LOCUS       NM_001107834            2318 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus PBX homeobox 3 (Pbx3), mRNA.
ACCESSION   NM_001107834 XM_001078717 XM_001078726 XM_001078743 XM_001078759
            XM_231158
VERSION     NM_001107834.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Han Y, Dong B, Chen M and Yao C.
  TITLE     LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate
            myocardial infarction in a PBX3/CYP1B1-dependent manner
  JOURNAL   Mol Cell Biochem 476 (3), 1387-1400 (2021)
   PUBMED   33389498
  REMARK    GeneRIF: LncRNA H19 suppresses pyroptosis of cardiomyocytes to
            attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner.
REFERENCE   2  (bases 1 to 2318)
  AUTHORS   Wang D, You D, Pan Y and Liu P.
  TITLE     Downregulation of lncRNA-HEIH curbs esophageal squamous cell
            carcinoma progression by modulating miR-4458/PBX3
  JOURNAL   Thorac Cancer 11 (7), 1963-1971 (2020)
   PUBMED   32449803
REFERENCE   3  (bases 1 to 2318)
  AUTHORS   Arrington CB, Dowse BR, Bleyl SB and Bowles NE.
  TITLE     Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes
            are associated with congenital heart defects
  JOURNAL   Eur J Med Genet 55 (4), 235-237 (2012)
   PUBMED   22426282
REFERENCE   4  (bases 1 to 2318)
  AUTHORS   Rottkamp CA, Lobur KJ, Wladyka CL, Lucky AK and O'Gorman S.
  TITLE     Pbx3 is required for normal locomotion and dorsal horn development
  JOURNAL   Dev Biol 314 (1), 23-39 (2008)
   PUBMED   18155191
REFERENCE   5  (bases 1 to 2318)
  AUTHORS   Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC,
            Longobardi E, Mazzieri R, Miccio A, Micali N, Selleri L, Ferrari G
            and Blasi F.
  TITLE     Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major
            reduction of Pbx and Meis proteins and a pleiotropic embryonic
            phenotype
  JOURNAL   Mol Cell Biol 26 (15), 5650-5662 (2006)
   PUBMED   16847320
REFERENCE   6  (bases 1 to 2318)
  AUTHORS   Onimaru H, Arata A, Arata S, Shirasawa S and Cleary ML.
  TITLE     In vitro visualization of respiratory neuron activity in the
            newborn mouse ventral medulla
  JOURNAL   Brain Res Dev Brain Res 153 (2), 275-279 (2004)
   PUBMED   15527896
REFERENCE   7  (bases 1 to 2318)
  AUTHORS   Rhee JW, Arata A, Selleri L, Jacobs Y, Arata S, Onimaru H and
            Cleary ML.
  TITLE     Pbx3 deficiency results in central hypoventilation
  JOURNAL   Am J Pathol 165 (4), 1343-1350 (2004)
   PUBMED   15466398
REFERENCE   8  (bases 1 to 2318)
  AUTHORS   Toresson H, Parmar M and Campbell K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
REFERENCE   9  (bases 1 to 2318)
  AUTHORS   Ferretti E, Schulz H, Talarico D, Blasi F and Berthelsen J.
