agcaaggaca
      901 agtgaaggaa gtgatccagc aagacagctc tcccaagtca gtatcttccc agcaagcaga
      961 aaaagtaaaa ccacaagccc ctggcacagg aaagccttcc caacagagtc cagcccaaac
     1021 accagctcag caagctagtc ctggaaaacc tgtagcccaa cagcctggat ctgcaaaggc
     1081 cacagtccag cagccagggc cagcaaagtc cccagctcaa ccagcaggga cagggaaatc
     1141 cccagcccaa cctccagcca agaccccagg tcagcaggct ggattagaga agacctcatc
     1201 atcgcagcag cctgggccaa agtctctagc ccagactcct ggtcatggga agtttccact
     1261 ggggccagta aagtctccag cccagcagcc agggacagca aaacacccag ctcaacagcc
     1321 tggcccacag actgcagcta aggtacctgg gcctacaaaa actccagctc agcaatctgg
     1381 acctggaaag acaccagctc aacagccagg tccaacaaag ccttcacctc agcaacccat
     1441 tccagcaaag ccccagcctc agcaacctgt tgccacaaaa actcagcctc aacagtctgc
     1501 cccagcaaaa ccccagcctc agcagccagc cccagcaaag ccccagcctc agcagccaac
     1561 tccagcaaag cctcagcctc aaccgcccac cccagcaaag ccccagcctc aaccgcccac
     1621 agcaacaaag ccccagcctc aaccgcccac agcaacaaag ccccaccatc aacagccagg
     1681 cctggcaaaa ccttcagctc agcaacctac aaaatcgata agccaaacgg taactggacg
     1741 acctctgcaa ccaccaccaa cttctgcagc acagactcca gcacaaggcc tctcgaaaac
     1801 catctgtcct ctttgcaaca ccactgaact tctgttgcat attccagaaa aggccaattt
     1861 taacacatgc actgagtgtc aaagcaccgt ctgtagcctc tgtggtttta accccaaccc
     1921 tcatttaact gagatcaaag agtggctctg tttaaactgt cagatgcaaa gagctctagg
     1981 aggggacctg gcagcggcaa tcccatcctc accacagcca accccaaagg ccgccacagc
     2041 acctacagca acagccagca aatcacctgt accgtcacag caggcttccc caaagaagga
     2101 acctccatcc aaacaggaca gtcccaaagc actggagtcg aaaaaaccgc cagagccgaa
     2161 aaaaccacca gagccgaaaa agccaccaga gccgaaaaag ccaccgccat tggtgaaaca
     2221 gccaaccctt catggaccta ccccagctac agccccacag cttccagtgg cagaggcctt
     2281 acctgagcca gcccctccca aggagccttc tggaccccta cctgaacaag ccaaggcccc
     2341 cgttggagat gttgaaccaa agcagcccaa gatgacagag acgcgcgcag acatccaatc
     2401 ttcgtcaacg acaaaacctg atattctgag ctctcaagtg cagtcacagg ctcaagtgaa
     2461 aacagcctct cctttgaaaa cagactctgc caaaccttca cagagtttcc caccaacagg
     2521 agaaaaaacc accccacttg actctaaagc catgcccagg cctgcatcag actcaaaaat
     2581 tatctcacaa cctgggcccg gttctgagag caaggatccg aaacacattg atccgattca
     2641 gaagaaagat gaacctaaga aagcacaacc caaggggagc cctaaaccag aaacaaagcc
     2701 agtgccaaaa ggatcaccga caccctctgg cacacgacct accgctggcc aagctgcacc
     2761 cccatctcag cagcccccga agcctcagga gcagtcaaga cgttttagct tgaatatggg
     2821 cggtatcact gatgccccca aatcacagcc cacgactcct caagaaaccg tgacggggaa
     2881 actcttcggc tttggagcat ccatctttag ccaagcatca aacttaattt ccacagcagg
     2941 tcagcaagga ccacatccac aaactgggcc agccgcccca tcaaagcaag cccctacccc
     3001 atcacagagt cctgctgctc agggacctgc caagtccacg ggtcagctcc caccggcacc
     3061 tgctaaggcg actgctgtga agaaggaggc aaaagctgca gcagctgaaa acttagagtc
     3121 caaacctgag caagcgccaa cagcgaagaa gacagagaaa gacaagaagc cgccacctgc
     3181 gaaggtcggc aaacctccac cctcagagcc cgaaaaggct gtcccggccc ataaaccaga
