LOCUS       NM_001107844            3736 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PAX interacting protein 1 (Paxip1), mRNA.
ACCESSION   NM_001107844 XM_017592607 XM_231271
VERSION     NM_001107844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3736)
  AUTHORS   Starnes,L.M., Su,D., Pikkupeura,L.M., Weinert,B.T., Santos,M.A.,
            Mund,A., Soria,R., Cho,Y.W., Pozdnyakova,I., Kubec Hojfeldt,M.,
            Vala,A., Yang,W., Lopez-Mendez,B., Lee,J.E., Peng,W., Yuan,J.,
            Ge,K., Montoya,G., Nussenzweig,A., Choudhary,C. and Daniel,J.A.
  TITLE     A PTIP-PA1 subcomplex promotes transcription for IgH class
            switching independently from the associated MLL3/MLL4
            methyltransferase complex
  JOURNAL   Genes Dev 30 (2), 149-163 (2016)
   PUBMED   26744420
REFERENCE   2  (bases 1 to 3736)
  AUTHORS   Shilatifard,A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   3  (bases 1 to 3736)
  AUTHORS   Daniel,J.A., Santos,M.A., Wang,Z., Zang,C., Schwab,K.R.,
            Jankovic,M., Filsuf,D., Chen,H.T., Gazumyan,A., Yamane,A.,
            Cho,Y.W., Sun,H.W., Ge,K., Peng,W., Nussenzweig,M.C., Casellas,R.,
            Dressler,G.R., Zhao,K. and Nussenzweig,A.
  TITLE     PTIP promotes chromatin changes critical for immunoglobulin class
            switch recombination
  JOURNAL   Science 329 (5994), 917-923 (2010)
   PUBMED   20671152
REFERENCE   4  (bases 1 to 3736)
  AUTHORS   Cho,Y.W., Hong,S., Jin,Q., Wang,L., Lee,J.E., Gavrilova,O. and
            Ge,K.
  TITLE     Histone methylation regulator PTIP is required for PPARgamma and
            C/EBPalpha expression and adipogenesis
  JOURNAL   Cell Metab 10 (1), 27-39 (2009)
   PUBMED   19583951
REFERENCE   5  (bases 1 to 3736)
  AUTHORS   Gong,Z., Cho,Y.W., Kim,J.E., Ge,K. and Chen,J.
  TITLE     Accumulation of Pax2 transactivation domain interaction protein
            (PTIP) at sites of DNA breaks via RNF8-dependent pathway is
            required for cell survival after DNA damage
  JOURNAL   J Biol Chem 284 (11), 7284-7293 (2009)
   PUBMED   19124460
REFERENCE   6  (bases 1 to 3736)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
REFERENCE   7  (bases 1 to 3736)
  AUTHORS   Issaeva,I., Zonis,Y., Rozovskaia,T., Orlovsky,K., Croce,C.M.,
            Nakamura,T., Mazo,A., Eisenbach,L. and Canaani,E.
  TITLE     Knockdown of ALR (MLL2) reveals ALR target genes and leads to
            alterations in cell adhesion and growth
  JOURNAL   Mol Cell Biol 27 (5), 1889-1903 (2007)
   PUBMED   17178841
REFERENCE   8  (bases 1 to 3736)
  AUTHORS   Jowsey,P.A., Doherty,A.J. and Rouse,J.
  TITLE     Human PTIP facilitates ATM-mediated activation of p53 and promotes
            cellular resistance to ionizing radiation
  JOURNAL   J Biol Chem 279 (53), 55562-55569 (2004)
   PUBMED   15456759
REFERENCE   9  (bases 1 to 3736)
  AUTHORS   Hoffmeister,A., Ropolo,A., Vasseur,S., Mallo,G.V., Bodeker,H.,
            Ritz-Laser,B., Dressler,G.R., Vaccaro,M.I., Dagorn,J.C., Moreno,S.
            and Iovanna,J.L.
