LOCUS       NM_013001               2191 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus paired box 6 (Pax6), mRNA.
ACCESSION   NM_013001
VERSION     NM_013001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Ma,R., Li,Y., Dong,X., Zhang,Y., Chen,X., Zhang,Y., Zou,H. and
            Wang,Y.
  TITLE     PAX6/CXCL14 regulatory axis promotes the repair of corneal injury
            by enhancing corneal epithelial cell proliferation
  JOURNAL   J Transl Med 22 (1), 458 (2024)
   PUBMED   38750454
  REMARK    GeneRIF: PAX6/CXCL14 regulatory axis promotes the repair of corneal
            injury by enhancing corneal epithelial cell proliferation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Ikeda,K., Onimaru,H., Inada,H., Tien Lin,S., Arata,S. and Osumi,N.
  TITLE     Structural and functional defects of the respiratory neural system
            in the medulla and spinal cord of Pax6 mutant rats
  JOURNAL   Brain Res Bull 152, 107-116 (2019)
   PUBMED   31301380
  REMARK    GeneRIF: Structural and functional defects of the respiratory
            neural system in the medulla and spinal cord of Pax6 mutant rats.
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   Mo,J.L., Liu,Q., Kou,Z.W., Wu,K.W., Yang,P., Chen,X.H. and Sun,F.Y.
  TITLE     MicroRNA-365 modulates astrocyte conversion into neuron in adult
            rat brain after stroke by targeting Pax6
  JOURNAL   Glia 66 (7), 1346-1362 (2018)
   PUBMED   29451327
  REMARK    GeneRIF: Results demonstrate that the miR-365-PAX6 system regulates
            the conversion of astrocytes into neurons in the ischemic brain.
            Both exogenous expression of PAX6 and administration of miR-365
            antagomir are likely to promote brain repair by enhancing
            neurogenesis in adult mammalian brain following ischemic injury.
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Lipponen,A., El-Osta,A., Kaspi,A., Ziemann,M., Khurana,I., Kn,H.,
            Navarro-Ferrandis,V., Puhakka,N., Paananen,J. and Pitkanen,A.
  TITLE     Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA
            methylation regulate chronic transcriptomics changes after
            experimental traumatic brain injury
  JOURNAL   Acta Neuropathol Commun 6 (1), 17 (2018)
   PUBMED   29482641
  REMARK    GeneRIF: Four upregulated transcription factors Pax6, Tp73, Cebpd,
            and Spi1, appeared as potent regulators of chronic post-traumatic
            brain injury (TBI) gene expression. They regulate molecular
            networks contributing to post-injury secondary damage, including
            apoptosis and inflammation, strengthening the feasibility of
            therapeutically targeting these molecular networks even after the
            acute post-TBI period.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2191)
  AUTHORS   So,K., Chung,Y., Yu,S.K. and Jun,Y.
  TITLE     Regional Immunoreactivity of Pax6 in the Neurogenic Zone After
            Chronic Prenatal Hypoxia
  JOURNAL   In Vivo 31 (6), 1125-1129 (2017)
   PUBMED   29102934
  REMARK    GeneRIF: These results suggest that Pax6 immunoreactivity showed
            diverse patterns in the neurogenic zone after prenatal hypoxia and
            Pax6 has important effects on neurogenesis
REFERENCE   6  (bases 1 to 2191)
  AUTHORS   Osumi-Yamashita,N., Kuratani,S., Ninomiya,Y., Aoki,K., Iseki,S.,
            Chareonvit,S., Doi,H., Fujiwara,M., Watanabe,T. and Eto,K.
  TITLE     Cranial anomaly of homozygous rSey rat is associated with a defect
            in the migration pathway of midbrain crest cells
  JOURNAL   Dev Growth Differ 39 (1), 53-67 (1997)
   PUBMED   9079035
REFERENCE   7  (bases 1 to 2191)
  AUTHORS   Mirzayans,F., Pearce,W.G., MacDonald,I.M. and Walter,M.A.
  TITLE     Mutation of the PAX6 gene in patients with autosomal dominant
            keratitis
  JOURNAL   Am J Hum Genet 57 (3), 539-548 (1995)
   PUBMED   7668281
REFERENCE   8  (bases 1 to 2191)
  AUTHORS   Martha,A., Strong,L.C., Ferrell,R.E. and Saunders,G.F.
  TITLE     Three novel aniridia mutations in the human PAX6 gene
  JOURNAL   Hum Mutat 6 (1), 44-49 (1995)
   PUBMED   7550230
REFERENCE   9  (bases 1 to 2191)
  AUTHORS   Matsuo,T., Osumi-Yamashita,N., Noji,S., Ohuchi,H., Koyama,E.,
            Myokai,F., Matsuo,N., Taniguchi,S., Doi,H., Iseki,S. et al.
  TITLE     A mutation in the Pax-6 gene in rat small eye is associated with
            impaired migration of midbrain crest cells
  JOURNAL   Nat Genet 3 (4), 299-304 (1993)
   PUBMED   7981749
REFERENCE   10 (bases 1 to 2191)
  AUTHORS   Favor,J.
