LOCUS       NM_080398               7640 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus PATJ, crumbs cell polarity complex component
            (Patj), mRNA.
ACCESSION   NM_080398 XM_006238423
VERSION     NM_080398.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7640)
  AUTHORS   Kim,J.Y., Song,J.Y., Karnam,S., Park,J.Y., Lee,J.J., Kim,S. and
            Cho,S.H.
  TITLE     Common and distinctive localization patterns of Crumbs polarity
            complex proteins in the mammalian eye
  JOURNAL   Gene Expr Patterns 17 (1), 31-37 (2015)
   PUBMED   25636444
REFERENCE   2  (bases 1 to 7640)
  AUTHORS   Zhang,J., Yang,X., Wang,Z., Zhou,H., Xie,X., Shen,Y. and Long,J.
  TITLE     Structure of an L27 domain heterotrimer from cell polarity complex
            Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly
            mode
  JOURNAL   J Biol Chem 287 (14), 11132-11140 (2012)
   PUBMED   22337881
  REMARK    GeneRIF: the crystal structure of a 4-L27 domain-containing
            heterotrimer derived from the tripartite complex Patj/Pals1/Mals2
REFERENCE   3  (bases 1 to 7640)
  AUTHORS   Nakajima,H. and Tanoue,T.
  TITLE     Lulu2 regulates the circumferential actomyosin tensile system in
            epithelial cells through p114RhoGEF
  JOURNAL   J Cell Biol 195 (2), 245-261 (2011)
   PUBMED   22006950
REFERENCE   4  (bases 1 to 7640)
  AUTHORS   Du,D., Xu,F., Yu,L., Zhang,C., Lu,X., Yuan,H., Huang,Q., Zhang,F.,
            Bao,H., Jia,L., Wu,X., Zhu,X., Zhang,X., Zhang,Z. and Chen,Z.
  TITLE     The tight junction protein, occludin, regulates the directional
            migration of epithelial cells
  JOURNAL   Dev Cell 18 (1), 52-63 (2010)
   PUBMED   20152177
REFERENCE   5  (bases 1 to 7640)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 7640)
  AUTHORS   Duning,K., Schurek,E.M., Schluter,M., Bayer,M., Reinhardt,H.C.,
            Schwab,A., Schaefer,L., Benzing,T., Schermer,B., Saleem,M.A.,
            Huber,T.B., Bachmann,S., Kremerskothen,J., Weide,T. and
            Pavenstadt,H.
  TITLE     KIBRA modulates directional migration of podocytes
  JOURNAL   J Am Soc Nephrol 19 (10), 1891-1903 (2008)
   PUBMED   18596123
REFERENCE   7  (bases 1 to 7640)
  AUTHORS   Wong,E.W., Mruk,D.D., Lee,W.M. and Cheng,C.Y.
  TITLE     Par3/Par6 polarity complex coordinates apical ectoplasmic
            specialization and blood-testis barrier restructuring during
            spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (28), 9657-9662 (2008)
   PUBMED   18621709
REFERENCE   8  (bases 1 to 7640)
  AUTHORS   Santillan,G., Baldi,C., Katz,S., Vazquez,G. and Boland,R.
  TITLE     Evidence that TRPC3 is a molecular component of the
            1alpha,25(OH)2D3-activated capacitative calcium entry (CCE) in
            muscle and osteoblast cells
  JOURNAL   J Steroid Biochem Mol Biol 89-90 (1-5), 291-295 (2004)
   PUBMED   15225788
REFERENCE   9  (bases 1 to 7640)
  AUTHORS   Chae,T.H., Kim,S., Marz,K.E., Hanson,P.I. and Walsh,C.A.
  TITLE     The hyh mutation uncovers roles for alpha Snap in apical protein
            localization and control of neural cell fate
  JOURNAL   Nat Genet 36 (3), 264-270 (2004)
   PUBMED   14758363
  REMARK    Erratum:[Nat Genet. 2004 Apr;36(4):427]
REFERENCE   10 (bases 1 to 7640)
  AUTHORS   Lemmers,C., Medina,E., Delgrossi,M.H., Michel,D., Arsanto,J.P. and
            Le Bivic,A.