     3241 caagaccacc aaacccaaac cagcctgtcc tctctgtaga actgagctca acctagggtc
     3301 tcaggagcct cccaacttca acacctgcac agaatgcaag aatcaagttt gcaatctctg
     3361 tggatttaac ccaacgcccc acctgactga gattcaagag tggctttgtt taaactgcca
     3421 gacacagaga gcaatttcag gacaacttgg agatatgggc aaaatgccac ctgcaccctc
     3481 aggacccaaa gcatccccta tgcctgctcc tgcagaacct tcatcgcaga aaacacccac
     3541 agggacccaa gtgaaaggca aaaagaaaga agcagaagga aaaacggaag ctgaaaaacc
     3601 ggttccagaa aaagaaacag catcaattga gaaaacccct ccaatggtca ccacagatca
     3661 aaaactagaa gaaagtgaag gaaagaaaag caaggtttca gcccttccgg agaagaaacc
     3721 atctgaagaa gaaaaggcaa tatctgcaga taaaaaggaa aggaagccac ctgctgaaga
     3781 aaagccaccg cttgaagaaa agaagccaat ccccgtagat aagaaattac ccccagaagc
     3841 aaaaccgttg tcctcagagg gggaagagaa acatgaaata cttaaagctc acgtacaaat
     3901 tcccgaagaa gaacccacag gcaaagtggc tgcaaagaca ggtgaagagg agcagcagcc
     3961 agactccagg cctgaagctc tgccaggcgc cacacctctg acattaccca aggcaggaga
     4021 gaaagaaaga gcggtagcac agccacaggc agaaggcagt tcaaaggatg gccaaggcga
     4081 gcggagcaaa gaaaagacag aaaaggaaga ggataaatca gacacttcca gttctcagca
     4141 acccaagagc ccacaaggcc tgagtgacac aggatattct tctgatggaa tatcaggttc
     4201 ccttggggaa atcccaagcc ttatacccag tgatgagaaa gatttgctga aaggactcaa
     4261 aaaagattct ttctcacaag aaagcagccc ttccagcccc tcagacttag ctaagttgga
     4321 aagtacagta ctatccattt tggaagctca ggcaagtaca cttgttggtg aaaaagcaga
     4381 aaagaaaaca cagccccaga agatttctcc tgaaaagcca caggaccagc agaaaactca
     4441 gactgcatcc gaaacactgg atattactat ttcagaagag gagatcaaag agagtcaaga
     4501 aaagaaagtt agtccaaaaa aggatagcga gcaaggtttt ccttccagaa aggagcacaa
     4561 agagaagcct gagctggttg atgacctaag tccgcgaagg gcatcctatg attcggtcga
     4621 agacagcagc gaaagtgaaa actcccctgt tgtccgtagg aagcggagaa ctagtattgg
     4681 ttcgtcaagc agcgatgagt ataagcagga agacagtcaa ggttcggggg aagaggagga
     4741 cttcattcga aaacagatta tagaaatgag tgctgatgag gatgcttcag gctctgagga
     4801 tgaagagttc atcaggagtc agctcaaaga gatcagtggc gttggtgaga gccagaagag
     4861 ggaggaagca aaggggaaag gaaaaggcgt ggccgggaaa caccgacgac tgactcgaaa
     4921 gagcagtacc agcttcgatg acgatgcagg gaggcgtcat tcctggcatg acgaggatga
     4981 tgaaactttt gatgaaagtc ctgaactcaa attccgagaa actaaaagcc aggagagtga
     5041 agaactcgtc gtcgctggag gaggagggtt gcggcgattt aagacaatag aactcaatag
     5101 tacaatagca gacaagtact cttcagaatc ctctcagaaa aagacaattt tgtatttcga
     5161 tgaagagcca gaattagaaa tggaaagtct gacagactca cccgaagaca gatctagggg
     5221 agagggatcc tctagtctcc atgcatccag cttcactcct ggcacatccc ctacgtcagt
     5281 atcgtccctt gatgaggaca gtgacagtag cccaagtcac aaaaaaggag aaagcaagca
     5341 gcagcgcaaa gctcggcaca ggtcgcatgg ccctctgtta cctaccattg aagattcctc
     5401 cgaggaagaa gaactgaggg aggaagaaga attactaaaa gaacaagaga agcagcgaga
     5461 attggaacag caacagagga agagttctag taagaaatcg aagaaagaca aagatgaact
     5521 tcgagcccag agaagacgag aaagaccaaa gacaccgccc agtaatctct ctcccatcga
     5581 ggacgcatcc cccacagaag aactgcgcca ggcagcagaa atggaggagc tacacagatc
