LOCUS       NM_001108520            4007 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PAT1 homolog 1, processing body mRNA decay factor
            (Patl1), mRNA.
ACCESSION   NM_001108520 XM_001079118 XM_342029
VERSION     NM_001108520.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4007)
  AUTHORS   Jonas,S. and Izaurralde,E.
  TITLE     The role of disordered protein regions in the assembly of decapping
            complexes and RNP granules
  JOURNAL   Genes Dev 27 (24), 2628-2641 (2013)
   PUBMED   24352420
  REMARK    Review article
REFERENCE   2  (bases 1 to 4007)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4007)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4007)
  AUTHORS   Totaro,A., Renzi,F., La Fata,G., Mattioli,C., Raabe,M., Urlaub,H.
            and Achsel,T.
  TITLE     The human Pat1b protein: a novel mRNA deadenylation factor
            identified by a new immunoprecipitation technique
  JOURNAL   Nucleic Acids Res 39 (2), 635-647 (2011)
   PUBMED   20852261
REFERENCE   5  (bases 1 to 4007)
  AUTHORS   Marnef,A., Maldonado,M., Bugaut,A., Balasubramanian,S., Kress,M.,
            Weil,D. and Standart,N.
  TITLE     Distinct functions of maternal and somatic Pat1 protein paralogs
  JOURNAL   RNA 16 (11), 2094-2107 (2010)
   PUBMED   20826699
REFERENCE   6  (bases 1 to 4007)
  AUTHORS   Ozgur,S., Chekulaeva,M. and Stoecklin,G.
  TITLE     Human Pat1b connects deadenylation with mRNA decapping and controls
            the assembly of processing bodies
  JOURNAL   Mol Cell Biol 30 (17), 4308-4323 (2010)
   PUBMED   20584987
REFERENCE   7  (bases 1 to 4007)
  AUTHORS   Braun,J.E., Tritschler,F., Haas,G., Igreja,C., Truffault,V.,
            Weichenrieder,O. and Izaurralde,E.
  TITLE     The C-terminal alpha-alpha superhelix of Pat is required for mRNA
            decapping in metazoa
  JOURNAL   EMBO J 29 (14), 2368-2380 (2010)
   PUBMED   20543818
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168974.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001108520.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132271, SAMD00132275
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4007
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /note="PAT1 homolog 1, processing body mRNA decay factor"
                     /db_xref="GeneID:361736"
                     /db_xref="RGD:1305514"
     exon            1..120
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2418
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /note="PAT1-like protein 1; protein PAT1 homolog b;
                     protein associated with topoisomerase II homolog 1"
                     /codon_start=1
                     /product="protein PAT1 homolog 1"
                     /protein_id="NP_001101990.1"
                     /db_xref="GeneID:361736"
                     /db_xref="RGD:1305514"
                     /translation="MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDD
                     DWQEAHERLAELEEKLPVAADEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDP
                     AVMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQ
                     GPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRP
                     PMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGR
                     MSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPPATPPPQQHPP
                     GPGPHLQNLRPQAPMFRPDTTHLHPQHRRLLHQRQLQSRNQHRNLNGTGDRGGHRVSH
                     QDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKSSAAEEMQ
                     GDGPKKERTKLITPQVARLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDD
                     ETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALTDERKHKIWSMY
                     DNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMATARNLPFLI
                     KKDAQDEVLPCLLSPFSLLLYHLPSVTVTSLLQQLMNLPQSATAPAPSNSHLTAVLQN
                     KFGLSLLLILLSRGEDLHSSDPTVESTQNNQWTEVMFMATQELLRIPQAALAKPISIP
                     TNLVSLFSRYVDRQKLNLLETKLQLVQGMR"
     exon            121..232
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            233..450
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            451..531
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            532..726
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            727..828
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            829..918
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1136
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1226
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1407
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1531
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1629
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1689
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1838
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1998
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2154
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2246
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2396
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..3983
                     /gene="Patl1"