  TITLE     hINADl/PATJ, a homolog of discs lost, interacts with crumbs and
            localizes to tight junctions in human epithelial cells
  JOURNAL   J Biol Chem 277 (28), 25408-25415 (2002)
   PUBMED   11964389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 21, 2015 this sequence version replaced XM_006238423.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.15508.1,
                                           SRR26643287.13554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000005.1  118177623-118177697
            76-134              JAXUCZ010000005.1  118191251-118191309
            135-301             JAXUCZ010000005.1  118191409-118191575
            302-496             JAXUCZ010000005.1  118194765-118194959
            497-636             JAXUCZ010000005.1  118198083-118198222
            637-832             JAXUCZ010000005.1  118199748-118199943
            833-961             JAXUCZ010000005.1  118203366-118203494
            962-1180            JAXUCZ010000005.1  118210778-118210996
            1181-1280           JAXUCZ010000005.1  118212591-118212690
            1281-1372           JAXUCZ010000005.1  118215140-118215231
            1373-1514           JAXUCZ010000005.1  118216723-118216864
            1515-1655           JAXUCZ010000005.1  118222079-118222219
            1656-1744           JAXUCZ010000005.1  118225597-118225685
            1745-1801           JAXUCZ010000005.1  118227147-118227203
            1802-1936           JAXUCZ010000005.1  118238027-118238161
            1937-2098           JAXUCZ010000005.1  118246520-118246681
            2099-2227           JAXUCZ010000005.1  118250769-118250897
            2228-2437           JAXUCZ010000005.1  118270123-118270332
            2438-2560           JAXUCZ010000005.1  118273901-118274023
            2561-2968           JAXUCZ010000005.1  118278349-118278756
            2969-3092           JAXUCZ010000005.1  118287864-118287987
            3093-3267           JAXUCZ010000005.1  118296198-118296372
            3268-3339           JAXUCZ010000005.1  118300284-118300355
            3340-3517           JAXUCZ010000005.1  118301954-118302131
            3518-3628           JAXUCZ010000005.1  118304791-118304901
            3629-3706           JAXUCZ010000005.1  118310036-118310113
            3707-3806           JAXUCZ010000005.1  118314753-118314852
            3807-4003           JAXUCZ010000005.1  118350575-118350771
            4004-4095           JAXUCZ010000005.1  118367973-118368064
            4096-4168           JAXUCZ010000005.1  118386376-118386448
            4169-4255           JAXUCZ010000005.1  118397837-118397923
            4256-4327           JAXUCZ010000005.1  118414780-118414851
            4328-4445           JAXUCZ010000005.1  118418395-118418512
            4446-4600           JAXUCZ010000005.1  118420462-118420616
            4601-4684           JAXUCZ010000005.1  118436429-118436512
            4685-4878           JAXUCZ010000005.1  118447382-118447575
            4879-5026           JAXUCZ010000005.1  118450432-118450579
            5027-5113           JAXUCZ010000005.1  118451473-118451559
            5114-5222           JAXUCZ010000005.1  118455025-118455133
            5223-5260           JAXUCZ010000005.1  118455671-118455708
