LOCUS       NM_033485               2114 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), mRNA.
ACCESSION   NM_033485
VERSION     NM_033485.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2114)
  AUTHORS   Hao,Y., Niu,H., An,S., Wang,M. and Wang,Z.
  TITLE     Downregulation of iNOS, IL-1beta, and P2X7 Expression in Mast Cells
            via Activation of PAR4 Contributes to the Inhibition of Visceral
            Hyperalgesia in Rats
  JOURNAL   J Immunol Res 2018, 3256908 (2018)
   PUBMED   29854833
  REMARK    GeneRIF: this study shows that downregulation of iNOS, IL-1beta,
            and P2X7 expression in mast cells via activation of PAR4
            contributes to the Inhibition of visceral hyperalgesia
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2114)
  AUTHORS   Du,W.W., Li,X., Li,T., Li,H., Khorshidi,A., Liu,F. and Yang,B.B.
  TITLE     The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence
            by targeting Par4
  JOURNAL   J Cell Sci 128 (2), 293-304 (2015)
   PUBMED   25472717
REFERENCE   3  (bases 1 to 2114)
  AUTHORS   de Thonel,A., Hazoume,A., Kochin,V., Isoniemi,K., Jego,G.,
            Fourmaux,E., Hammann,A., Mjahed,H., Filhol,O., Micheau,O.,
            Rocchi,P., Mezger,V., Eriksson,J.E., Rangnekar,V.M. and Garrido,C.
  TITLE     Regulation of the proapoptotic functions of prostate apoptosis
            response-4 (Par-4) by casein kinase 2 in prostate cancer cells
  JOURNAL   Cell Death Dis 5 (1), e1016 (2014)
   PUBMED   24457960
  REMARK    GeneRIF: Phosphorylation by CK2 impairs Par-4 proapoptotic
            functions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2114)
  AUTHORS   Wang,Z., Chen,D., Zhang,R., An,S., Zhang,Z. and Ma,Q.
  TITLE     Interleukin-1beta increased the expression of protease-activated
            receptor 4 mRNA and protein in dorsal root ganglion neurons
  JOURNAL   Neurochem Res 38 (9), 1895-1903 (2013)
   PUBMED   23775412
REFERENCE   5  (bases 1 to 2114)
  AUTHORS   MacDonald,J.A., Moffat,L.D., Al-Ghabkari,A., Sutherland,C. and
            Walsh,M.P.
  TITLE     Prostate-apoptosis response-4 phosphorylation in vascular smooth
            muscle
  JOURNAL   Arch Biochem Biophys 535 (1), 84-90 (2013)
   PUBMED   23219599
  REMARK    GeneRIF: Par-4 binding does not block MYPT1 phosphorylation in rat
            caudal arterial smooth muscle.
REFERENCE   6  (bases 1 to 2114)
  AUTHORS   Duan,W., Rangnekar,V.M. and Mattson,M.P.
  TITLE     Prostate apoptosis response-4 production in synaptic compartments
            following apoptotic and excitotoxic insults: evidence for a pivotal
            role in mitochondrial dysfunction and neuronal degeneration
  JOURNAL   J Neurochem 72 (6), 2312-2322 (1999)
   PUBMED   10349840
REFERENCE   7  (bases 1 to 2114)
  AUTHORS   Guo,Q., Fu,W., Xie,J., Luo,H., Sells,S.F., Geddes,J.W., Bondada,V.,
            Rangnekar,V.M. and Mattson,M.P.
  TITLE     Par-4 is a mediator of neuronal degeneration associated with the
            pathogenesis of Alzheimer disease
  JOURNAL   Nat Med 4 (8), 957-962 (1998)
   PUBMED   9701251
REFERENCE   8  (bases 1 to 2114)
  AUTHORS   Boghaert,E.R., Sells,S.F., Walid,A.J., Malone,P., Williams,N.M.,
            Weinstein,M.H., Strange,R. and Rangnekar,V.M.
  TITLE     Immunohistochemical analysis of the proapoptotic protein Par-4 in
            normal rat tissues
  JOURNAL   Cell Growth Differ 8 (8), 881-890 (1997)
   PUBMED   9269897
REFERENCE   9  (bases 1 to 2114)
  AUTHORS   Johnstone,R.W., See,R.H., Sells,S.F., Wang,J., Muthukkumar,S.,
            Englert,C., Haber,D.A., Licht,J.D., Sugrue,S.P., Roberts,T.,
            Rangnekar,V.M. and Shi,Y.
  TITLE     A novel repressor, par-4, modulates transcription and growth
            suppression functions of the Wilms' tumor suppressor WT1
  JOURNAL   Mol Cell Biol 16 (12), 6945-6956 (1996)
   PUBMED   8943350
REFERENCE   10 (bases 1 to 2114)
  AUTHORS   Sells,S.F., Wood,D.P. Jr., Joshi-Barve,S.S., Muthukumar,S.,
            Jacob,R.J., Crist,S.A., Humphreys,S. and Rangnekar,V.M.