     5641 ctcttgctct gaatactcac ctagcataga atcagatcca gaaggattcg aaataagccc
     5701 cgagaaaata atagaagttc aaaaagttta caaattgccc gcagctgtgt ctttatactc
     5761 accaacagac gagcaatctg ttatgcagaa agaaggtgtt cagaaggcat taaaaagtgc
     5821 tgaggagatg tatgaagaaa tgatgcagaa accccacaag tacaaagctt tcccagctgc
     5881 aaatgagaga gacgaagtgt ttgagaaaga gccattgtat ggtggtatgt taatagagga
     5941 ctacatttac gagtctttag tagaggacac gtacaatggg tcagtagatg gcagtctgct
     6001 caccaggcaa gaggagcaaa acgggtttat gcagcagaga gggagagaac aaaaagtaag
     6061 actgcaggaa cagatttacg atgaccccat gcagaaaatc tcagacctcc agaaggagtt
     6121 ttatgaatta gaaagcttac actctgttgt gcctcaagaa gacattgttt caagctctta
     6181 catcattcca gaaagccatg agatagtgga tctgggtagc atggtgatgt ctaccagcga
     6241 agaaaagaaa ttgttagatg ccgactcggc gtatgaagaa ctcatgaggc ggcagcaggt
     6301 gcaggtaaca gatggctcca gccccgtaca gactaccatt ggggatgaca tggcagagtc
     6361 cactctggac ttcgacaggg tgcaagatgc gtctttgaca tcaagtatcc tttctggagc
     6421 atctcttaca gactcaacca gcagtgccac tctctctatc ccagatgtta agataaccca
     6481 acatttttca gcagaagaac ttgaggatga atatgtaact gattatacaa gagaaattca
     6541 agaaataatt gcccacgagt cacttatatt gacttactct gagccttccg aaagtgcgac
     6601 gtctgtcccg ccttctgaca caccttctct cacgtcctct atttcttcgg tttgcaccac
     6661 agacagctcc tcacctgtca ctaccctcga cagcctaaca actgtttata cagagccagc
     6721 agatgtaatg actaaattta aagactctga ggaaatttct tcaacttatt ttccaggcag
     6781 cattatcgac tatccagaag atataagtgt atctttagat cggaccatca tgccagaaag
     6841 tcgaactaat gaggatcaga ttgtgctttc tttctccggt atggcacctt ctgtcgtaga
     6901 atctgtagga actaagcctg agaggccaca agctgacact atttccactg acttacctat
     6961 atctgaaaag gatttgataa aaggcaagaa agagactggg gatgggatta ttttggaagt
     7021 tttggatgct tacaaagata agagggaaga atcagaggct gaactaacga aaatcagctt
     7081 gcccgagcct gggttggccc aagcgccttc ttccgtaaca gcccctcaaa ttaaggaaca
     7141 acatgtgtct cctcattctg tatctggaaa aatttctggt caggaaaagc ccacatacag
     7201 gttaccatct ggcagtcttc ctgtttctac ccatccatct aaatctcgtc cgtttttccg
     7261 aagttcttct ttggacatat cagcccagcc acctcctccc cctccaccac ctcctcctcc
     7321 ccctccacct cctccccctc caccaccccc accattgcca ccagcaactt ctcctaagcc
     7381 acccacttat cccaaaaaaa agttggcggt tgcagctaca gtgacttcaa ctactattgt
     7441 tacaacccat gttgatgctc taactacggt agaggccgca gctgctcgca ggagcaatgg
     7501 gctgcctgcc actaaaatgt gtgctactgc acctcctcct gtgcctccta agccttctca
     7561 aattccaact ggacttgtat ttacacatag gccagaggca atcaaacctc caattgcccc
     7621 caagccagca gttcctcaga ttccagttac tacacagaaa ccaacagata cgtgtcccaa
     7681 gccaacaggt ctatctttaa cttcaactat gtccttaaat ttagtgactt cagcagacta
     7741 caagcttcct tcccctacct ctccactttc cccacactct aacaaatcct caccaagata
     7801 ttctaagtct ctcatggaca cttacgtggt tattacattg ccctcggaac ctgggactcc
     7861 aacagattct tctgctcaag ccattacaag ttggcccttg ggatcacccc caaaagatct
     7921 ggtttccctc gaaacagtat tttctgtcgt tcctcccatg acagctacag aaattccaag
     7981 tgcttcacag ccaacccttt atgcatctgg agctttgggg acattctctg ctggccctgc