            5261-5383           JAXUCZ010000005.1  118457831-118457953
            5384-5488           JAXUCZ010000005.1  118458620-118458724
            5489-5595           JAXUCZ010000005.1  118471412-118471518
            5596-7640           JAXUCZ010000005.1  118478257-118480301
FEATURES             Location/Qualifiers
     source          1..7640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..7640
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /note="PATJ, crumbs cell polarity complex component"
                     /db_xref="GeneID:140581"
                     /db_xref="RGD:1565362"
     exon            1..75
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            76..134
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..5623
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /note="PDZ domain protein; InaD-like 2; protein associated
                     to tight junctions; pals1-associated tight junction
                     protein; channel-interacting PDZ domain-containing
                     protein"
                     /codon_start=1
                     /product="inaD-like protein"
                     /protein_id="NP_536323.1"
                     /db_xref="GeneID:140581"
                     /db_xref="RGD:1565362"
                     /translation="MPENPAAEKMQVLQVLDRLRGKLQEKGDTTQNEKLSAFYETLKS
                     PLFNQILTLQQSIKQLKGQLSHIPSDCSANFDFSRKGLLVFTDGSITNGNAHRPCSSI
                     TASESLPWTQRSGNEDFTSVIQQMAQGRHIEYIDIERPSTGGLGFSVVALRSQSLGLI
                     DIFVKEVHPGSVADRDQRLKENDQILAINDTPLDQNISHQQAIALLQQATGSLRLVVA
                     REVGHTQSRTSTSSADTTLPETVRWGHTEDVELINDGSGLGFGIVGGKSSGVVVRTIV
                     PGGLADRDGRLQTGDHILKIGSTNVQGMTSEQVAQVLRNCGNSVRMLVARDPVGEIAV
                     TPPTPASLPVALPVVATRTLGSDSSPFETYNVELVKKDGQSLGIRIVGYVGTAHPGEA
                     SGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLV
                     RRKTSLSASPFEQPSSREAVAEPPEVPELTGSLKPETNSRMEAEEIGERLDNLRKDTV
                     QALEKPDVYPEDIPGCPENELKSRWENLLGPDYEVMVATLDTQIADDEELQKYSKLLP
                     IHTLRLGMEVDSFDGHHYISSIAPGGPVDTLNLLQPEDELLEVNGVQLYGKSRREAVS
                     FLKEVPPPFTLVCCRRLFDDEASVDEPRTVEPSLLEAEVDRSVDVSTEDDDGELALWS
                     PEVKTVELVKDCKGLGFSILDYQDPLDPMRSVIVIRSLVADGVAERSGELLPGDRLVS
                     VNEFSLDNATLAEAVEVLKAVPPGVVHLGICKPLVEEEKEEKEEHFIFHSNNNGDNSE
                     SPETVHEIHSSLILEAPQGFRDEPYLEELVDEPFLDLGKSLQFQQKDMDSSSEAWEMH
                     EFLSPRLERRGEEREMLVDEEYEIYQDRLRDMEAHPPPPHIREPTSASPRLDLQAGPQ
                     WLHADLSGGEILECHDTESMMTAYPQEMQDYSFSTTDMMKETFGLDSRPPMPSSEGNG
                     QHGRFDDLEHLHSLVSHGLDLGMMTPSDLQGPGVLVDLPAVTQRREQEELPLYRLPSA
                     RVVTKPSSHVGMVSSRHANAACELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLG
                     ISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTKALKTGDKILEVSGVDLQNASH
                     AEAVEAIKSAGNPVVFVVQSLSSTPRVIPSVNNKGKTPPQNQDQNTQEKKAKRHGTAP
                     PPMKLPPPYRAPSADTEESEEDSALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLA
                     GNKDRSRMSIFVVGINPDGPAAADGRMRVGDELLEINNQILYGRSHQNASAIIKTAPT
                     RVKLVFIRNEDAVNQMAVAPFPVPSHSPSPVEDLGGTEPVSSEEDSSVDAKPLPERES
