LOCUS       NM_017030               1833 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus propionyl-CoA carboxylase subunit beta (Pccb),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017030
VERSION     NM_017030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   Stadler,S.C., Polanetz,R., Meier,S., Mayerhofer,P.U.,
            Herrmann,J.M., Anslinger,K., Roscher,A.A., Roschinger,W. and
            Holzinger,A.
  TITLE     Mitochondrial targeting signals and mature peptides of
            3-methylcrotonyl-CoA carboxylase
  JOURNAL   Biochem Biophys Res Commun 334 (3), 939-946 (2005)
   PUBMED   16023992
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Tahara,T., Kraus,J.P., Ohura,T., Rosenberg,L.E. and Fenton,W.A.
  TITLE     Three independent mutations in the same exon of the PCCB gene:
            differences between Caucasian and Japanese propionic acidaemia
  JOURNAL   J Inherit Metab Dis 16 (2), 353-360 (1993)
   PUBMED   8411997
REFERENCE   5  (bases 1 to 1833)
  AUTHORS   Kraus,J.P., Firgaira,F., Novotny,J., Kalousek,F., Williams,K.R.,
            Williamson,C., Ohura,T. and Rosenberg,L.E.
  TITLE     Coding sequence of the precursor of the beta subunit of rat
            propionyl-CoA carboxylase
  JOURNAL   Proc Natl Acad Sci U S A 83 (21), 8049-8053 (1986)
   PUBMED   3464942
REFERENCE   6  (bases 1 to 1833)
  AUTHORS   Kalousek,F., Darigo,M.D. and Rosenberg,L.E.
  TITLE     Isolation and characterization of propionyl-CoA carboxylase from
            normal human liver. Evidence for a protomeric tetramer of
            nonidentical subunits
  JOURNAL   J Biol Chem 255 (1), 60-65 (1980)
   PUBMED   6765947
REFERENCE   7  (bases 1 to 1833)
  AUTHORS   KAZIRO,Y., OCHOA,S., WARNER,R.C. and CHEN,J.Y.
  TITLE     Metabolism of propionic acid in animal tissues. VIII. Crystalline
            propionyl carboxylase
  JOURNAL   J Biol Chem 236, 1917-1923 (1961)
   PUBMED   13752080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078855.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017030.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078855.1, M14634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1833
                     /gene="Pccb"
                     /note="propionyl-CoA carboxylase subunit beta"
                     /db_xref="GeneID:24624"
                     /db_xref="RGD:3265"
     exon            1..194
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1631
                     /gene="Pccb"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase beta chain,
                     mitochondrial; PCCase subunit beta; propanoyl-CoA:carbon
                     dioxide ligase subunit beta; propionyl coenzyme A
                     carboxylase, beta polypeptide; propionyl CoA carboxylase,
                     beta polypeptide; propionyl-CoA carboxylase beta subunit"
                     /codon_start=1
                     /product="propionyl-CoA carboxylase beta chain,
                     mitochondrial precursor"
                     /protein_id="NP_058726.2"
                     /db_xref="GeneID:24624"
                     /db_xref="RGD:3265"
                     /translation="MAAAIRIRAMAAGTRLRVLNCGLRTTIRSLCSQPVSVNERIENK
                     RHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAAEKN
                     KFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGL
                     NDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFM
                     VKDTSYLFITGPEVVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREF
                     FNFLPLSNQDPAPIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEI
                     MPNYAKNIVIGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFSIPLIT
                     FVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLL
                     GDTNYAWPTAEIAVMGAKGAVEIIFKGHQDVEAAQAEYVEKFANPFPAAVRGFVDDII
                     QPSSTRARICCDLEVLASKKVHRPWRKHANVPL"
     exon            195..314
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            315..383
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            384..440
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            441..554
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            555..665
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            666..774
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            775..895
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            896..977
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1101
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1209
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1310
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1409
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1509
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1810
                     /gene="Pccb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaaatggc ggcggcgatt cggattcggg cgatggcagc tggaacgagg ctcagagttc
       61 tgaactgcgg cctccgcacc acaatccgca gcctttgcag ccagccggtc tcagttaacg
      121 agcgcatcga aaacaagcgc catgccgcgc tgctgggagg aggccagcga cgcatcgacg
      181 cacagcacaa gcgaggaaag ctgacagcca gggagcggat cagtctcctg ctggatcctg
      241 gcagcttcgt ggagagtgac atgtttgtgg aacacaggtg tgccgacttc ggaatggctg
      301 ccgagaagaa taagtttcct ggagatagtg tggtcactgg acggggcaga atcaatggac
      361 gattggttta tgtcttcagt caggatttta cagtttttgg aggcagtctg tcaggcgcac
      421 atgctcagaa gatctgcaaa atcatggacc aggccataac agtgggggct ccagtgatcg
      481 gactcaatga ctccgggggc gccagaatcc aggagggggt ggagtccttg gctggctatg
      541 cagacatctt cctgaggaat gtcacagcgt ccggagtcat ccctcagatt tctctgatca
      601 tgggcccatg cgctggtggg gccgtctact cccccgccct gacagacttc acattcatgg
      661 tgaaggacac gtcctacctg tttatcactg gccctgaagt tgtgaagtct gttaccaatg
      721 aagacgtgac tcaggagcag ctgggtggtg ccaagaccca caccactgtg tcaggtgtgg
      781 cccacagagc tttcgacaat gacgtcgatg ctctgtgtaa cctgcgtgaa ttcttcaact
      841 ttctgcccct cagcaaccag gacccggctc ccatccgaga gtgccatgac cccagtgacc
      901 gtctggttcc tgagctggat acagttgtcc ctttggagtc aagcaaagcc tataacatgc
      961 tagacatcat acatgcagtg attgacgaga gagagttttt tgagataatg cccaattatg
     1021 caaaaaacat tgtcattggc tttgcaagaa tgaatgggag gaccgttgga attgttggca
     1081 accagcccaa cgtggcttca gggtgcctgg acattaattc atctgtgaag ggggctcgct
     1141 ttgtcagatt ctgtgatgct ttcagcattc ctctcatcac tttcgttgat gtccctggct
     1201 tcctgcctgg cacagcgcag gaatatggag gcatcatccg gcatggtgcc aagctgctct
     1261 acgcctttgc cgaggccacc gtgcccaaaa tcacggtcat caccaggaag gcctatggag
     1321 gtgcctatga tgtcatgagc tccaaacacc ttcttggtga taccaactat gcctggccca
     1381 cagctgagat tgcagtcatg ggtgcaaagg gtgccgtgga gatcatcttc aaaggacacc
     1441 aagacgtgga agccgcccag gcagagtatg tggaaaagtt tgccaatcct ttccctgcag
     1501 ccgtgagagg gttcgtggat gacatcatcc agccgtcctc tactcgtgct cggatatgct
     1561 gtgacctgga agtcctggcc agcaagaagg tccatcgtcc ttggaggaag catgccaatg
     1621 tcccactgtg aagagatcaa aagaagagag caacagtgga gaagctggcc ttttgcagcc
     1681 tacccctgcc ttctacaatc atgaaagaac ggatctacat accttggaca ctgattgaat
     1741 tgcataaaga gttcttgtgc ctggagaaaa attatgtgct ctattaaaat cttcactggt
     1801 gctttctgaa aaaaaaaaaa aaaaaaaaaa aaa
//