     8041 tgtaacgccg tctctgtttc aaacagtacc aactccactt acacagtttc ttccagcgga
     8101 agtttcaaaa cccgaagttt ctgcagtgag aagcacagtc ccaagtgttg ctcccagaag
     8161 tgtttccata ccaattcctc cagagccgct tgctctagac aggcatcagt acaaggaaaa
     8221 cggaaagttg ccccttgtag gcgatgccat tgatttgcgt acgataccaa aaacagagga
     8281 aaaagcaact gaaaaatgta tggatctttc tgcttctgca gtggatgtga aaaggcagac
     8341 cacagtgaac gaagtttaca ggagacaaat tagtgctgtc caaccgtcta tcataaacct
     8401 cagtgcagct tcctccttgg taactccaat caccatggac tctaagacag tggctgtggt
     8461 cacctgcaca gatactacag tgtacacaac aggcacagaa agccaaggag gtatagagca
     8521 tgcagtaaca tcaccactcc agctcactac atcaaaacat accgagttac catacaggaa
     8581 acctagtagc caggcttttc ctacaatccg agatgaagca cccatcaact tatcattagg
     8641 tccttcagct caggcagtga tgctggctgt cacgaagccc gtcactgtac ctcctgtcgg
     8701 cgtcacaaat ggatggactg acagcactct atctcagggg gtcgctgatg gagaagtagt
     8761 agatctcagc acatcaaaat ctcacagaac tgtcgtgaca atggatgaat ctacgtcaaa
     8821 cgtggtgacc aaaatcatag aggatgatga aaaaccagtt gatctgaccg caggaagacg
     8881 agcggtgtgc tgtgatatgg tttacacgtt gccctttgga aggagctgca cggcacagca
     8941 gcctgcaacc acccttcccg aagaccgttt tggttacagg gatgaccact atcaatatga
     9001 cagatcaggg ccctatggtt acagggggat tggcggaatg aaaccttcca tgtcagatac
     9061 caatttagca gaagctggac actttttcta taaaagtaag aatgcctttg attattctgg
     9121 aggaactggt gcagcagtag acctgacttc tgggagagtg tctacaggtg aggtaatgga
     9181 ttattcaagc aagactacag gtccataccc agaaacacgc caagtcattt cgggagttgg
     9241 gattagtacc ccacagtatt ccactgcaag aatgactcca cctcctggac cccagtatgg
     9301 tgtgggaagt gttttgaggt catctaatgg tgttgtctat tcttcagtag caactccaat
     9361 cccctccaca tttgctatca ccactcaacc gggctctatt ttcagcacca cggtcaggga
     9421 tttatctggc attcctacca cagatgcaat gacttcatta tcagccctgc atcaaagcca
     9481 gccaatgcct cgatcgtatt tcataacaac aggtgcgtca gaaacagaca tcgcagtaac
     9541 cggtattgac atcaatgcca gtctgcaaac tattaccatg gaaactcttc ctgctgaggc
     9601 aatggactct gttcctacct taaccacagc gtctgaggtg ttttctgagg tggtcggaga
     9661 ggaaagcacc cttctaattg tccctgatga agacaaacaa caacagcaac ttgacttgga
     9721 gcgagagctc ctggaactgg agaaaattaa gcaacagcgc tttgctgaag aactggagtg
     9781 ggaacgtcag gagattcaga ggttccgaga acaagagaag atcatggttc aaaagaagct
     9841 ggaggagctg cagtctatga agcagcacct tctctatcaa caagaggaag agcggcaggc
     9901 acagttcatg atgaggcagg agacgctagc tcagcaacag ttacagcttg agcagatcca
     9961 acagctgcaa caacagctcc accagcagct cgaggaacaa aaacttcgcc agatctacca
    10021 gtataattat gacccctctg ggacctcttc tcctcaaacc accactgaac aggccatttt
    10081 agagggtcaa tatgctgcta cagagggcag tcagttttgg gccactgaag atgccaccac
    10141 tacggcgtct actgtggttg ccattgaaat cccacagagc caaggatggt acaccgttca
    10201 gtctgatggt gtgactcagt acattgcccc acctggtatc ctgagcactg tttcagagat
    10261 acctctgaca gatgttgttg tgaaagagga gaagcaaccc aaaaagagaa gttctggagc
    10321 taaagttcgg gggcagtatg atgagatggg ggaaagcgtg gcagacgatc cacgaaattt
