LOCUS       NM_053944               4183 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus protocadherin 12 (Pcdh12), mRNA.
ACCESSION   NM_053944 XM_001068741 XM_344673
VERSION     NM_053944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4183)
  AUTHORS   Rampon,C., Bouillot,S., Climescu-Haulica,A., Prandini,M.H.,
            Cand,F., Vandenbrouck,Y. and Huber,P.
  TITLE     Protocadherin 12 deficiency alters morphogenesis and
            transcriptional profile of the placenta
  JOURNAL   Physiol Genomics 34 (2), 193-204 (2008)
   PUBMED   18477666
REFERENCE   2  (bases 1 to 4183)
  AUTHORS   Turowski,P., Martinelli,R., Crawford,R., Wateridge,D.,
            Papageorgiou,A.P., Lampugnani,M.G., Gamp,A.C., Vestweber,D.,
            Adamson,P., Dejana,E. and Greenwood,J.
  TITLE     Phosphorylation of vascular endothelial cadherin controls
            lymphocyte emigration
  JOURNAL   J Cell Sci 121 (Pt 1), 29-37 (2008)
   PUBMED   18096689
  REMARK    GeneRIF: Tyrosine phosphorylation of adherens junction vascular
            endothelial cadherin (VEC) is required for successful
            transendothelial lymphocyte migration.
REFERENCE   3  (bases 1 to 4183)
  AUTHORS   Bouillot,S., Rampon,C., Tillet,E. and Huber,P.
  TITLE     Tracing the glycogen cells with protocadherin 12 during mouse
            placenta development
  JOURNAL   Placenta 27 (8), 882-888 (2006)
   PUBMED   16269175
REFERENCE   4  (bases 1 to 4183)
  AUTHORS   Johnson,K.J., Patel,S.R. and Boekelheide,K.
  TITLE     Multiple cadherin superfamily members with unique expression
            profiles are produced in rat testis
  JOURNAL   Endocrinology 141 (2), 675-683 (2000)
   PUBMED   10650949
REFERENCE   5  (bases 1 to 4183)
  AUTHORS   Telo',P., Breviario,F., Huber,P., Panzeri,C. and Dejana,E.
  TITLE     Identification of a novel cadherin (vascular endothelial
            cadherin-2) located at intercellular junctions in endothelial cells
  JOURNAL   J Biol Chem 273 (28), 17565-17572 (1998)
   PUBMED   9651350
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_001068741.1, XM_344673.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.37621.1,
                                           SRR26643294.57301.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3213              JAXUCZ010000018.1  30367273-30370485   c
            3214-3311           JAXUCZ010000018.1  30364030-30364127   c
            3312-3463           JAXUCZ010000018.1  30361276-30361427   c
            3464-3465           JAXUCZ010000018.1  30355628-30355629   c
            3466-4183           JAXUCZ010000018.1  30354910-30355627   c
FEATURES             Location/Qualifiers
     source          1..4183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..4183
                     /gene="Pcdh12"
                     /note="protocadherin 12"
                     /db_xref="GeneID:116808"
                     /db_xref="RGD:619917"
     exon            1..3213
                     /gene="Pcdh12"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..3873
                     /gene="Pcdh12"
                     /note="vascular endothelial cadherin 2"
                     /codon_start=1
                     /product="protocadherin-12"
                     /protein_id="NP_446396.1"
                     /db_xref="GeneID:116808"
                     /db_xref="RGD:619917"
                     /translation="MLLLPFLLGLLGPGSYLFISGACQEVATVTVKFQVAEEVPSGTV
                     IGKLSQEPGVEERRGKAGDAFQILQLPQALPIQMNSEDGLLNTSSRLDREKLCRQQDP
