LOCUS       NM_001399236            4935 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus photoreceptor cilium actin regulator (Pcare),
            mRNA.
ACCESSION   NM_001399236 XM_006239772
VERSION     NM_001399236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4935)
  AUTHORS   Kevany,B.M., Zhang,N., Jastrzebska,B. and Palczewski,K.
  TITLE     Animals deficient in C2Orf71, an autosomal recessive retinitis
            pigmentosa-associated locus, develop severe early-onset retinal
            degeneration
  JOURNAL   Hum Mol Genet 24 (9), 2627-2640 (2015)
   PUBMED   25616964
REFERENCE   2  (bases 1 to 4935)
  AUTHORS   Nishimura,D.Y., Baye,L.M., Perveen,R., Searby,C.C.,
            Avila-Fernandez,A., Pereiro,I., Ayuso,C., Valverde,D., Bishop,P.N.,
            Manson,F.D., Urquhart,J., Stone,E.M., Slusarski,D.C., Black,G.C.
            and Sheffield,V.C.
  TITLE     Discovery and functional analysis of a retinitis pigmentosa gene,
            C2ORF71
  JOURNAL   Am J Hum Genet 86 (5), 686-695 (2010)
   PUBMED   20398886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006239772.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF543283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3908              JAXUCZ010000006.1  29469817-29473724
            3909-4935           JAXUCZ010000006.1  29477515-29478541
FEATURES             Location/Qualifiers
     source          1..4935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..4935
                     /gene="Pcare"
                     /gene_synonym="RGD1304963"
                     /note="photoreceptor cilium actin regulator"
                     /db_xref="GeneID:313891"
                     /db_xref="RGD:1304963"
     exon            1..3908
                     /gene="Pcare"
                     /gene_synonym="RGD1304963"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..4116
                     /gene="Pcare"
                     /gene_synonym="RGD1304963"
                     /note="uncharacterized protein C2orf71 homolog"
                     /codon_start=1
                     /product="photoreceptor cilium actin regulator"
                     /protein_id="NP_001386165.1"
                     /db_xref="GeneID:313891"
                     /db_xref="RGD:1304963"
                     /translation="MGCTPSHNVIVNSVAKSGIQFFKRPKAILPGCQWGSQKCPIPLL
                     IQSSTFCDPGGELHPGARLAEETASSRKLPDMTEGLCQLPESQTFHMNKSQSRMATDI
                     SFRTEGSHRTQEVEFSGKEGKENTPRETSERGREPKCHPSDSQDHCCQTVPEPKGKVD
                     FPESLVKAHQHAYAYLHTSLSRYEAIVHLVQQASQTWELLQSMLSFLLLGFEEASQLL
                     GEISKDGEVLLREVRGDLAWPVRKGEPWEHPDLLQQLLQYTVNKLQVVHSTVAALTGS
                     FLEGSSSYLRATAGHLEGKLSTKRGIDECLLRALGQLESLTSGSSDPGLLGPPLCSED
                     SGIGADNESVHSVEKLGKQASWDFAAELGEWKPGTAAQGEARPSGHAWQKGPYWTGPD
                     RPQDCPLSGPRIAKVQPAVQDEARSSNTSSTSPEAVTSRPPEAAKSIPWDSLGTEIPV
                     QTQLSRRSSGLMGSPYLSGDEDSSPEEEDELGSTDLHPEPQKALPSRPQSSPDPRESL
                     FQPYSTKLRSPQAQEMILKMKEAISERIKFVPVPSRPQDWAEEEEGRSVVPPRPRSVS
                     GCRRAPERQRRSQSEGCLKSHVEDPTLQELRRVQTDLSKRLEVFYALGATQQGQSREQ
                     CLPPRTSLLWPPTNCRVSPSSAISKFKASLTQNFSILPNQDKSIFQRGSPCFDSDQPC
                     QGKAEKLPSAIFCGKKNSRAPGDNERDIRACPTRTSVKKLIETFSPTESPRMPRDCRN
                     LGTSPCLRKWGVPAMPPRFPIYRGLAPLYPKPQISPAVGRDPLKLGMSWRPSAPFPSL
                     PPAEASEGEDIGGEMEEDLQNLPPPPLEILMDKSFTALEHPECSLEETLLPELQEARR