  TITLE     The HMG-I/Y-related protein p8 binds to p300 and Pax2
            trans-activation domain-interacting protein to regulate the
            trans-activation activity of the Pax2A and Pax2B transcription
            factors on the glucagon gene promoter
  JOURNAL   J Biol Chem 277 (25), 22314-22319 (2002)
   PUBMED   11940591
REFERENCE   10 (bases 1 to 3736)
  AUTHORS   Lechner,M.S., Levitan,I. and Dressler,G.R.
  TITLE     PTIP, a novel BRCT domain-containing protein interacts with Pax2
            and is associated with active chromatin
  JOURNAL   Nucleic Acids Res 28 (14), 2741-2751 (2000)
   PUBMED   10908331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Feb 17, 2022 this sequence version replaced
            XM_017592607.2, NM_001107844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000004.1  8258966-8259160
            196-330             JAXUCZ010000004.1  8261642-8261776
            331-374             JAXUCZ010000004.1  8266790-8266833
            375-438             JAXUCZ010000004.1  8269036-8269099
            439-552             JAXUCZ010000004.1  8274591-8274704
            553-1176            JAXUCZ010000004.1  8277666-8278289
            1177-1909           JAXUCZ010000004.1  8283915-8284647
            1910-2004           JAXUCZ010000004.1  8285003-8285097
            2005-2100           JAXUCZ010000004.1  8287646-8287741
            2101-2238           JAXUCZ010000004.1  8288636-8288773
            2239-2360           JAXUCZ010000004.1  8289485-8289606
            2361-2545           JAXUCZ010000004.1  8290373-8290557
            2546-2589           JAXUCZ010000004.1  8291502-8291545
            2590-2657           JAXUCZ010000004.1  8294242-8294309
            2658-2760           JAXUCZ010000004.1  8296061-8296163
            2761-2929           JAXUCZ010000004.1  8298569-8298737
            2930-3030           JAXUCZ010000004.1  8299952-8300052
            3031-3165           JAXUCZ010000004.1  8307428-8307562
            3166-3241           JAXUCZ010000004.1  8307648-8307723
            3242-3302           JAXUCZ010000004.1  8307804-8307864
            3303-3736           JAXUCZ010000004.1  8310057-8310490
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3736
                     /gene="Paxip1"
                     /note="PAX interacting protein 1"
                     /db_xref="GeneID:311944"
                     /db_xref="RGD:1307547"
     exon            1..195
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..3318
                     /gene="Paxip1"
                     /note="PAX interacting (with transcription-activation
                     domain) protein 1"
                     /codon_start=1
                     /product="PAX-interacting protein 1"
                     /protein_id="NP_001101314.2"
                     /db_xref="GeneID:311944"
                     /db_xref="RGD:1307547"
                     /translation="MSEPAPEVPEELFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNA
                     LASHIISEDGDNPEVGEAREVFDLPVVKPSWVTLSVQCGTLLPVNGFSPESCQIFFGL
                     TACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKI
                     VTPDWVLDCVSEKRRKDEASYHPRLIIYEEEEEEEEEEGDNEEQDSQNEGSTDKSSAA
                     SSAEASPADQPCSPKARAEVSKGELMFDDSSDSSPEKQERSLNWAPAEAPPLSTAQHR
                     LPQGKGPGLINLCANVPPVPGDILPPDMRGNLMAAGQNLQSSERPEMLGTWSPAVRTL
                     RNITNNADIQQISRPSNVAHILQSLSAPTKNLEQQVAHVQQGHPSASAVLFGQAKGAP
