LOCUS       NM_001106361            1400 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus paired box 2 (Pax2), mRNA.
ACCESSION   NM_001106361 XM_001062747 XM_239083
VERSION     NM_001106361.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Wang,X.L., Hou,L., Zhao,C.G., Tang,Y., Zhang,B., Zhao,J.Y. and
            Wu,Y.B.
  TITLE     Screening of genes involved in epithelial-mesenchymal transition
            and differential expression of complement-related genes induced by
            PAX2 in renal tubules
  JOURNAL   Nephrology (Carlton) 24 (2), 263-271 (2019)
   PUBMED   29280536
  REMARK    GeneRIF: Pax2 overexpression by kidney tubule cells alters the
            expression of complement system proteins to induce
            epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Hou,L., Du,Y., Zhao,C. and Wu,Y.
  TITLE     PAX2 may induce ADAM10 expression in renal tubular epithelial cells
            and contribute to epithelial-to-mesenchymal transition
  JOURNAL   Int Urol Nephrol 50 (9), 1729-1741 (2018)
   PUBMED   30117015
  REMARK    GeneRIF: PAX2 directly increased expression of ADAM10, the presence
            of which contributed to EMT in renal tubular epithelia and hence
            plays an important role in renal fibrosis.
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Larsson,M.
  TITLE     Pax2 is persistently expressed by GABAergic neurons throughout the
            adult rat dorsal horn
  JOURNAL   Neurosci Lett 638, 96-101 (2017)
   PUBMED   27939388
  REMARK    GeneRIF: Persistent Pax2 expression may be required to maintain a
            GABAergic phenotype.
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Jiang,Y., Jiang,T., Ouyang,J., Zhou,Q., Liang,Y., Cui,Y., Chen,P.
            and Huang,B.
  TITLE     Cell atavistic transition: Paired box 2 re-expression occurs in
            mature tubular epithelial cells during acute kidney injury and is
            regulated by Angiotensin II
  JOURNAL   PLoS One 9 (4), e93563 (2014)
   PUBMED   24710423
  REMARK    GeneRIF: Those findings suggest that mature TECs can
            trans-differentiate into progenitor-like cells by 'atavistic
            transition', which may participate in the recovery of tissue
            structure and Pax2 may play a pivotal role in this process.
            Erratum:[PLoS One. 2015 May 06;10(5):e0127718. doi:
            10.1371/journal.pone.0127718. PMID: 25945929]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Ryan,G., Steele-Perkins,V., Morris,J.F., Rauscher,F.J. 3rd and
            Dressler,G.R.
  TITLE     Repression of Pax-2 by WT1 during normal kidney development
  JOURNAL   Development 121 (3), 867-875 (1995)
   PUBMED   7720589
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Eccles,M.R., Yun,K., Reeve,A.E. and Fidler,A.E.
  TITLE     Comparative in situ hybridization analysis of PAX2, PAX8, and WT1
            gene transcription in human fetal kidney and Wilms' tumors
  JOURNAL   Am J Pathol 146 (1), 40-45 (1995)
   PUBMED   7856737
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Sharma,P.M., Bowman,M., Yu,B.F. and Sukumar,S.
  TITLE     A rodent model for Wilms tumors: embryonal kidney neoplasms induced
            by N-nitroso-N'-methylurea
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9931-9935 (1994)
   PUBMED   7937920
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Poleev,A., Fickenscher,H., Mundlos,S., Winterpacht,A., Zabel,B.,
            Fidler,A., Gruss,P. and Plachov,D.
  TITLE     PAX8, a human paired box gene: isolation and expression in
            developing thyroid, kidney and Wilms' tumors
  JOURNAL   Development 116 (3), 611-623 (1992)
   PUBMED   1337742
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Plachov,D., Chowdhury,K., Walther,C., Simon,D., Guenet,J.L. and
            Gruss,P.
  TITLE     Pax8, a murine paired box gene expressed in the developing
            excretory system and thyroid gland
  JOURNAL   Development 110 (2), 643-651 (1990)
   PUBMED   1723950
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_239083.4, XM_001062747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132274, SAMD00132279
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1400
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="paired box 2"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
     exon            1..75
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1283
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="paired box gene 2; paired box protein 2; paired box
                     homeotic gene 2"
                     /codon_start=1
                     /product="paired box protein Pax-2"
                     /protein_id="NP_001099831.1"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
                     /translation="MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELA
                     HQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYK
                     RQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAP
                     GHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKREEVEVYTDPAHIRGGG
                     GLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVF
                     QASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMAS
                     TTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLS
                     SPYYYSAAPRGSAPAAAAAAYDRH"
     exon            76..241
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..439
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..525
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..645
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..714
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..890
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1017
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1119
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1206
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1400
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcgct gctcccgctc ctctgcctcc ccatggatat gcactgcaaa gcagacccct
       61 tctccgcgat gcaccggcac gggggtgtga accagctcgg gggggtgttt gtgaacggcc
      121 ggcccctacc cgacgtggtg aggcagcgca tcgtggagct ggcccaccag ggtgtgcggc
      181 cctgtgacat ctcccggcag ctgcgggtca gccatggctg tgtcagcaaa atcctgggca
      241 ggtactacga gactggcagc atcaagcccg gagtgattgg tggctccaag cccaaggtgg
      301 caacgcccaa agtggtggac aagattgctg aatacaagcg acagaacccg actatgttcg
      361 cctgggagat ccgggacagg ctgctagctg agggcatctg cgacaatgat acagttccca
      421 gcgtctcatc catcaacagg atcatccgga ccaaagttca gcagcctttc cacccaacgc
      481 cggatggggc agggacagga gtgactgccc ctggccacac catcgttccc agcacggcct
      541 cccctcctgt ttccagcgcc tctaacgacc cagtgggatc ctactccatc aacgggatcc
      601 tggggattcc tcgctccaac ggtgagaaga ggaaacgaga ggaagtcgag gtatacactg
      661 atcctgccca cattagagga ggtggaggtt tgcatctggt ctggacttta agagatgtgt
      721 ccgagggctc tgtccctaat ggagactccc agagtggtgt ggacagtttg cggaagcacc
      781 tgcgagccga caccttcacc cagcagcagc tggaagcttt ggatcgagtc tttgagcgtc
      841 cttcctatcc cgatgtcttc caagcatcag agcacatcaa atcagaacag gggaatgaat
      901 actctctccc agccctgacc cctgggcttg atgaagtcaa gtccagtcta tctgcatcta
      961 ccaaccctga gctgggcagc aatgtgtcag gcacacagac gtaccccgtc gtgaccggtc
     1021 gtgatatggc gagcaccact ctacctggtt acccccctca tgtgcccccc actggccagg
     1081 gaagctaccc tacctccacc ctggcaggaa tggtgcctgg gagcgagttc tcaggcaacc
     1141 catacagcca tccccagtac accgcctaca atgaggcttg gagattcagc aaccccgcct
     1201 tactaagttc cccttattat tatagtgccg ccccccgggg ctccgcccct gccgctgctg
     1261 ccgctgccta tgaccgccac tagttaccgc ggggaccaca tcaagcttca ggcagacagc
     1321 ttcggcctcc acatcgtccc cgtctgaccg cccaccccag agggagggag gaccgaagcg
     1381 acgcgctgcc tctcggccac
//
