LOCUS       NM_001013223            1806 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus poly(rC) binding protein 2 (Pcbp2), mRNA.
ACCESSION   NM_001013223 XM_343338
VERSION     NM_001013223.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Yue,L., Luo,Y., Jiang,L., Sekido,Y. and Toyokuni,S.
  TITLE     PCBP2 knockdown promotes ferroptosis in malignant mesothelioma
  JOURNAL   Pathol Int 72 (4), 242-251 (2022)
   PUBMED   35089637
  REMARK    GeneRIF: PCBP2 knockdown promotes ferroptosis in malignant
            mesothelioma.
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Mao,X., Liu,J., Chen,C., Zhang,W., Qian,R., Chen,X., Lu,H., Ge,J.,
            Zhao,C., Zhang,D. and Wang,Y.
  TITLE     PCBP2 Modulates Neural Apoptosis and Astrocyte Proliferation After
            Spinal Cord Injury
  JOURNAL   Neurochem Res 41 (9), 2401-2414 (2016)
   PUBMED   27209304
  REMARK    GeneRIF: PCBP2 might play important roles in central nervous system
            pathophysiology after spinal cord injury
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Chen,Z., Zhang,W., Ni,L., Wang,G., Cao,Y., Wu,W., Sun,C., Yuan,D.,
            Ni,H., Wang,Y. and Yang,H.
  TITLE     Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2
            Modulates Schwann Cell Proliferation After Sciatic Nerve Injury
  JOURNAL   Cell Mol Neurobiol 36 (5), 725-735 (2016)
   PUBMED   26250704
  REMARK    GeneRIF: that the change of poly(C)-binding proteins protein
            expression was associated with Schwann cell proliferation after the
            trauma of the peripheral nervous system
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Bogdan,A.R., Miyazawa,M., Hashimoto,K. and Tsuji,Y.
  TITLE     Regulators of Iron Homeostasis: New Players in Metabolism, Cell
            Death, and Disease
  JOURNAL   Trends Biochem Sci 41 (3), 274-286 (2016)
   PUBMED   26725301
  REMARK    Review article
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Lane,D.J., Merlot,A.M., Huang,M.L., Bae,D.H., Jansson,P.J.,
            Sahni,S., Kalinowski,D.S. and Richardson,D.R.
  TITLE     Cellular iron uptake, trafficking and metabolism: Key molecules and
            mechanisms and their roles in disease
  JOURNAL   Biochim Biophys Acta 1853 (5), 1130-1144 (2015)
   PUBMED   25661197
  REMARK    Review article
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Walter,B.L., Parsley,T.B., Ehrenfeld,E. and Semler,B.L.
  TITLE     Distinct poly(rC) binding protein KH domain determinants for
            poliovirus translation initiation and viral RNA replication
  JOURNAL   J Virol 76 (23), 12008-12022 (2002)
   PUBMED   12414943
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Leffers,H., Dejgaard,K. and Celis,J.E.
  TITLE     Characterisation of two major cellular poly(rC)-binding human
            proteins, each containing three K-homologous (KH) domains
  JOURNAL   Eur J Biochem 230 (2), 447-453 (1995)
   PUBMED   7607214
REFERENCE   9  (bases 1 to 1806)
  AUTHORS   Goller,M., Funke,B., Gehe-Becker,C., Kroger,B., Lottspeich,F. and
            Horak,I.
  TITLE     Murine protein which binds preferentially to oligo-C-rich
            single-stranded nucleic acids
  JOURNAL   Nucleic Acids Res 22 (10), 1885-1889 (1994)
   PUBMED   8208614
REFERENCE   10 (bases 1 to 1806)
  AUTHORS   Hahm,K., Kim,G., Turck,C.W. and Smale,S.T.
