LOCUS       NM_019330               2495 bp    mRNA    linear   ROD 01-AUG-2016
DEFINITION  Rattus norvegicus propionyl-CoA carboxylase alpha subunit (Pcca),
            mRNA.
ACCESSION   NM_019330 XM_001075496
VERSION     NM_019330.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Ballhausen D, Mittaz L, Boulat O, Bonafe L and Braissant O.
  TITLE     Evidence for catabolic pathway of propionate metabolism in CNS:
            expression pattern of methylmalonyl-CoA mutase and propionyl-CoA
            carboxylase alpha-subunit in developing and adult rat brain
  JOURNAL   Neuroscience 164 (2), 578-587 (2009)
   PUBMED   19699272
  REMARK    GeneRIF: Methylmalonyl-CoA mutase and PCCA show a much higher
            expression level in the entire CNS than in the liver, suggesting a
            different, but important function of this pathway during brain
            development.
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J,
            Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz
            TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ and Jacob
            HJ.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res. 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Vitt U, Gietzen D, Stevens K, Wingrove J, Becha S, Bulloch S,
            Burrill J, Chawla N, Chien J, Crawford M, Ison C, Kearney L, Kwong
            M, Park J, Policky J, Weiler M, White R, Xu Y, Daniels S, Jacob H,
            Jensen-Seaman MI, Lazar J, Stuve L and Schmidt J.
  TITLE     Identification of candidate disease genes by EST alignments,
            synteny, and expression and verification of Ensembl genes on rat
            chromosome 1q43-54
  JOURNAL   Genome Res. 14 (4), 640-650 (2004)
   PUBMED   15060005
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Richard E, Desviat LR, Perez B, Perez-Cerda C and Ugarte M.
  TITLE     Three novel splice mutations in the PCCA gene causing identical
            exon skipping in propionic acidemia patients
  JOURNAL   Hum. Genet. 101 (1), 93-96 (1997)
   PUBMED   9385377
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Browner MF, Taroni F, Sztul E and Rosenberg LE.
  TITLE     Sequence analysis, biogenesis, and mitochondrial import of the
            alpha-subunit of rat liver propionyl-CoA carboxylase
  JOURNAL   J. Biol. Chem. 264 (21), 12680-12685 (1989)
   PUBMED   2745462
  REMARK    Erratum:[J Biol Chem 1991 Mar 5;266(7):4660]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CK228512.1,
            M22631.1, CK601565.1, CO574538.1, CX570803.1 and BQ191052.1.
            
            [WARNING] On Jun 28, 2023 this sequence was replaced by
            NM_019330.2.
            
            On Oct 17, 2007 this sequence version replaced XM_001075496.1.
            
            Summary: alpha subunit of propionyl coenzyme A carboxylase, which
            catalyzes the conversion of ATP, propanoyl-CoA, and HCO3- to ADP,
            phosphate, and (S)-methylmalonyl-CoA [RGD, Feb 2006].
            