                     SKPEDLTQAVDDSMVAEQEKASESPDSAARQMKQPGYSAQVSSSSQEIPSAPAPLCQS
                     THADVTGSGNFQAPLSVDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDT
                     PLDAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRSSSHEEAITALRQTPQKVRLV
                     IYRDEAQYRDEENLEVFLVDLQKKTGRGLGLSIVGKRSGSGVFISDIVKGGAADLDGR
                     LIRGDQILSVNGEDVRQASQETVATILKCVQGLVQLEIGRLRAGSWASSRKTSQNSQG
                     DQHSAHSSCRPSFAPVITSLQNLVGTKRSSDPPQKCTEEEPRTVEIIRELSDALGVSI
                     AGGKGSPLGDIPIFIAMIQANGVAARTQKLKVGDRIVSINGQPLDGLSHTDAVNLLKN
                     AFGRIILQVVADTNISAIATQLEMMSAGSQLGSPTADRHPQDPEELLQRTAD"
     exon            135..301
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            302..496
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            497..636
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            637..832
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            833..961
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1180
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1280
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1372
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1514
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1655
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1744
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1801
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1936
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2098
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2227
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2437
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2560
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2968
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3092
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3267
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3339
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3517
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3628
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3706
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3806
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..4003
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4095
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4168
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4255
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..4327
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4445
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4600
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4684
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..4878
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            4879..5026
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5113
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            5114..5222
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            5223..5260
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            5261..5383
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            5384..5488
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            5489..5595
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
     exon            5596..7640