  TITLE     Isolation of a murine gene encoding a nucleic acid-binding protein
            with homology to hnRNP K
  JOURNAL   Nucleic Acids Res 21 (16), 3894 (1993)
   PUBMED   8367306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 30, 2021 this sequence version replaced NM_001013223.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078906.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000007.1  135483901-135484165
            266-406             JAXUCZ010000007.1  135486651-135486791
            407-430             JAXUCZ010000007.1  135487387-135487410
            431-463             JAXUCZ010000007.1  135487502-135487534
            464-580             JAXUCZ010000007.1  135487900-135488016
            581-712             JAXUCZ010000007.1  135490737-135490868
            713-841             JAXUCZ010000007.1  135493731-135493859
            842-928             JAXUCZ010000007.1  135494717-135494803
            929-1021            JAXUCZ010000007.1  135496477-135496569
            1022-1063           JAXUCZ010000007.1  135497616-135497657
            1064-1136           JAXUCZ010000007.1  135498772-135498844
            1137-1175           JAXUCZ010000007.1  135499344-135499382
            1176-1228           JAXUCZ010000007.1  135500315-135500367
            1229-1398           JAXUCZ010000007.1  135501195-135501364
            1399-1806           JAXUCZ010000007.1  135507847-135508254
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1806
                     /gene="Pcbp2"
                     /note="poly(rC) binding protein 2"
                     /db_xref="GeneID:363005"
                     /db_xref="RGD:1309626"
     exon            1..265
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..406
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1435
                     /gene="Pcbp2"
                     /codon_start=1
                     /product="poly(rC)-binding protein 2"
                     /protein_id="NP_001013241.1"
                     /db_xref="GeneID:363005"
                     /db_xref="RGD:1309626"
                     /translation="MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESG
                     ARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRL
                     VVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVK
                     QICVVMLETLSQSPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCL
                     NPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVK
                     GYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQ
                     VTITGSAASISLAQYLINVRLSSETGGMGSS"
     exon            407..430
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..463
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..580
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..712
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..841
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..928
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1021
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1063
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1136
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1175
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1228
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1398
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1806
                     /gene="Pcbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc
       61 gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc
      121 cttcctcctc ctccaccccc cctcctccgc ccgctagcgg ggcccccctc gccttcccgc
      181 ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg ctcccctttt
      241 cccctcagtc gactcgcgcc tccagttttt ggctttcact ctcaccagtg accaaagact
      301 tgaccactca aagtccagct ccctgtaact gctagacatg gacaccggtg tgattgaagg
      361 tggattaaat gtcactctca ccatcaggct acttatgcac ggaaaggaag ttggcagtat
      421 catcggaaag aaaggagaat ctgttaagaa gatgcgcgag gagagtggtg cacgtatcaa
      481 catctcagaa gggaattgtc ctgagagaat tataactttg gctggaccga ctaatgccat
      541 cttcaaagcc tttgctatga tcattgacaa actggaagag gacataagca gctctatgac
      601 caatagcaca gctgccagta gacccccggt taccttacgg ctggtggttc ctgctagtca
      661 gtgtggctct cttattggaa aaggtggttg caagatcaag gaaataagag agagtacagg
      721 ggctcaggtc caggtggcag gggatatgct ccccaactca actgagcgag caatcactat
      781 tgctggcatt ccgcagtcca tcattgagtg tgtcaaacag atctgcgtgg tcatgttgga
      841 gactctctcc cagtcccccc cgaagggcgt gaccatcccg taccggccca agccctccag
      901 ttctccagtc atctttgcag gtggtcagga caggtacagc acaggcagcg acagtgcgag
      961 ctttccccac accaccccgt ccatgtgcct caaccctgac ctggagggac cacctctaga
     1021 ggcctatacc attcaaggac agtatgccat tccacagcca gatttgacca agctgcacca
     1081 gttggcaatg caacagtctc attttcccat gacccatggc aacaccggat tcagtggcat
     1141 tgaatccagc tctccagagg tgaaaggcta ttggggtttg gatgcatctg ctcaaactac
     1201 ttctcatgaa ctcaccattc caaatgattt gattggctgc ataattgggc gtcagggcgc
     1261 caaaatcaat gagatccgtc agatgtctgg ggcgcagatc aaaattgcaa acccagtgga
     1321 aggatctact gatcggcagg ttaccatcac tggatctgct gccagcatta gtctggctca
     1381 gtatctaatc aatgtcaggc tttcctcgga gacaggtggc atggggagca gctagaacag
     1441 agcagattca tccataatcc ctttctgctg ttcaccacca cccatgatcc atctgtgtag
     1501 tttctgaaca gtcagcgatt ccaggtttta aatagtttgt aaattttcag tttctacaca
     1561 ctttatcatc cactcatgat tttttaatta aagtgtttta attcttttct ctgttcagca
     1621 gttacgctga gatatccata tttagtttta taagcttctc cccctttttt gttttgtttt
     1681 gttttttttt tttggctcat gaatttttgt ttgtcatgga aatgtaagag tggattatta
     1741 atacatttca gtttagttct gtaatgtcag gaatttttca aaaaaagaat taaaagatgg
     1801 actgga
//
