LOCUS       NM_031141               2517 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus paired box 8 (Pax8), transcript variant 1, mRNA.
ACCESSION   NM_031141
VERSION     NM_031141.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Fernandez-Mendez,C. and Santisteban,P.
  TITLE     A Critical Balance Between PAX8 and the Hippo Mediator TAZ
            Determines Sodium/Iodide Symporter Expression and Function
  JOURNAL   Thyroid 32 (3), 315-325 (2022)
   PUBMED   34726504
  REMARK    GeneRIF: A Critical Balance Between PAX8 and the Hippo Mediator TAZ
            Determines Sodium/Iodide Symporter Expression and Function.
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Huang,C., Li,R., Yang,C., Ding,R., Li,Q., Xie,D., Zhang,R. and
            Qiu,Y.
  TITLE     PAX8-AS1 knockdown facilitates cell growth and inactivates
            autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in
            osteoporosis
  JOURNAL   Exp Mol Med 53 (5), 894-906 (2021)
   PUBMED   34012023
  REMARK    GeneRIF: PAX8-AS1 knockdown facilitates cell growth and inactivates
            autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in
            osteoporosis.
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Koumarianou,P., Gomez-Lopez,G. and Santisteban,P.
  TITLE     Pax8 controls thyroid follicular polarity through cadherin-16
  JOURNAL   J Cell Sci 130 (1), 219-231 (2017)
   PUBMED   27780871
  REMARK    GeneRIF: Pax8 controls apical-basal follicular polarization and
            follicle formation through Cdh16.
REFERENCE   4  (bases 1 to 2517)
  AUTHORS   Lucci,V., Di Palma,T. and Zannini,M.
  TITLE     Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells
  JOURNAL   PLoS One 10 (6), e0128315 (2015)
   PUBMED   26030152
  REMARK    GeneRIF: the novel interplay between PAX8 and Neuropilin-2
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2517)
  AUTHORS   Filippone,M.G., Di Palma,T., Lucci,V. and Zannini,M.
  TITLE     Pax8 modulates the expression of Wnt4 that is necessary for the
            maintenance of the epithelial phenotype of thyroid cells
  JOURNAL   BMC Mol Biol 15, 21 (2014)
   PUBMED   25270402
  REMARK    GeneRIF: The 5'-flanking region of the Wnt4 gene is responsive to
            Pax8. Pax8 modulates the expression of Wnt4 in thyroid cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2517)
  AUTHORS   Eccles,M.R., Yun,K., Reeve,A.E. and Fidler,A.E.
  TITLE     Comparative in situ hybridization analysis of PAX2, PAX8, and WT1
            gene transcription in human fetal kidney and Wilms' tumors
  JOURNAL   Am J Pathol 146 (1), 40-45 (1995)
   PUBMED   7856737
REFERENCE   7  (bases 1 to 2517)
  AUTHORS   Kozmik,Z., Kurzbauer,R., Dorfler,P. and Busslinger,M.
  TITLE     Alternative splicing of Pax-8 gene transcripts is developmentally
            regulated and generates isoforms with different transactivation
            properties
  JOURNAL   Mol Cell Biol 13 (10), 6024-6035 (1993)
   PUBMED   8413205
REFERENCE   8  (bases 1 to 2517)
  AUTHORS   Poleev,A., Fickenscher,H., Mundlos,S., Winterpacht,A., Zabel,B.,
            Fidler,A., Gruss,P. and Plachov,D.
  TITLE     PAX8, a human paired box gene: isolation and expression in
            developing thyroid, kidney and Wilms' tumors
  JOURNAL   Development 116 (3), 611-623 (1992)
   PUBMED   1337742
REFERENCE   9  (bases 1 to 2517)
  AUTHORS   Zannini,M., Francis-Lang,H., Plachov,D. and Di Lauro,R.
  TITLE     Pax-8, a paired domain-containing protein, binds to a sequence
            overlapping the recognition site of a homeodomain and activates
            transcription from two thyroid-specific promoters
  JOURNAL   Mol Cell Biol 12 (9), 4230-4241 (1992)
   PUBMED   1508216
REFERENCE   10 (bases 1 to 2517)
  AUTHORS   Plachov,D., Chowdhury,K., Walther,C., Simon,D., Guenet,J.L. and
            Gruss,P.
  TITLE     Pax8, a murine paired box gene expressed in the developing
            excretory system and thyroid gland
  JOURNAL   Development 110 (2), 643-651 (1990)
   PUBMED   1723950
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081779.1.
