LOCUS       NP_058726                541 aa            linear   ROD 19-SEP-2024
DEFINITION  propionyl-CoA carboxylase beta chain, mitochondrial precursor
            [Rattus norvegicus].
ACCESSION   NP_058726
VERSION     NP_058726.2
DBSOURCE    REFSEQ: accession NM_017030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 541)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 541)
  AUTHORS   Stadler,S.C., Polanetz,R., Meier,S., Mayerhofer,P.U.,
            Herrmann,J.M., Anslinger,K., Roscher,A.A., Roschinger,W. and
            Holzinger,A.
  TITLE     Mitochondrial targeting signals and mature peptides of
            3-methylcrotonyl-CoA carboxylase
  JOURNAL   Biochem Biophys Res Commun 334 (3), 939-946 (2005)
   PUBMED   16023992
REFERENCE   3  (residues 1 to 541)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (residues 1 to 541)
  AUTHORS   Tahara,T., Kraus,J.P., Ohura,T., Rosenberg,L.E. and Fenton,W.A.
  TITLE     Three independent mutations in the same exon of the PCCB gene:
            differences between Caucasian and Japanese propionic acidaemia
  JOURNAL   J Inherit Metab Dis 16 (2), 353-360 (1993)
   PUBMED   8411997
REFERENCE   5  (residues 1 to 541)
  AUTHORS   Kraus,J.P., Firgaira,F., Novotny,J., Kalousek,F., Williams,K.R.,
            Williamson,C., Ohura,T. and Rosenberg,L.E.
  TITLE     Coding sequence of the precursor of the beta subunit of rat
            propionyl-CoA carboxylase
  JOURNAL   Proc Natl Acad Sci U S A 83 (21), 8049-8053 (1986)
   PUBMED   3464942
REFERENCE   6  (residues 1 to 541)
  AUTHORS   Kalousek,F., Darigo,M.D. and Rosenberg,L.E.
  TITLE     Isolation and characterization of propionyl-CoA carboxylase from
            normal human liver. Evidence for a protomeric tetramer of
            nonidentical subunits
  JOURNAL   J Biol Chem 255 (1), 60-65 (1980)
   PUBMED   6765947
REFERENCE   7  (residues 1 to 541)
  AUTHORS   KAZIRO,Y., OCHOA,S., WARNER,R.C. and CHEN,J.Y.
  TITLE     Metabolism of propionic acid in animal tissues. VIII. Crystalline
            propionyl carboxylase
  JOURNAL   J Biol Chem 236, 1917-1923 (1961)
   PUBMED   13752080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078855.1.
            
            On Jun 10, 2007 this sequence version replaced NP_058726.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078855.1, M14634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     Protein         1..541
                     /product="propionyl-CoA carboxylase beta chain,
                     mitochondrial precursor"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase beta chain,
                     mitochondrial; PCCase subunit beta; propanoyl-CoA:carbon
                     dioxide ligase subunit beta; propionyl coenzyme A
                     carboxylase, beta polypeptide; propionyl CoA carboxylase,
                     beta polypeptide; propionyl-CoA carboxylase beta subunit"
                     /calculated_mol_wt=55640
     transit_peptide 1..28
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P07633.1)"
                     /calculated_mol_wt=3057
     mat_peptide     29..541
                     /product="Propionyl-CoA carboxylase beta chain,
                     mitochondrial. /id=PRO_0000000296"
                     /note="propagated from UniProtKB/Swiss-Prot (P07633.1)"
                     /calculated_mol_wt=55640
     Region          34..535
                     /region_name="Carboxyltransferase.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01138"
                     /note="propagated from UniProtKB/Swiss-Prot (P07633.1)"
     Region          39..539
                     /region_name="MmdA"
                     /note="Acetyl-CoA carboxylase, carboxyltransferase
                     component [Lipid transport and metabolism]; COG4799"
                     /db_xref="CDD:443827"
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P05166; propagated from
                     UniProtKB/Swiss-Prot (P07633.1)"
     Site            101
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99MN9; propagated from
                     UniProtKB/Swiss-Prot (P07633.1)"
     Region          327..360
                     /region_name="Acyl-CoA binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P07633.1)"
     Site            476
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99MN9; propagated from
                     UniProtKB/Swiss-Prot (P07633.1)"
     Site            491
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99MN9; propagated from
                     UniProtKB/Swiss-Prot (P07633.1)"
     CDS             1..541
                     /gene="Pccb"
                     /coded_by="NM_017030.2:6..1631"
                     /db_xref="GeneID:24624"
                     /db_xref="RGD:3265"
ORIGIN      
        1 maaairiram aagtrlrvln cglrttirsl csqpvsvner ienkrhaall gggqrridaq
       61 hkrgkltare risllldpgs fvesdmfveh rcadfgmaae knkfpgdsvv tgrgringrl
      121 vyvfsqdftv fggslsgaha qkickimdqa itvgapvigl ndsggariqe gveslagyad
      181 iflrnvtasg vipqislimg pcaggavysp altdftfmvk dtsylfitgp evvksvtned
      241 vtqeqlggak thttvsgvah rafdndvdal cnlreffnfl plsnqdpapi rechdpsdrl
      301 vpeldtvvpl esskaynmld iihavidere ffeimpnyak nivigfarmn grtvgivgnq
      361 pnvasgcldi nssvkgarfv rfcdafsipl itfvdvpgfl pgtaqeyggi irhgakllya
      421 faeatvpkit vitrkaygga ydvmsskhll gdtnyawpta eiavmgakga veiifkghqd
      481 veaaqaeyve kfanpfpaav rgfvddiiqp sstrariccd levlaskkvh rpwrkhanvp
      541 l
//
