LOCUS       NM_001134862            6793 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus PBX homeobox 1 (Pbx1), transcript variant 1,
            mRNA.
ACCESSION   NM_001134862 XM_222911
VERSION     NM_001134862.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6793)
  AUTHORS   Jia,D., Han,J., Cai,J., Huan,Z., Wang,Y. and Ge,X.
  TITLE     Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic
            shock-induced kidney damage by inhibiting NF-kappaB activation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119571 (2024)
   PUBMED   37673222
  REMARK    GeneRIF: Mesenchymal stem cells overexpressing PBX1 alleviates
            haemorrhagic shock-induced kidney damage by inhibiting NF-kappaB
            activation.
REFERENCE   2  (bases 1 to 6793)
  AUTHORS   Alankarage,D., Szot,J.O., Pachter,N., Slavotinek,A., Selleri,L.,
            Shieh,J.T., Winlaw,D., Giannoulatou,E., Chapman,G. and
            Dunwoodie,S.L.
  TITLE     Functional characterization of a novel PBX1 de novo missense
            variant identified in a patient with syndromic congenital heart
            disease
  JOURNAL   Hum Mol Genet 29 (7), 1068-1082 (2020)
   PUBMED   31625560
REFERENCE   3  (bases 1 to 6793)
  AUTHORS   Slavotinek,A., Risolino,M., Losa,M., Cho,M.T., Monaghan,K.G.,
            Schneidman-Duhovny,D., Parisotto,S., Herkert,J.C., Stegmann,A.P.A.,
            Miller,K., Shur,N., Chui,J., Muller,E., DeBrosse,S., Szot,J.O.,
            Chapman,G., Pachter,N.S., Winlaw,D.S., Mendelsohn,B.A., Dalton,J.,
            Sarafoglou,K., Karachunski,P.I., Lewis,J.M., Pedro,H.,
            Dunwoodie,S.L., Selleri,L. and Shieh,J.
  TITLE     De novo, deleterious sequence variants that alter the
            transcriptional activity of the homeoprotein PBX1 are associated
            with intellectual disability and pleiotropic developmental defects
  JOURNAL   Hum Mol Genet 26 (24), 4849-4860 (2017)
   PUBMED   29036646
REFERENCE   4  (bases 1 to 6793)
  AUTHORS   Wang,J., Qu,D., An,J., Yuan,G. and Liu,Y.
  TITLE     Integrated microarray analysis provided novel insights to the
            pathogenesis of glaucoma
  JOURNAL   Mol Med Rep 16 (6), 8735-8746 (2017)
   PUBMED   28990066
REFERENCE   5  (bases 1 to 6793)
  AUTHORS   Le Tanno,P., Breton,J., Bidart,M., Satre,V., Harbuz,R., Ray,P.F.,
            Bosson,C., Dieterich,K., Jaillard,S., Odent,S., Poke,G., Beddow,R.,
            Digilio,M.C., Novelli,A., Bernardini,L., Pisanti,M.A.,
            Mackenroth,L., Hackmann,K., Vogel,I., Christensen,R., Fokstuen,S.,
            Bena,F., Amblard,F., Devillard,F., Vieville,G., Apostolou,A.,
            Jouk,P.S., Guebre-Egziabher,F., Sartelet,H. and Coutton,C.
  TITLE     PBX1 haploinsufficiency leads to syndromic congenital anomalies of
            the kidney and urinary tract (CAKUT) in humans
  JOURNAL   J Med Genet 54 (7), 502-510 (2017)
   PUBMED   28270404
REFERENCE   6  (bases 1 to 6793)
  AUTHORS   Ferretti,E., Schulz,H., Talarico,D., Blasi,F. and Berthelsen,J.
  TITLE     The PBX-regulating protein PREP1 is present in different
            PBX-complexed forms in mouse
  JOURNAL   Mech Dev 83 (1-2), 53-64 (1999)
   PUBMED   10381567
REFERENCE   7  (bases 1 to 6793)
  AUTHORS   Piper,D.E., Batchelor,A.H., Chang,C.P., Cleary,M.L. and
            Wolberger,C.
