LOCUS       NM_001401899            2532 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus paired box 1 (Pax1), mRNA.
ACCESSION   NM_001401899 XM_039105048
VERSION     NM_001401899.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2532)
  AUTHORS   Singh,P., Bhadada,S.K., Arya,A.K., Saikia,U.N., Sachdeva,N.,
            Dahiya,D., Kaur,J., Brandi,M.L. and Rao,S.D.
  TITLE     Aberrant Epigenetic Alteration of PAX1 Expression Contributes to
            Parathyroid Tumorigenesis
  JOURNAL   J Clin Endocrinol Metab 107 (2), e783-e792 (2022)
   PUBMED   34453169
  REMARK    GeneRIF: Aberrant Epigenetic Alteration of PAX1 Expression
            Contributes to Parathyroid Tumorigenesis.
REFERENCE   2  (bases 1 to 2532)
  AUTHORS   Adham,I.M., Gille,M., Gamel,A.J., Reis,A., Dressel,R., Steding,G.,
            Brand-Saberi,B. and Engel,W.
  TITLE     The scoliosis (sco) mouse: a new allele of Pax1
  JOURNAL   Cytogenet Genome Res 111 (1), 16-26 (2005)
   PUBMED   16093716
REFERENCE   3  (bases 1 to 2532)
  AUTHORS   Rodrigo,I., Bovolenta,P., Mankoo,B.S. and Imai,K.
  TITLE     Meox homeodomain proteins are required for Bapx1 expression in the
            sclerotome and activate its transcription by direct binding to its
            promoter
  JOURNAL   Mol Cell Biol 24 (7), 2757-2766 (2004)
   PUBMED   15024065
REFERENCE   4  (bases 1 to 2532)
  AUTHORS   Rodrigo,I., Hill,R.E., Balling,R., Munsterberg,A. and Imai,K.
  TITLE     Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation
            in the sclerotome
  JOURNAL   Development 130 (3), 473-482 (2003)
   PUBMED   12490554
REFERENCE   5  (bases 1 to 2532)
  AUTHORS   Aubin,J., Lemieux,M., Moreau,J., Lapointe,J. and Jeannotte,L.
  TITLE     Cooperation of Hoxa5 and Pax1 genes during formation of the
            pectoral girdle
  JOURNAL   Dev Biol 244 (1), 96-113 (2002)
   PUBMED   11900462
REFERENCE   6  (bases 1 to 2532)
  AUTHORS   Su,D., Ellis,S., Napier,A., Lee,K. and Manley,N.R.
  TITLE     Hoxa3 and pax1 regulate epithelial cell death and proliferation
            during thymus and parathyroid organogenesis
  JOURNAL   Dev Biol 236 (2), 316-329 (2001)
   PUBMED   11476574
REFERENCE   7  (bases 1 to 2532)
  AUTHORS   Furumoto,T.A., Miura,N., Akasaka,T., Mizutani-Koseki,Y., Sudo,H.,
            Fukuda,K., Maekawa,M., Yuasa,S., Fu,Y., Moriya,H., Taniguchi,M.,
            Imai,K., Dahl,E., Balling,R., Pavlova,M., Gossler,A. and Koseki,H.
  TITLE     Notochord-dependent expression of MFH1 and PAX1 cooperates to
            maintain the proliferation of sclerotome cells during the vertebral
            column development
  JOURNAL   Dev Biol 210 (1), 15-29 (1999)
   PUBMED   10364424
REFERENCE   8  (bases 1 to 2532)
  AUTHORS   Cserjesi,P., Brown,D., Ligon,K.L., Lyons,G.E., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Olson,E.N.
  TITLE     Scleraxis: a basic helix-loop-helix protein that prefigures
            skeletal formation during mouse embryogenesis
  JOURNAL   Development 121 (4), 1099-1110 (1995)
   PUBMED   7743923
REFERENCE   9  (bases 1 to 2532)
  AUTHORS   Timmons,P.M., Wallin,J., Rigby,P.W. and Balling,R.
