LOCUS       NM_031799               1101 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus paired box 4 (Pax4), mRNA.
ACCESSION   NM_031799
VERSION     NM_031799.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1101)
  AUTHORS   Liang,X.D., Guo,Y.Y., Sun,M., Ding,Y., Wang,N., Yuan,L. and De,W.
  TITLE     Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat
            pancreatic alpha-cells
  JOURNAL   World J Gastroenterol 17 (23), 2812-2820 (2011)
   PUBMED   21734788
  REMARK    GeneRIF: Data show that Ngn3 and Pax4, a transcription factor that
            lies downstream of Ngn3 and plays an important role in beta-cell
            differentiation, were expressed in the alpha-cells of STZ-treated
            rats.
REFERENCE   2  (bases 1 to 1101)
  AUTHORS   Rath,M.F., Bailey,M.J., Kim,J.S., Ho,A.K., Gaildrat,P., Coon,S.L.,
            Moller,M. and Klein,D.C.
  TITLE     Developmental and diurnal dynamics of Pax4 expression in the
            mammalian pineal gland: nocturnal down-regulation is mediated by
            adrenergic-cyclic adenosine 3',5'-monophosphate signaling
  JOURNAL   Endocrinology 150 (2), 803-811 (2009)
   PUBMED   18818287
  REMARK    GeneRIF: The daily changes in Pax4 expression may influence gene
            expression in the pineal gland.
            GeneRIF: Pineal expression of Pax4 is undetectable prior to birth
            and increases thereafter; in the adult there is a daily rhythm in
            Pax4 expression with high levels during the day.
            GeneRIF: The daily rhythm in pineal Pax4 expression is controlled
            by a neural system which acts on pinealocytes through an
            adrenergic-cyclic AMP signalling mechanism.
REFERENCE   3  (bases 1 to 1101)
  AUTHORS   Rath,M.F., Bailey,M.J., Kim,J.S., Coon,S.L., Klein,D.C. and
            Moller,M.
  TITLE     Developmental and daily expression of the Pax4 and Pax6 homeobox
            genes in the rat retina: localization of Pax4 in photoreceptor
            cells
  JOURNAL   J Neurochem 108 (1), 285-294 (2009)
   PUBMED   19012751
  REMARK    GeneRIF: Retinal expression of Pax4 is undetectable prior to birth
            but increases thereafter; in the adult there are daily changes
            which may influence retinal gene expression
REFERENCE   4  (bases 1 to 1101)
  AUTHORS   Plengvidhya,N., Kooptiwut,S., Songtawee,N., Doi,A., Furuta,H.,
            Nishi,M., Nanjo,K., Tantibhedhyangkul,W., Boonyasrisawat,W.,
            Yenchitsomanus,P.T., Doria,A. and Banchuin,N.
  TITLE     PAX4 mutations in Thais with maturity onset diabetes of the young
  JOURNAL   J Clin Endocrinol Metab 92 (7), 2821-2826 (2007)
   PUBMED   17426099
REFERENCE   5  (bases 1 to 1101)
  AUTHORS   Brun,T., Duhamel,D.L., Hu He,K.H., Wollheim,C.B. and Gauthier,B.R.
  TITLE     The transcription factor PAX4 acts as a survival gene in INS-1E
            insulinoma cells
  JOURNAL   Oncogene 26 (29), 4261-4271 (2007)
   PUBMED   17260022
  REMARK    GeneRIF: Causal association between Pax4 mRNA levels and
            susceptibility of rat insulinoma cells to apoptosis suggests an
            important physiological function for Pax4 in cell survival.
REFERENCE   6  (bases 1 to 1101)
  AUTHORS   Wang,J., Elghazi,L., Parker,S.E., Kizilocak,H., Asano,M., Sussel,L.
            and Sosa-Pineda,B.
  TITLE     The concerted activities of Pax4 and Nkx2.2 are essential to
            initiate pancreatic beta-cell differentiation
  JOURNAL   Dev Biol 266 (1), 178-189 (2004)
   PUBMED   14729487
REFERENCE   7  (bases 1 to 1101)
  AUTHORS   Shimajiri,Y., Shimabukuro,M., Tomoyose,T., Yogi,H., Komiya,I. and
            Takasu,N.
  TITLE     PAX4 mutation (R121W) as a prodiabetic variant in Okinawans
  JOURNAL   Biochem Biophys Res Commun 302 (2), 342-344 (2003)
   PUBMED   12604352
REFERENCE   8  (bases 1 to 1101)
  AUTHORS   Campbell,S.C., Cragg,H., Elrick,L.J., Macfarlane,W.M., Shennan,K.I.
            and Docherty,K.