            Sequence Note: The sequence M22631.1 is from a chimeric clone. Only
            the propionyl-coenzyme A carboxylase sequence region was propagated
            into this RefSeq record.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMD00052296,
                              SAMD00052297 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                CK228512.1         1-87
            88-1107             M22631.1           945-1964
            1108-1743           CK601565.1         13-648
            1744-1982           CO574538.1         383-621
            1983-2476           CX570803.1         103-596
            2477-2495           BQ191052.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q25"
     gene            1..2495
                     /gene="Pcca"
                     /note="propionyl-CoA carboxylase alpha subunit"
                     /db_xref="GeneID:687008"
                     /db_xref="RGD:3264"
     CDS             33..2204
                     /gene="Pcca"
                     /EC_number="6.4.1.3"
                     /note="PCCase alpha subunit; propanoyl-CoA:carbon dioxide
                     ligase alpha subunit; PCCase subunit alpha;
                     propanoyl-CoA:carbon dioxide ligase subunit alpha;
                     Propionyl Coenzyme A carboxylase alpha polypeptide;
                     propionyl-coenzyme A carboxylase, alpha polypeptide;
                     propionyl CoA carboxylase, alpha polypeptide"
                     /codon_start=1
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial"
                     /protein_id="NP_062203.1"
                     /db_xref="GeneID:687008"
                     /db_xref="RGD:3264"
                     /translation="MAGLWVRTVALLAARRHWRRSSQQLLWTLKRAPVYSQQCLVVSR
                     SLSSVEYEPKEKTFDKILIANRGEIACRVIKTCRKMGIRTVAIHSDVDASSVHVKMAD
                     EAVCVGPAPTSKSYLNMDAIMEAIKKTGAQAVHPGYGFLSENKEFAKCLAAEDVTFIG
                     PDTHAIQAMGDKIESKLLAKRAKVNTIPGFDGVLKDADEAVRIAREIGYPVMIKASAG
                     GGGKGMRIPWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGN
                     ALWLNERECSIQRRNQKVVEEAPSIFLDPETRRAMGEQAVAWPKAVKYSSAGTVEFLV
                     DSQKNFYFLEMNTRLQVEHPVTECITGLDLVQEMILVAKGYPLRHKQEDIPISGWAVE
                     CRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQPGSDISIYYDPMISKLVTY
                     GSDRAEALKRMEDALDSYVIRGVTHNIPLLREVIINTRFVKGDISTKFLSDVYPDGFK
                     GHMLTPSERDQLLAIASSLFVASQLRAQRFQEHSRVPVIRPDVAKWELSVKLHDEDHT
                     VVASNNGPTFNVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTVQCLSRDAGGNMSIQF
                     LGTVYKVHILTKLAAELNKFMLEKVPKDTSSTLCSPMPGVVVAVSVKPGDMVAEGQEI
                     CVIEAMKMQNSMTAGKMGKVKLVHCKAGDTVGEGDLLVELE"
ORIGIN      
        1 gttcagcggc cagcaagtcg gctgggacga caatggcggg gctgtgggtc aggacagtgg
       61 cactattggc ggccaggcgg cattggcggc ggtcctccca gcaactgctg tggacgctga
      121 agcgtgctcc agtctattca cagcaatgcc tagtggtgtc ccgaagtctc agttctgtgg
      181 aatatgagcc taaagaaaaa acttttgata aaattcttat tgctaacaga ggagaaattg
      241 cttgtagggt cattaagact tgcaggaaga tgggcatcag gacagttgcc atccacagtg
      301 atgttgatgc cagctcggtt catgtgaaaa tggcggatga ggctgtctgt gttggcccag
      361 ctcccaccag taaaagctac ctcaacatgg atgccatcat ggaggccatt aagaaaaccg
      421 gggcccaagc tgtacaccca ggttatggat tcctgtcaga aaacaaagag tttgcaaagt
      481 gtttggcagc agaagatgtc actttcattg gacctgatac tcatgctatt caagccatgg
      541 gtgacaagat agaaagcaaa ctgttagcca agagagcaaa ggtcaacaca atccctggtt
      601 ttgatggggt actaaaggat gcagatgaag ccgtcagaat tgcaagggaa attggctacc
      661 ctgtgatgat caaggcctca gcaggcggtg gtgggaaagg catgcgcatc ccgtgggatg
      721 acgaagagac cagggatggc tttagatttt catcccagga agctgcttct agttttggtg
      781 atgatagact actaatagaa aaatttatcg ataaccctcg tcatatagaa atccaggttt
      841 taggggataa acatggcaat gctctgtggc tcaatgagag ggagtgctcg atccagagaa
      901 gaaaccagaa ggtggtagag gaggcgccga gcatttttct ggatcctgag acgcgccgag
      961 ccatgggaga gcaggccgtg gcttggccaa aagcggtgaa gtattcttct gctggaactg
     1021 tggaatttct tgtggactcc cagaagaatt tttacttctt ggagatgaat acaagactcc
     1081 aggttgaaca tcctgtcaca gagtgcatta ctggcctgga cttagtccaa gaaatgatcc
     1141 tggttgctaa gggttaccca ctcaggcaca agcaagagga tattcccatc agtggctggg
     1201 cagttgaatg tcgggtttat gctgaggacc cctacaagtc tttcggttta ccgtctattg
     1261 ggagactgtc tcagtaccaa gagcctatac atctacctgg tgtccgagtt gacagtggca
     1321 tccaaccagg aagtgacatc agcatctatt atgaccctat gatttcaaaa ctagtcacat
     1381 atggatctga cagagcagaa gccctgaaga ggatggaaga tgcattggac agttatgtta
     1441 tccggggtgt tacacacaac atcccactgc ttcgggaggt gataatcaac acgcgttttg
     1501 tgaaagggga catcagcact aagtttctct ctgatgtgta tcctgatggc ttcaaagggc
     1561 acatgttaac acccagtgag agagaccagt tattggctat tgcatcatcc ttgtttgtgg
     1621 catcccagct acgagcacag cgctttcaag aacattcaag agttccagtt ataaggccag
     1681 atgtggctaa gtgggagctc tcagtaaaat tacatgatga agaccatact gttgtggcat
     1741 ccaacaacgg gccaacattt aacgtggaag ttgatggctc gaaactaaat gtgaccagta
     1801 cgtggaacct ggcctcaccc ttattgtctg tcaacgttga tggcactcag aggactgtgc
     1861 agtgtctttc tcgggacgca ggtggaaaca tgagcatcca gtttcttggc acagtgtaca
     1921 aagtgcacat tttaaccaaa cttgctgcag aactgaacaa attcatgctt gaaaaagtac
     1981 ccaaggacac tagcagcact ctgtgctccc cgatgcctgg agtggtggtg gccgtttccg
     2041 tcaagcctgg agacatggta gcagaaggtc aggaaatctg tgtgattgaa gctatgaaaa
     2101 tgcagaacag tatgacagct ggtaaaatgg gcaaggtgaa actggtgcac tgcaaagctg
     2161 gagacacagt tggtgaagga gacctgctcg tggagctgga atgaagtact tgtagccctt
     2221 cagtcaccac tgctcactgc tttaattagc atttccatta ttctctaacc ctcaatttgc
     2281 tcaggcgttt acaggagcac tctgtgcagc aggttctaca gcatcgtatt tattcctcag
     2341 aagaggcaaa accgacactc tgccaaaaaa atcaccaatg ggaattttta ttgatataaa
     2401 tacttgtata tatgatttgt acttctgctg agatttccca gtgtcaaaat taaatcaata
     2461 aaaccaagca tttgtctaaa aaaaaaaaaa aaaaa
//