  TITLE     Commonality of the gene programs induced by effectors of apoptosis
            in androgen-dependent and -independent prostate cells
  JOURNAL   Cell Growth Differ 5 (4), 457-466 (1994)
   PUBMED   8043520
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_033485.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U05989.1, SRR22399484.1057280.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               JAXUCZ010000007.1  45532239-45532796
            559-690             JAXUCZ010000007.1  45582043-45582174
            691-725             JAXUCZ010000007.1  45590321-45590355
            726-873             JAXUCZ010000007.1  45605743-45605890
            874-978             JAXUCZ010000007.1  45608522-45608626
            979-2114            JAXUCZ010000007.1  45610357-45611492
FEATURES             Location/Qualifiers
     source          1..2114
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..2114
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="pro-apoptotic WT1 regulator"
                     /db_xref="GeneID:64513"
                     /db_xref="RGD:69065"
     exon            1..558
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1065
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="prostate apoptosis response 4 protein;
                     transcriptional repressor Par-4-like protein PAWR; par-4
                     induced by effectors of apoptosis; Prostate apoptosis
                     response protein 4; PRKC, apoptosis, WT1, regulator"
                     /codon_start=1
                     /product="PRKC apoptosis WT1 regulator protein"
                     /protein_id="NP_277020.2"
                     /db_xref="GeneID:64513"
                     /db_xref="RGD:69065"
                     /translation="MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAA
                     KSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDE
                     CPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNI
                     PAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRY
                     KSTTSAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQ
                     ENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR"
     exon            559..690
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            691..725
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..873
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            874..978
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            979..2114
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcggcgg cggcgggagt caggagtcgc ggcgtgaggg gcgcccccgc cggcccctct
       61 gggaacatgg cgaccggcgg ctatcggagc agcggcagca ccacggactt cctggaggag
      121 tggaaagcga agcgcgagaa gatgcgcgcc aagcagaacc ccgtgggccc gggttcgagc
      181 ggcggggatc cagccgccaa gtcccctgcg ggaccgctcg cccagactac ggccgcgggg
      241 acctcggaac tcaaccacgg ccccgccggc gcggccgcac ctgccgcccc cgggccgggc
      301 gccctgaact gcgctcacgg ctcgtccgcg ctgccccgcg gggctcccgg ctcccggcgg
      361 ccggaggacg agtgtcctat tgccgctggg gccgcgggag cacccgcgtc ccggggagac
      421 gaggaggagc cggatagcgc cccggagaag ggccgcagct cggggcccag cgccaggaaa
      481 ggcaaagggc agatcgagaa gaggaagctg cgggagaagc gccgctccac cggcgtggtc
      541 aacatccccg cggcggagtg cttagatgag tacgaagatg acgaagcagg acagaaggaa
      601 cggaagcgag aggatgctat cacacagcag aacaccatcc agaatgaagc tgcgagcctc
      661 ccagatccag gaacctccta cctgccccag gacccgtcga gaacagtccc aggcagatac
      721 aaaagcacaa ccagtgcccc agaagaagaa atcttaaata gatatccccg aacagataga
      781 agtggcttca gtagacacaa cagagatacc agtgcgcctg ctaacttcgc ttcaagtagc
      841 accttggaaa agagaattga agatcttgag aaggaagtct tgagagaaag gcaagaaaac
      901 cttcgactta cgaggctgat gcaagataaa gaagaaatga ttggaaaact caaggaagag
      961 attgatttgt taaatagaga cctcgatgac atggaagacg aaaacgagca actaaagcag
     1021 gaaaataaaa ctcttttgaa agttgttggg cagctgacaa ggtagaagac gcaaggctgc
     1081 ctcggtgtgg gaaacctgct tttaaaccgc ggatgaatgt catggcgaag gcgcccgtga
     1141 ttcagtgcgc tgagagaact gtatatttat ttctagaaaa cacatggatc tcttcttctc
     1201 aaaatttact ctttctcatt actagttttt aaaaagtgta aatccccgtc tttcacatag
     1261 aagttaacat ctttagctat taaaatgata ggtgatgcct cttggttctg tgtgatactc
     1321 agataatata tggttcgaag tagcagccat ttgcatatgt tttatctatg ttagcacata
     1381 ttctccctaa aggaagatgc atagtctttg tttacatgaa ttcaaatcct tgggggagtt
     1441 gcctacagat gccctattac taatgtgtgc gccttccgtg tgctaatgcc tactcataaa
     1501 gacgcatctg ccgtctcgtc ctcccacggg ctctcctgat tccgagtggt aatagataca
     1561 ctactttgta tagcagtaat cgttcaaagg aaagctattt tgcagttatt tcatatgttc
     1621 tagttggcta aatataaact taagaaaata cttgaactgt gttatagtaa gtgaaaaatt
     1681 actattttgt gtttgaatat tgaaaaaaat ttcagtaact tctgaaaaac agttaatgta
     1741 tagtttctta tgtaggtact atcattcttt tttttttatt gctctagggt ttactagtaa
     1801 ataatgggat atttaaaaag ttgtttattc ttcaggcctc aattgtgtac aatttcagta
     1861 ttgaagaaga aaattgatgc tgtgaatagc atgtgcttca aaaatcagaa ctaaaaaatt
     1921 tttccacact taaaatatgt acacatacgt cagcatgtgt aagcagagat aacacagata
     1981 tctcagccga ttcctgagtt ggagacaccc tgggatgctt tttgtcaata gagaatcatc
     2041 ccataaccct aacactgaag attttaaagc aaccatattt gaagatttat aaaataaagt
     2101 tgtcttctat taaa
//