  TITLE     Inhibitory effect of pax4 on the human insulin and islet amyloid
            polypeptide (IAPP) promoters
  JOURNAL   FEBS Lett 463 (1-2), 53-57 (1999)
   PUBMED   10601637
REFERENCE   9  (bases 1 to 1101)
  AUTHORS   Smith,S.B., Ee,H.C., Conners,J.R. and German,M.S.
  TITLE     Paired-homeodomain transcription factor PAX4 acts as a
            transcriptional repressor in early pancreatic development
  JOURNAL   Mol Cell Biol 19 (12), 8272-8280 (1999)
   PUBMED   10567552
REFERENCE   10 (bases 1 to 1101)
  AUTHORS   Tokuyama,Y., Yagui,K., Sakurai,K., Hashimoto,N., Saito,Y. and
            Kanatsuka,A.
  TITLE     Molecular cloning of rat Pax4: identification of four isoforms in
            rat insulinoma cells
  JOURNAL   Biochem Biophys Res Commun 248 (1), 153-156 (1998)
   PUBMED   9675102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF053100.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF053100.1, AF198155.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1101
                     /gene="Pax4"
                     /note="paired box 4"
                     /db_xref="GeneID:83630"
                     /db_xref="RGD:620433"
     exon            1..61
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1098
                     /gene="Pax4"
                     /note="paired box gene 4"
                     /codon_start=1
                     /product="paired box protein Pax-4"
                     /protein_id="NP_113987.1"
                     /db_xref="GeneID:83630"
                     /db_xref="RGD:620433"
                     /translation="MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDIS
                     RSLKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPAVVARIAQLKDEYPALFAWE
                     IQRQLCAEGLCTQDKAPSVSSINRVLRALQEDQRLHWTQLRSPAVLAPALPSPHSNCE
                     APRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVVRGKLAAATSLPEDTVRVWF
                     SNRRAKWRRQEKLKWETQMPGASQDLMVPKDSPGIISAQQSPGSVPSAALPVLEQLNP
                     SFCQLCWGAVPDRCSSDTTSQACLQPYWECHSLLPVASSSYMEFAWPCLTTHPVHHLI
                     GGPGQAPSTYYLHWP"
     exon            62..192
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            193..408
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            409..484
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            485..610
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..693
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            694..763
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..819
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            820..961
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1101
                     /gene="Pax4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgccagtt ggctttctgt ccttctgtga ggaataccag tgtgaagcat gcagcaggac
       61 ggtctcagca gtgtgaatca gctgggggga ctctttgtga atggccggcc ccttccactg
      121 gacacccgac agcagattgt gcagctagcg ataagaggga tgcgaccctg tgacatctca
      181 cggagcctta aggtatctaa cggctgtgtg agtaagatcc taggacgcta ctaccgcaca
      241 ggagtcttgg aacccaaggg tattggggga agcaaaccac gtctggccac acctgctgtg
      301 gtggctcgaa ttgcccagct aaaggatgag tatccagctc tttttgcctg ggagatccaa
      361 cgccagcttt gtgctgaagg gctttgtacc caggacaagg ctcccagtgt atcctctatc
      421 aatcgagtcc ttcgggcact acaggaagac cagaggttac actggacaca acttagatct
      481 ccagctgttt tggctccagc tcttcctagt ccccacagta actgtgaggc tccccgaggt
      541 ccccacccgg ggaccagcca caggaatcgg actatcttct ccccgggcca agctgaggca
      601 ctggagaaag agttccagcg tgggcagtat ccagattcag ttgtccgtgg aaagctggct
      661 gctgccacct ctctgcctga agacacagtg agggtctggt tttccaacag aagagccaaa
      721 tggcgcagac aagagaagtt gaaatgggaa acacagatgc caggtgcttc tcaggacctg
      781 atggtaccaa aagattctcc agggatcatc tctgcacagc agtcccctgg cagtgtaccc
      841 tcagcagccc tgcctgtgct ggaacaattg aatccttcct tctgtcagct gtgctggggg
      901 gcagtaccag acagatgttc cagtgacacc acatcccaag cctgtctcca accctactgg
      961 gaatgccact ccctccttcc tgtggcttct tcctcataca tggaatttgc ctggccctgc
     1021 ctcaccaccc atcctgtgca tcatctgatt ggaggcccag gacaagcgcc atcaacctat
     1081 tacttacact ggccataaga g
//