                     PKRTWASPKLKASMSPMDLLPSKGNGSSPRLQGTRPGSTSNVGNSRKLTLDLNSQQTA
                     NPSPEAEGGAQIQAPPENTAGLSKHHQKAIPRHHANPTSGQSRALEPSLARFSRDPHS
                     PEASRKGPERSPPGVRKASPPRAQWASQGGRRLQSLPSTHGPSQPGLRAVLSSPSPPL
                     SPRTLSPPATRKPTSPPCQYPQSNPAPGSPPVQRTETNTPSSASSSSPSVSPSRGSKD
                     SSHSEDSEGTTNKASRGTCSVLFPATAFCEAKSSFSTSHPQTLPEPGGLLRTPAGGWR
                     GSAGPRLRADSQKRTVLNALDALPFVRRTASDRQRQQGDPLQLPSSDWESHPCQNSSS
                     SSEENAKQELPPWNNSRVPELQSSSTKWTSPLELCVLGHGLQPEARPSRSQDRSQPES
                     QPQHKEVS"
     exon            3909..4935
                     /gene="Pcare"
                     /gene_synonym="RGD1304963"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttaacctaat aagcttaaag cgtcgcttgc catccacatc tgtcacgaca tgagcaaaac
       61 acgggctcat aatccgtgag accggggccc ctccgaaccg tcccaatgct cactaacagc
      121 atcaaaactt agggcatcag gcctgtcttc ctcttcacta tggcatggac gccaagtcta
      181 ggagtttgta ccatggactt ccaatccggc ctggagctgt ccagatagac cagccagaca
      241 gcttcctgtt accaaggatt ctccaaagac tgtgaaggta ggagatggtg acaagctgaa
      301 gccatggggt gcacaccgtc acacaatgtc atcgtcaaca gcgtcgccaa gagtggcatt
      361 cagttcttta agaggcctaa agcgattttg ccaggatgtc agtggggcag ccaaaaatgc
      421 cccatccctt tgctaattca aagttccacc ttctgtgacc ctggtgggga gctgcacccg
      481 ggagcgaggc tggcagagga gacagcaagt tccaggaagc tcccggacat gactgaaggt
      541 ctttgtcagc tcccagaaag ccaaaccttc cacatgaaca aatcacaaag ccgcatggct
      601 acagacattt cgttcaggac agaaggctcc cacaggacac aagaagtaga gttttctggg
      661 aaagagggta aggaaaacac tccccgggag acctcagagc ggggcagaga gccaaagtgc
      721 catccatcag acagccagga ccattgctgc caaacagttc ctgagccaaa aggcaaagtg
      781 gacttccctg agtccctggt aaaggcccac cagcatgctt acgcctacct gcacaccagc
      841 ctttccagat atgaagcaat tgtgcacctc gtccagcaag ccagccagac ctgggagctc
      901 ttgcagtcca tgcttagctt cctgctgctg ggcttcgagg aggccagcca gcttctggga
      961 gaaatctcta aagatggaga ggtgctcctc cgggaagtta gaggggatct ggcatggccg
     1021 gtgaggaagg gtgagccctg ggaacaccca gacctccttc aacagctgct gcagtataca
     1081 gtcaacaagc tgcaggtggt gcacagcaca gtggccgccc tcacggggag cttcctggaa
     1141 ggctccagca gctacctcag agccactgcc ggccacctcg aaggtaagct gagtaccaag
     1201 agaggtatag atgaatgtct cctgagggcc ctgggacagc tagagagtct gaccagtggc
     1261 tccagtgacc cggggctgct gggtccaccc ttatgctctg aggacagtgg catcggtgct
     1321 gacaatgagt ctgtgcactc cgtggagaag ctgggcaagc aagccagctg ggactttgca
     1381 gcagaacttg gagaatggaa gccagggact gcagcccaag gggaggccag gccgtcaggg
     1441 catgcctggc agaaaggtcc atactggaca ggtccagaca gaccccagga ctgtccactg
     1501 tcaggcccca ggatagcaaa ggttcaacct gcagtgcagg atgaagcccg gagttcgaac
     1561 acttccagca ctagcccaga agcagtcacc tccaggcctc cagaggctgc caaaagcatc
     1621 ccgtgggact ctctggggac cgagatccct gtgcagacac agctttctcg acgaagctca
     1681 ggactgatgg gttctccgta cctgagtgga gatgaggaca gcagcccaga ggaggaagat
     1741 gaacttggca gcacggatct gcatcctgag ccacagaaag cccttccttc aagaccacag
     1801 tcctcaccag acccccggga gagcctgttt cagccatact ccacgaagct taggagcccc
     1861 caggcccagg aaatgattct gaagatgaaa gaggccatca gtgaaaggat caagtttgtc
     1921 cccgtgcctt ccagacccca ggactgggct gaggaggagg aagggaggtc agtggtccct
     1981 ccgagaccca gatctgtcag tggctgcagg agggcccctg agagacaaag gaggtcgcaa
     2041 tcagagggat gcctcaagag ccatgtggaa gaccccaccc tccaggagct gaggagggtc
     2101 cagacagacc tcagtaagag gctggaggta ttttatgctc tgggtgccac acagcaggga
