LOCUS       NM_001002828            2858 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PBX homeobox 2 (Pbx2), mRNA.
ACCESSION   NM_001002828 XM_579091
VERSION     NM_001002828.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Qiu,Y., Morii,E., Tomita,Y., Zhang,B., Matsumura,A., Kitaichi,M.,
            Okumura,M. and Aozasa,K.
  TITLE     Prognostic significance of pre B cell leukemia transcription factor
            2 (PBX2) expression in non-small cell lung carcinoma
  JOURNAL   Cancer Sci 100 (7), 1198-1209 (2009)
   PUBMED   19356220
REFERENCE   2  (bases 1 to 2858)
  AUTHORS   Ota,T., Asahina,H., Park,S.H., Huang,Q., Minegishi,T., Auersperg,N.
            and Leung,P.C.
  TITLE     HOX cofactors expression and regulation in the human ovary
  JOURNAL   Reprod Biol Endocrinol 6, 49 (2008)
   PUBMED   18973687
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2858)
  AUTHORS   Capellini,T.D., Di Giacomo,G., Salsi,V., Brendolan,A., Ferretti,E.,
            Srivastava,D., Zappavigna,V. and Selleri,L.
  TITLE     Pbx1/Pbx2 requirement for distal limb patterning is mediated by the
            hierarchical control of Hox gene spatial distribution and Shh
            expression
  JOURNAL   Development 133 (11), 2263-2273 (2006)
   PUBMED   16672333
REFERENCE   4  (bases 1 to 2858)
  AUTHORS   Selleri,L., DiMartino,J., van Deursen,J., Brendolan,A., Sanyal,M.,
            Boon,E., Capellini,T., Smith,K.S., Rhee,J., Popperl,H., Grosveld,G.
            and Cleary,M.L.
  TITLE     The TALE homeodomain protein Pbx2 is not essential for development
            and long-term survival
  JOURNAL   Mol Cell Biol 24 (12), 5324-5331 (2004)
   PUBMED   15169896
REFERENCE   5  (bases 1 to 2858)
  AUTHORS   Villaescusa,J.C., Verrotti,A.C., Ferretti,E., Farookhi,R. and
            Blasi,F.
  TITLE     Expression of Hox cofactor genes during mouse ovarian follicular
            development and oocyte maturation
  JOURNAL   Gene 330, 1-7 (2004)
   PUBMED   15087118
REFERENCE   6  (bases 1 to 2858)
  AUTHORS   Brake,R.L., Kees,U.R. and Watt,P.M.
  TITLE     A complex containing PBX2 contributes to activation of the
            proto-oncogene HOX11
  JOURNAL   Biochem Biophys Res Commun 294 (1), 23-34 (2002)
   PUBMED   12054735
REFERENCE   7  (bases 1 to 2858)
  AUTHORS   Toresson,H., Parmar,M. and Campbell,K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
REFERENCE   8  (bases 1 to 2858)
  AUTHORS   Ferretti,E., Schulz,H., Talarico,D., Blasi,F. and Berthelsen,J.
  TITLE     The PBX-regulating protein PREP1 is present in different
            PBX-complexed forms in mouse
  JOURNAL   Mech Dev 83 (1-2), 53-64 (1999)
   PUBMED   10381567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883044.1.
            
            On Sep 22, 2009 this sequence version replaced NM_001002828.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               BX883044.1         205293-205597
            306-379             BX883044.1         206371-206444
            380-627             BX883044.1         206647-206894
            628-818             BX883044.1         207030-207220
            819-954             BX883044.1         207346-207481
            955-1108            BX883044.1         207566-207719
            1109-1197           BX883044.1         208018-208106
            1198-1284           BX883044.1         208438-208524
            1285-2858           BX883044.1         208645-210218
FEATURES             Location/Qualifiers
     source          1..2858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2858
                     /gene="Pbx2"
                     /note="PBX homeobox 2"
                     /db_xref="GeneID:406164"
                     /db_xref="RGD:1303084"
     exon            1..305
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1377
                     /gene="Pbx2"
                     /note="pre-B-cell leukemia homeobox 2"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 2"
                     /protein_id="NP_001002828.1"
                     /db_xref="GeneID:406164"
                     /db_xref="RGD:1303084"
                     /translation="MDERLLGPPPPGGGRGGLGLVGGEPGGPGEPPGGGDPGGGSGGV
                     PGGRGKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSI
                     RSSQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSD
                     YRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRK
