LOCUS       NM_001009362            4562 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PAS domain containing serine/threonine kinase
            (Pask), mRNA.
ACCESSION   NM_001009362 XM_217480
VERSION     NM_001009362.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4562)
  AUTHORS   Liu,Y.Q., Liu,Y.F., Ma,X.M., Xiao,Y.D., Wang,Y.B., Zhang,M.Z.,
            Cheng,A.X., Wang,T.T., Li,J.L., Zhao,P.X., Xie,F. and Zhang,X.
  TITLE     Hydrogen-rich saline attenuates skin ischemia/reperfusion induced
            apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway
  JOURNAL   J Plast Reconstr Aesthet Surg 68 (7), e147-e156 (2015)
   PUBMED   26003800
  REMARK    GeneRIF: Hydrogen-rich saline ameliorated inflammatory infiltration
            and decreased cell apoptosis;tissues with a high expression of
            Bcl-2 and a low expression of pASK-1, pJNK, and Bax, a larger
            survival area and a high level of blood perfusion.
REFERENCE   2  (bases 1 to 4562)
  AUTHORS   Vorontsova,I., Lam,L., Delpire,E., Lim,J. and Donaldson,P.
  TITLE     Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and
            human lenses
  JOURNAL   Invest Ophthalmol Vis Sci 56 (1), 310-321 (2014)
   PUBMED   25515571
  REMARK    GeneRIF: WNK 1, 3, 4, OSR1, and SPAK signaling system known to play
            a role in regulating the phosphorylation status, and hence activity
            of the CCCs in other tissues, is also present in the rat and human
            lenses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4562)
  AUTHORS   Hurtado-Carneiro,V., Roncero,I., Blazquez,E., Alvarez,E. and
            Sanz,C.
  TITLE     PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic
            cells required for the normal expression and activity of other
            cellular nutrient and energy sensors
  JOURNAL   Mol Neurobiol 48 (3), 904-920 (2013)
   PUBMED   23765195
  REMARK    GeneRIF: PASK is a key kinase in GLP-1 actions and exerts a
            coordinated response with the other metabolic sensors.
REFERENCE   4  (bases 1 to 4562)
  AUTHORS   Semache,M., Zarrouki,B., Fontes,G., Fogarty,S., Kikani,C.,
            Chawki,M.B., Rutter,J. and Poitout,V.
  TITLE     Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1
            protein stability via phosphorylation of glycogen synthase kinase
            3beta in pancreatic beta-cells
  JOURNAL   J Biol Chem 288 (34), 24825-24833 (2013)
   PUBMED   23853095
  REMARK    GeneRIF: PASK phosphorylates and inactivates GSK3beta, thereby
            preventing PDX-1 serine phosphorylation and alleviating
            GSK3beta-mediated PDX-1 protein degradation in pancreatic
            beta-cells.
REFERENCE   5  (bases 1 to 4562)
  AUTHORS   Semplici,F., Vaxillaire,M., Fogarty,S., Semache,M., Bonnefond,A.,
            Fontes,G., Philippe,J., Meur,G., Diraison,F., Sessions,R.B.,
            Rutter,J., Poitout,V., Froguel,P. and Rutter,G.A.
  TITLE     Human mutation within Per-Arnt-Sim (PAS) domain-containing protein
            kinase (PASK) causes basal insulin hypersecretion
  JOURNAL   J Biol Chem 286 (51), 44005-44014 (2011)
   PUBMED   22065581
  REMARK    GeneRIF: Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK)
            has a role in insulin hypersecretion
REFERENCE   6  (bases 1 to 4562)
  AUTHORS   Fontes,G., Semache,M., Hagman,D.K., Tremblay,C., Shah,R.,
            Rhodes,C.J., Rutter,J. and Poitout,V.
  TITLE     Involvement of Per-Arnt-Sim Kinase and extracellular-regulated
            kinases-1/2 in palmitate inhibition of insulin gene expression in
            pancreatic beta-cells
  JOURNAL   Diabetes 58 (9), 2048-2058 (2009)
   PUBMED   19502418
  REMARK    GeneRIF: PASK is a novel mediator of glucolipotoxicity on the
            insulin gene in pancreatic beta-cells
REFERENCE   7  (bases 1 to 4562)
  AUTHORS   Soliz,J., Soulage,C., Borter,E., van Patot,M.T. and Gassmann,M.
  TITLE     Ventilatory responses to acute and chronic hypoxia are altered in
            female but not male Paskin-deficient mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 295 (2), R649-R658 (2008)
   PUBMED   18509100
REFERENCE   8  (bases 1 to 4562)
  AUTHORS   Hao,H.X., Cardon,C.M., Swiatek,W., Cooksey,R.C., Smith,T.L.,
            Wilde,J., Boudina,S., Abel,E.D., McClain,D.A. and Rutter,J.