     2161 cagagcaggg agcaatgtct gccacccagg acatcactgc tatggcctcc caccaactgc
     2221 agggtgagtc ccagtagtgc catcagcaag ttcaaggcct ctctcaccca aaacttcagc
     2281 attttgccca accaggacaa gagcatcttc caaagaggta gtccctgctt tgacagtgac
     2341 cagccttgcc aggggaaggc tgaaaagctg ccaagtgcca tcttttgtgg caagaagaac
     2401 agtagggctc ccggagacaa tgaaagggac atcagggcct gtcccaccag aacatcagtc
     2461 aagaagctta ttgaaacttt cagtcctacc gagagtccga ggatgccaag ggactgcagg
     2521 aacttgggga caagcccctg cctcaggaag tggggtgttc ctgccatgcc tcccagattt
     2581 cctatataca gggggctagc ccccctgtat cctaagcccc agatttctcc agcagtaggc
     2641 agagaccctc tcaagctggg catgagctgg aggccttctg caccctttcc ctcccttcct
     2701 ccagcggaag catctgaggg tgaagacata ggcggtgaaa tggaggaaga cctgcagaac
     2761 ctccctccac cacctctgga aatcctgatg gacaaatcgt tcactgctct ggaacatcca
     2821 gaatgtagcc tggaggagac cctgttacca gagcttcagg aggccagacg tccaaaaaga
     2881 acatgggctt cccccaagct gaaagcctcc atgagcccca tggacttgct ccccagcaag
     2941 ggcaatggca gctccccgag gctacagggc accaggcccg ggagcaccag taatgtgggc
     3001 aattccagaa agttgacctt ggaccttaac tctcagcaaa cagctaaccc aagcccagag
     3061 gcggagggtg gagctcagat tcaggcaccc ccagagaata cggcaggcct ctccaagcat
     3121 caccaaaagg caattcccag gcatcacgct aaccctacat ctgggcaaag cagggccttg
     3181 gagcccagcc tagccagatt ttcacgagat ccacactctc cagaagcgtc caggaagggt
     3241 ccagagagaa gccctccagg agtcagaaag gcctctcccc caagagctca gtgggcatcc
     3301 caaggaggca ggaggctgca gagcctgccc tccactcatg gaccgtccca gccgggcctc
     3361 cgtgctgtcc tcagctcccc cagcccaccc ctgagcccca ggacactgag cccaccggcc
     3421 acaagaaaac caacttcccc accatgccag tacccgcagt ccaacccagc cccagggagc
     3481 cctcctgtcc aaaggacaga aacaaacacc ccctcctctg cttcctcttc atccccctca
     3541 gtgtctccat ctcgagggtc caaggactca agtcactctg aggacagcga aggtaccaca
     3601 aacaaagcat ccaggggcac atgttccgta ctcttcccgg ccacagcttt ctgtgaagct
     3661 aaatcgtcat tctcaacatc ccatccacag acgctaccag aacctggggg ccttctgagg
     3721 accccagcag gaggctggag gggcagcgca gggccacgac tgagggcaga ttcacagaag
     3781 agaacagttc tgaacgccct cgacgccctg ccttttgtca gaaggacagc ttccgaccgc
     3841 cagcgccagc agggcgaccc acttcagctg cccagctcag actgggaatc ccatccctgc
     3901 caaaacagca gcagtagcag tgaggagaac gccaagcaag aactcccacc ttggaacaac
     3961 tcccgagtcc cagaattgca gagtagtagc accaagtgga cctctccttt ggagctctgt
     4021 gtgctgggcc atgggttgca gccagaagcc cggccgagcc gtagccagga cagatcccag
     4081 ccagagtcac agccccagca caaggaagtt tcgtgatggg tggccggtgg ggtcacatac
     4141 actgatgcca gtcaccctag aacacgaaaa actagagaca tgttcacact gcaccatggg
     4201 tggcaggcaa accagtccac acctcagagt tgacttggaa agacctcgaa gatgcccccg
     4261 ccaaagggtc tccaaaatct taagcaacag ttggattcac ttccagagcc tgctctgcct
     4321 tggtttaaat gttaatgaaa actttagacc ctaggatgat actctttatc tttctgagtg
     4381 ctggccttaa ttagagggat aacgtattca tgctcagagg gccatgtgtc ttacaagata
     4441 accggtggta atcatttaaa ccacaacagc ctgtgaaaca gtgtcctcca gttttacaga
     4501 gaggaaaacc aaatgtgtcg ggggtggggg aagcccaagg gtcaagctgg gggtcagaca
     4561 gatgtgaggg tacggacgta ggtggccttc tttgtgttcc attgcctttg agtgttccac
     4621 ccctgtaccc gcctgcggca tacgaataaa gagaagcctt ttcgatttaa ggttaaatgt
     4681 tatgacggtt aatgtttggt catgtctgtg agggattttc tagattgagt tcactgaggt
     4741 aggaagaccc acccccactg tcattggcac cattccacag agagtcctga actgcagaaa
     4801 gaagtcaact ggctaccagc attcactttt tcctgcttcc tgagtgggga tacgatgtaa
     4861 ccagcaacct ccaactcccg ccacaagcat cccccaaccc gtgagccaaa ataaagcctt
     4921 ccccccttaa gccga
//