  TITLE     Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the
            hexapeptide and a fourth homeodomain helix in complex formation
  JOURNAL   Cell 96 (4), 587-597 (1999)
   PUBMED   10052460
REFERENCE   8  (bases 1 to 6793)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   9  (bases 1 to 6793)
  AUTHORS   Chang,C.P., Jacobs,Y., Nakamura,T., Jenkins,N.A., Copeland,N.G. and
            Cleary,M.L.
  TITLE     Meis proteins are major in vivo DNA binding partners for wild-type
            but not chimeric Pbx proteins
  JOURNAL   Mol Cell Biol 17 (10), 5679-5687 (1997)
   PUBMED   9315626
REFERENCE   10 (bases 1 to 6793)
  AUTHORS   Shen,W.F., Rozenfeld,S., Lawrence,H.J. and Largman,C.
  TITLE     The Abd-B-like Hox homeodomain proteins can be subdivided by the
            ability to form complexes with Pbx1a on a novel DNA target
  JOURNAL   J Biol Chem 272 (13), 8198-8206 (1997)
   PUBMED   9079637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1, FN805837.1 and BC098847.1.
            
            On Aug 5, 2017 this sequence version replaced NM_001134862.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.45138.1,
                                           SRR26643296.32137.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000013.1  83120738-83121046   c
            310-1041            FN805837.1         1-732
            1042-1095           JAXUCZ010000013.1  82896758-82896811   c
            1096-1231           JAXUCZ010000013.1  82888476-82888611   c
            1232-1391           JAXUCZ010000013.1  82884106-82884265   c
            1392-1504           JAXUCZ010000013.1  82877772-82877884   c
            1505-1594           JAXUCZ010000013.1  82876364-82876453   c
            1595-5528           JAXUCZ010000013.1  82846192-82850125   c
            5529-6793           BC098847.1         1-1265
FEATURES             Location/Qualifiers
     source          1..6793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..6793
                     /gene="Pbx1"
                     /note="PBX homeobox 1"
                     /db_xref="GeneID:304947"
                     /db_xref="RGD:1308213"
     exon            1..585
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1687
                     /gene="Pbx1"
                     /note="isoform a is encoded by transcript variant 1;
                     pre-B-cell leukemia transcription factor 1; pre-B-cell
                     leukemia homeobox 1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform a"
                     /protein_id="NP_001128334.1"
                     /db_xref="GeneID:304947"
                     /db_xref="RGD:1308213"
                     /translation="MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIG
                     DILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTD
                     PQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQI
                     YHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQS
                     TCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGIT
