LOCUS       NM_001109261            1208 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus paired box 5 (Pax5), mRNA.
ACCESSION   NM_001109261 XM_001070941 XM_575815
VERSION     NM_001109261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Ohtsuka N, Badurek S, Busslinger M, Benes FM, Minichiello L and
            Rudolph U.
  TITLE     GABAergic neurons regulate lateral ventricular development via
            transcription factor Pax5
  JOURNAL   Genesis 51 (4), 234-245 (2013)
   PUBMED   23349049
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela
            T, Moffat J, Hudson TJ and Sladek R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Holmes ML, Carotta S, Corcoran LM and Nutt SL.
  TITLE     Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
  JOURNAL   Genes Dev 20 (8), 933-938 (2006)
   PUBMED   16618805
REFERENCE   4  (bases 1 to 1208)
  AUTHORS   Johnson K, Pflugh DL, Yu D, Hesslein DG, Lin KI, Bothwell AL,
            Thomas-Tikhonenko A, Schatz DG and Calame K.
  TITLE     B cell-specific loss of histone 3 lysine 9 methylation in the V(H)
            locus depends on Pax5
  JOURNAL   Nat Immunol 5 (8), 853-861 (2004)
   PUBMED   15258579
REFERENCE   5  (bases 1 to 1208)
  AUTHORS   Wu CX, Zhao WP, Kishi H, Dokan J, Jin ZX, Wei XC, Yokoyama KK and
            Muraguchi A.
  TITLE     Activation of mouse RAG-2 promoter by Myc-associated zinc finger
            protein
  JOURNAL   Biochem Biophys Res Commun 317 (4), 1096-1102 (2004)
   PUBMED   15094381
REFERENCE   6  (bases 1 to 1208)
  AUTHORS   Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale
            G and Pucillo C.
  TITLE     CD40 stimulation induces Pax5/BSAP and EBF activation through a
            APE/Ref-1-dependent redox mechanism
  JOURNAL   J Biol Chem 279 (3), 1777-1786 (2004)
   PUBMED   14594818
REFERENCE   7  (bases 1 to 1208)
  AUTHORS   Jin ZX, Kishi H, Wei XC, Matsuda T, Saito S and Muraguchi A.
  TITLE     Lymphoid enhancer-binding factor-1 binds and activates the
            recombination-activating gene-2 promoter together with c-Myb and
            Pax-5 in immature B cells
  JOURNAL   J Immunol 169 (7), 3783-3792 (2002)
   PUBMED   12244173
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575815.2, XM_001070941.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680425
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1208
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="paired box 5"
                     /db_xref="GeneID:500453"
                     /db_xref="RGD:1565236"
     exon            1..78
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1208
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /codon_start=1
                     /product="paired box protein Pax-5"
                     /protein_id="NP_001102731.1"
                     /db_xref="GeneID:500453"
                     /db_xref="RGD:1565236"
                     /translation="MDLEKNYPTPRTIRTGHGGVNQLGGVFVNGRPLPDVVRQRIVEL
                     AHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEY
                     KRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVS
                     TGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRD
                     FLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGSLDD
                     MKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTG
                     MVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH"
     exon            79..244
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            245..442
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            443..507
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            508..636
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            637..812
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            813..942
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1044
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1131
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1208
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatccatttc atcaaatcct gaaataatca aaatggattt agagaaaaat tacccaactc
       61 ctcggaccat caggacagga catggaggag tgaatcagct tgggggggtt tttgtgaatg
      121 gacggccact cccagatgta gtccgccaaa ggatagtgga acttgcccat caaggtgtca
      181 ggccctgcga catctccagg cagcttcggg tcagccatgg ttgtgtcagc aaaattcttg
      241 gcaggtatta tgagacagga agcatcaagc cgggggtgat cggaggatcc aaaccaaagg
      301 ttgccactcc caaagtggtg gaaaaaatcg ctgagtacaa acgccaaaat cctaccatgt
      361 ttgcctggga gatcagggac cggctgctgg cagagcgagt gtgtgacaat gacacagtgc
      421 ccagtgtcag ctccatcaac aggatcatcc ggacaaaagt acagcagccc cccaatcagc
      481 cggtcccagc ttccagtcac agcatagtgt ctacaggctc cgtgacgcag gtgtcgtcgg
      541 tgagcaccga ctctgcaggc tcctcgtact ccatcagcgg catcctgggc atcacgtccc
      601 ccagtgccga caccaacaag cgcaagaggg atgaaggtat tcaggagtct cccgtgccga
      661 atggccactc acttccaggc cgagacttcc tccgaaagca gatgcgggga gatctgttca
      721 cacagcagca gctggaggtg ctggaccgcg tgttcgagag acagcactac tcagacatct
      781 tcaccaccac ggagcccatc aagccagagc agaccacaga gtattcagcc atggcttcac
      841 tggctggaag cctggatgat atgaaagcca acttgacaag ccccaccccc gctgacatcg
      901 ggagcagcgt tccaggcccg cagtcctacc ccattgtcac aggccgagac ttggcaagca
      961 cgacccttcc ggggtaccct ccgcacgtgc cccccgctgg acagggcagc tactctgcac
     1021 cgacgctgac agggatggtg cctgggagcg aattttctgg gagtccctac agccaccctc
     1081 aatattcctc ctacaatgat tcatggaggt tccccaaccc agggctgctc ggctccccat
     1141 actattacag cgccgcagcc cgaggagccg ccccaccggc cgcagccacc gcctacgacc
     1201 gccactga
//