  TITLE     PAS kinase is required for normal cellular energy balance
  JOURNAL   Proc Natl Acad Sci U S A 104 (39), 15466-15471 (2007)
   PUBMED   17878307
  REMARK    GeneRIF: PASK acts in a cell-autonomous manner to maintain cellular
            energy homeostasis and is a potential therapeutic target for
            metabolic disease
REFERENCE   9  (bases 1 to 4562)
  AUTHORS   Eckhardt,K., Troger,J., Reissmann,J., Katschinski,D.M.,
            Wagner,K.F., Stengel,P., Paasch,U., Hunziker,P., Borter,E.,
            Barth,S., Schlafli,P., Spielmann,P., Stiehl,D.P., Camenisch,G. and
            Wenger,R.H.
  TITLE     Male germ cell expression of the PAS domain kinase PASKIN and its
            novel target eukaryotic translation elongation factor eEF1A1
  JOURNAL   Cell Physiol Biochem 20 (1-4), 227-240 (2007)
   PUBMED   17595531
REFERENCE   10 (bases 1 to 4562)
  AUTHORS   Wilson,W.A., Skurat,A.V., Probst,B., de Paoli-Roach,A., Roach,P.J.
            and Rutter,J.
  TITLE     Control of mammalian glycogen synthase by PAS kinase
  JOURNAL   Proc Natl Acad Sci U S A 102 (46), 16596-16601 (2005)
   PUBMED   16275910
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087047.1.
            
            [WARNING] On Jul 27, 2024 this sequence was replaced by
            NM_001009362.2.
            
            On Jan 7, 2005 this sequence version replaced XM_217480.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087047.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..4562
                     /gene="Pask"
                     /note="PAS domain containing serine/threonine kinase"
                     /db_xref="GeneID:301617"
                     /db_xref="RGD:1306146"
     exon            1..69
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            70..299
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..4276
                     /gene="Pask"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="PAS domain-containing serine/threonine-protein
                     kinase"
                     /protein_id="NP_001009362.1"
                     /db_xref="GeneID:301617"
                     /db_xref="RGD:1306146"
                     /translation="MEDRGPPVLAEDWKSESLPAQEGPATQAFVEPSKPLSIAHRHLN
                     RKNGLSRLCQSRMALSEDRWSSYCLSSLAAQNICTSKLHCAATPDYADPIAGPLGSTS
                     CCSLLRGLASGCSGPLLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIG
                     QKLTQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQ
                     DRGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPS
                     IQLPPPGQHVPKSLKIQRSVGRARDGTTFPLSLKLKSKTSGKAVAESEVASEPGYQAS
                     VWVFCTISGLITLLPDGTIYGINHSFALMLFGYGKTELLGKNITCLIPGFYHCMDLAY
                     DSSVQLPDLVNCLDIGSKSGPGEMSSDAKQDWELASGAQDPRIDVLTRGHMPSQDETL
                     KLRGGQVSPRTQTQLETGRHILPSCASQPSLGVDSSPVDGERSLPTDQRNVPKRNLLA
                     HAEQLLSQTQPDTLEISPPVLKELSEIQKNISEESPLTHRKWLLSKAQKDTTKGSLPI
                     HDEKLLLASQHIHVLGKENPSAAESYREGLLAESRSKPVDAKPFASCEDSELLVPAKD
                     RSNRADMSSLQQEAQLELMGISSPGSPNPWADATMPEPHTTGQIPGGSLTYCPQHRSE
                     WILQQRGQDSAPSPSAMGCVFVGTPTLDEPWPGVRNDREELQTCLIKEQLSKSSFGGA
                     LGISCVELVPAEHPPFTAPVSFCDWGGRDLHASRSGSSSACYALATDLPGVLEAVEAQ
                     EADVSSYSWNLRELFLNDRTDRTPSHCSCTTSELSETPSLSGVGSDLDVGILHRQTSD
                     ILAHREMLLLSGTYFDLREGHRFQEMGAGHDGAELSNISLVSSEHYETSDIESLGCDP
                     PIPDPGPNNMCLSAEKPRLSAQITSTPVAPGPTSLQQEIQEGIFSGSCYHRDGLRLSV
                     QFEVKRVQLQGSATLFCCWLVKDFLHSHRDSATRTRLFLASLPSSTHSMPDLSGSSFG
                     EMLRAKPWFEESPTPAELEGLAACEGEYSHKYNTLRPLGSGAFGFVWTAVEKEGNKEV