  TITLE     A comparison of the dominant cataract and recessive specific-locus
            mutation rates induced by treatment of male mice with
            ethylnitrosourea
  JOURNAL   Mutat Res 110 (2), 367-382 (1983)
   PUBMED   6877261
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128741.1.
            
            On Jun 10, 2007 this sequence version replaced NM_013001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128741.1, U69644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q33"
     gene            1..2191
                     /gene="Pax6"
                     /note="paired box 6"
                     /db_xref="GeneID:25509"
                     /db_xref="RGD:3258"
     exon            1..28
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            29..109
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            110..170
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1429
                     /gene="Pax6"
                     /note="paired box homeotic gene 6; oculorhombin; paired
                     box gene 6"
                     /codon_start=1
                     /product="paired box protein Pax-6"
                     /protein_id="NP_037133.1"
                     /db_xref="GeneID:25509"
                     /db_xref="RGD:3258"
                     /translation="MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISR
                     ILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEI
                     RDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRP
                     GWYPGTSVPGQPTQDGCQQQEGQGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFT
                     QEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRR
                     QASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPS
                     FTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTT
                     STGLISPGVSVPVQVPGSEPDMSQYWPRLQ"
     exon            171..301
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            302..517
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            518..683
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            684..842
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            843..925
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1076
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1192
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1343
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..2148
                     /gene="Pax6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgacgaaag agaggatgcc tcttaaaggc agaagacttt aactaggggc gggcgagcag
       61 atgtgtgaga tcttctattc aaagagtgga catatagccc agttttcaga gccacgtatt
      121 cgagccccgt gggatccgga ggctgccaac cagctccagc atgcagaaca gtcacagcgg
      181 agtgaatcag cttggtggtg tctttgtcaa cgggcggcca ctgccggact ccacccggca
      241 gaagatcgta gagctagctc acagcggggc ccggccgtgc gacatttccc gaattctgca
      301 ggtgtccaac ggatgtgtga gtaaaattct gggcaggtat tacgagactg gctccatcag
      361 acccagggca atcggaggca gtaagccaag agtggcgact ccagaagttg taagcaaaat
      421 agcccagtat aaacgggagt gcccgtccat ctttgcttgg gaaatccgag acagattact
      481 ctccgagggg gtctgtacca acgacaatat acccagtgtg tcatcaataa acagagttct
      541 tcgcaacctg gctagcgaaa agcaacagat gggcgcagac ggcatgtatg ataaactaag
      601 gatgctgaac ggacagaccg gaagctgggg cacccgccct ggttggtatc ccgggacgtc
      661 agtaccaggg caacccacgc aagacggctg ccagcaacag gaaggacagg gagaaaacac
      721 caactccatc agctccaatg gagaagactc ggatgaggct caaatgcggc tgcagctgaa
      781 gcggaagctg cagagaaata gaacatcttt tacccaggag cagattgagg ctctggagaa
      841 agagtttgag aggacccatt atccagatgt gtttgcccgg gaaagactag cagccaaaat
      901 agatctacct gaagcaagga tacaggtgtg gttttctaac cgaagggcca agtggagaag
      961 agaagaaaaa ctgaggaacc agagaagaca ggccagcaac accccgagtc acatccctat
     1021 cagcagcagt ttcagtacca gtgtctacca gccaattcca cagcccacca cacctgtctc
     1081 ctcctttaca tcgggttcca tgttgggccg cacagacacc gccctcacca acacgtacag
     1141 tgctttgccg ccgatgccca gcttcaccat ggcaaataac ctgcctatgc aacccccagt
     1201 ccccagtcag acctcctcgt actcctgcat gctgcccacc agcccttcag tgaatgggcg
     1261 gagttatgat acctacaccc ctccgcacat gcaaacacac atgaacagtc agcccatggg
     1321 cacctcggga accacttcaa caggactcat ttcacctgga gtgtcagttc ccgtccaagt
     1381 tcccggaagt gaacctgaca tgtctcagta ctggcctcga ttacagtaaa gagagagaaa
     1441 gagagagaat gtgatcgaga gggggattgt gttcactcag ccaatgacta tgtggacaca
     1501 gcggttgggt attcaggaaa gaaagagaaa tggctgttag aagcacttca ctttacaact
     1561 gtgtcctata ctggagcccg ggaatggact agaaaccagg acctttgcgt acagaaggca
     1621 cggtatcagt tggaacaaat cttcattttg gtatccaaac ttttattcat tttggtgtat
     1681 tatttgtaaa tgggcatttg tatgttataa tgaagaaaag aacaacacag gctgttggat
     1741 cttggatctg tgttggctca tgtggttgtt taaaggaaac catgatcgac aagatttgcc
     1801 atggatttaa gagttttatc aagatatatc gaatacttct acccatctgt tcatagttta
     1861 tggactgatg ttccaagttt gtatcattcc tttgcatata attaaacatg gaacaacata
     1921 cactagatat atgtaaaaaa tatctgttgg tttttccaaa ggttgttaac agataaagtt
     1981 tatgtgcaaa aaagggtaag atatgaattc gaggagaagt tgatagctaa aaggtagagt
     2041 gtgtcttcga tataatccaa tttgttttat gtcaaaatgt aagtatttgt cttccctaga
     2101 aatcctcaga atgatttcta taataaagtt aatttcattt atatttgaaa aaaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