                     ETHTLQQHHPPQQPQQQHPALHLQPQIMQLQQQQQQQQQQPQPYPQPPSHQFPQQVHQ
                     HQFSQQQLQFPQQPLHPQQQLHRPQQQLQPFQQQHALQQQLHQLQQQQLQQHQLAQLQ
                     QQQQQQQQQQHNLLQQQQQQQLQRLHQQQQMQNQAAHLSQTSQALQHQVLPQQPLQLP
                     LQPPPQQQQQQQQQQQQQQQQQQLFGHDPAVEIPEESFLLGCVFAIADYPEQMSDKQL
                     LATWKRIIQAHGGTVDPTFTSRCTHLLCESQVSSMYAQALRERKRCVTAHWLNTVLKK
                     KKLMPPHRALHFPVAFPPGGKPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCR
                     SNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQVQYSRYTAFNLPDP
                     FVPTPHLVLSLLDAWRTPVKVTAELLMSIRLPPKLKPNEVANIQPSKRARIEDLPPPT
                     KKLTPELTPYVLFTGFEPVQVQQYIKKLYILGGEVAESTKKCTHLIASKVTRTVKFLT
                     AISVVKHIVTPDWLEECFKRQMFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFK
                     TKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLMEHKQNKSLSEIILISCEND
                     LHLCREYFARGIDVHNAEFVLTGVLTQTLDYESYKFN"
     exon            196..330
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..374
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..438
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..552
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1176
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1909
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2004
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2100
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2238
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2360
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2545
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2589
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2657
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2760
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2929
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3030
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3165
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3241
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3302
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3736
                     /gene="Paxip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgcggct gcggctgcgg gccgggctgt gcggccgggc agttggcata gctgcgacgc
       61 tgggcgcggc gggccgggtg acgcggggcc gggcgccgcc gcgccgccgc gatcatgtcg
      121 gagccggcgc ccgaagttcc ggaggagctg ttccgcgagg tcaagtacta cgcggtggga
      181 gacatcgacc cgcaggttat tcagcttctt aaagctggga aagccaagga agtctcctac
      241 aacgctctgg cctctcacat catttcggag gatggtgaca acccagaggt gggagaagcc
      301 cgtgaggtct ttgacttgcc cgttgtaaag ccttcctggg tgactctgtc cgtgcaatgt
      361 ggcactctcc tgccagtcaa tggtttctct ccagagtcct gtcagatttt ttttggactc
      421 actgcctgcc tttctcaggt gtcgtctgaa gacagaagtg ccctgtgggc cttggttacg
      481 ttccacgggg gcagctgcca gctaaacctt aacaagaagt gcacacacct gattgtccca
      541 gagccgaagg gggagaagta cgagcgtgct gtcaagagaa caagcattaa gattgttacc
      601 cctgactggg tcctggactg tgtgtctgag aagaggagga aggatgaagc ttcttaccat
      661 ccacgtctga tcatctatga ggaggaagag gaggaggagg aggaagaggg agacaacgag
      721 gagcaggact ctcagaacga gggtagcact gacaagtcca gtgcagccag ctctgcggag
      781 gcctcccctg ctgaccagcc gtgctctccc aaggccaggg ctgaggtatc caaaggggag
      841 ttgatgtttg atgactcttc tgactcatcc cctgaaaagc aggagcgcag cttgaactgg
      901 gcccccgctg aagccccgcc actcagcaca gcccagcaca ggctgcctca gggaaaagga
      961 ccgggactca ttaacctgtg tgccaatgtc ccacctgtcc caggggacat tctgcctcct
