LOCUS       NP_062203                723 aa            linear   ROD 01-AUG-2016
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial [Rattus
            norvegicus].
ACCESSION   NP_062203 XP_001075496
VERSION     NP_062203.1
DBSOURCE    REFSEQ: accession NM_019330.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 723)
  AUTHORS   Ballhausen D, Mittaz L, Boulat O, Bonafe L and Braissant O.
  TITLE     Evidence for catabolic pathway of propionate metabolism in CNS:
            expression pattern of methylmalonyl-CoA mutase and propionyl-CoA
            carboxylase alpha-subunit in developing and adult rat brain
  JOURNAL   Neuroscience 164 (2), 578-587 (2009)
   PUBMED   19699272
  REMARK    GeneRIF: Methylmalonyl-CoA mutase and PCCA show a much higher
            expression level in the entire CNS than in the liver, suggesting a
            different, but important function of this pathway during brain
            development.
REFERENCE   2  (residues 1 to 723)
  AUTHORS   Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J,
            Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz
            TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ and Jacob
            HJ.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res. 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   3  (residues 1 to 723)
  AUTHORS   Vitt U, Gietzen D, Stevens K, Wingrove J, Becha S, Bulloch S,
            Burrill J, Chawla N, Chien J, Crawford M, Ison C, Kearney L, Kwong
            M, Park J, Policky J, Weiler M, White R, Xu Y, Daniels S, Jacob H,
            Jensen-Seaman MI, Lazar J, Stuve L and Schmidt J.
  TITLE     Identification of candidate disease genes by EST alignments,
            synteny, and expression and verification of Ensembl genes on rat
            chromosome 1q43-54
  JOURNAL   Genome Res. 14 (4), 640-650 (2004)
   PUBMED   15060005
REFERENCE   4  (residues 1 to 723)
  AUTHORS   Richard E, Desviat LR, Perez B, Perez-Cerda C and Ugarte M.
  TITLE     Three novel splice mutations in the PCCA gene causing identical
            exon skipping in propionic acidemia patients
  JOURNAL   Hum. Genet. 101 (1), 93-96 (1997)
   PUBMED   9385377
REFERENCE   5  (residues 1 to 723)
  AUTHORS   Browner MF, Taroni F, Sztul E and Rosenberg LE.
  TITLE     Sequence analysis, biogenesis, and mitochondrial import of the
            alpha-subunit of rat liver propionyl-CoA carboxylase
  JOURNAL   J. Biol. Chem. 264 (21), 12680-12685 (1989)
   PUBMED   2745462
  REMARK    Erratum:[J Biol Chem 1991 Mar 5;266(7):4660]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CK228512.1,
            M22631.1, CK601565.1, CO574538.1, CX570803.1 and BQ191052.1.
            
            [WARNING] On Jun 28, 2023 this sequence was replaced by
            NP_062203.2.
            
            On Oct 17, 2007 this sequence version replaced XP_001075496.1.
            
            Summary: alpha subunit of propionyl coenzyme A carboxylase, which
            catalyzes the conversion of ATP, propanoyl-CoA, and HCO3- to ADP,
            phosphate, and (S)-methylmalonyl-CoA [RGD, Feb 2006].
            
            Sequence Note: The sequence M22631.1 is from a chimeric clone. Only
            the propionyl-coenzyme A carboxylase sequence region was propagated
            into this RefSeq record.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMD00052296,
                              SAMD00052297 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q25"
     Protein         1..723
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial"
                     /EC_number="6.4.1.3"
                     /note="PCCase alpha subunit; propanoyl-CoA:carbon dioxide
                     ligase alpha subunit; PCCase subunit alpha;
                     propanoyl-CoA:carbon dioxide ligase subunit alpha;
                     Propionyl Coenzyme A carboxylase alpha polypeptide;
                     propionyl-coenzyme A carboxylase, alpha polypeptide;
                     propionyl CoA carboxylase, alpha polypeptide"
                     /calculated_mol_wt=79863
     CDS             1..723
                     /gene="Pcca"
                     /coded_by="NM_019330.1:33..2204"
                     /db_xref="GeneID:687008"
                     /db_xref="RGD:3264"
ORIGIN      
        1 maglwvrtva llaarrhwrr ssqqllwtlk rapvysqqcl vvsrslssve yepkektfdk
       61 ilianrgeia crviktcrkm girtvaihsd vdassvhvkm adeavcvgpa ptsksylnmd
      121 aimeaikktg aqavhpgygf lsenkefakc laaedvtfig pdthaiqamg dkieskllak
      181 rakvntipgf dgvlkdadea vriareigyp vmikasaggg gkgmripwdd eetrdgfrfs
      241 sqeaassfgd drlliekfid nprhieiqvl gdkhgnalwl nerecsiqrr nqkvveeaps
      301 ifldpetrra mgeqavawpk avkyssagtv eflvdsqknf yflemntrlq vehpvtecit
      361 gldlvqemil vakgyplrhk qedipisgwa vecrvyaedp yksfglpsig rlsqyqepih
      421 lpgvrvdsgi qpgsdisiyy dpmisklvty gsdraealkr medaldsyvi rgvthnipll
      481 reviintrfv kgdistkfls dvypdgfkgh mltpserdql laiasslfva sqlraqrfqe
      541 hsrvpvirpd vakwelsvkl hdedhtvvas nngptfnvev dgsklnvtst wnlaspllsv
      601 nvdgtqrtvq clsrdaggnm siqflgtvyk vhiltklaae lnkfmlekvp kdtsstlcsp
      661 mpgvvvavsv kpgdmvaegq eicvieamkm qnsmtagkmg kvklvhckag dtvgegdllv
      721 ele
//
