LOCUS       NM_001105836            1385 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus polycomb group ring finger 2 (Pcgf2), mRNA.
ACCESSION   NM_001105836 XM_001081335 XM_213447
VERSION     NM_001105836.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Almeida M, Pintacuda G, Masui O, Koseki Y, Gdula M, Cerase A, Brown
            D, Mould A, Innocent C, Nakayama M, Schermelleh L, Nesterova TB,
            Koseki H and Brockdorff N.
  TITLE     PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome
            inactivation
  JOURNAL   Science 356 (6342), 1081-1084 (2017)
   PUBMED   28596365
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Taherbhoy AM, Huang OW and Cochran AG.
  TITLE     BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase
  JOURNAL   Nat Commun 6, 7621 (2015)
   PUBMED   26151332
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Vandamme J, Volkel P, Rosnoblet C, Le Faou P and Angrand PO.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H and Iwama A.
  TITLE     A novel zinc finger protein Zfp277 mediates transcriptional
            repression of the Ink4a/arf locus through polycomb repressive
            complex 1
  JOURNAL   PLoS One 5 (8), e12373 (2010)
   PUBMED   20808772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Maertens GN, El Messaoudi-Aubert S, Racek T, Stock JK, Nicholls J,
            Rodriguez-Niedenfuhr M, Gil J and Peters G.
  TITLE     Several distinct polycomb complexes regulate and co-localize on the
            INK4a tumor suppressor locus
  JOURNAL   PLoS One 4 (7), e6380 (2009)
   PUBMED   19636380
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R,
            Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H and Brockdorff N.
  TITLE     Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
            to heritable gene silencing and X inactivation
  JOURNAL   Dev Cell 7 (5), 663-676 (2004)
   PUBMED   15525528
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T,
            Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H,
            Vidal M, Isono K and Koseki H.
  TITLE     Involvement of the Polycomb-group gene Ring1B in the specification
            of the anterior-posterior axis in mice
  JOURNAL   Development 129 (18), 4171-4183 (2002)
   PUBMED   12183370
REFERENCE   8  (bases 1 to 1385)
  AUTHORS   Yamaki M, Isono K, Takada Y, Abe K, Akasaka T, Tanzawa H and Koseki
            H.
  TITLE     The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and
            36-kDa polypeptides
  JOURNAL   Gene 288 (1-2), 103-110 (2002)
   PUBMED   12034499
REFERENCE   9  (bases 1 to 1385)
  AUTHORS   Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno
            M, Taniguchi M, Vidal M, Alkema M, Berns A and Koseki H.
  TITLE     Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1
            reveal synergy and requirement for maintenance but not initiation
            of Hox gene expression
  JOURNAL   Development 128 (9), 1587-1597 (2001)
   PUBMED   11290297
REFERENCE   10 (bases 1 to 1385)
  AUTHORS   Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M and Koseki H.
  TITLE     A role for mel-18, a Polycomb group-related vertebrate gene, during
            theanteroposterior specification of the axial skeleton
  JOURNAL   Development 122 (5), 1513-1522 (1996)
   PUBMED   8625838
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC167059.1.
            
            On May 11, 2008 this sequence version replaced NM_001105836.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1385
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /note="polycomb group ring finger 2"
                     /db_xref="GeneID:287662"
                     /db_xref="RGD:1305097"
     exon            1..241
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1158
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /note="ring finger protein 110"
                     /codon_start=1
                     /product="polycomb group RING finger protein 2"
                     /protein_id="NP_001099306.1"
                     /db_xref="GeneID:287662"
                     /db_xref="RGD:1305097"
                     /translation="MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIV
                     RYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYP
                     LTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKSLVENGDGDKEK
                     TGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWR
                     RNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSL
                     PSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNCLQTPSSTSRGRKMT
                     VNGAPCPP"
     exon            242..338
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     exon            339..394
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     exon            395..445
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     exon            446..554
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     exon            555..609
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     exon            610..705
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     exon            706..786
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1361
                     /gene="Pcgf2"
                     /gene_synonym="Rnf110"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaaagaa acgggctttg ggcccagggg gaagcagtgc agggaagcaa ctaagggtgg
       61 ctgggtttct gaccccattt ctgtttccca gggtgaccct tctcaggtct cagtcctgac
      121 cccggcaaca tgcatcggac cacacggatt aaaatcacgg agctgaaccc tcacctcatg
      181 tgtgccctct gtgggggcta cttcatcgac gccaccacga ttgtggaatg cttacattcc
      241 ttctgcaaaa cctgcatcgt gcgctacttg gagaccaaca aatactgccc catgtgtgat
      301 gtccaggtcc ataaaacacg gccactgctc agcatcagat cagacaaaac cctccaggac
      361 attgtctaca agttggtgcc tgggcttttt aaagatgaga tgaaacggag acgggacttc
      421 tacgcggcat accccctgac agaggtcccc aacggctcca acgaggaccg aggtgaggtc
      481 ctggaacagg agaagggggc tctgggtgac gacgagattg tcagcctgtc cattgagttc
      541 tatgaaggcg tcagggaccg agaggagaag aagagcctcg tggagaatgg ggacggggac
      601 aaggagaaga caggagtgcg gttcctgcga tgcccggcgg ccatgaccgt gatgcacctc
      661 gccaagttcc tccgcaacaa aatggatgtg cccagcaagt acaaggtgga gatcctctat
      721 gaagacgagc ccctgaagga atactacacc ttaatggaca tagcctacat ctacccgtgg
      781 cggaggaatg ggcctctccc cctcaagtac cgtgtccagc cagcctgcaa gaggctcacc
      841 ctacccacag tgccaactcc ctcagaaggc accaacacca gcggggcctc cgagtgtgag
      901 tcagtcagcg acaaggctcc cagccctgcc acccttccgg ccacctcctc ctccttgccc
      961 agccctgcga ccccatccca tggctctccc agctcccacg gccccccagc cacccatcct
     1021 acctccccca ctccaccttc aactgctgct ggaaccacca cagctaccaa tgggggcact
     1081 tcgaactgcc tgcagacgcc atcctccacc agcagggggc gcaagatgac tgttaatgga
     1141 gctccttgcc ccccttaact tgaggaaagg gaccctctcc ttccgcagcc atcttttccc
     1201 tcctttttac tttttctggc cccccttttc cactttgact ttccctggtt cctcccatct
     1261 tcagagtggg aggtgggttt tataaataaa tctatctata tatatataaa tatatatatg
     1321 tacataggaa aaaccaaata tacatactta ttttctatgg aaaaaaaaaa aaaaaaaaaa
     1381 aaaaa
//