                     /gene="Patj"
                     /gene_synonym="Inadl; Inadl2; RGD1565362"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagctgta cttccgccag gtgaggaggc cgtgatcgca gcctcggggc tcccacccgg
       61 ctgtcgcctg atcagactta ggattgaaag tgcttgaaaa gagtgatcca aaatgcctga
      121 aaaccctgct gcagagaaaa tgcaggtcct gcaggtcctc gaccgcctga gggggaagct
      181 gcaagagaag ggagacacga cgcagaacga gaagctgtct gcgttttatg agacgctgaa
      241 gagccctctc ttcaaccaga tccttacact gcagcagtcc atcaagcagc tgaagggaca
      301 gctcagccat atcccctcag attgttcagc caactttgac ttttctcgga agggcttgtt
      361 agtgttcacg gatggttcca ttacaaatgg gaatgcccac aggccttgta gtagtataac
      421 tgcatctgaa tcgttgcctt ggactcaaag atcaggaaat gaagacttta cctcagtcat
      481 tcagcagatg gctcagggcc ggcacattga gtatatagat atagaacgcc cttcaactgg
      541 aggccttgga ttcagtgtgg tggctctgag aagccaaagt ctgggattaa ttgacatctt
      601 tgtgaaggaa gtccatccgg ggagtgtagc agacagggat cagagattga aggaaaatga
      661 ccagattttg gccattaatg acaccccatt ggatcagaat atttcccatc agcaggcgat
      721 tgcattacta caacaagcca ctggatctct gcggctggtt gtggccaggg aagtgggcca
      781 cacacagagc cgaacatcca ccagctcagc tgatacaact ctgccagaaa cggtgcgttg
      841 gggccacact gaagatgttg agctcattaa tgatggctct ggattaggtt ttgggatagt
      901 tggaggcaaa tccagtggtg tggtcgtgag gactattgtc cctggaggat tggcggaccg
      961 agatggaaga ctacagacag gggaccacat cttaaagatt ggaagtacaa acgtgcaagg
     1021 aatgaccagt gaacaagttg ctcaggtgct aagaaattgt gggaattcag tgaggatgct
     1081 ggtggccaga gaccctgttg gtgaaattgc agtaacacct ccgacgcctg catccttacc
     1141 tgttgccctc cctgttgtag ccacaaggac ccttggttct gacagttctc cttttgagac
     1201 ttacaatgtt gaacttgtca aaaaagatgg acagagtctt gggattagaa ttgttggcta
     1261 tgttggaaca gctcatccag gggaagcttc agggatttat gtgaaaagta taatcccagg
     1321 cagcgctgca taccacaatg gccaaattca agtgaacgat aaaattgtgg ctgtggatgg
     1381 tgtgaatatt cagggttttg ccaatcagga cgttgttgaa gttctgcgga acgcagggca
     1441 ggtggtgcac ctgaccctag ttcgaaggaa aacatcttta tctgcttctc catttgaaca
     1501 accttcaagc agagaagctg ttgcagaacc acctgaagtg ccagaactaa ctggatccct
     1561 gaaaccagaa actaattcga gaatggaagc agaggaaatc ggagaaagac tggataatct
     1621 gagaaaggac accgtacaag ccttagaaaa accagacgta tatccagagg acatcccagg
     1681 ctgtccagaa aatgagctga aatccagatg ggaaaaccta ctgggcccag attatgaagt
     1741 aatggtagcc acgttggaca cgcagatagc agatgatgag gagcttcaga agtactccaa
     1801 gctgctgcct atccacactc tgaggcttgg tatggaggtg gactccttcg atgggcacca
     1861 ctatatctcc tccattgctc ctgggggtcc tgtggatacc ctgaacctcc tgcagccaga
     1921 ggatgagctt ctcgaggtca atggcgtgca gctttatggg aagtctcgcc gagaagcagt
     1981 ctcctttctt aaagaagtgc ccccaccatt taccttggtt tgctgccgcc ggctgtttga
     2041 tgacgaggcc tcagttgatg agccgagaac tgtggaacct tctcttcttg aggcagaggt
     2101 cgaccgcagt gtagatgtca gcactgaaga tgatgatgga gaattagccc tgtggtctcc
     2161 tgaagtcaag actgtggagc tggtcaaaga ctgcaaaggc ttaggattca gcattttgga
     2221 ttatcaggac cccctggatc ccatgaggtc agtgattgtg attcgctcct tggtggcaga
     2281 tggcgtagca gaaagaagtg gagaactttt gcctggagat cgcctagtct ccgtcaatga
     2341 gttctctctg gacaatgcca ctcttgctga ggctgtggaa gtgttgaagg ctgtaccccc
     2401 aggtgtggtg caccttggca tctgtaagcc tttggtggag gaggagaagg aggagaagga