                     VSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGS
                     SSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQ
                     MYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN"
     exon            586..659
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..904
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1095
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1231
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1391
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1504
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1594
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..6768
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcccatt tctgccttgc acaggagatc ggactgaaaa acccaaaggc agctctgatt
       61 tcttttcgcc aagtgggaag gtggtttatt tttcttgctt ttttggagtc aacacccttc
      121 cccaccagcc cttatcccca ccctcacccc gcaacccctt cacgccccct ccccctcccc
      181 atcctcccac catcctctaa agaggcaaag agattttttt tttccctttt ggtcttcttc
      241 ttcttcttct tcttcttttt ttttttaaac cctggtccct gtttatcctg aaaaggattt
      301 gaagacagct tgaaggataa aaagcctcgg tgcttcccag gcgccgagcc gaggagccga
      361 agaggaagag ccggggctgc cggagccttc agagatggac gagcagccga ggctgatgca
      421 ttcccacgct ggggtcggga tggccggaca ccccggcctg tcccagcact tgcaggatgg
      481 ggccggaggg accgaggggg agggcgggag gaagcaggac atcggggaca ttttacagca
      541 aattatgacc atcacagacc agagtttgga tgaagcgcag gccagaaaac atgctttaaa
      601 ctgccacaga atgaagcctg ccttgtttaa tgtgttgtgt gaaatcaaag aaaaaacagt
      661 tttgagtatt cggggagccc aagaagagga gcccacagac ccccagctca tgcgactgga
      721 caacatgctg ctagcagaag gggtggcggg gcctgagaag ggcggaggct cggcagcggc
      781 agcggcagca gcggcagctt ctgggggtgc aggttcagac aactcagtgg agcattccga
      841 ttacagagcc aaactctcac agatcagaca aatctaccac acagagctgg agaagtatga
      901 acaggcatgc aatgaattca ccacccacgt gatgaacctc cttcgggagc aaagccggac
      961 cagacccatc tctccgaagg agatcgagcg gatggtcagc attattcacc gcaagttcag
     1021 ctccatccag atgcagctga agcaaagcac gtgcgaggca gtcatgatcc tgcgctcccg
     1081 gtttctggat gcgaggcgga agagacggaa tttcaacaag caagccacag aaattctgaa
     1141 tgaatatttc tattcccatc tcagcaaccc ttaccccagt gaggaagcca aagaggagtt
     1201 agccaagaag tgcggcatca cagtctccca ggtatcaaac tggtttggaa ataagcgaat
     1261 ccggtacaag aagaacatag gtaaatttca agaggaagcc aatatttatg ctgccaaaac
     1321 ggctgtcact gccaccaatg tgtcagccca tggaagccaa gctaactcgc cctccactcc
     1381 caactcagcg ggttcttcca gttcttttaa catgtcaaac tctggagatt tgttcatgag
     1441 cgtgcagtca ctcaatgggg attcttacca aggggcccag gttggagcca acgtgcaatc
     1501 acaggtggat acccttcgcc atgttatcag ccagacagga ggatacagtg acggactcgc
     1561 agccagtcag atgtacagtc cgcagggcat cagtgctaat ggaggttggc aggatgctac
     1621 taccccttca tcagtgacct cccctacaga aggccctggc agtgttcact ctgatacctc
     1681 caactgatct cccagcaatc gcatcccggc tgaccctgtg ccgcagttgg ggcaggggca
     1741 ggagggaggg tttctctccc aacgctgaag cggtcagact ggaggtcgaa gcaatcagca
     1801 aacacaataa gagtctcctt ctcttctctt ctttgggatg ctatttcagc caatctggac
     1861 acttctttat actctcttcc ctttttttct gggtagaagc cacccttccc tgcctccagc
