LOCUS       NM_001079937            1839 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus PDZ binding kinase (Pbk), mRNA.
ACCESSION   NM_001079937 XM_001066776 XM_224300
VERSION     NM_001079937.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1839)
  AUTHORS   Rizkallah R, Batsomboon P, Dudley GB and Hurt MM.
  TITLE     Identification of the oncogenic kinase TOPK/PBK as a master mitotic
            regulator of C2H2 zinc finger proteins
  JOURNAL   Oncotarget 6 (3), 1446-1461 (2015)
   PUBMED   25575812
REFERENCE   2  (bases 1 to 1839)
  AUTHORS   Zhao H, Wang R, Tao Z, Yan F, Gao L, Liu X, Wang N, Min L, Jia Y,
            Zhao Y, Ji X and Luo Y.
  TITLE     Activation of T-LAK-cell-originated protein kinase-mediated
            antioxidation protects against focal cerebral ischemia-reperfusion
            injury
  JOURNAL   FEBS J 281 (19), 4411-4420 (2014)
   PUBMED   25065601
  REMARK    GeneRIF: TOPK confers neuroprotection against focal cerebral
            ischemia-reperfusion injury by antioxidative function.
REFERENCE   3  (bases 1 to 1839)
  AUTHORS   Li S, Zhu F, Zykova T, Kim MO, Cho YY, Bode AM, Peng C, Ma W,
            Carper A, Langfald A and Dong Z.
  TITLE     T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1
            protein prevents solar ultraviolet light-induced inflammation
            through inhibition of the p38 protein signaling pathway
  JOURNAL   J Biol Chem 286 (34), 29601-29609 (2011)
   PUBMED   21715333
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129099.1.
            
            On or before Jan 11, 2007 this sequence version replaced
            XM_224300.4, XM_001066776.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129099.1, SRR8487230.49919.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1839
                     /gene="Pbk"
                     /note="PDZ binding kinase"
                     /db_xref="GeneID:290326"
                     /db_xref="RGD:1309565"
     exon            1..229
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
     exon            230..307
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1263
                     /gene="Pbk"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="lymphokine-activated killer T-cell-originated
                     protein kinase"
                     /protein_id="NP_001073406.1"
                     /db_xref="GeneID:290326"
                     /db_xref="RGD:1309565"
                     /translation="MEGISNFKTPNKLSEKRKSVLCSTPCVNIPASPFMQKLGFGTGV
                     SVYLMKRSPRGLSHSPWAVKKINPLCDDHYRTVYQKRLTDEAKILKNLNHPNIVGYRA
                     FTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQE
                     KKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAL
                     EENGIITDKADMFAFGLTLWEMMTLCIPHINLPDDDDDEDATFDESDFDDEAYYAALG
                     TRPSINMEELDESYQKVIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKHSLY
                     GNC"
     exon            308..401
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
     exon            402..544
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
     exon            545..714
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
     exon            715..844
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1021
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1813
                     /gene="Pbk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagtgttgg cgggagggag ctgttcctgc actttcggaa gcaagacagc tttgagttct
       61 aactccagtg tctcccgacc ggccagcggc ctttaaaaac gcgcgcgccc taaacgccgc
      121 ggcggttaca gagttggcgg gagctgttcc tgcaccttcc gggctaggtg tccagacagc
      181 tttgagccag ctcattactt tcaccttttt acccgagtgt gtgactgtgg acctaaagtg
      241 attgctacaa tggaaggaat cagtaatttc aagacgccaa acaaattatc tgaaaaaagg
      301 aaatctgtat tatgttcaac tccatgtgta aatatccctg cctctccatt tatgcagaag
      361 ctcggctttg ggactggggt cagtgtttac ctaatgaaaa gatctccgag agggttgtcc
      421 cattctcctt gggctgtgaa aaagataaat cctttatgcg atgatcatta tcgaactgtg
      481 tatcagaaga gactaactga tgaagctaag attttaaaaa accttaatca cccaaacatt
      541 gtaggctatc gtgcttttac tgaagccagt gatggtagtc tgtgccttgc tatggagtat
      601 ggaggtgaaa agtctctgaa tgacttaata gaagagcgga acaaagacag tggaagtcct
      661 tttccagcag ctgtaattct cagagttgct ttgcacatgg caagagggct aaagtatctg
      721 catcaggaaa agaagctgct gcatggagac ataaagtctt caaatgttgt aattaaaggt
      781 gactttgaaa caattaaaat ctgtgatgta ggagtctctc tgccattgga tgaaaatatg
      841 actgtgactg atcctgaggc ctgttatatt ggtactgagc catggaaacc caaagaagca
      901 ttggaggaaa atggcattat tactgacaag gcagatatgt ttgcttttgg ccttactctt
      961 tgggaaatga tgactttatg tattccacac atcaaccttc cagatgatga tgatgatgaa
     1021 gatgcaacat ttgatgagag tgacttcgat gatgaagctt actatgcagc tctggggaca
     1081 agaccatcca tcaatatgga agaactggat gaatcctacc agaaggtcat tgaactcttc
     1141 tgtgtgtgta ctaatgagga tcctaaagat cgcccatctg ctgcacacat cgttgaagct
     1201 ttggaactag atggccaatg ttgtggtcta agctcgaagc atagcttgta tgggaactgt
     1261 taactagatg tatttattta gctaatataa cttatagtag ctagattcta gaagtagctt
     1321 attttaagac cattgtacat agttaataat tgtataacct tctgacatgt tatttcctat
     1381 atatgcattt attgtactgg atagtctttg aagtttaaaa aactctccag gtatctagat
     1441 gctgctgccc ctactgattt aaacactagt gacctctgtt ctaagatgac ttagaatcaa
     1501 gggaccattg ctttgttaaa gaccgtttta gatattcttg cttctttaat gggttactaa
     1561 aaatttcact atacacacag tacagttaat tgtctgctca tagtgtccac cttttagttg
     1621 gcctgttggc ccatgtgccc tgaagcttaa gagcttggtg cagaagcata gcccctagaa
     1681 tgtttcagac cctggttact gtcttgcctc tctccactcc ttagcatcta atttactttg
     1741 tttttactga ctgtatacga agtcttctaa aagctatgta agaataaaca ataaaaacag
     1801 ttttagtacc aggaaaaaaa aaaaaaaaaa aaaaaaaaa
//