  TITLE     Expression and function of Pax 1 during development of the pectoral
            girdle
  JOURNAL   Development 120 (10), 2773-2785 (1994)
   PUBMED   7607069
REFERENCE   10 (bases 1 to 2532)
  AUTHORS   Chalepakis,G., Fritsch,R., Fickenscher,H., Deutsch,U., Goulding,M.
            and Gruss,P.
  TITLE     The molecular basis of the undulated/Pax-1 mutation
  JOURNAL   Cell 66 (5), 873-884 (1991)
   PUBMED   1889089
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 1, 2022 this sequence version replaced XM_039105048.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.14783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840109, SAMN17050755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               JAXUCZ010000003.1  155245529-155245844
            317-946             JAXUCZ010000003.1  155246298-155246927
            947-1089            JAXUCZ010000003.1  155248377-155248519
            1090-1312           JAXUCZ010000003.1  155248897-155249119
            1313-2532           JAXUCZ010000003.1  155253617-155254836
FEATURES             Location/Qualifiers
     source          1..2532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2532
                     /gene="Pax1"
                     /gene_synonym="Pax-1"
                     /note="paired box 1"
                     /db_xref="GeneID:311505"
                     /db_xref="RGD:1588548"
     exon            1..316
                     /gene="Pax1"
                     /gene_synonym="Pax-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1404
                     /gene="Pax1"
                     /gene_synonym="Pax-1"
                     /note="Paired box homeotic gene 1; paired box gene 1"
                     /codon_start=1
                     /product="paired box protein Pax-1"
                     /protein_id="NP_001388828.1"
                     /db_xref="GeneID:311505"
                     /db_xref="RGD:1588548"
                     /translation="MKFTLGLGSRAWRVSWERAAAAAAAVPGAGGALGSGSLRVSSRR
                     GPRLARALPLCLSGGGGARALPDCAGPSPRRSGARQLAGPRAMEQTYGEVNQLGGVFV
                     NGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGS
                     KPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIG
                     SLAQPGPYEASKQPPPQPALPYNHIYQYPYPSPVSPTGTKMGSHPGVPGSAGHVSIPR
                     SWPSAHSVSNILGIRTFMEQTGALAGSEGAAYSPKVEDWASVNRAAFSTSSAVNGLEK
                     PALEADIKYTQSASSLSAVGGFLPACAYPASNQHGVYSAPAAGYLSPGPPWPPAQAPP
                     LAPHGAGVAVHGGELAAAMTFKHPSREGTDRKPPSPGGKATDALGSLHGLSIPASTS"
     exon            317..946
                     /gene="Pax1"
                     /gene_synonym="Pax-1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1089
                     /gene="Pax1"
                     /gene_synonym="Pax-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1312
                     /gene="Pax1"
                     /gene_synonym="Pax-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..2532
                     /gene="Pax1"
                     /gene_synonym="Pax-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaattgattc tcgcaccccg cagcttcccg gtcagacgaa tttctcccaa tcggatgaag
