LOCUS       NP_001178812             403 aa            linear   ROD 31-MAR-2024
DEFINITION  poly(rC)-binding protein 4 [Rattus norvegicus].
ACCESSION   NP_001178812 XP_343469
VERSION     NP_001178812.1
DBSOURCE    REFSEQ: accession NM_001191883.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 403)
  AUTHORS   Bogdan,A.R., Miyazawa,M., Hashimoto,K. and Tsuji,Y.
  TITLE     Regulators of Iron Homeostasis: New Players in Metabolism, Cell
            Death, and Disease
  JOURNAL   Trends Biochem Sci 41 (3), 274-286 (2016)
   PUBMED   26725301
  REMARK    Review article
REFERENCE   2  (residues 1 to 403)
  AUTHORS   Lane,D.J., Merlot,A.M., Huang,M.L., Bae,D.H., Jansson,P.J.,
            Sahni,S., Kalinowski,D.S. and Richardson,D.R.
  TITLE     Cellular iron uptake, trafficking and metabolism: Key molecules and
            mechanisms and their roles in disease
  JOURNAL   Biochim Biophys Acta 1853 (5), 1130-1144 (2015)
   PUBMED   25661197
  REMARK    Review article
REFERENCE   3  (residues 1 to 403)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   4  (residues 1 to 403)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 403)
  AUTHORS   Scoumanne,A., Cho,S.J., Zhang,J. and Chen,X.
  TITLE     The cyclin-dependent kinase inhibitor p21 is regulated by
            RNA-binding protein PCBP4 via mRNA stability
  JOURNAL   Nucleic Acids Res 39 (1), 213-224 (2011)
   PUBMED   20817677
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XP_343469.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.874304.1,
                                           SRR26360194.2396096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..403
                     /product="poly(rC)-binding protein 4"
                     /calculated_mol_wt=41322
     Region          17..86
                     /region_name="KH-I_PCBP4_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in poly(rC)-binding protein 4 (PCBP4) and similar
                     proteins; cd22517"
                     /db_xref="CDD:411945"
     Site            order(26,30..31,33..37,40,44,52..55,57,61)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411945"
     Region          101..172
                     /region_name="KH-I_PCBP4_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in poly(rC)-binding protein 4 (PCBP4) and similar
                     proteins; cd22520"
                     /db_xref="CDD:411948"
     Site            order(109,114..115,117..121,124,128,136..139,144,148)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411948"
     Region          241..308
                     /region_name="KH-I_PCBP4_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in poly(rC)-binding protein 4 (PCBP4) and similar
                     proteins; cd22523"
                     /db_xref="CDD:411951"
     Site            order(251..255,257..261,263..265,268,276..277,279,287)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411951"
     CDS             1..403
                     /gene="Pcbp4"
                     /coded_by="NM_001191883.1:221..1432"
                     /db_xref="GeneID:363133"
                     /db_xref="RGD:1307910"
ORIGIN      
        1 msssdaglee epelsitltl rmlmhgkevg siigkkgetv krireqssar itisegscpe
       61 rittitgsta avfhavsmia fkldedlcaa panggsvsrp pvtlrlvipa sqcgsligka
      121 gtkikeiret tgaqvqvagd llpnsterav tvsgvpdaii lcvrqicavi lesppkgati
      181 pyhpslslgt vllsanqgfs vqgqygavtp aevtklqqls ghavpfasps vvpgldpstq
      241 tssqeflvpn dligcvigrq gskiseirqm sgahikignq aegagerhvt itgspvsial
      301 aqylitacle takstsggtp gsapadlptp fsppltalpt appgllgtpy aislsnfigl
      361 kpvpflalpp aspgpppgla aytakmaaan gskkaerqkf spy
//