                     VVKFIKKEKVLEDCWVEDPKLGRVPLEISILSKVEHANIIKIVDVFENQGFFQLVMEK
                     HGSGLDLFAFIDRHPCLDEPLASYIFRQLVSAVRYLRSQGIIHRDIKDENIVIAEDFT
                     IKLIDFGSAAYLEKGKLFYTFCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFE
                     ENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIVDPWVTQPVNL
                     DNYTWEEVCRTSQPESGLMSAASLELASRSPSEVAQTEGLCRPPAPKEAPGNHCLHLE
                     DPSSPVS"
     exon            300..535
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            536..706
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            707..847
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            848..982
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1243
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1412
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1563
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..3029
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3211
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3379
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3505
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3640
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            3641..3840
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..3974
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4121
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4533
                     /gene="Pask"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtttgaccc gcgctcagga gccgccagcg cccgaaagtc tctgactgaa ctggaagctt
       61 tgctttaagg tgagggctgt tggaagcaag agcttggtga ccagttgctc tgctcttcat
      121 ggaggacaga ggtccaccag ttcttgctga ggactggaag tctgagagtc ttcctgccca
      181 agagggccca gctacccagg ctttcgttga gcccagcaag cctctctcca tagcccatag
      241 acacctgaac aggaagaatg ggctttctag actctgccag agccgaatgg cactctccga
      301 ggataggtgg agctcttact gtctttcatc attggctgcc caaaacatct gcacaagcaa
      361 actgcactgc gctgctacac ctgactatgc tgaccctata gctggcccac tgggcagtac
      421 atcgtgctgc tccttgctac gtggcctagc ttcagggtgc tctggacctc tgctctcgac
      481 ccctgtgtgc aaccctaaca aggctgtctt tactgtggat gccaagacca cagagattct
      541 ggttgccaat gacaaagcct gcagcctcct ggggtatagc agtcatgacc tgattggcca
      601 aaagcttaca cagttcttcc tcaagtctga ttccgaggtt gtggaagccc tcagcgagga
      661 gcatgtggag gctgatggcc acgctgcagt agtgttcggc acggtggtgg acattgtcag
      721 ccgaagtggg gagaagattc ccgtctctgt gtggataaag aggttgcaac aagatcgtgg
      781 cttgtgctgt gtagtggttc tggagcctgt ggagagggtc tcagcctggg tcgccttcca
      841 gagtgatgga actatcacgt catgcgacag cctctttgct catcttcatg ggttcacatc
      901 tccaaaggat gtggttgggc agtgtgtcat agacttgatt ccatctatac agctccctcc
      961 tcctggccaa catgtcccaa agagtctcaa gattcaaagg tctgttggga gagccagaga
     1021 cgggaccacc ttccctctca gtctgaagtt gaaatctaag accagtggaa aggctgtagc
     1081 tgaaagtgag gtggcctcag aaccaggtta ccaggcttct gtgtgggtgt tctgcaccat
     1141 cagtggcctc atcactctcc tgcctgatgg cacaatttat ggcatcaacc acagctttgc
     1201 actaatgttg tttggttatg gaaaaacaga gctcctgggc aagaacatca cttgcctgat
     1261 tcctggtttc taccactgca tggaccttgc atatgatagt tctgtccagc tgccagatct
     1321 ggtcaactgc ctggacattg gcagcaagag tgggcctggg gagatgagtt ctgatgccaa
     1381 gcaggactgg gagctggcca gtggggccca agatccaaga attgatgtgt tgacacgggg
     1441 ccacatgcca tcacaagatg agaccctgaa gctgcgggga ggacaagtct cgcctaggac
     1501 tcagactcag ctggaaactg gacgccacat acttccttct tgtgcatctc agccctccct
     1561 gggggtagac agcagcccag tggacggtga gcggtcatta cccacagacc agcggaacgt
     1621 tccaaagaga aacctgctag cccatgctga acagttacta tctcagaccc aaccagacac