    10381 aaaaaagata gtggacagtg gcgtgcaaac tgacgacgaa gaaactgctg atcggagtta
    10441 cgcaagtagg agaagaagaa ctaaaaaaag cgtggatacc agtgtccaaa ctgatgacga
    10501 agatcaggat gagtgggaca tgccttctag gtccaggaga aaagcgcgaa cagggaaata
    10561 cggagatagc accgcagagg gtgacaagac caagcccctt tccaaagtct ccagtgtagc
    10621 ggttcagaca gttgcagaga tatctgtgca aactgagcca gtgggaacca taagaacacc
    10681 ttccatacga gcacgggtgg atgccaaggt agaaataatt aaacacattt cagcacctga
    10741 aaagacttac aaagggggca gtttaggatg ccaaacagaa acagattcag acacacagag
    10801 ccctccatat ctgggtgcca catctccacc caaagacaag aaacgcccaa cacctttaga
    10861 aattggttat tcttcttctc accttcgggc agaccccaca gtccagctgg ctccttcccc
    10921 acccaaatct ccaaaagtcc tttactcacc catctcacca ctttccccag gcaacgcctt
    10981 agaaccagcc tttgtacctt atgaaaaacc cctccctgat gacataagtc cacagaaagt
    11041 actccatcca gatatggcta aagttccccc ggcaagccct aagacagcca agatgatgca
    11101 gcgttcaatg tctgacccaa agcctctgag tccaacagca gacgaaagtt ccagggctcc
    11161 ttttcagtat tccgagggct tcacgactaa aggttcccaa accatgacag cctctggtac
    11221 tcagaaaaaa gtgaagagaa cacttccaaa tccccctcct gaggaggtgt ccacgggaac
    11281 acagtcaact tacagcacca tgggcactgc ttctaggaga agaatgtgca gaaccaatac
    11341 catggctcga gccaagattc tccaggacat agaccgagag ctcgacctcg tggaaaggga
    11401 gtctgccaag cttagaaaga agcaagcaga acttgatgaa gaagaaaagg agattgatgc
    11461 caagctgcgg tatctggaaa tgggaattaa caggagaaaa gaagcgttat tgaaggagag
    11521 agaaaagaga gagcgtgcct acctgcaggg ggtagctgag gaccgcgatt acatgtctga
    11581 cagtgaggtc agcagtacca gaccgagccg agtagaaagt cagcacggcg ttgagcggcc
    11641 aagaacagct cctcaaactg aattcagtca gttcatacca ccacagaccc aaacagaagc
    11701 tcaactagtt cctcctacaa gtccttacac acaataccag tactcatcac cggcccttcc
    11761 cacccaagcc ccgaccccat acacacagca atctcatttt caacagcaga cactatacca
    11821 tcagcaagtt tcaccttatc agactcagcc aaccttccaa gctgtggcaa caatgtcctt
    11881 cacaccccag gctcaaccca ctccaactcc acagccatcc tatcaactac cgtcacagat
    11941 gatggtgata caacagaagc ctcgacaaac cacattgtat ttggagccta agataacttc
    12001 taactatgaa gtgattcgca accaacccct gatgatcgct ccggtttcta ctgataatac
    12061 atacgctgtt tcccatcttg ggagtaagta caatagttta gacttgagaa tcggtttgga
    12121 ggaaagaagc agcatggcaa gcagtccaat atcaagcata tctgcagact ccttctatgc
    12181 agacattgac caccacactt caaggaatta tgtcctaata gatgacattg gagacattac
    12241 caaagggaca gcagcactga gcactgcatt tagtcttcat gaaaaggatc tgtccaaaac
    12301 agatcgtctc cttagaacca ctgagacacg gaggtctcag gaagtgacag acttcctagc
    12361 gcctttgcag acttcctcca gattgcatag ctatgtgaaa gcagaggagg atccgatgga
    12421 ggatccttat gagttaaagc ttctgaaaca tcagattaag caagaattcc gtagaggcac
    12481 agagagcttg gatcaccttg ctggtctctc acattattac catgccgata ctagctatag
    12541 gcactttccc aagtctgaaa agtatagcat cagtagactc acccttgaga agcaagctgc
    12601 caaacaatta cctgcagcca tactttacca aaagcaatca aagcataaga aatcattaat
    12661 tgaccctaaa atgtcaaagt tttcacctat tcaagaaagt agagaccttg aacctgacta
    12721 tcccacttac atgagttctg gcacttcatc cattggtggc atttcttcta gggcaaggct