       61 ttcaccttgg gcctggggtc gcgggcctgg agagtgtcct gggaacgggc ggcggcggct
      121 gcggcagcgg tccctggggc gggcggcgcg ctgggcagcg gctcactgcg cgtctccagc
      181 cgccgcggcc ctcggctcgc gcgcgccctc cctctatgcc tctccggcgg tggcggcgcc
      241 cgagctctcc cggactgtgc cgggcccagc ccccgccgct ccggcgccag gcagctggcc
      301 ggcccgcgcg cgatggagca gacgtacggc gaagtgaacc agcttggtgg tgtgttcgtc
      361 aacggccgtc ccctgcccaa tgccatccgc ctgcgcatcg tggaattagc acagctgggt
      421 atccgaccct gtgacatcag taggcaactg cgggtctctc atggctgtgt gagcaaaatc
      481 ctggcgcgct acaacgagac cggttccatc ctgcccgggg ccattggggg cagcaaacct
      541 cgagttacca cccccaatgt agtgaagcac atccgggact acaagcaggg cgatcctggc
      601 atctttgcct gggagattcg tgaccggcta ctggctgacg gcgtctgtga caagtacaac
      661 gtgccttccg tgagctctat tagtcgcatc ctgcgaaata agattggcag cctggcacag
      721 ccagggccat acgaagcaag taaacagccg ccgccgcagc ccgcgctgcc ctacaatcat
      781 atctaccagt acccgtaccc cagcccagtg tcacccacgg gcactaagat gggcagtcat
      841 cccggggttc ccggctcagc gggccacgtc agtatcccgc gttcatggcc ctccgcacat
      901 tcagtcagca acattctggg catccggaca tttatggagc aaacaggggc cctggccggg
      961 agcgaaggcg ctgcctactc ccccaaggtg gaagactggg cgagtgtgaa tcgtgccgcc
     1021 ttctccacct cgtcagcagt gaatggactc gagaaacctg ccttggaggc agacattaaa
     1081 tatacccagt cggcttccag cctctccgca gtgggcggct tccttcctgc ctgcgcctac
     1141 ccggcttcca accagcacgg agtatacagc gctccagcag ccggctacct atcccccggc
     1201 ccgccctggc caccagccca ggcacccccg ctggcgcccc acggagctgg tgtggcggtg
     1261 cacggcgggg agcttgccgc ggcaatgacc ttcaaacacc ccagccgaga agggaccgac
     1321 aggaagcccc ctagcccggg aggcaaggcc acggacgcac tcggtagctt acacggactt
     1381 tccatcccgg cttcgacctc ctaggggctg tcccctcgta gagccacaga tcagctcaga
     1441 ggggccggcc ggaccgcggc tccgctcact cgacctctgg ctggcagcat cctgaagttg
     1501 gggctccggc actgcctccg ccccaacagt tccttcacga gctcctggga tcttttcggt
     1561 ctttcccaac cttggttttt gaaggctgcg ctaaccttcc ttgcttgaga gaggctcctg
     1621 aatccacagc gtcgacttac cttttttttt ttaatcttct cctccctcct cctgttctct
     1681 ctctctcttc cctcctctat tttctcgtcc caattctttc cctttttgca ttcttccctc
     1741 tccatctcct ggtttctctc tcacttttct cacaatcaaa ggtctgatct ttacagcttc
     1801 cctgactcta ctgctccaat ctgggcaaac ttcagtacac tctgcaagga cccaaccctc
     1861 ctctattacc cccacccgac ccccgccatc ccctcctccc ctgaacaccc tccgtcccaa
     1921 gggagtgggg cttgaaccta ggagcaaagc caaaaccctt gttcatatat ttttatagta
     1981 acaaaaagga gtacaacttc cctgggttgc tgccccttcc ctgagaatat ttttttctgt
     2041 gcccaatgac taggctggct ttatttctaa gttaatgcca cctgaaagaa gacagtgcaa
     2101 gagaaagaga tgctgggacg ggtagtgttt tcagtaatta aaaactaggc acacctctct
     2161 tagcccggct acacccaatg ctccctaatg tacctcccga cccaacagca ttgtttcagg
     2221 tgttttcccc tccatacatt tgttgatttt gaggaacaaa ctgcttcagg gtgctgaggt
     2281 ccattctggc ttctggtttg caaggaattg gagtgggtaa aaacccagga acccaggagg
     2341 ctcttctgga gtaaggcaag agggctatta actgatttca agttcagatg aactggtggc
     2401 gggactctga gtataattca atttttgtag tcataaacat attactggtg agagtctggc
     2461 ttcacctgtt aaacatgggc gggcgtcttt gaataaagga aattctgaaa ttcaccagct
     2521 tggtgaggga ga
//