                     /gene_synonym="Pat1b; RGD1305514"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagccggtg ggagacccgc gcgcgcggag cagcccgggg agtcggcgct ttttttccct
       61 ccctcccccc actcccctcc ccgctccctt cccccttccc caagaatgtt ccgctacgag
      121 tctttggagg attgtcctct agatgaagat gaagatgcat ttcagggcct gggagaagaa
      181 gatgaagaaa ttgatcaatt taatgatgat acatttggat caggtgcagt tgatgacgat
      241 tggcaggaag cacatgagcg cctggctgag ttggaagaga agttacctgt ggcagctgat
      301 gaacaaacag gcaatggaga gagagatgag atggacttgt tgggtgacca tgaggagaat
      361 ctagcagaaa ggctcagcaa gatggtgatt gaaaatgagc tagaagatcc agctgtcatg
      421 agggcagtgc agaccaggcc agttttacaa cctcaaccag gaagtctgaa ttccagcatc
      481 tgggatggat ctgaagttct gaggcgaatc cgtggaccac tgcttgctca ggaaatgcct
      541 acagtgtctg tattagaata tgccttgcct cagaggcccc cacagggccc agaagatgac
      601 cgggaccttt ctgagcgagc tttaccaagg cggtcaacat cacctatcat tggaagtcct
      661 cctgttagag ctgttcctat aggcacccca cctaagcaga tggcggttcc cagcttcaac
      721 caacagattc tgtgtccgaa gcctgttcat gtccggcccc caatgccacc acgttatcct
      781 gctccctatg gtgagaggat gtctccaaac cagctctgca gtgtcccgaa ctcctccctc
      841 ctgggccacc cttttcctcc tagtgttcct cctgtactca gtcctctgca gagagcacag
      901 cttctgggag gagcacaact acagcctgga cgaatgtctc ccagccagtt cgcacgggtc
      961 cctggatttg ttggtagccc attggctgcc atgaatccta agttgctaca agggcgtgtt
     1021 gggcagatgc ttcctccagc accaggcttc cgtgccttct tcagtgctcc accccctgcc
     1081 acgccacctc cacagcaaca ccctcctggc ccaggacctc acctccagaa cctaagacct
     1141 caggccccaa tgtttagacc agacacaact caccttcatc cacagcaccg gcgcctgctg
     1201 caccagaggc agctgcaaag tagaaatcag catcgaaatc tcaatggtac tggagacaga
     1261 ggaggtcacc gggttagtca tcaagatcat ctccggaagg atccatatgc taatctaatg
     1321 ttgcagcggg aaaaggattg ggtctctaaa atccaaatga tgcagctgca gagcactgat
     1381 ccctacctgg atgatttcta ttaccagaat tactttgaaa agctggagaa atcgtcagct
     1441 gctgaagaaa tgcaaggtga cggccctaag aaggagcgca ccaagctcat cacccctcag
     1501 gtggccagac tggagcacgc ctacaagcct gtgcagtttg agggctcttt ggggaaactt
     1561 actgtctcta gtgtgaataa tcctcggaag atgatagatg ctgttgtgac atctcggagt
     1621 gaggatgatg aaacaaaaga aaaacaagtt cgggataaaa gaagaaaaac ccttgtcata
     1681 attgagaaaa cctatagttt actccttgat gtggaggatt atgaaaggcg ctatctccta
     1741 agtctagagg aagagcggcc tgccctgaca gatgaaagaa agcacaaaat ctggagcatg
     1801 tatgacaacc tgagaggcaa attgcctggg caagagaggc caagtgatga ccactttgta
     1861 caaatcatgt gtatccgaaa agggaagaga atggttgccc gcattctccc tttcctctcc
     1921 acagagcaag cagctgacat tctcatggca actgccagga acctcccttt ccttatcaag
     1981 aaggacgcac aagatgaggt gctgccatgc ttactgagtc ccttctctct cctcctctat
     2041 catcttcctt cagtgactgt caccagcctt ctgcaacagc taatgaacct acctcaaagt
     2101 gcaactgcac cagcaccctc taactctcac ctcactgctg tgctccagaa caagtttggc
     2161 ttgtcactgc tcctaatcct cttaagccgt ggggaagacc tacatagttc agatcctact
     2221 gtagaatcaa cgcaaaataa ccagtggaca gaggtgatgt tcatggcaac ccaagaactt
     2281 ctacggatcc cccaagcagc cctggccaag ccaatctcta tacccacaaa tctagtgtct
     2341 ctcttttctc gctatgttga ccggcagaaa ctgaacttgc tggagacaaa actgcagctg
     2401 gttcagggga tgcgataaaa gacctccaga gtgtcctgta tctccttctg gctgccacct
     2461 gcactgctga catcaccaat ggagtggttc taatgagaga ggggaggtag cttaggaccc
     2521 aaagcaaagt cttgtgggat ccttgcctgt tttcagaagt tagctctgaa tgccagatat
     2581 tccctactgc tctggtactt ccgctgggtg gtacttctgc tggtttcttt taccttctgt
     2641 gttacacttt tgcatgtcct acttttactc aattcttctc agttttgcat tttctttgcc
     2701 ctagagacac aaatataata tcctttatcc catcaccact attacaattc aaagtaggtt
     2761 gtagtctacc aaagggctcc tcctcccttt gagttcttca tcttccctta ataatatgac
     2821 tataagagag ccaaaattaa gtagaattca ggatataagt aaatatatac acacccatac
     2881 acaaacattc atatggtctc cagagggtcc ttaaagaatg agctttagtt tgaaaagtat
     2941 ttagttaaca tatacctcta aaaataaacc agctgatata tttttactct gtttctgttc
     3001 catcttgtca tttggtggat tctacttttc taatatataa atacagggta cacagcacat
     3061 tacattaaat caaacttgtt aattggctga tgcccagctc taggctgaga gaacttttct
     3121 ttctcccttc ctgtatttcc tttgttcttc aagaccataa tagaaacagc acacacacgg
     3181 ttaagccttt tcctgtgatg actacagtgc ttgagtctgt gccctcaagt ccattcagga
     3241 gtacccaaga tgagcctcac ccagagcctg ctttctgcag tgcagcttct atgcacctgc
     3301 actgtcttcc tgacgtgact tctgtaagcc atgcttctgc ttctcttccc cattttcatt
     3361 tactgtcttg ggtagaaacc tccaaatgta atcatggctg ctaagcttgg gctctgctct
     3421 tcagtctgct ctaccctgca gcagaactgc tgtcctggct gcttagtctc acctgagccc
     3481 catccactgg cagccagtgg ggcctgggtt tgaatcttag ggacacttcc ctttcactca
     3541 cctttcttct cctcagcagt cagccaggat aagggactct gctcccttgg ggttgcagtt
     3601 ctgaaaacta aattgaattt attttatatt cccgtcctga tcctactttc tgctgttctc
     3661 acctttttga atgtagtcgg gggacaggct atgatattta aagagaataa atgttttgca
     3721 catacctgta taacagtgaa gccctccgtt gcaaccagct atctttgtac tcatctccat
     3781 ttcttctcat tttgtggcct caggctctac cagctgctcc ccagtgacag tccctagctt
     3841 ccttctacca tctgctgact gtctccactg agcctttcct accttccctt cacacccaat
     3901 caagtaaaca cttgattatt ttttcttctt tattgtgctt tttgttcagt tctaattaat
     3961 aaaaataaaa gtttctaaat ttaaaaaaaa aaaaaaaaaa aaaaaaa
//