                     CLVSFDVLATGASALIHVEIQVLDINDHQPQFPKDEQELEISESASLHTRIPLDRALD
                     QDTGPNSLYSYSLSPSEHFALDVIVGPDETKHAELVVVKELDREVHSYFDLVLTAYDN
                     GNPPKSGTSVVKVNVLDSNDNSPVFAESSLALEIPEDTAPGTLLINLTATDPDQGPNG
                     EVEFFFGKHVSPEVMNTFGIDAKTGQIVLLQPLDYEKNPAYEVDVQARDLGPNSIPGH
                     CKVLIKVLDVNDNAPSIHITWASQMSLVSEDLPRDSFIALVSANDLDSGNNGLVNCWL
                     NQELGHFRLKRTNGNTYMLLTSAMLDREQWPTYTLTVFAQDQGPQALSAEKELQIQVS
                     DVNDNAPVFEKSRYEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVI
                     IDSETGEVTAQRSLDYEEMAGFEFQVIAEDRGQPQLSSSISVWVSLLDANDNTPEVIQ
                     PALSEGKATLSVLVNASTGHLLLPIESPSGMDPAGTGPTPPKATHSPWSFLLVTIVAR
                     DADSGANGELLYSIQSGNDAHLFVLSPSLGQLFINVTNASSLIGSQWDLGIVVEDQGS
                     PSLQTQVSLKVVFVTSMDHLRDSAHEPGILSTPALAMICLAVLLAVFGLILALLVSIC
                     RIEKRDNRAYNCREAESMYRHQPKRPQKHIQKADIHLVPMLRAQEDEAEEVRPPHKDT
                     SKETLMEAGWDSCLQAPFHLTPTLYRTLRNQGNQGALAESQEVLQDTFNFLFNHPRQR
                     NASRENLNLPESPPTLRQPLLKPLKVPGSPIARVTGDQGSKEAPQSPPASSATLRRQR
                     NLNGKVSPKGESSPHQILRSLVRLSVAAFAERNPVEELAGDSPPVQQISQLLSLLHQG
                     QFQPKPNHRGNKYSAKPGSSRATIPDTDGLGIRPGGLSEPDLEEGPPSPEEDLSVKRL
                     LEEELSSLLDPNTGLALDKLSPPDPAWMARLSLPLTTNYRDNLSSPDAAASEEPRTFQ
                     TFGKTVGPGPELSATGTRLASTFVSEMSSLLEMLLEQNTVPVEAASAALRRLSVCGRT
                     LSLDLATSGASGSEAQLGRKKAAESSLGCGRNL"
     exon            3214..3311
                     /gene="Pcdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3463
                     /gene="Pcdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..4183
                     /gene="Pcdh12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcaaatccc tacatcctgc tttactaggt caagtctctc tcagcccggt gcttgcccat
       61 cactgctaag tggaccagct ggtgctgctg tggaacgaga aactcttcta gcaatttctc
      121 tgttctggga cctctcagat cacttgtcac gaagatggcc ttgcttggga atcctgcctc
      181 ttacagcatc ttctaattat gggacaaagt tgtaccagca ggtctgaagt gggagagcca
      241 ggctgaccga gccattcagg aactacttgg ggacgagtcc tgcctttgaa aaagtccagt
      301 gggtccagtc cagccctccc tccggtaagc acgatgctac ttctgccttt cctgctaggg
      361 ctcttaggac caggaagcta cttgttcatt tcaggggctt gtcaggaggt ggccactgtc
      421 acggtgaaat tccaagtggc agaggaagtg ccatctggca ccgtgatagg gaaactgtcc
      481 caagaaccag gagtggagga gaggcgtggg aaggcaggag atgcctttca gattctgcag
      541 ctgcctcagg cactgccgat tcagatgaac tctgaggatg gcctgctcaa cacttccagc
      601 cggctggatc gggagaagct ctgtcggcag caagatccct gcctggtgtc ctttgatgtg
      661 cttgccacag gggcttctgc tctaattcat gtggagattc aggtgctgga catcaatgac
      721 caccagcctc agtttcccaa agatgagcag gagctggaaa tctctgagag tgcttctctg
      781 cacacacgaa ttcccttgga cagagctctt gaccaagaca ctggccctaa cagcttatat
      841 tcctattccc tgtctcccag tgaacacttt gccctggatg ttattgtggg ccctgatgag
      901 accaaacacg cagaacttgt ggtggtgaag gagttggaca gggaagtcca ctcatatttt
      961 gatctggtgc tgactgccta tgacaatggg aatcccccca agtcaggtac cagcgtggtc
     1021 aaggtcaatg tcctagattc caatgacaat agcccagtgt ttgctgagag ttcactagca
     1081 ctagaaatcc cagaagacac tgcccctggt actcttctca taaacctgac tgctacggat
     1141 ccagaccaag gccccaatgg ggaggtagaa ttcttctttg gcaagcatgt gtccccagag
     1201 gtgatgaata cctttggtat agatgctaag acaggccaga tcgttctgct ccaaccccta
     1261 gactacgaga aaaaccctgc ctatgaggtg gatgtccagg caagggactt aggtcccaat
     1321 tccatcccag gccattgcaa agttctcatc aaagttctgg atgtcaatga caacgcccca
