LOCUS       NM_001399307             920 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus PAXX, non-homologous end joining factor (Paxx),
            transcript variant 1, mRNA.
ACCESSION   NM_001399307 XM_006233588
VERSION     NM_001399307.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 920)
  AUTHORS   Craxton,A., Somers,J., Munnur,D., Jukes-Jones,R., Cain,K. and
            Malewicz,M.
  TITLE     XLS (c9orf142) is a new component of mammalian DNA double-stranded
            break repair
  JOURNAL   Cell Death Differ 22 (6), 890-897 (2015)
   PUBMED   25941166
REFERENCE   2  (bases 1 to 920)
  AUTHORS   Xing,M., Yang,M., Huo,W., Feng,F., Wei,L., Jiang,W., Ning,S.,
            Yan,Z., Li,W., Wang,Q., Hou,M., Dong,C., Guo,R., Gao,G., Ji,J.,
            Zha,S., Lan,L., Liang,H. and Xu,D.
  TITLE     Interactome analysis identifies a new paralogue of XRCC4 in
            non-homologous end joining DNA repair pathway
  JOURNAL   Nat Commun 6, 6233 (2015)
   PUBMED   25670504
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 920)
  AUTHORS   Ochi,T., Blackford,A.N., Coates,J., Jhujh,S., Mehmood,S.,
            Tamura,N., Travers,J., Wu,Q., Draviam,V.M., Robinson,C.V.,
            Blundell,T.L. and Jackson,S.P.
  TITLE     DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to
            promote DNA double-strand break repair
  JOURNAL   Science 347 (6218), 185-188 (2015)
   PUBMED   25574025
REFERENCE   4  (bases 1 to 920)
  AUTHORS   Young,L.H., Yang,X. and Voigt,J.M.
  TITLE     Alteration of gene expression in rat mammary tumors induced by
            N-methyl-N-nitrosourea
  JOURNAL   Mol Carcinog 15 (4), 251-260 (1996)
   PUBMED   8634083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 6, 2022 this sequence version replaced XM_006233588.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U30788.1, SRR22582419.2039932.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000003.1  28674219-28674466   c
            249-309             JAXUCZ010000003.1  28674087-28674147   c
            310-359             JAXUCZ010000003.1  28673877-28673926   c
            360-550             JAXUCZ010000003.1  28673599-28673789   c
            551-616             JAXUCZ010000003.1  28673441-28673506   c
            617-701             JAXUCZ010000003.1  28673201-28673285   c
            702-920             JAXUCZ010000003.1  28672908-28673126   c
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..920
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /note="PAXX, non-homologous end joining factor"
                     /db_xref="GeneID:296565"
                     /db_xref="RGD:1306215"
     exon            1..248
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..741
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C9orf142 homolog"
                     /codon_start=1
                     /product="protein PAXX isoform 1"
                     /protein_id="NP_001386236.1"
                     /db_xref="GeneID:296565"
                     /db_xref="RGD:1306215"
                     /translation="MAPPPLSLPLCILPPGSGSPRLVCYCEPENGGDWDRDDFNLYVT
                     DAAELWSTCFSPDSLATLKARFGLSGTEDIHSRFRAACQQQAVTVRLQEDRALMTLSG
                     DTSALAFDLSKVPSPEAAPRLQALTLSLAEHVCNLERRLAATEETAISPRKSTQPAGT
                     QFLPELDHQRGSSGSGVRRRCPGESLVNPGFKSKKPAGGVDFDET"
     exon            249..309
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /inference="alignment:Splign:2.1.0"
     exon            310..359
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /inference="alignment:Splign:2.1.0"
     exon            360..550
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /inference="alignment:Splign:2.1.0"
     exon            551..616
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /inference="alignment:Splign:2.1.0"
     exon            617..701
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /inference="alignment:Splign:2.1.0"
     exon            702..920
                     /gene="Paxx"
                     /gene_synonym="RGD1306215"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaccaga agttccgcct ctgaacggac gtcttagctt gcgagtcacc gagttcatac
       61 ttctgcgcag gcgccctgag cctgtctctg gcttggctct tgcggcgaga ccgccctgct
      121 gtcatggctc ctccgccctt gtcgctgccg ctttgcattc tgccgccggg ctccggctct
      181 ccccgcttgg tgtgctactg cgagccggag aatggtggag actgggaccg cgacgatttc
      241 aacctctatg tgacggacgc cgcggagctc tggagcacct gcttctcgcc tgacagcctg
      301 gcgacgctca aagcccgatt tggcctaagt gggactgagg atatccattc ccggttcagg
      361 gcagcctgcc aacagcaggc agtgactgta agactgcaag aggacagagc attgatgacc
      421 ctttcagggg atacctctgc cctggccttt gacctctcca aggtgcccag cccagaggca
      481 gcccccaggc tgcaggcttt gactctcagc ctggcagagc atgtatgcaa cctggagagg
      541 cggctggcag ccacagaaga gaccgccatt agccccagga agagcaccca gccagcaggc
      601 actcagttct taccagaact tgatcaccag agaggcagct ctgggtctgg ggtcaggaga
      661 cggtgtccag gggagtctct cgtcaaccct ggtttcaaaa gtaagaaacc agctggtggt
      721 gtagacttcg atgagacctg aagctagcaa agcctgtgtg accttgccag gagtctgtct
      781 gcaaggaaag gggacatcta ggacccctaa ccagagacac cctttgcttc acttcccctg
      841 tggtcctgct gatgggcaaa agtacctctc atcccttccc catcaaataa actgctccct
      901 tggggagaga tgctaggcca
//