    12781 tcttcaagat gatatcacat ttggcctcag aaaaaatatt acagatcaac aaaaatttat
    12841 gggctcatca cttgggtcag gactgggcac actaggaaat actatccggt cagctctaca
    12901 ggatgaagca gataaaccat acagcagtgg gagcaggtcc aggccttcct ccaggccttc
    12961 ttctgtctat ggccttgatt tatcaattaa gagggattct tctagctcat cgctaagatt
    13021 gaaagctcaa gaggctgaag ctctggatgt ctcctttggc cattcttcat cttctgccag
    13081 aactaagccc accagcttac caatcagcca gagcagagga agaataccaa ttgtggccca
    13141 gaattcagaa gaagaaagtc cgctaagtcc tgttggccaa ccaatgggaa tggccagggc
    13201 tgcggctgga cctttgccgc ccatatctgc agatacgagg gatcagtttg gatcaagcca
    13261 ctcattgcct gaagttcagc aacacatgag agaagagtca cggacaaggg gttatgaccg
    13321 tgacatagca ttcatcatgg atgacttcca acatgctatg tcagacagtg aagcctatca
    13381 cttgcgtcgg gaggaaacgg attggtttga taaacccagg gagtctcggt tggaaaatgg
    13441 ccatggtctg gatcggaaac tgccagaaag actggttcac tctagacccc tcagtcaaca
    13501 ccaggagcaa attctgcaga tgaatggaaa gacaatacat tacatctttc ctcatgcaag
    13561 gataaaaatc accagagact ccaaggatca cactgtttca ggtaatgggc taggaattag
    13621 aattgttggt ggtaaagaaa tccctggaca tagtggagaa attggagcct atattgctaa
    13681 gattcttcct ggtggaagtg cggaacacac ggggaaactt atggaaggga tgcaagtttt
    13741 ggagtggaat ggggtcccct tgacttctaa aacatatgaa gaagtgcaga gtatcattaa
    13801 ccaacaaagt ggggaagcag aaatatgtgt aagactggac ctcaatatgt tgtcggattc
    13861 cgaaaatccc cagcatctgg aacttcatga accgccaaaa gttgataagg caaagtctcc
    13921 aggcgtggat cccaagcagt tggcggcaga gctgcagaaa gtctcactcc agcagtcccc
    13981 actggtcatg tcgtcagtcg tggagaaagg gtctcatgct cactcaggtc ccacatcagc
    14041 aggatccagt tctgttccca gccccgggca gccagggtcg ccttcagtaa gcaaaaagaa
    14101 gcatagcagt accaagccta ctgatgcgac caaggctgcc tctcacccaa ttacaggaga
    14161 gattcagctt caaatcaact acgatcttgg aaatcttata atacatatcc ttcaagcaag
    14221 aaacctagtc cccagagaca acaatggcta ctctgacccg tttgttaagg tgtacctact
    14281 tccagggaga ggtcaagtca tggttgtcca gaatgcaagt gctgagtaca agagaaggac
    14341 aaaatatgtc cagaaaagtc ttaatcctga gtggaatcaa acagtaattt ataaaagtat
    14401 ttccatggag cagctcatga agaagacctt ggaggtgaca gtttgggatt atgatagatt
    14461 ctcttccaac gacttccttg gagaggtatt gattgattta tctagcacat ctcatctgga
    14521 caacactcct cggtggtatc ctctgaaaga acaaactgag agcattgacc atggcaagtc
    14581 tcactccagt caaaacagcc agcagtcccc aaagccctct gtgatcaaaa gcagaagcca
    14641 cggtatcttc cctgacccat ccaaggacat gcaggttccc accattgaga agtcccacag
    14701 tagtcctggg agctcaaaat catcatctga aggccatctc cgatctcacg gaccatctcg
    14761 cagtcaaagc aaaaccagtg tcgcccagac ccacctggaa gatgcagggg tggccatagc
    14821 cgcagctgaa gccgctgtgc aacaactccg cattcaacca acaaagccca ccaaccaccg
    14881 gcctgcagag agctccgtgt caaccggctc ctcgggcagc agcgttggca gtgggtatag
    14941 cgtggacagc gaaggaagca gctgtgtggc cggggagccc aatctacttc ccatcccgag
    15001 gataggaaag atgggacaga atggacagga ccctgtgaaa cagccaggaa tgggagcaac
    15061 agacacagag ggtaaaactc aagtaatggg agaaatcaag ctagcattga agaaggaaat
    15121 gaaaacagat ggtgaacagc taatagttga aattctccag tgcagaaata ttacctacaa