                     FSAIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEA
                     KEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVAQGGHSRTSS
                     PTPPSSAGSGGSFNLSGSGDMFLGMPGLNGDSYPASQVESLRHSMGPASYGDNIGGGQ
                     IYSPREMRANGGWQEAVTPSSVTSPTEGPGSVHSDTSN"
     exon            306..379
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..627
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..818
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..954
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1108
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1197
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1284
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..2858
                     /gene="Pbx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggcccca gcgagtttgg gggggaagtc acccggcggg gggaggggcg agcagggagg
       61 gggcctcagg gccccccccc agctatggac gagcggctgc tggggccgcc ccctccgggc
      121 gggggccgtg ggggtctggg gctggtaggt ggggagcccg ggggccctgg cgagcctccc
      181 ggtggcggag accccggtgg ggggagtggg ggggtcccgg gaggccgagg gaagcaagac
      241 atcggggaca ttctgcaaca gataatgacc atcaccgacc agagcctgga cgaggcccag
      301 gccaagaaac acgccctaaa ctgtcaccga atgaagcctg ccctgtttag tgtcctgtgt
      361 gaaatcaagg agaaaactgg ccttagcatt cgcagctccc aagaggagga gccagtggac
      421 ccacagctga tgcgcctgga caacatgctt ctggcagaag gtgtggctgg acccgagaag
      481 gggggcggct ctgcagcggc agctgcagcc gcggcagcct ccggaggtgg cgtgtccccg
      541 gataactcca tcgaacactc ggactatcga agcaagcttg cccaaatccg ccacatctac
      601 cactcagaac tggagaagta tgagcaggca tgcaatgaat tcacaactca tgtcatgaac
      661 ctgctgaggg agcagagccg cactcgtcct gtggccccca aggagatgga gcgcatggtg
      721 agcattatcc accggaagtt cagcgccatc cagatgcagc tgaagcagag cacctgtgag
      781 gccgtcatga tcctgcgctc tcgattcctg gatgccaggc gaaaacgccg gaacttcagc
      841 aaacaggcca ctgaggtcct gaatgaatat ttctactccc acctgagtaa cccctaccct
      901 agtgaggaag ccaaagagga gctcgccaag aagtgcggca tcaccgtctc tcaggtttcc
      961 aactggtttg gtaacaagcg gatccgctat aagaaaaaca tcgggaagtt ccaagaggag
     1021 gcaaatatct atgctgtgaa gacagccgtg tccgtcgccc agggcggcca cagccgcacc
     1081 agctctccaa cgcccccttc ctctgcaggc tctggcggct ctttcaatct ctcaggatcc
     1141 ggagacatgt ttctggggat gcccgggctc aatggagatt cctaccctgc ttcccaggtg
     1201 gaatctctcc gacactcgat ggggccagcg agctatgggg ataacatcgg gggaggccag
     1261 atatatagtc ctcgagaaat gcgggccaat ggtggctggc aggaggctgt gaccccgtcc
     1321 tcggtgacat ccccgacaga gggaccagga agtgttcact ctgacacctc caactgacct
     1381 tgcccctcaa ggtcacaggg ttgggggctc ccaccaggca actcttgagg aggactctgg
     1441 gcacctagag gactaacccc acagaagcac aaaacagggc gattggggtt gtgccctccc
     1501 caactagaca ctcggtgctg gggtgctgac tacatggcag ggagagtggg gtgtctccgt
     1561 ttcttttctc cccctccacg aaaaacagat acttatttct cagatatctc tcttaaatct
     1621 acaacgtaat gccaattgtg tttggcttgg gctcccccta cttctattcc ccaccccact
     1681 tgtatactct ggaatctgaa gacgtcagcc ctgcccgacc cagagatgcc aaaaatgggg
     1741 actcttggac agaggccctg ggacgacacc ccctccccca tgcatcccca ccttctgccc
     1801 ctccagacgg ctttattacc tcatacgcag ctcatcttaa accaatagaa tcgctcggtg
     1861 gacaagagtg tctgactcag atatctacct cggagggact ttctgctact ttagagaatt
     1921 gttgaccagg ttttgaagtt ggactttttt ttttttttag aaaagaaacc ctgaatctgt
     1981 attttttttt tttgtttgtt ttgtttttgt ttttgttggt agtggtgatc attaattttt
     2041 taatagtttg aagaagtagg gtttggggtg tgtatgtggg tgtgtgtgtg tatgttttaa
     2101 ataaacatgc tgatttattt ttgtttaccc actcgagaag taagcgccaa aggggcctag
     2161 taagagaaca gacagcgctg gtggtggcta tttgctccag gcctaccagt ggggaagtgg
     2221 attttgcggg acaccgtgtc ctcagcctgg acacttaggt gtttcttagc ttgtgcagcc
     2281 aaatccctgc tgtatctgat gtggatcacg atgcagctgt agcctcctgt ctccccccac
     2341 acctccccag taacctttgg gcaaggctgg actgaactca gtgatttttg aaaaagtcaa
     2401 aaagctttcg gttttgtttt ttaaactgtt tgcagaatgg agaagatcga tcaggaaggg
     2461 gagttcttgc caaatacgct aaatacgggc tgggtgcttc tctacgtgtc tccgccagtt
     2521 tcccagaaat aagtctttct attcagttct taatctcatg ccaaaatcaa gggggtgggg
     2581 agaggaggga ggtcatgcaa agccaggtat gagggaagat taaaagtgtc tcatctcagc
     2641 ccggaaccct tctatctgac ccttcagaca tcctcaggat cttccagacc tgtcacagtg
     2701 ggaacccctc ccatcagtgg cccaggcggg ccggagggag tgtgtggaga gggcggtggg
     2761 agggtgccag gggcagtttc tctcctcact tgtaaacttg tagattcaca aaaaaagaaa
     2821 tggcagtttt aaataaagag atttcttttt cccctggg
//