     2461 ggaacatttt attttccatt caaacaacaa tggagataac agtgagtctc cagaaaccgt
     2521 tcacgagatc cactcatctt taatcctcga ggcaccccag ggatttagag atgagccgta
     2581 tcttgaagaa ctcgtggatg aaccttttct agatttggga aagtctttgc agttccaaca
     2641 aaaagacatg gacagcagct cagaagcctg ggaaatgcat gaattcctga gccctcggct
     2701 ggagagaagg ggtgaggaaa gagagatgct tgttgacgag gagtatgaga tctaccaaga
     2761 ccgcctccgg gacatggaag cacacccacc acctcctcac attcgggagc ccacttctgc
     2821 atctcccagg ctggatctcc aggccggccc ccagtggctg catgctgacc tctcaggagg
     2881 agagatactc gagtgtcacg acacagagtc catgatgact gcttatcccc aggagatgca
     2941 ggactatagc ttcagcacca cagacatgat gaaagaaaca tttggccttg actcccggcc
     3001 gcccatgccc tcctctgaag gaaatggtca gcacggccga tttgatgact tggaacatct
     3061 tcactcacta gtgagccacg gcctggattt aggcatgatg actccaagtg acttgcaagg
     3121 ccctggcgtg cttgtagatc ttccagctgt cacccaaaga agagaacagg aagagttgcc
     3181 cctgtaccga ctccccagtg cccgtgtggt caccaagcct tcctcgcacg tgggaatggt
     3241 gtcttcacga catgcaaatg ctgcatgtga attacctgag agagaggaag gtgaaggaga
     3301 ggaaacaccg aacttcagtc actggggccc accaagaatt gttgaaatct ttagagaacc
     3361 taatgtgtct cttggcatca gcattgttgg tggacaaaca gttataaaac gcctcaagaa
     3421 tggagaagaa ctcaagggta tattcatcaa gcaagtgtta gaagacagtc ctgcggggaa
     3481 gaccaaggcc cttaaaactg gagataaaat acttgaggtg tctggtgtag acctgcagaa
     3541 tgcctcgcat gcagaagccg tggaggcaat caagagtgca gggaaccctg tggtgttcgt
     3601 ggtacagagc ctgtcatcca ccccaagggt catcccaagt gtgaataaca aaggcaaaac
     3661 acctccccag aatcaggacc aaaacactca agaaaagaaa gctaagaggc acggaacagc
     3721 tccaccgcca atgaaactgc ccccacctta cagagctccc tctgcagaca ctgaggagag
     3781 tgaagaagac agtgccctga ccgacaaaaa gatcaggcaa agatatgcag acctgcctgg
     3841 agaattgcac atcatcgaac tggaaaagga taagaatgga ctgggactca gtctcgctgg
     3901 caacaaggac cggtcacgga tgagcatatt tgtggtgggg attaacccag atggacctgc
     3961 tgctgcagat ggacggatgc gggttggaga tgagctgcta gagataaaca atcagatcct
     4021 ttatggaaga agtcatcaga atgcatctgc cattattaag actgccccga ccagggtcaa
     4081 actggttttc attagaaacg aagatgcagt caatcagatg gccgtcgctc ccttccccgt
     4141 accatcacat tccccatcgc ctgttgagga tctgggtggc actgaacctg tcagtagtga
     4201 ggaagacagc agtgtggatg ctaaacccct gcctgaaaga gaaagctcca agccggaaga
     4261 cctgacccag gcggttgatg acagcatggt ggcagagcag gagaaggcat cagagtcacc
     4321 tgacagtgct gcccgccaga tgaaacagcc aggatactca gcacaagtct cctccagctc
     4381 acaagagatc ccgtcagcac cagctccctt gtgtcagtca acacatgcag acgtcacagg
     4441 ctctggtaac ttccaggctc ccctctcagt ggaccctgct cctctctcag tggaccctgc
     4501 aacatgtccc attgtccctg gccaagaaat gatcatagaa atatccaagg ggcgctccgg
     4561 gcttggactc agcatcgttg gaggaaagga cacgcctttg gatgctatcg ttatccatga
     4621 agtctatgaa gaaggtgcag cagcccgaga tggaagatta tgggctggag accagatatt
     4681 agaggttaat ggggttgatc tgaggagctc cagccatgaa gaagccatca cagccctgag
     4741 gcagacgccc cagaaggtga ggctggtgat atacagagat gaagcacagt acagagatga
     4801 ggagaacttg gaggtgttcc ttgtggatct gcagaagaag actggccgag gactaggcct
     4861 gagcattgtt gggaaacgga gtggaagcgg agtgttcatc tctgacattg tgaaaggcgg
     4921 agccgcagac ctcgatggga ggctaattcg aggagaccag atcttgtctg tgaatggaga
     4981 ggacgtgaga caagcctcac aggagacagt ggccaccatc ctgaagtgcg tccagggcct