    15181 atttaagtct ccagatcatt taccagattt atatgtgaaa ctatatgtga taaacatctc
    15241 tacccaaaaa aaggttatta aaaagaagac aagggtatgc cgacatgatc gagagccttc
    15301 ttttaatgaa acttttagat tcagcctaag tcctgcgggc cattcgcttc agattttact
    15361 tttctccaat ggagggaagt ttatgaagaa gacgttgatt ggagaagcat gtatctggct
    15421 tgacaaagtg gatctgagga aaagaatagt caattggcac aaattgttgg tgagtcccac
    15481 tcaaacacac tgaggacgtt gtctgctcag ggtgaggaaa cagctctgca gcctcagatc
    15541 gaaactggag ttgaacacta ctgtgctgat ctacattttc cagggcaaac atgagatcgc
    15601 aagcaagaag caaacagaca gccttgctgt ggcacacaaa gagacttgaa aagttcacgt
    15661 gttgaaagca aactgacgaa aacaggccag agacactgga ttgctcatag ctgtgaagag
    15721 aagctctgag agaagatttg actttttaag ataaatatct ttgatcagac tgagttggaa
    15781 ctggaaaaaa agtggcacaa aggttattaa ggtgttgaaa ggtagtgtga aagcaatcgc
    15841 ttaaatacac gtaaccttgt tgaggaaaaa aaattgatgt aatgaatctt ggttttcaaa
    15901 agatcaaaat tccttgtctt atattctcat gaaacttcct gttttggaat tctgacataa
    15961 gattcaattc tgagttttct acaggaccag aaggtgactg tgtttatggg gaaaattaag
    16021 ccagagttat gaacaatgga tttttagatt acacagtgca tgttttccct gtgtctaagt
    16081 tagaaagcta tacagcagta ggtctaaatt ctatgtgaca aaagcacatc agttttggtg
    16141 tattttaaaa tagtgaagag tgaagatact agtaggttaa agtgaaattt tatttatcta
    16201 gaacaaaaac aaaacaaaaa aattagagac tggatattaa agaagaatgt taacccacaa
    16261 aacatgtacc ttggttgaaa acattacaat atccataatt tgcatcaagt caaggtgttc
    16321 tcaactgtac acatgaaggt atatagagta ataggtgtgc cctaagaaaa gggttgcccg
    16381 ttctctgagg aactgctatt acatgtatca tattgcatat ttcctttctc ttgcaaaatg
    16441 tactgtcaga gacctaaaat tattgttctc gcaaacgaac tctatttgtc atatgacatt
    16501 aattaaactc ttgtcatttc ctgattttcc atgtttttct ctaaactgaa tgactacata
    16561 atgaacattc tgatgtcaat gccatgttcc ttctcctctt ctgctttctt gctagggata
    16621 tcagaattag aaatcacacg ggatgggaaa ggatgtaagg gtcaatgttt gaaattaaaa
    16681 catatttgac ttgttttaat agtatagact caaacaaccc atgtacgaac cagtaaaaat
    16741 gaagcattct ctttccccat caaccaccaa tgccaataga gaaagtaaca cagaaactgt
    16801 gggaaacaca ttcagctggg atgaaaattc tggcttctag tcctgatttt actactcact
    16861 ttgcacagat caccttgcaa atctcatgta aactcactat cccccaaaat aatggtgtat
    16921 aaagaacata tgagatgggg aagcacattt tcaaatatag ctttatatat aaactgagag
    16981 ttaattatta ggtagctttt taattctcaa attttatatg tgaggaacaa cttccaacta
    17041 ttggtgagca ttaccatgga aaaaagcagt caattgttcc aaatcgcgtt tgtatttaaa
    17101 tataaacttc catttcacat gaaaaagatt ggatattaag taaaaattat ttgtcacacc
    17161 aaatttatcg aagtgcacga ttagaatcca atccccaaaa caaaccaaaa aataaactaa
    17221 cttgctttgt agagttttga acccaaaagc tgttgcttta cttaagatga aagtctagtc
    17281 ggattaaagg aaatcatctc aaaattattg gttggatatt gaattttctc atattttaga
    17341 gaaaaacatt atgtaaaaca cttggagtaa aggatttctg gtatatgaca aattatatat
    17401 cttacgctga tgaaaaaaat ttaaatccac attgcttgtc ctaaaatacc accactcact
    17461 tccctccatc tttttctccc tcttcccaga caatgcgatg ccctttacca ctgatggtct