     1021 gacatgcggg gtaacttgat ggccgctgga caaaacctcc agagttctga gcggccggaa
     1081 atgttaggga cctggagccc agctgtccgg acgttgcgaa acattacaaa caacgctgat
     1141 atccagcaaa tcagccggcc atccaatgtt gcacatatct tacaatccct ttcagcaccc
     1201 acaaaaaacc tagagcagca ggtggcacat gtacagcagg gacaccccag tgccagtgct
     1261 gtgctctttg gccaggctaa aggtgctcct gagacacaca cgttgcagca gcaccatcct
     1321 ccccagcagc ctcagcagca gcacccagcc ctgcacctcc agccccagat catgcagctc
     1381 cagcagcaac agcagcagca gcagcagcag ccccagcctt acccccagcc gccatcacat
     1441 cagttcccac agcaagtcca tcagcatcag ttctctcagc agcagctcca gtttccacag
     1501 caaccattac accctcagca gcagttgcat cgccctcaac agcaactgca gccatttcag
     1561 cagcagcatg ccctgcagca gcagctccat cagttgcagc agcaacagct ccagcagcac
     1621 cagttagcac agctccagca gcagcagcag cagcagcagc agcagcagca caacctcctc
     1681 cagcagcaac agcagcagca gctccagcgc ttgcaccagc agcagcagat gcagaatcaa
     1741 gcagcacact tgagccaaac gtcccaggca ctacaacacc aggttctacc ccagcagccc
     1801 ctgcagctgc ccctgcagcc cccacctcag cagcagcagc agcagcagca gcagcagcag
     1861 cagcagcagc agcagcagca gctttttgga catgacccag cagtggagat tccagaagaa
     1921 agcttcttgc tgggctgtgt gtttgccatt gcggactatc ccgagcagat gtcggacaag
     1981 cagctgctgg ccacctggaa gaggataatc caggcacatg gtggcactgt ggaccccacc
     2041 ttcactagcc gatgcacaca tctactctgc gagagtcaag tcagcagtat gtacgcacag
     2101 gcactacggg agagaaagcg gtgtgtcact gcgcattggc tcaacacagt gctgaagaag
     2161 aagaagctga tgccgcctca tcgagccctg catttccctg tggcattccc acccgggggc
     2221 aaaccctgtt cacagcatat tatctctgtg actggatttg ttgacaatga cagagatgac
     2281 ctgaagttaa tggcatacct ggcgggtgcc aagtacacgg ggtacctgtg ccggagcaac
     2341 acagtcctca tctgtaaaga accaagcggc ttgaagtacg agaaggccaa agagtggagg
     2401 atcccgtgtg tgaatgcaca gtggctgggg gacattctgc tggggaactt cgaggccctg
     2461 cggcaagtcc agtacagccg gtacactgcc ttcaacctgc cggacccctt cgtgcccact
     2521 ccacacttgg tcttgagtct tctagatgct tggaggaccc cagtgaaggt gactgcagag
     2581 ctattgatga gtataagatt acctcctaag ctgaagccga atgaggtcgc caacatccag
     2641 ccttctaaaa gagccagaat cgaagacctg cctcccccca ctaagaagct gactccggag
     2701 ctgacgccat acgtgctctt taccgggttt gagcctgttc aagttcagca gtacattaag
     2761 aagctgtaca ttcttggtgg ggaagttgcc gagtccacga agaagtgtac tcacctcatt
     2821 gccagcaagg tgacacgcac agtgaaattc ctgacggcca tttctgtggt gaagcacatc
     2881 gtgactccgg actggctgga ggagtgcttc aagcgccaga tgtttatcga tgagcagaac
     2941 tacatcctgc gagatgctga ggcagaagtg ctcttctctt tcagtctgga ggagtccttg
     3001 aagcgagccc acgtctctcc cctctttaag acaaagtatt tttacatcac ccctggcatc
     3061 tgcccaagcc ttgccactat gaaggcaatt gtggagtgtg caggggggaa ggtgttagcc
     3121 aagcagccgt cctttcggaa gctcatggag cacaagcaga ataagagtct gtcggagata
     3181 attttaatat cctgtgagaa tgacctgcac ttatgtcgag agtactttgc cagggggata
     3241 gatgttcaca atgcggagtt tgttctgact ggagtgctca cacagacact ggactacgaa
     3301 tcatataaat ttaactgatg gcctcttggt gctgctagcc tggagcctgg agcacaaggg
     3361 cagctgctgg cagcgcaaac caggactccc tccctgcaga gggcttgttt tccagctctg
     3421 ccttagggag acatgaaata ctaactgcat cgtgttaaga tgtgtgacct tattctagga
     3481 aacataaatt atgtttgtat tatatgccta agagcccaca ttaagtcttc tgattaattt
     3541 gccaggtttt taatgtgttt tcagaaagct gtatgaaatt tcatctacaa ataaaaatga
     3601 tgtaaataaa gactttgctg tctaaattat ggatgttaaa gatatgagat gttttgtact
     3661 ttgattattt ttatttctta cttttctttt atattgataa cttgctcaca tttaaataaa
     3721 tgtacttttg aactta
//