  TITLE     The PBX-regulating protein PREP1 is present in different
            PBX-complexed forms in mouse
  JOURNAL   Mech Dev 83 (1-2), 53-64 (1999)
   PUBMED   10381567
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_231158.4, XM_001078726.1, XM_001078759.1, XM_001078717.1,
            XM_001078743.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2318
                     /gene="Pbx3"
                     /note="PBX homeobox 3"
                     /db_xref="GeneID:311876"
                     /db_xref="RGD:1307198"
     exon            1..245
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1350
                     /gene="Pbx3"
                     /note="pre-B-cell leukemia homeobox 3; pre-B-cell leukemia
                     transcription factor 3-like"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 3"
                     /protein_id="NP_001101304.1"
                     /db_xref="GeneID:311876"
                     /db_xref="RGD:1307198"
                     /translation="MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQ
                     DIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEED
                     PPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIR
                     QIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLK
                     QSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCS
                     ITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTP
                     NSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGL
                     GANSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN"
     exon            246..319
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..561
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..752
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..888
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1054
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1167
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1257
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..2318
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgcctcc gccgccgccg cccgctcccg cccgcgcgcg gcgggatgga cgatcaatcc
       61 aggatgctgc agactctggc cggggtgaac ctggccggcc actcggtcca agggggtatg
      121 gctctgccgc ctccccctca cggccacgaa ggggcggacg gcgacggcag gaagcaggac
      181 atcggcgaca tcctccacca gatcatgacc atcaccgacc agagcttgga cgaggcgcaa
      241 gcaaagaaac atgctctgaa ctgtcacaga atgaaaccgg cgctcttcag cgtcttgtgt
      301 gagatcaaag agaaaacagg tctcagcatc agaggagccc aggaggaaga ccctcccgac
      361 ccccagctaa tgagactgga caatatgctt ttggcagaag gggtttcagg tcctgagaaa
      421 ggtgggggat cggcggcagc agctgcagcc gcggcagcct ctggaggttc ttcagataac
      481 tctattgaac actcagatta cagagccaaa ttgacccaga tcagacaaat ctatcacaca
      541 gaactggaga aatatgaaca ggcatgtaat gaattcacaa cacacgtgat gaaccttctc
      601 cgagaacaga gtagaacgcg tcccatttcc ccgaaagaga tcgaaaggat ggtgggcatc
      661 atccacagga agtttagctc catccaaatg cagctcaagc agagcacgtg tgaagcagtc
      721 atgattttaa gatcaaggtt ccttgatgcc agacggaaaa ggcgtaactt cagtaaacag
      781 gctacagaaa tcttgaatga atatttttac tcacacctca gcaaccccta ccccagtgaa
      841 gaagccaaag aggagctggc caagaaatgc agcatcacag tatcacaggt atccaactgg
      901 tttggcaaca aacgaatcag gtacaagaag aacatcggca aatttcaaga ggaggccaat
      961 ctctatgctg caaaaacagc cgtgacagcc gcacacgcag tggccgcagc cgtgcagaac
     1021 aaccagacca actcacccac cacgccaaac tctggttctt ctggttcttt taacctccca
     1081 aattctgggg acatgttcat gaacatgcag agtctgaatg gggattctta ccaagggtcc
     1141 caagtcggag ccaatgtgca gtcacaggtg gataccctcc gtcatgttat caatcagacg
     1201 ggaggctaca gtgacggcct tggagcaaac tcactgtaca gtccgcataa cttaaacgct
     1261 aatggaggct ggcaggacgc aacaactcca tcttctgtga cttctcctac ggaaggcccg
     1321 ggcagcgtgc actcggatac ctctaactaa tcctggcctc tcccagctgt catgccttga
     1381 caagcgcatt cggagcaata ggaggaggag ggaagcgttt tgtaacccac cacctacagc
     1441 tttactgtaa accctgtctt cttagagaac tcgggaaacc tgttttttaa ggaatcataa
     1501 ccatttgtat ttaaacttaa gacacacgtt taaaggaaag cactttatcc gattaggccg
     1561 agacgtaaca ttgttgacag ttcttaactg tctcatccta atttattatt acattttaca
     1621 gtaatggttc cacagttgcc agttccttgg ccttaagggt aagaagtacc atctatgcta
     1681 gaccccaatt atagagcagg caaggttcac cctgcctacg ctgagccctg gcggatttcc
     1741 atgcaggctc tcatcgttct cacgtcacgg atgggcttgg agggaaggcg atgtctgcct
     1801 gtcttcttaa ggaaggcatt tcagaacttc cctcgccatg tttgtgttgc catctcttat
     1861 gttgtaatta ggtcaaagac tggtggcctc ctttctccct ctgaagtacc agagcccgga
     1921 gtctgcgcta atgagaccat ggatccagat tgccctgaga tgaagatctt gctgctacag
     1981 aggtgaaaac aagacctgtc tggggtttga ccgtgtgcgc tgggtgctgc acagacttgt
     2041 caaggtgtgc tcttcctctg ggcagcctgg aaaggccctg ctctctggag tgctgtatat
     2101 agtgtagcaa aagagtattt atacatccca ccaatcaaaa cacagcttta ttacctcatg
     2161 cgaactcata caaaccaata gaatcccaac atgttctgta gcttagagcg ctcacttact
     2221 acctctgaac aatactcacg ctgtagttcg tctctttctt atctttttgc atcttgtaat
     2281 taactctttg tttcccttca caaaatgtaa tgtacatt
//