     1921 tatcagactg gttctgtcat cttccctggc ccccgctctc tgttatagac tccctggttc
     1981 ctgccttcta ttatttcact gaaggatttt ttccccccac aattagagaa atttaaaaag
     2041 gaaagacaaa ttacaaagaa acaataaacg cgtttgtatg ttttcatgct ggtggtttga
     2101 ggagccaaat ttacctcacg aggagccctc atccctacat tgacaggcaa tccttctgtt
     2161 tcccttgtta ctcttactac ctcttagcag gaatacacca cactgcccta ctcattccag
     2221 gccaccctat ctccatttcc cccttctttc tgggaacaat cctgatttct tcctctcctt
     2281 tctggcccca ggtgtttgct agggactgcc atacctgggc ttctaaaggt gccacatgtc
     2341 ccagtgtagc tccatcaggt tgagtcctag gcaggaagtc tagcagcgga ggacacaagg
     2401 aatggcaaag gcaggactcc taccagcttt ctcatcctct tagaaacagt tcttggtctc
     2461 agaggcacag tctatggtga ccattcgacc attcaatttg cagaacctca ggcaagccag
     2521 gtctaagaga ggcgtcctga tgaggctgtt tataaagagt gaaggatctc atcctgaaag
     2581 gcttcactgt cccttcatag acatgtgcac acatacacaa catacaggtg gacacatgca
     2641 caacctcaca gctttgcttc gcaggatgct actaaccttt catcagtgac ctcccctgta
     2701 gaaggccctg gcagtgttta ctgatacctc ccaaatggtc tcccaacaat caagtcctat
     2761 acagacttac actagtgatc atagtactct atctggtgag cccgagagag aagcggtatg
     2821 tggctggggc ttttaggacc cactaacatg tacttactac agtcagatgt acaggacttg
     2881 gttaacatgc aggtcaggat tcaagtgtaa accgtcttca ttcctaccac ctctgcagct
     2941 ctcagggagc cacacacagg acttccaatg tctatgacag atttgaacgc tttgtttgtg
     3001 tttttattat gttatctttc caaaatatta tagtcaacca tggtcttgat tctggctttc
     3061 cctccagaga agagaacggt ataggtatac ggttaacttt tactaattac ttggaagaca
     3121 ttgaatcata gagtaagggt gatgaatttt tttttttttt gttgtcgttg aaataatcac
     3181 ggtgatctat ctatatgcca agggattgac agaaaatata agttgctaga aaggtagtct
     3241 tgcttttgat atgaacttaa attctccaga tgagtctgcc agccataaag atggcagctt
     3301 taccagtagg ttaagtgaca agtggccaga tatctttgga gcctcatgca cttcctctgt
     3361 aaaatgggaa ttggtatact tggctcacca aggggcttgt aagacacccc ccccaaaaaa
     3421 gctggttttg tttatattta atctccaggt ctgatggtca ggaaaagcaa tgtctctatg
     3481 ccaaacattt catgctaagt cagaacgata catggttttc ttcttctaat ctctgcttgt
     3541 tatccagacc ttggtgccat cgtagtaatg acagagtgct gtgtcagagg ctttctgctc
     3601 tgatttggtt ttgctccatt tgtcttctta ggatagagag gagattcaaa gctagaggag
     3661 tagaacctgg ttttattagt ttcaacttga atccagttat gaggctctgc aagtccttgt
     3721 ccctatcaca actcttctgc ttcagggact cccaggaaga agtacaagag cttgagggct
     3781 gagagacaag cccacagcac cacacacatt ccacaatact acagtgataa atgggaaaca
     3841 cgcttcatgt gtgttcggag gagtcaggct tgtatactgg aaacctgagg ggaccgagta
     3901 tttgaagata atgcagaaca gaattatttg gcaaatgaaa atttgtctag ctgacccgtt
     3961 actagaaaga ctgtcatcaa acctgagcca tgcatagatc tttgtccttg tggcaagaat
     4021 atattgaaac cattaacaga agcatggctg gatcacatca tgtaacatgg agcaaattgt
     4081 aagaattgct gaagggctct cttgaaaaca agaatgaccc cagctgtgga ttgaacacat
     4141 gaagggacat gagtggatcg tgctgcaata gtaccatcct caaagcttgc ttctctccag
     4201 gcagtagctg cacagagaga cccacccagc acttgattag gccgccttta gctccaacac
     4261 atagccagtg gtctgacatc catgctcact gctgcctcca acatggcagc caccagatct
     4321 ctgttgtcaa gcaaggctag ggaaaactgg cagtccccag atagaattgg aatgagtgtg
