LOCUS       NM_001402494             548 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus pterin-4 alpha-carbinolamine dehydratase 2
            (Pcbd2), mRNA.
ACCESSION   NM_001402494 XM_003751642
VERSION     NM_001402494.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 548)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 548)
  AUTHORS   Rose,R.B., Pullen,K.E., Bayle,J.H., Crabtree,G.R. and Alber,T.
  TITLE     Biochemical and structural basis for partially redundant enzymatic
            and transcriptional functions of DCoH and DCoH2
  JOURNAL   Biochemistry 43 (23), 7345-7355 (2004)
   PUBMED   15182178
REFERENCE   3  (bases 1 to 548)
  AUTHORS   Lim,S., Jin,K. and Friedman,E.
  TITLE     Mirk protein kinase is activated by MKK3 and functions as a
            transcriptional activator of HNF1alpha
  JOURNAL   J Biol Chem 277 (28), 25040-25046 (2002)
   PUBMED   11980910
  REMARK    Erratum:[J Biol Chem. 2004 Feb 6;279(6):5047]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Mar 15, 2022 this sequence version replaced XM_003751642.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK841359.1, BI295097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000017.1  8901161-8901267     c
            108-239             JAXUCZ010000017.1  8896076-8896207     c
            240-320             JAXUCZ010000017.1  8851760-8851840     c
            321-548             JAXUCZ010000017.1  8850349-8850576     c
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..548
                     /gene="Pcbd2"
                     /note="pterin-4 alpha-carbinolamine dehydratase 2"
                     /db_xref="GeneID:685729"
                     /db_xref="RGD:1590239"
     exon            1..107
                     /gene="Pcbd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..416
                     /gene="Pcbd2"
                     /EC_number="4.2.1.96"
                     /note="dimerization cofactor of hepatocyte nuclear factor
                     1 alpha 2; pterin 4 alpha carbinolamine
                     dehydratase/dimerization cofactor of hepatocyte nuclear
                     factor 1 alpha (TCF1) 2"
                     /codon_start=1
                     /product="pterin-4-alpha-carbinolamine dehydratase 2"
                     /protein_id="NP_001389423.1"
                     /db_xref="GeneID:685729"
                     /db_xref="RGD:1590239"
                     /translation="MAAAVGVRGAGRWLVALRCRGASGAAMSSDAQWLTPEERSQLIP
                     DLKAAGWSELSERDAIYKEFSFKNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQIT
                     LTSHDCGGLSKRDVKLAQFIEKAAASR"
     exon            108..239
                     /gene="Pcbd2"
                     /inference="alignment:Splign:2.1.0"
     exon            240..320
                     /gene="Pcbd2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..548
                     /gene="Pcbd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcgcgc ggggcagccc ggggccatgg cggcggcggt gggcgtgcgc ggcgcggggc
       61 gctggttggt ggcgctgcgc tgccggggcg cgagcggggc ggccatgtct tcagatgcgc
      121 agtggttgac gccagaggag aggagccagc ttattcctga cttgaaagca gcagggtggt
      181 cggagttgag cgagagagac gccatctaca aagagttctc cttcaaaaat tttaaccagg
      241 cgtttggctt tatgtccagg gttgccctgc aagcagagaa gatgaatcac cacccggaat
      301 ggttcaacgt gtacaacaag gtccagatca ccctcacctc gcatgactgt ggaggcctga
      361 gcaagcgaga cgtgaagctg gcccagttca ttgaaaaagc tgctgcttct cggtgatcgc
      421 ctttgaaacg cacataaagg cctaatgcct gcctcgtttg cagttttctg aaagccattt
      481 gtgttaataa attacgtcac aaattagttc atatttgcct gaataaattg ttttgtatga
      541 ttgataca
//