     1681 cctggaaata tccccaccag tccttaaaga actgtctgaa attcagaaaa atatctcaga
     1741 agaaagccca ctaacccaca ggaaatggtt attgtccaag gcccagaaag acaccacaaa
     1801 aggaagcctg ccaatccatg atgagaagtt actgcttgca agccagcata tccatgtctt
     1861 gggaaaggaa aatccttcag cagcagagag ctacagggag ggtcttttag cagaaagcag
     1921 gtccaaacca gtggatgcaa aaccgtttgc ttcatgtgaa gattctgagc ttctagtccc
     1981 agctaaggac agaagcaaca gagcggacat gagtagtctg caacaggaag ctcaattgga
     2041 gctgatgggt atcagtagtc ccggtagtcc taacccctgg gctgatgcca ccatgcctga
     2101 gccccacacc acagggcaga taccaggagg gagcctgaca tactgcccac agcatagaag
     2161 cgagtggatc ttacaacagc gaggccagga ctcggctccc agcccctctg caatggggtg
     2221 tgtctttgtt gggacaccca ctctggatga accatggcca ggagtgagaa atgatcgaga
     2281 agagctgcag acttgcttga ttaaggaaca gttgtccaag tcaagctttg ggggagctct
     2341 aggaatctcc tgtgtggaac ttgtcccagc agaacatcct cctttcactg cccccgtgtc
     2401 cttctgtgat tggggaggcc gagacctaca tgctagccgc tcaggcagct cctcagcctg
     2461 ctatgctttg gccactgacc tccctggtgt cttggaggca gtggaagccc aggaggctga
     2521 tgtgagttct tattcctgga acctcaggga gctctttctc aatgaccgga cagacagaac
     2581 tccatcacat tgttcctgta ccacttctga acttagcgag acaccatctc tttcaggggt
     2641 ggggtcagat ttagatgtgg gtattctgca caggcagact tcagatattt tagctcaccg
     2701 agagatgttg cttcttagtg ggacctattt tgaccttagg gaaggccatc ggttccagga
     2761 gatgggagca ggacatgatg gagcagaact gtctaacatt tctttggtat cctctgaaca
     2821 ctatgaaact agtgacatag aaagcctagg ttgtgaccct cccataccag atcctggtcc
     2881 taacaatatg tgcctatcag cagagaagcc tagactgagt gcccagatca cttccactcc
     2941 tgtggcacct gggcccacca gcctgcagca ggagatccag gagggcatct tctctggaag
     3001 ctgctaccac cgagatggct tacgactgag tgtacagttt gaagtaaagc gtgtgcagct
     3061 ccagggctct gcaaccctgt tctgctgctg gctggtgaag gacttcttac acagtcaccg
     3121 ggactcagcc acccgaaccc gcctgttcct tgccagcctg ccaagctcta cccactccat
     3181 gcctgacctc tctggatcca gctttggaga gatgctcaga gccaagcctt ggtttgagga
     3241 gtccccaaca cccgcagagc tggaggggct ggcagcctgt gagggcgagt actcccataa
     3301 gtacaacacc ctgcgcccac tcggcagtgg cgcctttggc tttgtgtgga ctgcagtgga
     3361 gaaggaaggc aacaaagagg tggtggtgaa gtttattaag aaggagaagg ttttagagga
     3421 ttgttgggtt gaagatccca aacttggaag agttccttta gagatttcaa ttctgtccaa
     3481 ggtggaacat gccaacataa tcaagattgt ggatgtattc gaaaaccaag ggttctttca
     3541 gctagtgatg gaaaagcatg gctctggctt ggacctcttt gctttcattg accgtcatcc
     3601 ctgcttggat gagcccctgg cgagttacat cttccgacaa ctggtgtctg ctgtaagata
     3661 cttgcgttcc caaggcatca tccatagaga catcaaggat gagaacattg tgattgctga
     3721 ggacttcaca attaagctga tagattttgg ctcagctgcc tacttagaga agggcaaact
     3781 attttatacc ttttgtggaa caattgaata ctgtgcacct gaagttctca ttggaaatcc
     3841 ctacagaggg ccagagctgg agatgtggtc tctcggggtc acgctgtaca cgctcatctt
     3901 cgaggagaat cccttctgtg aggtggagga gaccatggag gcagttattc atcccccctt
     3961 cctggtttcc caagaactta tgagtcttct gtctgggctg ctgcagcctt gccctgagca
     4021 gcggaccact ttggagaagc tgattgtgga cccctgggtg acacagcctg tgaaccttga
     4081 taactacacc tgggaagagg tgtgtcggac cagccagcca gaaagtggcc tgatgtcagc
     4141 tgcaagtctg gagcttgcga gtaggagtcc aagtgaagtg gctcagacag agggtctttg
     4201 tagacctcct gctcccaagg aggctcctgg taaccactgc ttgcatcttg aggatccctc
     4261 gtcaccagtc agctgagcaa gtgctcctct tctccacatg gtttggggaa ttgtatggat
     4321 tttagggctt ccactggaga aaggagttgt gaagaatcgg catgaatccc tctatagatt
     4381 cctgtgcgaa tctacaagag cctgcggtac tatttttctt aggtttgtga tacagacttg
     4441 taacatgtta ttttttataa ccttgaaaat cattctaatg ttcgattaca ttgtactatt
     4501 aaagggcttt aagttgtgag cctcagaaag acaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4561 aa
//