            
            On Oct 5, 2005 this sequence version replaced NM_031141.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081779.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2517
                     /gene="Pax8"
                     /note="paired box 8"
                     /db_xref="GeneID:81819"
                     /db_xref="RGD:620434"
     exon            1..80
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            81..190
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1539
                     /gene="Pax8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paired box protein Pax-8; Pax-8 protein; paired box gene
                     8"
                     /codon_start=1
                     /product="paired box protein Pax-8 isoform 1"
                     /protein_id="NP_112403.2"
                     /db_xref="GeneID:81819"
                     /db_xref="RGD:620434"
                     /translation="MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRP
                     CDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTM
                     FAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLI
                     PSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDNKRKMDDSDQDSCRLSIDSQSSSS
                     GPRKHLRTDTFGQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGK
                     ATLTPSNTPLGRNLSTHQTYPVVADPHSPYAIKQETPELSSSSSTPSSLSSSAFLDLQ
                     QVGSGGPAGASVPPFNAFSHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGS
                     YASSAIAGMVAGSEYSGNAYSHTPYASYSEAWRFPNSSLLSSPYYYSSTTRPSAPPTS
                     ATAFDHL"
     exon            191..356
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            357..554
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            555..643
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            644..769
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            770..945
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1066
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1273
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1375
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1462
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..2486
                     /gene="Pax8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcagaaga agaaacgcct gggccctggg caccctcggg ggcagaccca ggcagaaagg
       61 gcctgaggcc agccggctag ggcagcggcg tggcagctgg agctgccagg acctgcgtaa
      121 gagagctgcg agtgttccgc agctgtgagc gactccccag cggcgatgcc tcacaactcg
      181 atcagatccg gccacggagg gctgaatcag ttaggagggg cttttgtgaa tggcaggcct
      241 ctgccagaag ttgtccggca acgcattgtg gacttggccc accagggagt gagaccctgt
      301 gatatctctc gccagcttcg tgtcagccat ggctgtgtaa gcaagatcct tggcaggtac
      361 tacgagactg gcagcatccg gcctggagtg atagggggct ccaagcccaa ggtggccacc
      421 cccaaggtgg tggagaagat aggggactac aagcggcaga accctaccat gtttgcttgg
      481 gagatccggg accggctctt ggcagaaggc gtttgtgaca atgacactgt gcccagtgtc
      541 agctccatca acagaatcat ccggaccaaa gtgcagcagc cattcaacct ccccatggac
      601 agctgcgtgg ccaccaaatc tctgagccca ggacacacac tgatccccag ctcagctgtc
      661 acacccccag agtcacccca gtcggattcc ttgggctcta cctactctat caacgggctc
      721 ctaggaattg ctcagcctgg cagtgacaac aagagaaaga tggatgatag tgaccaggac
      781 agttgtcgac tgagcatcga ttcccagagc agcagtagtg gtcctcgaaa gcatcttcgt
      841 acagacacct tcgggcagca ccacctcgag ccgctcgagt gcccgtttga gcggcagcat
      901 tacccggagg cctatgcctc ccccagccac accaaaggcg agcaggggct atacccactg
      961 cccttactca acagtaccct ggatgacgga aaggccaccc tgacaccttc caatacacct
     1021 ctgggacgca acctctcaac tcaccagacc taccctgtgg tggcagatcc tcattcaccc
     1081 tacgccataa agcaggaaac cccagagctc tccagttcta gctccacccc ttcctcttta
     1141 tctagctccg cctttttgga tctgcagcaa gtcggctctg ggggcccagc aggtgcctcg
     1201 gtcccaccct tcaatgcctt ttcccatgct gcctccgtgt atgggcagtt cacgggccag
     1261 gccctcctct cagggcgaga gatggtgggg cccacgctgc ctggataccc accccacatc
     1321 cccaccagtg gacagggcag ctatgcctct tccgctattg caggcatggt ggcaggaagt
     1381 gagtattctg gcaatgccta cagccacacc ccgtacgcct cctacagtga ggcctggcgc
     1441 ttccccaact ccagcctgct gagttcccca tattattaca gctctacaac aaggccaagc
     1501 gcaccgccca cctctgccac ggcctttgac catctgtagt tgtcatgggg acagtgggaa
     1561 caaccaggca acaggaggac ttggcctgag acgggcccca gagagtcaca caaaggaatc
     1621 tttatttatt acatgaaaaa taaccacaat tccagcattg ccgctcactc cctgtgtggt
     1681 caattaaatg aaccatgaaa gtcaggatga ccttggggaa ggccaaactg tcctccaaga
     1741 gtcatttcgt gagtgacagg agttccagga accaagaacc atccatttca aaagagtcac
     1801 ggaggagaaa tggaccaagg ctggtaccca ccaagagaaa gaaacaggat ttgcaaagaa
     1861 cttagagggt gtacagggcc acctgtgtgg tcttcatcac tacaactcca gcaattatgg
     1921 acagtaagca agtccttctg gcctagagtc atggcctagg gccaaggctc tacttatcag
     1981 ttatcctggg agttaccacc tctaccacct gatgggcact tctctgggga ttcagctgac
     2041 ctcccacttc cagttgttat gagcctacaa acacccccta gcctctcaac tagtgggcta
     2101 cccctttggc agcaatgaac ctgtcccctg gaaaattcag tgagcacagg aagacacaat
     2161 agatgggact ggccatgtcc tcttctcaac agccctgcca actcaagtgt gctttctgca
     2221 gctccagccc tcacgagtca ctgaagagac cccgaggcca gcaacaagat tccctctctg
     2281 gctccccagc tctttccccc acacaacctt actgtaaata ccgtaaatga agctctgttt
     2341 cggtcaagct tccctctttc catcccccag accttggctt ctaaaatgtc tccctactat
     2401 gttgggcttt tctccttgat ttttttttta aaaaagacaa cccatcatta ccatatgact
     2461 caataaacca ttactcttgg tctcagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