    17521 tctaaagtaa acaatgggag acgtgaaatt tcaaagctag gatgttgcta ccactctagt
    17581 tttagagact gctacatctg ctggtggttg ccatggatat ttccagcaga caatctcact
    17641 tgaggaagcc tataatcagt cccaaaggag ggggaaagac gtctaagacg atcttctgac
    17701 atcaaaaggc tctgccattt gttcctcaca gtgggctctg gttctgttct acagcactgg
    17761 tactccaact gttccctgga aggttgtata gcacagcacg gtagcttact cctttctagt
    17821 tacaccttac acagacagac caccagagca agatcatcct gagtagctag ctattaagca
    17881 tggaagaatg gaaggcttcc taatacagct gcccctcagt tctaagaagc tagtgatggg
    17941 ttagatcgat cagaccaatc aagagagtca gtgacagagc ttctgatcat gcaccagcat
    18001 tccccttgag aaaggaaaag atcctgccag tgtgccaagt ttgcagctga tgaaactcct
    18061 aggttgtaac tggaattgct ctatgcaaca ccaattctta tacgagtgca cttctgaggg
    18121 acgctgattg cccttctcac aacaaaacta tttctttttt aattgcaaat agggctctta
    18181 gtgttttttt acttttttgt aaataacacg atacatgatt ttccactttt tattttactt
    18241 tatgttatta gaattagctt tttatcttaa tagtaacaat ttataatctc taattactag
    18301 attagtaatc ttcttgcaac acttgaacct tgagaagtat ttcatttccc tactagtcca
    18361 ttgagtcatc agatatgaaa gttacctgct ggtttaaatt tattattaag aggtctttca
    18421 atagagaaga aaaagcacag agtgaatttt tatataagat gggaaattat agaatcataa
    18481 ttatagatac agataacact agtagcaaga agttggtgtt ttctctgatt ttacttaata
    18541 ttaagaaaaa ttttggtgac tctaaactca tttgattacc ttttgtgttt taaaggaaaa
    18601 atactgaata ttaagggata gtaattaccc ttgaatcctt actatggtcc atattttaat
    18661 agatcatgat agttaaatat acattctctg catatctatg aggttgactg ggggaatcat
    18721 atacactaga ctagttgtat cctgggaata ttatagctgg taaccagctg atattgattc
    18781 tcactataga atggttgtta tgatgttggt ggtagtcata gtagcaatag cggtggcagt
    18841 gatacggagt aaaataaatt atttgttact atattgtgcc cagtttctta gaaatgattt
    18901 aatcaatgct tcatttcatt aaagtatcat aaagatgttt atagtatttt tttactttat
    18961 tatttaaatc ataactaaca atatttttaa aagcttattt taattgctat aatgtcaaac
    19021 tgtccaaaat tagccaacta cagctacatg tgtttataac tatacgtatg agaggtgtaa
    19081 ctttccctcc ttttgagttt gaaatgaaag tgaaagctca ataaccatga gcttttccct
    19141 taatagttgt ttgcctttag tgacacaagg atgaatgaat gagtgaaacc tatattctca
    19201 ttgactatga cacatggatg ttttctgtat gtctcgtgtg gctattattg aagatttaca
    19261 ttaaacaaaa atctaatcaa gtcctttatc tgataggtag actgagagct ttttctgagt
    19321 ctgttaccct gtatatacct agacatttgg aaacatagca actgtagaac tagcctcatc
    19381 ctttggaagt cagcatgtga ctgtgattat cattcgactg tatctgtaca ttcgttccgt
    19441 gatgtgctca ggtgctccca ctactgatta aatgtgtgtg ctaatatctt aacaacacat
    19501 ctgtttaaaa acggtgtttc ttgtctaaga aaagtttaaa aacctaataa aatttatttc
    19561 caaccgaaca tgaagttctt ggagatgtgt ctcgtttctg atgatacgtt gcatgctttc
    19621 ttggtgattt gctaatcttt ttattatttt cttgtttacc aaacagtctg aaaccttaat
    19681 gaacaaatgc taactcttgg gctagtgatt gtataaaccg acctgaaaat aaacaagaat
    19741 tgtgtagaga caaaatgctt gtaaatctgt cttgagtttt attctctgta aaaaacatgt
    19801 cttggttttg tgactgtaca cagttgtatc ttgataactt atgtaaactg tgctgtataa
    19861 aggctgtcat atcagtctta ccaataaata atgaaaatat caa
//
