LOCUS       NM_001108605            3977 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus phosphorylated CTD interacting factor 1 (Pcif1),
            mRNA.
ACCESSION   NM_001108605 XM_001070779 XM_342577
VERSION     NM_001108605.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3977)
  AUTHORS   Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T,
            Navarrete-Perea J, Sheng W, Gygi SP, Adelman K and Shi Y.
  TITLE     PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression
  JOURNAL   Mol Cell 75 (3), 620-630 (2019)
   PUBMED   31279659
REFERENCE   2  (bases 1 to 3977)
  AUTHORS   Boulias K, Toczydlowska-Socha D, Hawley BR, Liberman N, Takashima
            K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR
            and Greer EL.
  TITLE     Identification of the m6Am Methyltransferase PCIF1 Reveals the
            Location and Functions of m6Am in the Transcriptome
  JOURNAL   Mol Cell 75 (3), 631-643 (2019)
   PUBMED   31279658
REFERENCE   3  (bases 1 to 3977)
  AUTHORS   Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani
            R, Sugita A, Hirose Y, Iwasaki S, Nureki O and Suzuki T.
  TITLE     Cap-specific terminal N6-methylation of RNA by an RNA polymerase
            II-associated methyltransferase
  JOURNAL   Science 363 (6423) (2019)
   PUBMED   30467178
REFERENCE   4  (bases 1 to 3977)
  AUTHORS   Sun H, Zhang M, Li K, Bai D and Yi C.
  TITLE     Cap-specific, terminal N6-methylation by a mammalian m6Am
            methyltransferase
  JOURNAL   Cell Res 29 (1), 80-82 (2019)
   PUBMED   30487554
REFERENCE   5  (bases 1 to 3977)
  AUTHORS   Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A,
            Nicolaescu E, Lesage B and Bollen M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   6  (bases 1 to 3977)
  AUTHORS   Hirose Y, Iwamoto Y, Sakuraba K, Yunokuchi I, Harada F and Ohkuma
            Y.
  TITLE     Human phosphorylated CTD-interacting protein, PCIF1, negatively
            modulates gene expression by RNA polymerase II
  JOURNAL   Biochem Biophys Res Commun 369 (2), 449-455 (2008)
   PUBMED   18294453
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342577.3, XM_001070779.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3977
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /note="phosphorylated CTD interacting factor 1"
                     /db_xref="GeneID:362269"
                     /db_xref="RGD:1310800"
     exon            1..1324
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1495
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1638
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     CDS             1515..3629
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /EC_number="2.1.1.62"
                     /note="PDX1 C-terminal inhibiting factor 1"
                     /codon_start=1
                     /product="mRNA
                     (2'-O-methyladenosine-N(6)-)-methyltransferase"
                     /protein_id="NP_001102075.1"
                     /db_xref="GeneID:362269"
                     /db_xref="RGD:1310800"
                     /translation="MANENHGSPREEASLLSHSPGTSNQNQPCSPKPVRLVQDLPEEL
                     VHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPLPQDSTLVE
                     TPPVENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPILKIWGAST
                     EDKQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYREL
                     CQQREGIEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSR
                     IKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYM
                     DRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNIPEEVE
                     ASELEPRLVYCYPVRLAVSAPPMPSVEMHMENSVVCIRYKGEMVKVSRSYFSKLWLLY
                     RYSCVDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSF
                     ECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFTPLSGSFEANPPFCEELMDAMVSH
                     FEKLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLSAFEHEYRSGSQHI
                     CKKEEMHYKAVHNTAVLFLQNDPGFAKWGPTPERLQELTAAYKQSGRSHGSSSSSSSS
                     SSEAKDRDSGREQGPSREPHPT"
     exon            1639..1763
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1901
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2029
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2184
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2332
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2416
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2516
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2679
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2852
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2939
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3124
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3218
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3394
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3977
                     /gene="Pcif1"