     4381 gcctttagaa actcagctcc ccaggatttc agatcaggtc aatgctatag actccccatt
     4441 taaaaaacaa actgtgtccc agaatttctt cgtattctct aagtacgagt gtgagtgctc
     4501 tgtttccaac agcagcaatt ccctcctgag aaatggcgtt gccgtgtata ccttggttta
     4561 ccatcacctc ttcctgctgg agtagaatgg acttctgggt agctgttaag cccacagaca
     4621 ccttctctcc atttcctccc ctgtggtagt agtacttaat tattaatatt attattttta
     4681 tttcggttgc tttttcctca cacttatctt cgcttctttc ttcctcctct ttattttttt
     4741 ctgcccagaa aaacctgact tcgataccaa aaaaagataa aactacagaa actcaaatta
     4801 aaaaaaaaaa atcttaggaa aaaaagaatg caaaaaaaaa aaaaaaaact caacaattct
     4861 ttcagcttta ttaacatttt tccattgttt cttgcgactt gtgtctcgtt ctttgtagta
     4921 ttgatgatga acatttgata atgaatgttc ttgtatattc agataaagaa aaaaaaccaa
     4981 aaaagcggtc tgaatttaat agtgtttata ataaaaaaaa gttttaaaaa tgaccctcat
     5041 agcacgcaaa acaggaaggg gaagcgtccc ttctctctgt aacaatacac atcattcctg
     5101 caaatgtttt ttaacaccga actacctatg ttcctcattt ctcccgtttt tcttttttat
     5161 tttctcgcat ttgtgaatta gttcaagaat gctagaaaag tgtcaaggtg tgtacatcca
     5221 tttcttcttt catgatgttt aaaagtgacc gtaattcatt ttgtaaacta aaaaaggaaa
     5281 aaaaaaagga aaaaaaaaag aaaaaaagga aaaaaaaagg ttggaatagt gaacataata
     5341 ggttcaacct aacacattat gtttattaat tttgacccag aaatgaattc ttctctttat
     5401 tcctgctctt aaaaatacag aaaaagaaag ttttgttttg tcttcttttt ggttttgttt
     5461 atttgagggg ggggtgctcc ttttccgctg ttgggtttat gggtcttact aggtttgttc
     5521 cttacatatg tgtacagggt gatgtgaaaa gagacagcta ggagagaagg ctgcttctcc
     5581 cctctgcttt gctgcagtca atgtcaaaac caacgataaa gcccacggcc acatgcccct
     5641 gctctcttgc atgccagggt gtgtggcact ctgcagtccc cgagataatg aggcagggac
     5701 ttccttcctt aaatactcac cgagtctgtc caggggattt cttacattga aaacaaaagc
     5761 gcttgttgat tctgaatgtc ccaatcaagg gctttctttc tccctgacta acatcaacag
     5821 tccacaggaa gctcccaaca aggtgggatc tctctccagg tagaactcta caggcagtac
     5881 tgccatggaa gccgatgtta cccagtacag tagatccgtg aagcccaccc tgggcccatc
     5941 ttcttgggat ccagattccc acattctgga cgcagtgtgg atgaagttag gagccagggt
     6001 cacggctggg atttgaatac taagaagctg tcttttaatc tgggtgcact tgtcgctcac
     6061 ctctggtgag gttaactcta aaatgccagg tgggcttcac cagaacgttt gtcacggtct
     6121 tagggaaaaa gaaggccatg tggttggaca gacactcagt ttcagacatt gctcatgcag
     6181 acactcaagt gttcagaaag cagacagaat tcccgccaga tgcatgaaga agggaagcca
     6241 cagtcccggg tctctgctgt aggaagcatt ccacctagag acagtttagc tcttgtttct
     6301 atgtcctggg agatgaaagg cagccttttc acgtcacctc tgtgctctcc agcctagctc
     6361 aaagctttct ggaaactttt attttatttt tttttgtaaa ctttttcttt ccctttcatt
     6421 aaaataaaat atcgaatgtt ttccctcttt cttcttccct ctggggggtt tcattttgaa
     6481 gtgtgttcct ttggttgttg gttttattcc cccccccccc gcattttctt ttcttttctt
     6541 ttttctttat tattgagagt ataaacctgc aaagctcggt tctactttgg ttttgaaagt
     6601 ttaagctttt tctgcttctg tgcgagcaca ggcctctgtc ccctttgatt ccagctgaac
     6661 tttttgtgtt ctctaatgat actaacacga tgtaggtttt acagtctcct aatttgtact
     6721 ggtaatgcag attccaaata aatagtttct tttgttgcaa aaaatataaa aaaaaaaaaa
     6781 aaaaaaaaaa aaa
//