     1381 agcatccaca tcacgtgggc ctcccagatg tcgctggtgt cagaagatct tcccagggac
     1441 agcttcattg ctcttgtcag tgcgaatgac ttggactcag gaaacaatgg tctagtcaac
     1501 tgttggctga atcaagagct aggtcacttc agactgaaaa ggactaatgg caacacgtac
     1561 atgctgctca ccagtgccat gctggacaga gagcaatggc ccacatacac tctcactgtg
     1621 tttgcccaag accaaggacc ccaggcctta tcagctgaga aggagctcca gattcaggtc
     1681 agtgatgtca atgacaatgc ccctgtattt gagaagagcc ggtatgaggt ctccacttgg
     1741 gaaaacaacc ccccctctct tcaccttatc acgctcaaag ctcatgatgc tgacttgggc
     1801 agtaatggaa aagtgtcata ccgtatcaag gactcccctg tttctcactt agtcattatt
     1861 gactctgaaa caggagaagt cactgctcag aggtcgctgg actatgaaga gatggcaggc
     1921 tttgagttcc aggtgatagc agaggacaga gggcaacccc agctctcatc cagcatctcg
     1981 gtgtgggtta gcctcttgga tgccaacgac aataccccag aagtgattca gcctgcgctc
     2041 agtgaaggca aagccaccct ttcagtgctt gtaaatgcct ccacgggcca ccttctgttg
     2101 cccattgaga gccccagtgg catggatcca gcaggtactg gtccaacacc accaaaggct
     2161 acccacagcc cctggtcctt ccttttggtg acaatcgtgg caagggatgc agactcgggg
     2221 gccaatgggg aactccttta cagcattcaa agtgggaatg atgctcatct ctttgtcctc
     2281 agcccttccc tggggcagct attcattaat gtcaccaatg ccagcagcct catcgggagt
     2341 caatgggacc taggcatagt ggtagaggac caggggagcc cctccttgca gacccaagtt
     2401 tcactgaagg tcgtgtttgt caccagcatg gaccacctaa gggactctgc tcacgagccc
     2461 ggaattctga gcacaccagc gctggctatg atctgcctgg ctgtactgct ggccgtcttt
     2521 ggattgatct tggctttgct tgtatccatc tgccggatag agaaaaggga taatagggcc
     2581 tacaactgtc gggaagctga gtctatgtac cgccaccagc ccaagaggcc ccagaaacac
     2641 attcagaagg cagatatcca cctggtgcct atgcttaggg cccaggagga tgaggctgag
     2701 gaagttaggc cacctcacaa ggataccagt aaagagacat tgatggaggc aggttgggac
     2761 tcctgcctac aggccccctt ccacctcaca ccaaccctat accggaccct gcgtaaccaa
     2821 ggcaaccagg gagcactggc agagagccag gaggtactgc aggacacctt caactttctc
     2881 ttcaaccacc ccaggcagag gaatgcctcc cgagagaacc tcaaccttcc tgagtcccca
     2941 cccaccctac gccagccact cttaaagcct ctgaaggtgc ctggcagccc catagcgagg
     3001 gtgactggag accaaggcag caaggaggca ccacagagcc caccagcgtc ctctgcaacc
     3061 ctaagacgac agaggaatct caatggcaaa gtgtctccta aaggcgagtc cagtcctcat
     3121 cagattctca ggagcctggt tcgactctct gtagctgctt ttgcagaacg gaaccctgtg
     3181 gaggagcttg ctggggactc tcctcctgtt cagcaaatct cccagctgct gtccttgctg
     3241 catcagggcc aattccagcc caaaccaaac caccgaggaa ataaatactc ggccaagccc
     3301 ggcagcagca gagctaccat cccagacaca gatggcttag gcatcaggcc tggtggccta
     3361 tcagaacctg acttggaaga agggccccca agcccagagg aggatctttc tgtaaagcga
     3421 cttctagaag aagagttgtc cagcctgttg gatcctaata caggtctagc cctggacaag
     3481 ctgagtcccc ctgacccagc ctggatggcg agactgtcat tgcccctcac taccaattac
     3541 cgagacaact tgtcttcccc tgatgctgca gcatcagagg aaccgagaac cttccagaca
     3601 ttcggcaaga cagtcggacc cggtcccgag ctaagcgcaa caggcacgcg cctggccagc
     3661 actttcgtct cggagatgag ctcactgctg gagatgttgt tggagcagaa cacggtgcct
     3721 gtggaagctg cgtctgcggc tttgcggagg ctctcagtgt gcgggaggac cctgagtcta
     3781 gacctagcca ccagtggggc ctcgggctca gaagcacagc tgggtagaaa aaaggcagct
     3841 gagagcagtc ttggctgtgg caggaatcta tgaatatggt tggaacatct ttggatccag
     3901 gacttgggtc ccctgggaaa tgttaggaca ctcaggtctt gaggatctca gggaataagc
     3961 tggtttctaa acttgtggaa ttcattggcc agagataacc ctaactttgg agtaacggat
     4021 gctatgctat tccccacaga ggaagcagga gcccaggact aacaagcaac tgactagagc
     4081 agacattgtc tgggtggctg agctttactg acaagaggga cagcttgttt ctctctagga
     4141 gtttgtggta taacacatgc agagtgtaaa gaggtgatcc tca
//