     5041 tgtccagctg gagattggga gactccgagc cggttcctgg gcctcctcga ggaagacctc
     5101 acagaacagc cagggagatc agcacagtgc acacagcagc tgtcggcctt cctttgcccc
     5161 agtcatcacc agcctacaaa acctggttgg cacaaaaaga tcttcagatc ctccccagaa
     5221 atgcacagag gaggaaccac ggactgttga gataatcaga gagctcagtg atgctcttgg
     5281 agtcagtatc gctggaggaa aaggaagtcc tttaggagat ataccgatat ttattgccat
     5341 gattcaggcc aatggagtgg ccgcacgtac ccagaagctg aaggttggag atcggattgt
     5401 gagcattaat ggacaacctc tggacggact gtctcacaca gatgccgtta atctactaaa
     5461 gaacgccttc gggcgcatta tcctgcaggt cgtggcagac accaacatca gcgccatagc
     5521 gactcagctt gaaatgatgt ctgcaggctc ccagcttggc tctcccactg ctgaccgaca
     5581 tccgcaagac ccggaggagc tgttgcagag gaccgccgat taaagcgagg tgggcagctc
     5641 ttcagtggtg ttacccggaa ggcgttaccc ggaaggcgtt acccatgagc aagctgtctc
     5701 cattctaaag cagcagagag gggccgtggc cctgcctgct gctgccgccg tgagctacgg
     5761 gtcctgactt tttaacgaga atacagcaga attatgcggc ttccggttgg gatgaaaagt
     5821 tgcctcggct caaacccagt atcatcattg gctctgattc tgtttacaga aactggagct
     5881 gtggtctctg cttcctactc acatccccgg ttcccacaga ggcttaactg caaactcctg
     5941 tggtttcatc taatgagtag aaacaaaggt ttagcttgtc atcttaactc gtgatttact
     6001 tatgctaatt tgcctcttca aataaaccag aaaacattag cagtgtaatt aacttcctcg
     6061 caatgaacta ttcatatgct accgctggga attacagcag actgttctgt gtgactcagt
     6121 caagtggacc tcccgtccct gtctccggat aggtctgtat gttagccgtt ggcgattctg
     6181 aggagtccat ttacagacgc tgtaagctac tcaccatcct aataggcttt gtttctgagt
     6241 ttgacagcgc acactccaca ggaacaagta gccctcctgt ttgtgttcta tccacactag
     6301 ctcacattac tgggaagcta ctgggagtga tgggcatctt agcaggtcaa aatcaccggt
     6361 tcccaacccc tgcagactgc aggcgaggag gtggaaaccc tagaccacac tgcagagata
     6421 agcaagtttg agcggcctca gccctattgg aagcgagtta caagtttggt ttgcctctcc
     6481 ttcgccttca taccagtctg cagagggctg tgtgcagccc ttgaacataa aggaactgag
     6541 caaatgccct gggaatcaga cacagaagtg cttagcccga gtttcccagt ctccgcttcc
     6601 tattggctga agttctgtag ctgaaacagc aactgtggct gaagcctaag agtgcttgta
     6661 gagtgaaagg ggctgggaag ggagatgctc gtcactgaga acaaaggaaa gtgccatgaa
     6721 gggtgagtac agggtcagca gcagacatag tttagcatcc tagaactata actcagtgca
     6781 gcagattgct cagcaattac ccggagttta atgggcccta atttaaaatg ttatttaact
     6841 agtgaggatg ttaactgaag ttccctttga gtagatgtaa tcacaaagtg cactgactct
     6901 tgttgagata tttttcgtgg ctattagaaa gtgcagaatg cctcactttt atgctgacag
     6961 cgtattgcga tgaccggcat taaggttttt tgagattcta taggtttttt tagaatttat
     7021 aatgtatcta agatacatgg tttggttagc atctcatccc cagttcatga gaagccacca
     7081 acctcagtgt cctgtgtgaa tggtacccac aagaagacct caagcagcag aaaccaaatg
     7141 aagcccaatg aaagtgcacc ttaaacaata aagatagtga cattaatgct ttccaagtgg
     7201 gatcccgctc acttttaatg gaatggaatg gcgttaaata cacatattga aataacgtgt
     7261 tgttttgtct tcatttatac atcatctgtt taggggatgc ctctcgaagt ctattaatgt
     7321 agtaactgat acttgatgca tcgagttcct cagggaccca gtgagtaatt gctgtgcccg
     7381 aaatggtgtg atcccttcag agcttcctac acaccgagaa tgccacaatt gacaagagga
     7441 attttctaaa aattacacat actacatttt tggcccttta agcctagtat tagtgttgtt
     7501 aattggagtg agtccaagag gtaagcaaac tagaaaacta aaagttcaga gtggttttca
     7561 tgtagatgtt tctaaaggtt ctgaataaag cagctgccta aggagcaaga agagacacgg
     7621 ttggtgctgt ccacgtttta
//