                     /gene_synonym="RGD1310800"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaaactagt gatccttctt tatcagtctc ccaagtacta gggttacagc tgtaagccaa
       61 gaggcccagc tgctatgctt ttattttgat aaggtctcat gtaggcaagg attcctgatt
      121 ctcctgcctc cacctcccca agtgcacacc actaccaccc ttaaagattt taagaggcat
      181 gatggtgcac ttttaattcc agcactcacg aagcagatgg atctgagttc ttggcctgcc
      241 agggttatag caagactatc cccaccagcc cccaagacat acaagatgga cacacctggg
      301 atcaagggtc aggtgtttga ggacagacta gataagatcc tccagttctt actagtttat
      361 actgctgatc accatttttc ctgacctcct aacattccac ctccaaacta ctggcagcca
      421 gtatcatcac tgtcacagac ctcagtggct atcccagtcc agcagcaggt ggcaaacttg
      481 tcctcctttc aagatacctt aaatggtgat agcttcctta ggaggccaca agtgggtgga
      541 gctagtagcc taattgtggc agggagcccg tccaagactt gcagaagcgt ctcctaagct
      601 gtgtagtctt cacaacttta caactgccca gagccagctc tgccctacca gcactcctcc
      661 aaaagctacg attatgcaag agcaatttgt gaacaggttg ctaacgggaa aaggttcgat
      721 ttgcacgtca tctggcctct aggcagagag agaaaacatt ccaggaccct tagagcgcag
      781 agaacgagac tggttggaag cagcagagca ctgtgcagac taggacccag gcatctacca
      841 cgtgcagggc ctacgtcacc actccgctcc tgggtcggca actgagccag agcccccaga
      901 agattctaga ccagcttcat gccccctaaa gtgtccaagt agatcttcgg cccctgcgag
      961 cgtgttcggc aggggcgtac gtatagattc attccttccc acctacattt caagaagagc
     1021 aaagctgctt ttcctcctct tgaggaccac aagggacaca gagaaggacc ggaaaatggg
     1081 gagttgggga gggggaggga gaaagcaatc acggtctggg gaaccagcca acattgccac
     1141 actcaagatg gcggcgcggc cgtggcgagg tccttcagag gcggtaccaa cgcatgcgca
     1201 gcgcagagtc ccggcccggg acacaagatg gcggcagcgg cgctggggag ggcgaggcgg
     1261 aggcggcaaa acgggcggtc gagcagaacg tgtggccgca tcccctcgag tccgcttcga
     1321 gcagctgctg attcacggag tcccctgggt ccttgtcaac tgaactgctg accagcccac
     1381 ccacttctgc tgcgccttcc tgtgggcctc ccccctcttc tgtgggaccc cgtgacgtgg
     1441 gttcaatcag ccagagaaga aaacactctc atgctagtat cgcagacccc agagggtccc
     1501 gagtgggtgc tgagatggcc aatgagaatc acggcagccc ccgggaagaa gcatcccttc
     1561 taagtcactc tccaggcacc tccaatcaga accagccctg ttctccaaag ccagttcgcc
     1621 tggtacagga cctcccagag gaactggtac atgcaggctg ggagaagtgc tggagccgaa
     1681 gggagagccg tccctactac ttcaaccgat tcaccaacca gtccctgtgg gagatgcctg
     1741 tgctgggtca gcacgatgtg ctttcggacc ctttggggct aaatgcaacc ccactgcccc
     1801 aagactcaac cttagtggaa actcccccag tagagaacaa gcccagaaag cgacagctct
     1861 cagaagagca gccaagtggc aatggagtga agaagcccaa gattgaaata cctgtgacac
     1921 ccacaagcca gtcggtgccc agttccccca gcatcccagg aaccccaata ctaaagattt
     1981 ggggtgcatc cactgaagat aaacaagcag ctctcctccg acccactgag gtgtactggg
     2041 acctggacat ccagaccaat gctgtcatca agcacagggg tccttctgag gtcctgcccc
     2101 cacaccctga ggttgagctg ctccgctctc agctcatctt gaagctgcgc cagcactacc
     2161 gggaactgtg ccagcagcgg gagggcattg agccaccccg ggaatctttc aaccgctgga
     2221 tgctagagcg caaagtggtg gacaaaggct gtgatcctct gttgccaagc aactgtgaac
     2281 cagttgtgtc tccgtccatg tttcgtgaaa ttatgaatga cattcccatc aggttatctc
     2341 gaatcaagtt ccgggaggaa gccaaacgcc tgctctttaa atatgcagaa gctgccaggc
     2401 ggctcattga gtccaggagt gcatcccctg acagcagaaa agtggtcaag tggaatgtgg
     2461 aggacacctt tagctggctg cggaaggagc actcagcctc gaaggaggac tacatggacc
     2521 gcctggagca cctgcggagg cagtgtgggc cccatgtctc tgctgcagcc aaggactctg
     2581 tggagggcat ctgcagcaag atctaccaca tctccctgga atatgttaaa cggatccgag
     2641 agaagcacct tgccatcctc aaggagaaca acatcccaga ggaagtagag gcctcagagt
     2701 tggagccccg cctggtatac tgctacccag tgcgcctggc cgtgtctgca ccccccatgc
     2761 ctagtgtgga gatgcacatg gagaacagtg tagtctgcat ccgctacaag ggagagatgg
     2821 tcaaggtcag ccgcagctac ttcagcaaac tgtggctcct ctaccgctac agctgtgtgg
     2881 atgactctgc ctttgagagg ttcctgccta gagtctggtg tcttctccgt cgatatcaga
     2941 tgatgtttgg tgtgggcctc tatgagggga ctggcctgca ggggtcactg ccagtgcacg
     3001 tctttgaggc cctccacaga ctctttggtg tcagtttcga gtgcttcgcc tcacccctca
     3061 actgctactt ccgccagtac tgttctgcct tccctgacac agatggctac tttggctccc
     3121 gcgggccctg cctggacttc accccgctga gtggttcctt tgaggccaac cctccgttct
     3181 gcgaggagct catggatgct atggtctctc acttcgagaa actgctggag agctcaccag
     3241 aacccctgtc cttcattgtg ttcatcccgg agtggcggga gcccccaaca ccagcgctca
     3301 cccgaatgga gcagagccgc ttcaaacgcc accagctggt cttgtctgcc tttgagcacg
     3361 agtaccgcag tggctcccag cacatctgca agaaggagga aatgcactac aaggccgtcc
     3421 acaacacggc agtgctcttc ttgcagaatg accccgggtt cgccaagtgg gggccgacgc
     3481 cagagcggct gcaggagctc accgctgctt ataagcagtc gggccgcagc catggctcca
     3541 gctcttcctc ctcctcctcc tcctcagagg ccaaggaccg ggactccggc cgggagcagg
     3601 gccctagtcg agagcctcac cccacctaac atatcctgcg gggaaggagg aactccaggg
     3661 gtgctgttac agactgctgg gactcagtcc tcagggctgg agggccctgg ggtggcagca
     3721 ggacttgagc tgccagggac ataggaatat tatggctctg ccagggctcc cccttcctgc
     3781 tcccaccctt tcagattcac caagtccctt gtaaataggc ccgtgcctcc ccagccccat
     3841 actgaccctg ttgctgcctt gtttcatttg taaaaggaaa tacagaaact ccccaagagt
     3901 gtgtgagggt cttggggtgg ttgcctcggt gaccattccc taggtgccct ttattaaggt
     3961 cccaggcctt cacaccc
//
