LOCUS       NM_019125                776 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus probasin (Pbsn), mRNA.
ACCESSION   NM_019125
VERSION     NM_019125.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Zhang,J., Gao,N., Kasper,S., Reid,K., Nelson,C. and Matusik,R.J.
  TITLE     An androgen-dependent upstream enhancer is essential for high
            levels of probasin gene expression
  JOURNAL   Endocrinology 145 (1), 134-148 (2004)
   PUBMED   14500578
  REMARK    GeneRIF: the -705/+28 PB promoter contains a second androgen
            response region, PB enhancer element (-705/-426 PB), in addition to
            the first
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Asamoto,M., Hokaiwado,N., Cho,Y.M. and Shirai,T.
  TITLE     Effects of genetic background on prostate and taste bud
            carcinogenesis due to SV40 T antigen expression under probasin gene
            promoter control
  JOURNAL   Carcinogenesis 23 (3), 463-467 (2002)
   PUBMED   11895861
  REMARK    GeneRIF: effects of genetic background on prostate and taste bud
            carcinogenesis due to SV40 T antigen expression under probasin gene
            promoter control
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Kasper,S. and Matusik,R.J.
  TITLE     Rat probasin: structure and function of an outlier lipocalin
  JOURNAL   Biochim Biophys Acta 1482 (1-2), 249-258 (2000)
   PUBMED   11058766
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Spence,A.M., Sheppard,P.C., Davie,J.R., Matuo,Y., Nishi,N.,
            McKeehan,W.L., Dodd,J.G. and Matusik,R.J.
  TITLE     Regulation of a bifunctional mRNA results in synthesis of secreted
            and nuclear probasin
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7843-7847 (1989)
   PUBMED   2682630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M27156.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M27156.1, BC062035.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..776
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /note="probasin"
                     /db_xref="GeneID:54193"
                     /db_xref="RGD:708571"
     exon            1..121
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..574
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /note="M-40"
                     /codon_start=1
                     /product="probasin precursor"
                     /protein_id="NP_061998.1"
                     /db_xref="GeneID:54193"
                     /db_xref="RGD:708571"
                     /translation="MRVILLLLTLDVLGVSSMMTDKNLKKKIEGNWRTVYLAASSVEK
                     INEGSPLRTYFRRIECGKRCNRINLYFYIKKGAKCQQFKIVGRRSQDVYYAKYEGSTA
                     FMLKTVNEKILLFDYFNRNRRNDVTRVAGVLAKGRQLTKDEMTEYMNFVEEMGIEDEN
                     VQRVMDTDTCPNKIRIR"
     exon            122..261
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /inference="alignment:Splign:2.1.0"
     exon            262..329
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /inference="alignment:Splign:2.1.0"
     exon            330..440
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /inference="alignment:Splign:2.1.0"
     exon            441..542
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /inference="alignment:Splign:2.1.0"
     exon            543..570
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /inference="alignment:Splign:2.1.0"
     exon            571..776
                     /gene="Pbsn"
                     /gene_synonym="PB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgtcagtg aggtccagat acctacagag ctcacacacg atgagggtca tcctcctcct
       61 gctcacactg gatgtgctag gtgtctccag tatgatgaca gacaagaatc tcaaaaagaa
      121 gattgaaggg aattggagaa ccgtttactt agctgccagt agcgtggaga agataaatga
      181 aggctcacca ttgaggacct acttccgtcg cattgagtgt gggaagagat gcaaccgaat
      241 caatctctac ttttatatta agaaaggggc caagtgccaa cagtttaaaa tcgtgggaag
      301 gagatcccaa gacgtttact atgcaaagta tgaagggagc acggcattca tgttaaagac
      361 agtgaatgag aagatattgc tgtttgatta ttttaacaga aacagaagaa atgacgttac
      421 acgagtggct ggagttttgg cgaaaggcag gcaactgact aaggatgaga tgacagaata
      481 catgaacttc gtggaagaaa tgggcattga ggatgagaat gtacaacgtg tcatggacac
      541 agacacctgt ccaaacaaga tcagaattag atgacatcag gaattttcca ctatattctt
      601 cctggaacct gaaacatcaa tatgaagatg aagcaatctt ttctttcaga tcatatcttc
      661 ctatttgctg caaattacaa ttcttgtctc catactttct ctttcattca tactttccca
      721 tgttctaatt ggtattagta catctttgaa tgtttaaata aatctatttc acttgc
//
